HRP20010562B1 - S-nitrosothiols as agents for the treatment of circulatory dysfunctions - Google Patents

S-nitrosothiols as agents for the treatment of circulatory dysfunctions

Info

Publication number: HRP20010562B1
Authority: HR; Croatia
Prior art keywords: residue; group; nitrosothiols; agents; treatment
Prior art date: 1999-01-27

Application number

HR20010562A

Other languages

English (en)

Croatian (hr)

Inventor

Repolles Moliner Jose

Salas Perez-Rasilla Eduardo

Pubill Coy Francisco

Antonio Cerda Riudavets Juan

Negrie Rofes Cristina

Cabeza Llorente Lydia

Ferrer Siso Alicia

Trias Adroher Nuria

Carbo Banus Marcel.Li

Murat Moreno Jesus

Michelena Llaguno Pedro

Original Assignee

Lacer S.A.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-01-27

Filing date

2000-01-19

Publication date

2010-08-31

2000-01-19 Application filed by Lacer S.A. filed Critical Lacer S.A.

2002-08-31 Publication of HRP20010562A2 publication Critical patent/HRP20010562A2/hr

2010-08-31 Publication of HRP20010562B1 publication Critical patent/HRP20010562B1/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C381/00—Compounds containing carbon and sulfur and having functional groups not covered by groups C07C301/00 - C07C337/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/54—Sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Genetics & Genomics (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Biophysics (AREA)
Hematology (AREA)
Vascular Medicine (AREA)
Diabetes (AREA)
Urology & Nephrology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Hydrogenated Pyridines (AREA)
Pyrane Compounds (AREA)
Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)

HR20010562A 1999-01-27 2000-01-19 S-nitrosothiols as agents for the treatment of circulatory dysfunctions HRP20010562B1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
ES009900159A ES2147162B1 (es)	1999-01-27	1999-01-27	"s-nitrosotioles como agentes para el tratamiento de disfunciones circulatorias".
PCT/ES2000/000019 WO2000044714A1 (es)	1999-01-27	2000-01-19	S-nitrosotioles como agentes para el tratamiento de disfunciones circulatorias

Publications (2)

Publication Number	Publication Date
HRP20010562A2 HRP20010562A2 (en)	2002-08-31
HRP20010562B1 true HRP20010562B1 (en)	2010-08-31

Family

ID=8307080

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR20010562A HRP20010562B1 (en)	1999-01-27	2000-01-19	S-nitrosothiols as agents for the treatment of circulatory dysfunctions

Country Status (37)

Country	Link
US (1)	US6800612B2 (is)
EP (1)	EP1157987B1 (is)
JP (1)	JP3795330B2 (is)
KR (1)	KR100671878B1 (is)
CN (1)	CN1166631C (is)
AP (1)	AP1439A (is)
AT (1)	ATE249428T1 (is)
AU (1)	AU764725B2 (is)
BG (1)	BG64983B1 (is)
BR (1)	BR0007395B1 (is)
CA (1)	CA2359027C (is)
CU (1)	CU23098A3 (is)
CZ (1)	CZ298871B6 (is)
DE (2)	DE60005154T2 (is)
DK (1)	DK1157987T3 (is)
EA (1)	EA003577B1 (is)
EE (1)	EE04524B1 (is)
ES (2)	ES2147162B1 (is)
GB (1)	GB2363604B (is)
GE (1)	GEP20043220B (is)
HK (1)	HK1043586A1 (is)
HR (1)	HRP20010562B1 (is)
HU (1)	HUP0105203A3 (is)
ID (1)	ID29777A (is)
IL (1)	IL144381A (is)
IS (1)	IS2153B (is)
MX (1)	MXPA01007570A (is)
NO (1)	NO326806B1 (is)
NZ (1)	NZ513162A (is)
OA (1)	OA11823A (is)
PL (1)	PL202372B1 (is)
PT (1)	PT1157987E (is)
RS (1)	RS50072B (is)
SI (1)	SI1157987T1 (is)
TR (1)	TR200102003T2 (is)
WO (1)	WO2000044714A1 (is)
ZA (1)	ZA200106182B (is)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2173044B1 (es) *	2001-03-13	2004-01-16	Lacer Sa	Derivados de glicina, n-(n-l-gamma-glutamil-3-(nitrosotio)-l-valil) y sus aplicaciones.
JP2007518697A (ja) *	2003-09-26	2007-07-12	ニトロメッドインコーポレーティッド	ニトロソ化グルタミン酸化合物、組成物、および使用方法
EP1939179A1 (en) *	2006-12-28	2008-07-02	Lacer, S.A.	Stable S-nitrosothiols, method of synthesis and use
EP2197417B1 (en)	2007-10-17	2012-03-14	Pharmagenix Ag	Pharmaceutical composition comprising s-nitrosoglutathione and polysaccharide

