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HRP20020379A2 - Indeno-, naphtho- and benzocyclohepta-dihydrothiazole derivatives, the production thereof and their use as anorectic medicaments - Google Patents

Indeno-, naphtho- and benzocyclohepta-dihydrothiazole derivatives, the production thereof and their use as anorectic medicaments Download PDF

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Publication number
HRP20020379A2
HRP20020379A2 HR20020379A HRP20020379A HRP20020379A2 HR P20020379 A2 HRP20020379 A2 HR P20020379A2 HR 20020379 A HR20020379 A HR 20020379A HR P20020379 A HRP20020379 A HR P20020379A HR P20020379 A2 HRP20020379 A2 HR P20020379A2
Authority
HR
Croatia
Prior art keywords
alkyl
phenyl
cycloalkyl
substituted
coo
Prior art date
Application number
HR20020379A
Other languages
English (en)
Croatian (hr)
Inventor
Gerhard Jaehne
Matthias Gossel
Hans Jochen Lang
Martin Bickel
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE2000113306 external-priority patent/DE10013306A1/de
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Publication of HRP20020379A2 publication Critical patent/HRP20020379A2/hr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
HR20020379A 1999-11-05 2000-10-21 Indeno-, naphtho- and benzocyclohepta-dihydrothiazole derivatives, the production thereof and their use as anorectic medicaments HRP20020379A2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19953205 1999-11-05
DE2000113306 DE10013306A1 (de) 2000-03-17 2000-03-17 Polycyclische, in 2-Stellung mit substituierten Alkylresten versehene Dihydrothiazole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
PCT/EP2000/010396 WO2001032638A1 (de) 1999-11-05 2000-10-21 Indeno-, naphtho- und benzocyclohepta-dihydrothiazol derivate, deren herstellung und deren verwendung als anorektische arzneimittel

Publications (1)

Publication Number Publication Date
HRP20020379A2 true HRP20020379A2 (en) 2004-02-29

Family

ID=26004890

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20020379A HRP20020379A2 (en) 1999-11-05 2000-10-21 Indeno-, naphtho- and benzocyclohepta-dihydrothiazole derivatives, the production thereof and their use as anorectic medicaments

Country Status (26)

