DE60005154D1 - S-nitrosothiole als agentien zur behandlung von fehlfunktionen des kreislaufs - Google Patents

S-nitrosothiole als agentien zur behandlung von fehlfunktionen des kreislaufs

Info

Publication number: DE60005154D1
Authority: DE; Germany
Prior art keywords: nitrosothiole; agents; circuit; malfunctions; treating
Prior art date: 1999-01-27
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE60005154T

Other languages

English (en)

Other versions

DE60005154T2 (de

Inventor

Moliner Jose Repolles

Perez-Rasilla Eduardo Salas

Coy Francisco Pubill

Riudavets Juan Antonio Cerda

Rofes Cristina Negrie

Llorente Lydia Cabeza

Siso Alicia Ferrer

Adroher Nuria Trias

Banus Marcel Li Carbo

Moreno Jes S Murat

Llaguno Pedro Michelena

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Lacer SA

Original Assignee

Lacer SA

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-01-27

Filing date

2000-01-19

Publication date

2003-10-16

2000-01-19 Application filed by Lacer SA filed Critical Lacer SA

2003-10-16 Publication of DE60005154D1 publication Critical patent/DE60005154D1/de

2004-07-08 Application granted granted Critical

2004-07-08 Publication of DE60005154T2 publication Critical patent/DE60005154T2/de

2020-01-20 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C381/00—Compounds containing carbon and sulfur and having functional groups not covered by groups C07C301/00 - C07C337/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/54—Sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Vascular Medicine (AREA)
Hematology (AREA)
Diabetes (AREA)
Urology & Nephrology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Hydrogenated Pyridines (AREA)
Pyrane Compounds (AREA)
Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)

DE60005154T 1999-01-27 2000-01-19 S-nitrosothiole als agentien zur behandlung von fehlfunktionen des kreislaufs Expired - Lifetime DE60005154T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
ES9900159		1999-01-27
ES009900159A ES2147162B1 (es)	1999-01-27	1999-01-27	"s-nitrosotioles como agentes para el tratamiento de disfunciones circulatorias".
PCT/ES2000/000019 WO2000044714A1 (es)	1999-01-27	2000-01-19	S-nitrosotioles como agentes para el tratamiento de disfunciones circulatorias

Publications (2)

Publication Number	Publication Date
DE60005154D1 true DE60005154D1 (de)	2003-10-16
DE60005154T2 DE60005154T2 (de)	2004-07-08

Family

ID=8307080

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DE60005154T Expired - Lifetime DE60005154T2 (de)	1999-01-27	2000-01-19	S-nitrosothiole als agentien zur behandlung von fehlfunktionen des kreislaufs
DE10083902T Ceased DE10083902T1 (de)	1999-01-27	2000-01-19	S-Nitrosothiole als Mittel zur Behandlung von Kreislauf-Fehlfunktionen

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DE10083902T Ceased DE10083902T1 (de)	1999-01-27	2000-01-19	S-Nitrosothiole als Mittel zur Behandlung von Kreislauf-Fehlfunktionen

Country Status (37)

Country	Link
US (1)	US6800612B2 (de)
EP (1)	EP1157987B1 (de)
JP (1)	JP3795330B2 (de)
KR (1)	KR100671878B1 (de)
CN (1)	CN1166631C (de)
AP (1)	AP1439A (de)
AT (1)	ATE249428T1 (de)
AU (1)	AU764725B2 (de)
BG (1)	BG64983B1 (de)
BR (1)	BR0007395B1 (de)
CA (1)	CA2359027C (de)
CU (1)	CU23098A3 (de)
CZ (1)	CZ298871B6 (de)
DE (2)	DE60005154T2 (de)
DK (1)	DK1157987T3 (de)
EA (1)	EA003577B1 (de)
EE (1)	EE04524B1 (de)
ES (2)	ES2147162B1 (de)
GB (1)	GB2363604B (de)
GE (1)	GEP20043220B (de)
HK (1)	HK1043586A1 (de)
HR (1)	HRP20010562B1 (de)
HU (1)	HUP0105203A3 (de)
ID (1)	ID29777A (de)
IL (1)	IL144381A (de)
IS (1)	IS2153B (de)
MX (1)	MXPA01007570A (de)
NO (1)	NO326806B1 (de)
NZ (1)	NZ513162A (de)
OA (1)	OA11823A (de)
PL (1)	PL202372B1 (de)
PT (1)	PT1157987E (de)
RS (1)	RS50072B (de)
SI (1)	SI1157987T1 (de)
TR (1)	TR200102003T2 (de)
WO (1)	WO2000044714A1 (de)
ZA (1)	ZA200106182B (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2173044B1 (es) *	2001-03-13	2004-01-16	Lacer Sa	Derivados de glicina, n-(n-l-gamma-glutamil-3-(nitrosotio)-l-valil) y sus aplicaciones.
WO2005030135A2 (en) *	2003-09-26	2005-04-07	Nitromed, Inc.	Nitrosated glutamic acid compounds, compositions and methods of use
EP1939179A1 (de) *	2006-12-28	2008-07-02	Lacer, S.A.	Stabile S-Nitrosothiole, Syntheseverfahren und Verwendung
ES2383846T3 (es)	2007-10-17	2012-06-26	Pharmagenix Ag	Composición farmacéutica que comprende S-nitrosoglutatión y un polisacárido

