MX2009003882A - Compuestos heteroaromaticos biciclicos. - Google Patents
Compuestos heteroaromaticos biciclicos.Info
- Publication number
- MX2009003882A MX2009003882A MX2009003882A MX2009003882A MX2009003882A MX 2009003882 A MX2009003882 A MX 2009003882A MX 2009003882 A MX2009003882 A MX 2009003882A MX 2009003882 A MX2009003882 A MX 2009003882A MX 2009003882 A MX2009003882 A MX 2009003882A
- Authority
- MX
- Mexico
- Prior art keywords
- alkyl
- alkoxy
- aryl
- halo
- group
- Prior art date
Links
- -1 Bicyclic heteroaromatic compounds Chemical class 0.000 title abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 4
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 229910052757 nitrogen Inorganic materials 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 3
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 2
- 101100134925 Gallus gallus COR6 gene Proteins 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000002704 decyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 150000002431 hydrogen Chemical group 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 1
- 125000000081 (C5-C8) cycloalkenyl group Chemical group 0.000 abstract 1
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 abstract 1
- 125000005865 C2-C10alkynyl group Chemical group 0.000 abstract 1
- 125000005915 C6-C14 aryl group Chemical group 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000005864 Sulphur Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000005157 alkyl carboxy group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 125000004043 oxo group Chemical group O=* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Obesity (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Un compuesto de fórmula (I) (ver fórmula (I)) en donde: R1 es un grupo arilo, sustituido o no sustituido por 1, 2, 3 o 4 sustituyentes que pueden ser iguales o diferentes seleccionados del grupo que consiste de alquilo de C1-C6, alcoxi de C1-C6, alquiltio de C1-C6 arilalcoxi de C1-C6, hidroxi, halógeno, CN, COR6, COOR6, NR6COR7, CONR8R9, SO2NR8R9, NR6SO2R7, NR8R9, halógeno alquilo de C1-C4, y halógeno alcoxi de C1-C4; W es CH y X es N, o W es N y X es CH, o W y X son CH; Y es alquilo de C2-C4, R2 es hidrógeno, alquilo de C1-C6, alcoxi de C1-C6, alquilito de C1-C6, arilalcoxi de C1-C6, hidroxi, halógeno, CN, COR6, carboxi COOR6, NR6COR7, CONR8R9, SO2NR8R9, NR6SO2R7, NR8R9, mono a perfluoro-alquilo de C1-C6, o mono a perfluoro-alcoxi de C1-C6; n es 0-5; R3 es alquilo de C1-C4; R4 es alquilo de C1-C4; R5 es hidrógeno, alquilo de C1-C10, alquenilo de C2-C10, alquinilo de C2-C10, halógeno alquilo de C1-C4, cicloalquilo de C3-C8, cicloalquilo de C3-C8, cicloalquilo de C3-C8 alquilo de C1-C4, cicloalquenilo de C5-C8, cicloalquenilo de C5-C8 alquilo de C1-C4, heterocicloalquiolo de C3-C8-miembros, heterocicloalquilo de 3-8 miembros alquilo de C1-C4, arilo de C6-C14, arilo de C6-C14 alquilo de C1-C10, heteroarilo, o heteroarilalquilo de C1-C10; en donde cada grupo es opcionalmente uno o más veces el mismo y/o diferente de un grupo que es alcoxi de C1-C6, alquiltio de C1-C6 arilalcoxi de C1-C6, hidroxi, halógeno, CN, NR8R9, o halógeno alcoxi de C1-C4; R6 y R7 son independientemente hidrógeno o alquilo de C1-C10; R8 y R9 son iguales o diferentes y son hidrógeno o alquilo de C1-C10, o R9 y R10 conjuntamente con el nitrógeno al cual están unidos forman un anillo de 5-7 miembros que contienen opcionalmente uno o más heteroátomos adicionales seleccionados de oxigeno, nitrógeno y azufre, y opcionalmente sustituidos por uno o dos sustituyentes seleccionados del grupo que consiste de hidroxi, oxo, alquilo de C1-C4, alquilcarboxi de C1-C4, arilo, y arilalquilo de C1-C4; o una sal farmacéuticamente aceptable del mismo; estos compuestos son útiles para el tratamiento de ateroesclerosis u otras enfermedades inflamatorias.