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HN2009002099A - Nuevos compuesto heterociclicos nitrogenos, su preparacion y su utilizacion como medicamentos antibacterianos. - Google Patents

Nuevos compuesto heterociclicos nitrogenos, su preparacion y su utilizacion como medicamentos antibacterianos.

Info

Publication number
HN2009002099A
HN2009002099A HN2009002099A HN2009002099A HN2009002099A HN 2009002099 A HN2009002099 A HN 2009002099A HN 2009002099 A HN2009002099 A HN 2009002099A HN 2009002099 A HN2009002099 A HN 2009002099A HN 2009002099 A HN2009002099 A HN 2009002099A
Authority
HN
Honduras
Prior art keywords
heterociclic
compound
preparation
nitrogen
antibacterial medicines
Prior art date
Application number
HN2009002099A
Other languages
English (en)
Inventor
Lampillas Maxime
Alum Rowlands David
Kebsi Adel
Ledoussail Benoit
Pierres Camile
Original Assignee
Novexel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novexel filed Critical Novexel
Publication of HN2009002099A publication Critical patent/HN2009002099A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/529—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

ESTA INVENCION SE REIERE A COMPUIESTOS HETEROCICLICOS NITROGENADOS, SU PREPAPARACION Y SU UTILIZACION COMO MEDICAMENTOS ANTIBACTERIANOS, LOS COMPUESTOS DE FORMULA GENERAL (I), EN EL CUAL R1 REPRESENTA RADIACAL (CH2)-NH2 o (CH2)-NHR, SIENDO R UN ALQUILO (C1-C6) Y SIENDO UN IGUAL A 1 o 2; R2 REPRESENTA UN ATOMO HIDROGENO R3 Y R4 FORMA JUNTOS UN HETEROCICLICO NITROGENADO DE CQARACTER AROMATICO EN VERTICES QUE COMPRENDEN 1,2 O 3 ATOMOS DE NOTROGENO EVENTUALMENTE SUSTITUIDOS POR UNO O VARIOS GRUPOS R SIENDO R ESCOGIDO ENTRE EL GRUPO FORMADO POR UN ATOMO DE HIDROGENO Y RADICALES ALQUILO QUE COMPRENDEN DE 1 A 6 ATOMOS DE CARBONO DE FORMA LIBRE, DE ZWITTERIONES Y EN FORMA DE SALES CON BASES Y ACIDOS MINERALES U ORGANICOS FARMACEUTICAMENTE ACEPTABLES.
HN2009002099A 2007-04-12 2009-10-09 Nuevos compuesto heterociclicos nitrogenos, su preparacion y su utilizacion como medicamentos antibacterianos. HN2009002099A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0702663A FR2914923B1 (fr) 2007-04-12 2007-04-12 Nouveaux composes heterocycliques azotes,leur preparation et leur utilisation comme medicaments antibacteriens.

Publications (1)

Publication Number Publication Date
HN2009002099A true HN2009002099A (es) 2012-01-05

Family

ID=38704839

Family Applications (1)

Application Number Title Priority Date Filing Date
HN2009002099A HN2009002099A (es) 2007-04-12 2009-10-09 Nuevos compuesto heterociclicos nitrogenos, su preparacion y su utilizacion como medicamentos antibacterianos.

Country Status (30)