Citations (3)

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Publication number	Priority date	Publication date	Assignee	Title
EP0412699A2 (en) *	1989-08-07	1991-02-13	Takeda Chemical Industries, Ltd.	Nitrosothiol derivatives, their production and use
US5187305A (en) *	1990-11-26	1993-02-16	Glaxo Inc.	S-nitroso-N-alkonoylpenicillamines
WO1995007691A1 (en) *	1993-09-17	1995-03-23	Brigham And Women's Hospital	Use of nitric oxide-adducts to prevent thrombosis on artificial and vascular surfaces

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GB1567561A (en)	1977-01-18	1980-05-14	Ucb Sa	Amino-spiro(oxa-(orthia)cycloalkane-penam) - carboxylic acids
GB2052497B (en)	1979-06-25	1983-06-29	Ucb Sa	6 - amino - spiro - (penam - 2,4' - piperidine) - 3 - carboxylic acid derivatives
DE3805965A1 (de)	1988-02-25	1989-09-07	Tamas Geb Szenasi Eszter	Verwendung der pflanze euphorbia hirta l. und ihrer extrakte sowie ihrer wirkstoffe
US5025001A (en)	1988-06-15	1991-06-18	Brigham And Women's Hospital	S-nitroso derivatives of ACE inhibitors and the use thereof
KR970002904B1 (ko)	1990-04-26	1997-03-12	센쥬 세이야꾸 가부시끼가이샤	S-저급지방산 글루타티온 유도체
DE69233474T2 (de)	1991-11-14	2006-03-30	The Brigham And Women's Hospital Inc., Boston	Pharmazeutische Zusammensetzung enthaltend S-Nitrosoimmunoglobuline und Verwendung davon
FI933472A7 (fi)	1992-08-07	1994-02-08	Sankyo Co	Peptider med foermaoga att inhibera effekten av HIV-proteas, deras framstaellning och terapeutiska anvaendning
US5728705A (en)	1993-10-04	1998-03-17	The Trustees Of Columbia University In The City Of New York	Method of inducing vasorelaxation to treat pulmonary hypertension
DK0726768T3 (da)	1993-11-02	2000-10-02	Us Health	Anvendelse af nitrogenoxidfrigørende forbindelser til fremstillingen af et medikament til beskyttelse i iskæmisk reperfusio
GB9423868D0 (en)	1994-11-25	1995-01-11	Wellcome Found	Compounds for use in medicine
US6627738B2 (en)	1995-09-15	2003-09-30	Duke University	No-modified hemoglobins and uses therefor
AU6782198A (en)	1997-03-27	1998-10-20	Trustees Of Boston University	Novel antiplatelet agent