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US82932806P | 2006-10-13 | 2006-10-13 | |
| US11/626,882 US7705005B2 (en) | 2006-10-13 | 2007-01-25 | Bicyclic heteroaromatic compounds |
| PCT/US2007/081165 WO2008048866A2 (en) | 2006-10-13 | 2007-10-12 | Bicyclic heteroaromatic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2009003882A true MX2009003882A (es) | 2009-04-22 |
Family
ID=39303784
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2009003882A MX2009003882A (es) | 2006-10-13 | 2007-10-12 | Compuestos heteroaromaticos biciclicos. |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US7705005B2 (es) |
| EP (1) | EP2081915A4 (es) |
| JP (1) | JP2010506851A (es) |
| KR (1) | KR20090079227A (es) |
| AU (1) | AU2007312995A1 (es) |
| BR (1) | BRPI0719861A2 (es) |
| CA (1) | CA2672926A1 (es) |
| CO (1) | CO6180449A2 (es) |
| CR (1) | CR10729A (es) |
| EA (1) | EA200970379A1 (es) |
| IL (1) | IL197960A0 (es) |
| MA (1) | MA30867B1 (es) |
| MX (1) | MX2009003882A (es) |
| NO (1) | NO20091451L (es) |
| WO (1) | WO2008048866A2 (es) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080090852A1 (en) * | 2006-10-13 | 2008-04-17 | Colin Andrew Leach | Bicyclic Heteroaromatic Compounds |
| US20080090851A1 (en) * | 2006-10-13 | 2008-04-17 | Colin Andrew Leach | Bicyclic Heteroaromatic Compounds |
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| US8933024B2 (en) | 2010-06-18 | 2015-01-13 | Sanofi | Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| UY33766A (es) | 2010-12-06 | 2012-06-29 | Glaxo Group Ltd | COMPUESTOS CON ESTRUCTURA DE PIRIMIDINONA PARA USO EN EL TRATAMIENTO DE ENFERMEDADES MEDIADAS POR Lp-PLA2 |
| WO2012080497A2 (en) | 2010-12-17 | 2012-06-21 | Glaxo Group Limited | Methods of treatment and prevention of eye diseases |
| TW201321382A (zh) | 2011-07-27 | 2013-06-01 | Glaxo Group Ltd | 化合物 |
| WO2013013503A1 (en) | 2011-07-27 | 2013-01-31 | Glaxo Group Limited | 2,3-dihydroimidazo[1,2-c] pyrimidin-5(1h)-one compounds use as lp-pla2 inhibitors |
| EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| WO2013045413A1 (en) | 2011-09-27 | 2013-04-04 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| PE20151251A1 (es) | 2013-01-25 | 2015-09-10 | Glaxosmithkline Ip Dev Ltd | Derivados [5,6] biciclicos de imidazo pirimidona con actividad sobre enzimas lp-pla2 |
| WO2014114249A1 (en) | 2013-01-25 | 2014-07-31 | Glaxosmithkline Intellectual Property Development Limited | Bicyclic pyrimidone compounds as inhibitors of lp-pla2 |
| AU2014210259B2 (en) | 2013-01-25 | 2016-11-03 | Glaxosmithkline Intellectual Property Development Limited | Compounds |
| WO2016012917A1 (en) | 2014-07-22 | 2016-01-28 | Glaxosmithkline Intellectual Property Development Limited | 1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidine derivatives useful in the treatment of diseases and disorders mediated by lp-pla2 |