Country Link
US (1) US8063219B2 (es)
EP (1) EP2146994B1 (es)
JP (1) JP2010523630A (es)
KR (1) KR20090130126A (es)
CN (1) CN101687870B (es)
AR (1) AR066023A1 (es)
AU (1) AU2008252799B2 (es)
BR (1) BRPI0809593A2 (es)
CA (1) CA2683350A1 (es)
CL (1) CL2008001048A1 (es)
CO (1) CO6220973A2 (es)
CR (1) CR11057A (es)
CU (1) CU23854B1 (es)
EC (1) ECSP099682A (es)
FR (1) FR2914923B1 (es)
GT (1) GT200900266A (es)
HN (1) HN2009002099A (es)
IL (1) IL201252A (es)
MX (1) MX2009010837A (es)
MY (1) MY152839A (es)
NI (1) NI200900181A (es)
NZ (1) NZ580238A (es)
PA (1) PA8776401A1 (es)
PE (1) PE20090235A1 (es)
RU (1) RU2465276C2 (es)
SV (1) SV2009003391A (es)
TW (1) TWI403323B (es)
UY (1) UY31016A1 (es)
WO (1) WO2008142285A1 (es)
ZA (1) ZA200906784B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1392679B1 (de) * 2001-05-10 2005-11-02 Solvay Pharmaceuticals GmbH Neue 1-amidomethylcarbonyl-piperidinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
FR2936798B1 (fr) * 2008-10-03 2012-09-28 Novexel Nouveaux composes heterocycliques azotes, leur preparation et leur utilisation comme medicaments antibacteriens.
FR2937034B1 (fr) * 2008-10-10 2012-11-23 Novexel Nouveaux composes heterocycliques azotes, leur preparation et leur utilisation comme medicaments antibacteriens
US9505761B2 (en) 2011-12-02 2016-11-29 Fedora Pharmaceuticals Inc. Bicyclic compounds and their use as antibacterial agents and beta-lactamase inhibitors
US8796257B2 (en) 2011-12-02 2014-08-05 Naeja Pharmaceutical Inc. Bicyclic compounds and their use as antibacterial agents and β-lactamase inhibitors
AR090539A1 (es) 2012-04-02 2014-11-19 Astrazeneca Ab COMPUESTOS INHIBIDORES DE b LACTAMASA
UA111925C2 (uk) 2012-12-11 2016-06-24 Федора Фармасьютікалз Інк. БІЦИКЛІЧНІ СПОЛУКИ ТА ЇХ ВИКОРИСТАННЯ ЯК АНТИБАКТЕРІАЛЬНИХ АГЕНТІВ ТА ІНГІБІТОРІВ β-ЛАКТАМАЗИ
AU2015350128B2 (en) 2014-11-17 2019-05-16 Entasis Therapeutics Limited Combination therapy for treatment of resistant bacterial infections
CN114591223B (zh) 2016-09-16 2025-01-24 恩塔西斯治疗有限公司 β-内酰胺酶抑制剂化合物
HUE057592T2 (hu) 2017-05-08 2022-05-28 Entasis Therapeutics Inc Vegyületek és eljárások bakteriális fertõzések kezelésére
WO2022047603A1 (en) 2020-09-01 2022-03-10 Ningxia Academy Of Agriculture And Forestry Sciences Beta-lactamase inhibitors and their preparation
WO2022233181A1 (en) 2021-05-07 2022-11-10 Ningxia Academy Of Agriculture And Forestry Sciences Sulfonylamidine substituted compounds and their use as beta-lactamase inhibitors
CN119998293A (zh) * 2023-08-08 2025-05-13 成都四面体药物研究有限公司 一种含脲三环的β-内酰胺酶抑制剂、其制备方法及其用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2812635B1 (fr) * 2000-08-01 2002-10-11 Aventis Pharma Sa Nouveaux composes heterocycliques, preparation et utilisation comme medicaments notamment comme anti- bacteriens
FR2825705B1 (fr) * 2001-06-08 2005-05-20 Aventis Pharma Sa Nouveaux composes heterocycliques, leur preparation et leur utilisation comme medicaments, notamment comme anti-bacteriens
US7439253B2 (en) * 2002-12-06 2008-10-21 Novexel Heterocyclic compounds, their preparation and their use as medicaments, in particular as antibacterials and beta-lactamase inhibitors
FR2848210B1 (fr) * 2002-12-06 2007-10-19 Aventis Pharma Sa Nouveaux composes heterocycliques, leur preparation et leur utilisation comme medicaments, notamment comme anti-bacteriens et inhibiteurs de beta-lactamases
RU2228934C1 (ru) * 2003-05-20 2004-05-20 ООО "Исследовательский институт химического разнообразия" Замещенные 3,7-диазобицикло[3.3.1]нонаны, фокусированная библиотека и комбинаторная библиотека

Also Published As

Publication number Publication date
AU2008252799A1 (en) 2008-11-27
CN101687870B (zh) 2013-06-19
ECSP099682A (es) 2009-12-28
IL201252A0 (en) 2010-05-31
FR2914923B1 (fr) 2013-06-14
GT200900266A (es) 2011-09-23
FR2914923A1 (fr) 2008-10-17
PE20090235A1 (es) 2009-03-12
CR11057A (es) 2010-04-12
KR20090130126A (ko) 2009-12-17
CU23854B1 (es) 2012-11-15
AR066023A1 (es) 2009-07-15
MY152839A (en) 2014-11-28
AU2008252799B2 (en) 2013-08-15
TW200904445A (en) 2009-02-01
ZA200906784B (en) 2011-03-30
SV2009003391A (es) 2010-07-02
EP2146994B1 (fr) 2015-07-01
TWI403323B (zh) 2013-08-01
UY31016A1 (es) 2008-11-28
NI200900181A (es) 2011-07-25
PA8776401A1 (es) 2008-11-19
RU2009137255A (ru) 2011-05-20
BRPI0809593A2 (pt) 2014-09-30
EP2146994A1 (fr) 2010-01-27
JP2010523630A (ja) 2010-07-15
CL2008001048A1 (es) 2008-08-08
NZ580238A (en) 2012-03-30
CA2683350A1 (fr) 2008-11-27
US8063219B2 (en) 2011-11-22
CU20090173A7 (es) 2011-10-14
US20100137355A1 (en) 2010-06-03
RU2465276C2 (ru) 2012-10-27
MX2009010837A (es) 2010-01-15
WO2008142285A1 (fr) 2008-11-27
CO6220973A2 (es) 2010-11-19
CN101687870A (zh) 2010-03-31
IL201252A (en) 2014-08-31

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