Country Link
US (1) US6387935B1 (es)
EP (1) EP1230230B1 (es)
JP (1) JP2003524632A (es)
KR (1) KR20020047331A (es)
CN (1) CN1176080C (es)
AR (1) AR026338A1 (es)
AT (1) ATE250045T1 (es)
AU (1) AU777569B2 (es)
BR (1) BR0015322A (es)
CA (1) CA2389703A1 (es)
CZ (1) CZ20021528A3 (es)
DE (1) DE50003761D1 (es)
DK (1) DK1230230T3 (es)
EE (1) EE200200235A (es)
ES (1) ES2206320T3 (es)
HR (1) HRP20020379A2 (es)
HU (1) HUP0203290A3 (es)
IL (1) IL149400A0 (es)
MX (1) MXPA02003477A (es)
NO (1) NO322309B1 (es)
NZ (1) NZ518751A (es)
PL (1) PL354533A1 (es)
PT (1) PT1230230E (es)
SK (1) SK6132002A3 (es)
WO (1) WO2001032638A1 (es)
YU (1) YU29602A (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
EP1734963A4 (en) 2004-04-02 2008-06-18 Merck & Co Inc METHOD FOR TREATING PEOPLE WITH METABOLIC AND ANTHROPOMETRIC DISORDER
US7879802B2 (en) 2007-06-04 2011-02-01 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
AU2009256157B2 (en) 2008-06-04 2014-12-18 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
JP2011528375A (ja) 2008-07-16 2011-11-17 シナジー ファーマシューティカルズ インコーポレイテッド 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト
MX2011004258A (es) 2008-10-22 2011-06-01 Merck Sharp & Dohme Derivados de bencimidazol ciclicos novedosos utiles como agentes anti-diabeticos.
WO2010051206A1 (en) 2008-10-31 2010-05-06 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
WO2011106273A1 (en) 2010-02-25 2011-09-01 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
WO2012116145A1 (en) 2011-02-25 2012-08-30 Merck Sharp & Dohme Corp. Novel cyclic azabenzimidazole derivatives useful as anti-diabetic agents
CA3100941C (en) 2011-03-01 2024-03-05 Synergy Pharmaceuticals Inc. Process of preparing guanylate cyclase c agonists
WO2014022528A1 (en) 2012-08-02 2014-02-06 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
CA2898482A1 (en) 2013-02-22 2014-08-28 Linda L. Brockunier Antidiabetic bicyclic compounds
EP2970119B1 (en) 2013-03-14 2021-11-03 Merck Sharp & Dohme Corp. Novel indole derivatives useful as anti-diabetic agents
AU2014235209B2 (en) 2013-03-15 2018-06-14 Bausch Health Ireland Limited Guanylate cyclase receptor agonists combined with other drugs
JP2016514671A (ja) 2013-03-15 2016-05-23 シナジー ファーマシューティカルズ インコーポレイテッド グアニル酸シクラーゼのアゴニストおよびその使用
AU2014274812B2 (en) 2013-06-05 2018-09-27 Bausch Health Ireland Limited Ultra-pure agonists of guanylate cyclase C, method of making and using same
WO2015051496A1 (en) 2013-10-08 2015-04-16 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
WO2018106518A1 (en) 2016-12-06 2018-06-14 Merck Sharp & Dohme Corp. Antidiabetic heterocyclic compounds
WO2018118670A1 (en) 2016-12-20 2018-06-28 Merck Sharp & Dohme Corp. Antidiabetic spirochroman compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3507868A (en) * 1968-10-21 1970-04-21 Sandoz Ag Imidazo(2,1-b)thiazoles and thiazolo(3,2-a)pyrimidines
DE2640358A1 (de) * 1976-09-08 1978-03-16 Hoechst Ag Thiazolidinderivate und verfahren zu ihrer herstellung
DE19831878C2 (de) * 1998-07-17 2001-05-17 Aventis Pharma Gmbh Polycyclische Thiazolidin-2-yliden Amine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE19844547C2 (de) * 1998-09-29 2002-11-07 Aventis Pharma Gmbh Polycyclische Dihydrothiazole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE19908539A1 (de) * 1999-02-26 2000-08-31 Aventis Pharma Gmbh Polycyclische 2-Amino-Dihydrothiazolsysteme, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel

Also Published As

Publication number Publication date
NO20022021D0 (no) 2002-04-29
CN1384827A (zh) 2002-12-11
CA2389703A1 (en) 2001-05-10
JP2003524632A (ja) 2003-08-19
NO322309B1 (no) 2006-09-11
WO2001032638A1 (de) 2001-05-10
EP1230230A1 (de) 2002-08-14
AU777569B2 (en) 2004-10-21
ATE250045T1 (de) 2003-10-15
KR20020047331A (ko) 2002-06-21
AU1274601A (en) 2001-05-14
SK6132002A3 (en) 2002-11-06
AR026338A1 (es) 2003-02-05
PT1230230E (pt) 2003-12-31
CZ20021528A3 (cs) 2002-07-17
US6387935B1 (en) 2002-05-14
MXPA02003477A (es) 2002-08-20
ES2206320T3 (es) 2004-05-16
HUP0203290A3 (en) 2004-12-28
IL149400A0 (en) 2002-11-10
HUP0203290A2 (hu) 2003-01-28
DK1230230T3 (da) 2003-12-15
EE200200235A (et) 2003-06-16
HK1050524A1 (en) 2003-06-27
EP1230230B1 (de) 2003-09-17
DE50003761D1 (de) 2003-10-23
BR0015322A (pt) 2002-07-09
NZ518751A (en) 2004-06-25
NO20022021L (no) 2002-04-29
CN1176080C (zh) 2004-11-17
YU29602A (sh) 2006-01-16
PL354533A1 (en) 2004-01-26

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ARAI Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application
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Owner name: SANOFI-AVENTIS DEUTSCHLAND GMBH, DE

ODRP Renewal fee for the maintenance of a patent

Payment date: 20060920

Year of fee payment: 7

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