1999
- 1999-01-27 ES ES009900159A patent/ES2147162B1/es not_active Expired - Fee Related
2000
- 2000-01-19 JP JP2000595971A patent/JP3795330B2/ja not_active Expired - Fee Related
- 2000-01-19 BR BRPI0007395-4A patent/BR0007395B1/pt not_active IP Right Cessation
- 2000-01-19 TR TR2001/02003T patent/TR200102003T2/xx unknown
- 2000-01-19 DK DK00900518T patent/DK1157987T3/da active
- 2000-01-19 OA OA1200100195A patent/OA11823A/en unknown
- 2000-01-19 CZ CZ20012678A patent/CZ298871B6/cs not_active IP Right Cessation
- 2000-01-19 EA EA200100823A patent/EA003577B1/ru not_active IP Right Cessation
- 2000-01-19 DE DE60005154T patent/DE60005154T2/de not_active Expired - Lifetime
- 2000-01-19 GB GB0120581A patent/GB2363604B/en not_active Expired - Fee Related
- 2000-01-19 CN CNB008030847A patent/CN1166631C/zh not_active Expired - Fee Related
- 2000-01-19 PL PL349006A patent/PL202372B1/pl not_active IP Right Cessation
- 2000-01-19 ID IDW00200101662A patent/ID29777A/id unknown
- 2000-01-19 AP APAP/P/2001/002247A patent/AP1439A/en active
- 2000-01-19 AU AU30460/00A patent/AU764725B2/en not_active Ceased
- 2000-01-19 EE EEP200100389A patent/EE04524B1/xx not_active IP Right Cessation
- 2000-01-19 HK HK02103982.2A patent/HK1043586A1/en unknown
- 2000-01-19 PT PT00900518T patent/PT1157987E/pt unknown
- 2000-01-19 AT AT00900518T patent/ATE249428T1/de not_active IP Right Cessation
- 2000-01-19 RS YUP-536/01A patent/RS50072B/sr unknown
- 2000-01-19 NZ NZ513162A patent/NZ513162A/xx not_active IP Right Cessation
- 2000-01-19 SI SI200030236T patent/SI1157987T1/xx unknown
- 2000-01-19 MX MXPA01007570A patent/MXPA01007570A/es not_active IP Right Cessation
- 2000-01-19 HU HU0105203A patent/HUP0105203A3/hu unknown
- 2000-01-19 HR HR20010562A patent/HRP20010562B1/xx not_active IP Right Cessation
- 2000-01-19 WO PCT/ES2000/000019 patent/WO2000044714A1/es not_active Ceased
- 2000-01-19 DE DE10083902T patent/DE10083902T1/de not_active Ceased
- 2000-01-19 ES ES00900518T patent/ES2206178T3/es not_active Expired - Lifetime
- 2000-01-19 IL IL14438100A patent/IL144381A/xx not_active IP Right Cessation
- 2000-01-19 KR KR1020017009522A patent/KR100671878B1/ko not_active Expired - Fee Related
- 2000-01-19 EP EP00900518A patent/EP1157987B1/en not_active Expired - Lifetime
- 2000-01-19 CA CA002359027A patent/CA2359027C/en not_active Expired - Fee Related
- 2000-01-19 GE GEAP20006075A patent/GEP20043220B/en unknown
2001
- 2001-07-06 NO NO20013385A patent/NO326806B1/no not_active IP Right Cessation
- 2001-07-23 IS IS6020A patent/IS2153B/is unknown
- 2001-07-24 US US09/912,164 patent/US6800612B2/en not_active Expired - Fee Related
- 2001-07-26 ZA ZA200106182A patent/ZA200106182B/en unknown
- 2001-07-30 CU CU20010181A patent/CU23098A3/es not_active IP Right Cessation
- 2001-08-16 BG BG105824A patent/BG64983B1/bg unknown

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0412699A2 (en) *	1989-08-07	1991-02-13	Takeda Chemical Industries, Ltd.	Nitrosothiol derivatives, their production and use
US5187305A (en) *	1990-11-26	1993-02-16	Glaxo Inc.	S-nitroso-N-alkonoylpenicillamines
WO1995007691A1 (en) *	1993-09-17	1995-03-23	Brigham And Women's Hospital	Use of nitric oxide-adducts to prevent thrombosis on artificial and vascular surfaces