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US37839A (en) *		1863-03-03		Improved spoke-machine
GB1567561A (en)	1977-01-18	1980-05-14	Ucb Sa	Amino-spiro(oxa-(orthia)cycloalkane-penam) - carboxylic acids
GB2052497B (en)	1979-06-25	1983-06-29	Ucb Sa	6 - amino - spiro - (penam - 2,4' - piperidine) - 3 - carboxylic acid derivatives
DE3805965A1 (de)	1988-02-25	1989-09-07	Tamas Geb Szenasi Eszter	Verwendung der pflanze euphorbia hirta l. und ihrer extrakte sowie ihrer wirkstoffe
US5025001A (en)	1988-06-15	1991-06-18	Brigham And Women's Hospital	S-nitroso derivatives of ACE inhibitors and the use thereof
EP0412699B1 (de) *	1989-08-07	1994-04-27	Takeda Chemical Industries, Ltd.	Nitrolsothiolderivate, ihre Herstellung und Verwendung
EP0480060B1 (de)	1990-04-26	1996-10-23	Senju Pharmaceutical Co., Ltd.	S-(niedere fettsäuren)-substituierte glutathionderivate
US5187305A (en) *	1990-11-26	1993-02-16	Glaxo Inc.	S-nitroso-N-alkonoylpenicillamines
DE69231666T2 (de)	1991-11-14	2001-05-10	Brigham And Women's Hospital, Boston	Die nitrosylierung von enzym-sh gruppen als eine therapeutische massnahme
AU662434B2 (en)	1992-08-07	1995-08-31	Sankyo Company Limited	Peptides capable of inhibiting the activity of HIV protease, their preparation and their use
AU698748B2 (en) *	1993-09-17	1998-11-05	Brigham And Women's Hospital	Use of nitric oxide-adducts to prevent thrombosis on artificial and vascular surfaces
US5728705A (en)	1993-10-04	1998-03-17	The Trustees Of Columbia University In The City Of New York	Method of inducing vasorelaxation to treat pulmonary hypertension
EP0726768B1 (de)	1993-11-02	2000-05-17	THE UNITED STATES OF AMERICA, represented by THE SECRETARY, Department of Health and Human Services	Verwendung von stickstoffoxid freisetzenden verbindungen zur herstellung eines arzneimittels zum schutz gegen die ischämischen reperfusionsschäden
GB9423868D0 (en)	1994-11-25	1995-01-11	Wellcome Found	Compounds for use in medicine
US6627738B2 (en)	1995-09-15	2003-09-30	Duke University	No-modified hemoglobins and uses therefor
US6489290B2 (en)	1997-03-27	2002-12-03	Trustees Of Boston University	Antiplatelet agent

