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GT200600213A - Metodos para sintetizar 3-cianoquinolinas sustituidas y sus intermediarios - Google Patents

Metodos para sintetizar 3-cianoquinolinas sustituidas y sus intermediarios

Info

Publication number
GT200600213A
GT200600213A GT200600213A GT200600213A GT200600213A GT 200600213 A GT200600213 A GT 200600213A GT 200600213 A GT200600213 A GT 200600213A GT 200600213 A GT200600213 A GT 200600213A GT 200600213 A GT200600213 A GT 200600213A
Authority
GT
Guatemala
Prior art keywords
methods
syntheize
cianoquinolins
intermediaries
substituted
Prior art date
Application number
GT200600213A
Other languages
English (en)
Inventor
Warren Chew
Gloria Karen Cheal
Jacqueline Francesca Lunetta
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37037465&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GT200600213(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed filed Critical
Publication of GT200600213A publication Critical patent/GT200600213A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Quinoline Compounds (AREA)

Abstract

LA INVENCIÓN SE REFIERE A MÉTODOS PARA PRODUCIR 3-CIANOQUINOLINAS SUSTITUIDAS, QUE INCLUYEN LOS COMPUESTOS DE ACUERDO CON LA SIGUIENTE FÓRMULA (IV), DICHOS MÉTODOS SON ADECUADOS PARA LA PRODUCCIÓN A GRAN ESCALA, ADEMÁS EVITA EL USO DE SEPARACIONES CROMATOGRÁFICAS, Y SE OBTIENE UN PRODUCTO ESTABLE DE PUREZA ELEVADA, EN FORMA MÁS EFICIENTE QUE EN LA TÉCNICA ANTERIOR.
GT200600213A 2005-05-25 2006-05-22 Metodos para sintetizar 3-cianoquinolinas sustituidas y sus intermediarios GT200600213A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US68439105P 2005-05-25 2005-05-25

Publications (1)

Publication Number Publication Date
GT200600213A true GT200600213A (es) 2007-01-12

Family

ID=37037465

Family Applications (1)

Application Number Title Priority Date Filing Date
GT200600213A GT200600213A (es) 2005-05-25 2006-05-22 Metodos para sintetizar 3-cianoquinolinas sustituidas y sus intermediarios

Country Status (19)

Country Link
US (1) US20060270668A1 (es)
EP (1) EP1883631A1 (es)
JP (1) JP2008545688A (es)
KR (1) KR20080016671A (es)
CN (1) CN101203494A (es)
AR (1) AR053872A1 (es)
AU (1) AU2006249600A1 (es)
BR (1) BRPI0610147A2 (es)
CA (1) CA2609186A1 (es)
CR (1) CR9544A (es)
GT (1) GT200600213A (es)
IL (1) IL187532A0 (es)
NO (1) NO20076067L (es)
PA (1) PA8676201A1 (es)
PE (1) PE20061417A1 (es)
RU (1) RU2007143161A (es)
TW (1) TW200716557A (es)
WO (1) WO2006127207A1 (es)
ZA (1) ZA200710148B (es)

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CN109320686B (zh) * 2018-08-29 2021-06-08 华南理工大学 一种聚异脲类聚合物及其制备方法和应用
CN112679473B (zh) * 2019-10-18 2024-03-05 四川科伦药物研究院有限公司 来那替尼中间体晶体、制备方法及其用途
CN111875539B (zh) * 2020-07-15 2022-06-21 苏中药业集团股份有限公司 一种egfr类分子靶向抗肿瘤药物的制备方法
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Also Published As

Publication number Publication date
US20060270668A1 (en) 2006-11-30
KR20080016671A (ko) 2008-02-21
NO20076067L (no) 2007-12-21
AR053872A1 (es) 2007-05-23
ZA200710148B (en) 2008-09-25
IL187532A0 (en) 2008-03-20
BRPI0610147A2 (pt) 2010-06-01
CN101203494A (zh) 2008-06-18
PE20061417A1 (es) 2007-01-20
CR9544A (es) 2008-03-07
RU2007143161A (ru) 2009-07-10
WO2006127207A1 (en) 2006-11-30
PA8676201A1 (es) 2009-03-31
EP1883631A1 (en) 2008-02-06
AU2006249600A1 (en) 2006-11-30
TW200716557A (en) 2007-05-01
CA2609186A1 (en) 2006-11-30
JP2008545688A (ja) 2008-12-18

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