Also Published As

Publication number	Publication date
ID29777A (id)	2001-10-11
AP1439A (en)	2005-06-27
IL144381A (en)	2005-08-31
RS50072B (sr)	2009-01-22
PL202372B1 (pl)	2009-06-30
ES2147162A1 (es)	2000-08-16
HRP20010562A2 (en)	2002-08-31
EE200100389A (et)	2002-12-16
PL349006A1 (en)	2002-06-17
ES2147162B1 (es)	2001-03-16
ATE249428T1 (de)	2003-09-15
YU53601A (sh)	2004-03-12
CZ298871B6 (cs)	2008-02-27
NO20013385L (no)	2001-09-17
HK1043586A1 (en)	2002-09-20
WO2000044714A1 (es)	2000-08-03
EE04524B1 (et)	2005-08-15
IL144381A0 (en)	2002-05-23
DE60005154D1 (de)	2003-10-16
JP3795330B2 (ja)	2006-07-12
DE60005154T2 (de)	2004-07-08
EP1157987A1 (en)	2001-11-28
KR20010101767A (ko)	2001-11-14
CN1337946A (zh)	2002-02-27
IS2153B (is)	2006-10-13
SI1157987T1 (en)	2004-02-29
CU23098A3 (es)	2005-11-18
HUP0105203A2 (en)	2002-06-29
AU764725B2 (en)	2003-08-28
KR100671878B1 (ko)	2007-01-19
BG64983B1 (bg)	2006-11-30
US20020058629A1 (en)	2002-05-16
ZA200106182B (en)	2002-10-28
ES2206178T3 (es)	2004-05-16
TR200102003T2 (tr)	2001-12-21
AU3046000A (en)	2000-08-18
OA11823A (en)	2005-08-16
EP1157987B1 (en)	2003-09-10
CZ20012678A3 (cs)	2001-10-17
CA2359027A1 (en)	2000-08-03
NZ513162A (en)	2003-01-31
CA2359027C (en)	2008-10-28
JP2002535385A (ja)	2002-10-22
US6800612B2 (en)	2004-10-05
EA200100823A1 (ru)	2002-02-28
AP2001002247A0 (en)	2001-09-30
DE10083902T1 (de)	2002-01-10
NO20013385D0 (no)	2001-07-06
HUP0105203A3 (en)	2002-08-28
GB0120581D0 (en)	2001-10-17
EA003577B1 (ru)	2003-06-26
MXPA01007570A (es)	2003-05-14
GB2363604B (en)	2003-09-10
BR0007395A (pt)	2001-10-30
NO326806B1 (no)	2009-02-16
BR0007395B1 (pt)	2010-11-16
IS6020A (is)	2001-07-23
GEP20043220B (en)	2004-04-26
DK1157987T3 (da)	2003-11-24
PT1157987E (pt)	2004-01-30
BG105824A (en)	2002-06-28
CN1166631C (zh)	2004-09-15
GB2363604A (en)	2002-01-02

Publication	Publication Date	Title
CO5640126A2 (es)	2006-05-31	Derivados de aminoalcohol y composiciones farmaceuticas que las contienen
AR016665A1 (es)	2001-07-25	Derivados de nitrilos de dipeptido, un proceso para su preparacion, una composicion farmaceutica que los comprende y el uso de los mismos para lafabricacion de un medicamento
EA200100970A1 (ru)	2002-04-25	Аминопроизводные как ингибиторы протеазы
ATE102923T1 (de)	1994-04-15	Isoindolonderivate, ihre herstellung und diese enthaltende pharmazeutische zusammensetzungen.
RU2011129764A (ru)	2013-01-27	Лекарственные средства, связанные с дипептидами
TR200100438T2 (tr)	2001-06-21	Hepatit C inhibitörü peptitler
HUP9903766A2 (en)	2000-09-28	Pyridyl alkene- and pyridyl alkine- acid amides, use of them as cytostatics and immunosuppressives, process for their preparation and pharmaceuticals containing the same
AR015470A1 (es)	2001-05-02	Acido beta-arilo-alfa-alquilcarboxilico, su uso para la manufactura de un medicamento, procedimientos para su preparacion, composiciones farmaceuticas quelos contienen, compuestos intermediarios y procedimiento para su preparacion
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DK0892794T3 (da)	2002-04-15	Acylerede N-hydroxymethyl thalidomid-promedikamenter med immunmodulatorisk virkning
CA2250861A1 (en)	1997-10-16	Cyclic adhesion inhibitors
BR9501612A (pt)	1997-09-16	Composto bicíclicos aromáticos utilização de um composto composição farmacêutica composição cosmética e utilização de uma composição cosmética
FI906296A0 (fi)	1990-12-20	Nya metylenbisfosfonsyrederivat.
AR047486A1 (es)	2006-01-25	Derivados de indolizina1,2,3,6,7,8, substituida, inhibidores de los fgfs, su procedimiento de preparacion y composiciones farmaceuticas que los contienen
FI932351A0 (fi)	1993-05-24	Cyklopeptider och deras anvaendning som resorptionsbefraemjande medel vid applikation pao slemhinnor
HRP20010562B1 (en)	2010-08-31	S-nitrosothiols as agents for the treatment of circulatory dysfunctions
HU896606D0 (en)	1990-02-28	Process for the preparation of aminoacid derivatives inhibiting enzymes and pharmaceutical compositions thereof
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