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EE200200235A - Indeno-, nafto- ja bensotsükloheptadihüdrotiasooli derivaadid, nende valmistamine ja kasutamine anorektiliste ravimitena - Google Patents

Indeno-, nafto- ja bensotsükloheptadihüdrotiasooli derivaadid, nende valmistamine ja kasutamine anorektiliste ravimitena

Info

Publication number
EE200200235A
EE200200235A EEP200200235A EEP200200235A EE200200235A EE 200200235 A EE200200235 A EE 200200235A EE P200200235 A EEP200200235 A EE P200200235A EE P200200235 A EEP200200235 A EE P200200235A EE 200200235 A EE200200235 A EE 200200235A
Authority
EE
Estonia
Prior art keywords
benzocycloheptadihydrothiazole
indeno
naphtho
derivatives
preparation
Prior art date
Application number
EEP200200235A
Other languages
English (en)
Inventor
Jaehne Gerhard
Gossel Matthias
Lang Hans-Jochen
Bickel Martin
Original Assignee
Aventis Pharma Deutschland Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE2000113306 external-priority patent/DE10013306A1/de
Application filed by Aventis Pharma Deutschland Gmbh filed Critical Aventis Pharma Deutschland Gmbh
Publication of EE200200235A publication Critical patent/EE200200235A/et

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EEP200200235A 1999-11-05 2000-10-21 Indeno-, nafto- ja bensotsükloheptadihüdrotiasooli derivaadid, nende valmistamine ja kasutamine anorektiliste ravimitena EE200200235A (et)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19953205 1999-11-05
DE2000113306 DE10013306A1 (de) 2000-03-17 2000-03-17 Polycyclische, in 2-Stellung mit substituierten Alkylresten versehene Dihydrothiazole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
PCT/EP2000/010396 WO2001032638A1 (de) 1999-11-05 2000-10-21 Indeno-, naphtho- und benzocyclohepta-dihydrothiazol derivate, deren herstellung und deren verwendung als anorektische arzneimittel

Publications (1)

Publication Number Publication Date
EE200200235A true EE200200235A (et) 2003-06-16

Family

ID=26004890

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200200235A EE200200235A (et) 1999-11-05 2000-10-21 Indeno-, nafto- ja bensotsükloheptadihüdrotiasooli derivaadid, nende valmistamine ja kasutamine anorektiliste ravimitena

Country Status (26)