1999
- 1999-01-27 ES ES009900159A patent/ES2147162B1/es not_active Expired - Fee Related
2000
- 2000-01-19 DE DE60005154T patent/DE60005154T2/de not_active Expired - Lifetime
- 2000-01-19 PL PL349006A patent/PL202372B1/pl not_active IP Right Cessation
- 2000-01-19 CN CNB008030847A patent/CN1166631C/zh not_active Expired - Fee Related
- 2000-01-19 HU HU0105203A patent/HUP0105203A3/hu unknown
- 2000-01-19 CA CA002359027A patent/CA2359027C/en not_active Expired - Fee Related
- 2000-01-19 BR BRPI0007395-4A patent/BR0007395B1/pt not_active IP Right Cessation
- 2000-01-19 AU AU30460/00A patent/AU764725B2/en not_active Ceased
- 2000-01-19 DE DE10083902T patent/DE10083902T1/de not_active Ceased
- 2000-01-19 DK DK00900518T patent/DK1157987T3/da active
- 2000-01-19 PT PT00900518T patent/PT1157987E/pt unknown
- 2000-01-19 ES ES00900518T patent/ES2206178T3/es not_active Expired - Lifetime
- 2000-01-19 SI SI200030236T patent/SI1157987T1/xx unknown
- 2000-01-19 ID IDW00200101662A patent/ID29777A/id unknown
- 2000-01-19 CZ CZ20012678A patent/CZ298871B6/cs not_active IP Right Cessation
- 2000-01-19 MX MXPA01007570A patent/MXPA01007570A/es not_active IP Right Cessation
- 2000-01-19 GE GEAP20006075A patent/GEP20043220B/en unknown
- 2000-01-19 KR KR1020017009522A patent/KR100671878B1/ko not_active Expired - Fee Related
- 2000-01-19 JP JP2000595971A patent/JP3795330B2/ja not_active Expired - Fee Related
- 2000-01-19 OA OA1200100195A patent/OA11823A/en unknown
- 2000-01-19 HK HK02103982.2A patent/HK1043586A1/en unknown
- 2000-01-19 EE EEP200100389A patent/EE04524B1/xx not_active IP Right Cessation
- 2000-01-19 HR HR20010562A patent/HRP20010562B1/xx not_active IP Right Cessation
- 2000-01-19 GB GB0120581A patent/GB2363604B/en not_active Expired - Fee Related
- 2000-01-19 WO PCT/ES2000/000019 patent/WO2000044714A1/es not_active Ceased
- 2000-01-19 TR TR2001/02003T patent/TR200102003T2/xx unknown
- 2000-01-19 AP APAP/P/2001/002247A patent/AP1439A/en active
- 2000-01-19 EA EA200100823A patent/EA003577B1/ru not_active IP Right Cessation
- 2000-01-19 IL IL14438100A patent/IL144381A/xx not_active IP Right Cessation
- 2000-01-19 RS YUP-536/01A patent/RS50072B/sr unknown
- 2000-01-19 NZ NZ513162A patent/NZ513162A/xx not_active IP Right Cessation
- 2000-01-19 EP EP00900518A patent/EP1157987B1/de not_active Expired - Lifetime
- 2000-01-19 AT AT00900518T patent/ATE249428T1/de not_active IP Right Cessation
2001
- 2001-07-06 NO NO20013385A patent/NO326806B1/no not_active IP Right Cessation
- 2001-07-23 IS IS6020A patent/IS2153B/is unknown
- 2001-07-24 US US09/912,164 patent/US6800612B2/en not_active Expired - Fee Related
- 2001-07-26 ZA ZA200106182A patent/ZA200106182B/en unknown
- 2001-07-30 CU CU20010181A patent/CU23098A3/es not_active IP Right Cessation
- 2001-08-16 BG BG105824A patent/BG64983B1/bg unknown

Also Published As

Publication number	Publication date
CA2359027C (en)	2008-10-28
BR0007395A (pt)	2001-10-30
JP3795330B2 (ja)	2006-07-12
AU3046000A (en)	2000-08-18
NZ513162A (en)	2003-01-31
AP2001002247A0 (en)	2001-09-30
ES2147162B1 (es)	2001-03-16
DK1157987T3 (da)	2003-11-24
JP2002535385A (ja)	2002-10-22
EE200100389A (et)	2002-12-16
IS6020A (is)	2001-07-23
CZ20012678A3 (cs)	2001-10-17
GB2363604A (en)	2002-01-02
BG64983B1 (bg)	2006-11-30
MXPA01007570A (es)	2003-05-14
KR100671878B1 (ko)	2007-01-19
AU764725B2 (en)	2003-08-28
CA2359027A1 (en)	2000-08-03
AP1439A (en)	2005-06-27
PL202372B1 (pl)	2009-06-30
EP1157987B1 (de)	2003-09-10
OA11823A (en)	2005-08-16
TR200102003T2 (tr)	2001-12-21
HUP0105203A2 (en)	2002-06-29
PL349006A1 (en)	2002-06-17
HUP0105203A3 (en)	2002-08-28
YU53601A (sh)	2004-03-12
IS2153B (is)	2006-10-13
NO326806B1 (no)	2009-02-16
CN1337946A (zh)	2002-02-27
EP1157987A1 (de)	2001-11-28
HRP20010562B1 (en)	2010-08-31
GEP20043220B (en)	2004-04-26
BG105824A (en)	2002-06-28
US20020058629A1 (en)	2002-05-16
EA200100823A1 (ru)	2002-02-28
BR0007395B1 (pt)	2010-11-16
WO2000044714A1 (es)	2000-08-03
KR20010101767A (ko)	2001-11-14
GB2363604B (en)	2003-09-10
NO20013385L (no)	2001-09-17
ID29777A (id)	2001-10-11
ES2206178T3 (es)	2004-05-16
DE10083902T1 (de)	2002-01-10
EA003577B1 (ru)	2003-06-26
US6800612B2 (en)	2004-10-05
PT1157987E (pt)	2004-01-30
ZA200106182B (en)	2002-10-28
HRP20010562A2 (en)	2002-08-31
NO20013385D0 (no)	2001-07-06
CU23098A3 (es)	2005-11-18
HK1043586A1 (en)	2002-09-20
SI1157987T1 (en)	2004-02-29
DE60005154T2 (de)	2004-07-08
RS50072B (sr)	2009-01-22
ATE249428T1 (de)	2003-09-15
CN1166631C (zh)	2004-09-15
EE04524B1 (et)	2005-08-15
CZ298871B6 (cs)	2008-02-27
GB0120581D0 (en)	2001-10-17
IL144381A0 (en)	2002-05-23
ES2147162A1 (es)	2000-08-16
IL144381A (en)	2005-08-31

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Legal Events

Date	Code	Title	Description
2004-10-07	8364	No opposition during term of opposition