| WO2016012916A1 (en) | 2014-07-22 | 2016-01-28 | Glaxosmithkline Intellectual Property Development Limited | 1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidine derivatives useful in the treatment of diseases and disorders mediated by lp-pla2 |
| EP4056571A4 (en) | 2019-11-09 | 2024-01-24 | Shanghai Simr Biotechnology Co., Ltd. | TRICYCLIC DIHYDROIMIDAZOPYRIMIDONE DERIVATIVE, METHOD FOR THE PRODUCTION THEREOF, PHARMACEUTICAL COMPOSITION AND USE THEREOF |
| CN115304620A (zh) | 2021-05-07 | 2022-11-08 | 上海赛默罗生物科技有限公司 | 嘧啶酮衍生物、其制备方法、药物组合物和用途 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE437862T1 (de) | 2000-02-16 | 2009-08-15 | Smithkline Beecham Plc | Pyrimidin-5-onderivate als ldl-pla2 inhibitoren |
| GB0024808D0 (en) * | 2000-10-10 | 2000-11-22 | Smithkline Beecham Plc | Novel compounds |
| GB0024807D0 (en) * | 2000-10-10 | 2000-11-22 | Smithkline Beecham Plc | Novel compounds |
| GB0119795D0 (en) | 2001-08-14 | 2001-10-03 | Smithkline Beecham Plc | Novel process |
| GB0127141D0 (en) | 2001-11-10 | 2002-01-02 | Smithkline Beecham Plc | Novel compounds |
| GB0127139D0 (en) | 2001-11-10 | 2002-01-02 | Smithkline Beecham | Novel compounds |
| AU2002361972A1 (en) * | 2001-12-07 | 2003-06-17 | Societe De Technologie Michelin | Method for preparing butadiene/isoprene copolymers and resulting copolymers |
| GB0208279D0 (en) | 2002-04-10 | 2002-05-22 | Glaxo Group Ltd | Novel compounds |
| GB0208280D0 (en) | 2002-04-10 | 2002-05-22 | Glaxo Group Ltd | Novel compounds |
| US20080090851A1 (en) | 2006-10-13 | 2008-04-17 | Colin Andrew Leach | Bicyclic Heteroaromatic Compounds |
| US20080090852A1 (en) | 2006-10-13 | 2008-04-17 | Colin Andrew Leach | Bicyclic Heteroaromatic Compounds |
-
2007
- 2007-01-25 US US11/626,882 patent/US7705005B2/en not_active Expired - Fee Related
- 2007-10-12 JP JP2009532588A patent/JP2010506851A/ja active Pending
- 2007-10-12 EA EA200970379A patent/EA200970379A1/ru unknown
- 2007-10-12 AU AU2007312995A patent/AU2007312995A1/en not_active Abandoned
- 2007-10-12 WO PCT/US2007/081165 patent/WO2008048866A2/en not_active Ceased
- 2007-10-12 KR KR1020097009494A patent/KR20090079227A/ko not_active Withdrawn
- 2007-10-12 MX MX2009003882A patent/MX2009003882A/es unknown
- 2007-10-12 CA CA002672926A patent/CA2672926A1/en not_active Abandoned
- 2007-10-12 EP EP07844195A patent/EP2081915A4/en not_active Withdrawn
- 2007-10-12 BR BRPI0719861-2A patent/BRPI0719861A2/pt not_active IP Right Cessation
-
2009
- 2009-04-05 IL IL197960A patent/IL197960A0/en unknown
- 2009-04-07 CO CO09035905A patent/CO6180449A2/es not_active Application Discontinuation
- 2009-04-14 NO NO20091451A patent/NO20091451L/no not_active Application Discontinuation
- 2009-04-17 CR CR10729A patent/CR10729A/es not_active Application Discontinuation
- 2009-05-06 MA MA31844A patent/MA30867B1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2672926A1 (en) | 2008-04-24 |
| WO2008048866A2 (en) | 2008-04-24 |
| BRPI0719861A2 (pt) | 2014-06-03 |
| CO6180449A2 (es) | 2010-07-19 |
| CR10729A (es) | 2009-05-25 |
| NO20091451L (no) | 2009-07-02 |
| US7705005B2 (en) | 2010-04-27 |
| US20080090853A1 (en) | 2008-04-17 |
| EP2081915A4 (en) | 2011-11-16 |
| WO2008048866A3 (en) | 2008-12-24 |
| IL197960A0 (en) | 2009-12-24 |
| EA200970379A1 (ru) | 2009-08-28 |
| AU2007312995A1 (en) | 2008-04-24 |
| JP2010506851A (ja) | 2010-03-04 |
| KR20090079227A (ko) | 2009-07-21 |
| MA30867B1 (fr) | 2009-11-02 |
| EP2081915A2 (en) | 2009-07-29 |
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