Country Link
US (1) US6387935B1 (et)
EP (1) EP1230230B1 (et)
JP (1) JP2003524632A (et)
KR (1) KR20020047331A (et)
CN (1) CN1176080C (et)
AR (1) AR026338A1 (et)
AT (1) ATE250045T1 (et)
AU (1) AU777569B2 (et)
BR (1) BR0015322A (et)
CA (1) CA2389703A1 (et)
CZ (1) CZ20021528A3 (et)
DE (1) DE50003761D1 (et)
DK (1) DK1230230T3 (et)
EE (1) EE200200235A (et)
ES (1) ES2206320T3 (et)
HR (1) HRP20020379A2 (et)
HU (1) HUP0203290A3 (et)
IL (1) IL149400A0 (et)
MX (1) MXPA02003477A (et)
NO (1) NO322309B1 (et)
NZ (1) NZ518751A (et)
PL (1) PL354533A1 (et)
PT (1) PT1230230E (et)
SK (1) SK6132002A3 (et)
WO (1) WO2001032638A1 (et)
YU (1) YU29602A (et)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
US20080125403A1 (en) 2004-04-02 2008-05-29 Merck & Co., Inc. Method of Treating Men with Metabolic and Anthropometric Disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
EP2170930B3 (en) 2007-06-04 2013-10-02 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
JP2011522828A (ja) 2008-06-04 2011-08-04 シナジー ファーマシューティカルズ インコーポレイテッド 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト
EP2321341B1 (en) 2008-07-16 2017-02-22 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
AU2009307884B2 (en) 2008-10-22 2014-07-31 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
CN102271509A (zh) 2008-10-31 2011-12-07 默沙东公司 用于抗糖尿病药的新型环苯并咪唑衍生物
US8895596B2 (en) 2010-02-25 2014-11-25 Merck Sharp & Dohme Corp Cyclic benzimidazole derivatives useful as anti-diabetic agents
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CN103476258B (zh) 2011-02-25 2017-04-26 默沙东公司 用作抗糖尿病药剂的新的环状氮杂苯并咪唑衍生物
CN103764672A (zh) 2011-03-01 2014-04-30 辛纳吉制药公司 制备鸟苷酸环化酶c激动剂的方法
US20140045746A1 (en) 2012-08-02 2014-02-13 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
EP2958562B1 (en) 2013-02-22 2025-09-10 Merck Sharp & Dohme LLC Antidiabetic bicyclic compounds
EP2970119B1 (en) 2013-03-14 2021-11-03 Merck Sharp & Dohme Corp. Novel indole derivatives useful as anti-diabetic agents
CA2905435A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
US9708367B2 (en) 2013-03-15 2017-07-18 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
RS65632B1 (sr) 2013-06-05 2024-07-31 Bausch Health Ireland Ltd Ultra-prečišćeni agonisti guanilat-ciklaze c, postupak njihove pripreme i upotrebe
WO2015051496A1 (en) 2013-10-08 2015-04-16 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
WO2018106518A1 (en) 2016-12-06 2018-06-14 Merck Sharp & Dohme Corp. Antidiabetic heterocyclic compounds
WO2018118670A1 (en) 2016-12-20 2018-06-28 Merck Sharp & Dohme Corp. Antidiabetic spirochroman compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3507868A (en) * 1968-10-21 1970-04-21 Sandoz Ag Imidazo(2,1-b)thiazoles and thiazolo(3,2-a)pyrimidines
DE2640358A1 (de) * 1976-09-08 1978-03-16 Hoechst Ag Thiazolidinderivate und verfahren zu ihrer herstellung
DE19831878C2 (de) * 1998-07-17 2001-05-17 Aventis Pharma Gmbh Polycyclische Thiazolidin-2-yliden Amine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE19844547C2 (de) * 1998-09-29 2002-11-07 Aventis Pharma Gmbh Polycyclische Dihydrothiazole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE19908539A1 (de) * 1999-02-26 2000-08-31 Aventis Pharma Gmbh Polycyclische 2-Amino-Dihydrothiazolsysteme, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel

Also Published As

Publication number Publication date
EP1230230B1 (de) 2003-09-17
AU777569B2 (en) 2004-10-21
US6387935B1 (en) 2002-05-14
AU1274601A (en) 2001-05-14
AR026338A1 (es) 2003-02-05
DK1230230T3 (da) 2003-12-15
NO20022021D0 (no) 2002-04-29
MXPA02003477A (es) 2002-08-20
BR0015322A (pt) 2002-07-09
HUP0203290A2 (hu) 2003-01-28
HUP0203290A3 (en) 2004-12-28
ATE250045T1 (de) 2003-10-15
DE50003761D1 (de) 2003-10-23
CA2389703A1 (en) 2001-05-10
ES2206320T3 (es) 2004-05-16
CN1176080C (zh) 2004-11-17
NO322309B1 (no) 2006-09-11
CN1384827A (zh) 2002-12-11
YU29602A (sh) 2006-01-16
IL149400A0 (en) 2002-11-10
JP2003524632A (ja) 2003-08-19
EP1230230A1 (de) 2002-08-14
WO2001032638A1 (de) 2001-05-10
PL354533A1 (en) 2004-01-26
HRP20020379A2 (en) 2004-02-29
SK6132002A3 (en) 2002-11-06
HK1050524A1 (en) 2003-06-27
CZ20021528A3 (cs) 2002-07-17
NZ518751A (en) 2004-06-25
KR20020047331A (ko) 2002-06-21
PT1230230E (pt) 2003-12-31
NO20022021L (no) 2002-04-29

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