[go: up one dir, main page]

GT200600112A - Composiciiones de tigeciclina y metodos de preparacion - Google Patents

Composiciiones de tigeciclina y metodos de preparacion

Info

Publication number
GT200600112A
GT200600112A GT200600112A GT200600112A GT200600112A GT 200600112 A GT200600112 A GT 200600112A GT 200600112 A GT200600112 A GT 200600112A GT 200600112 A GT200600112 A GT 200600112A GT 200600112 A GT200600112 A GT 200600112A
Authority
GT
Guatemala
Prior art keywords
tigecicline
compositions
preparation methods
regulator
development
Prior art date
Application number
GT200600112A
Other languages
English (en)
Inventor
Mahdi B Fawzi
Tianmin Zhu
Syed M Shah
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36648809&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GT200600112(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed filed Critical
Publication of GT200600112A publication Critical patent/GT200600112A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

LA PRESENTE INVENCIÓN SE RELACIONA CON NUEVAS COMPOSICIONES DE TIGECICLINA CON MEJOR ESTABILIDAD, TANTO EN ESTADOS SÓLIDOS COMO EN SOLUCIÓN, Y CON PROCESOS PARA SU ELABORACIÓN. ESTAS COMPOSICIONES COMPRENDEN TIGECICLINA, UN CARBOHIDRATO ADECUADO Y UN ÁCIDO O REGULADOR.
GT200600112A 2005-03-14 2006-03-13 Composiciiones de tigeciclina y metodos de preparacion GT200600112A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US66103005P 2005-03-14 2005-03-14

Publications (1)

Publication Number Publication Date
GT200600112A true GT200600112A (es) 2006-11-29

Family

ID=36648809

Family Applications (1)

Application Number Title Priority Date Filing Date
GT200600112A GT200600112A (es) 2005-03-14 2006-03-13 Composiciiones de tigeciclina y metodos de preparacion

Country Status (25)

Country Link
US (5) US7879828B2 (es)
EP (1) EP1858488B2 (es)
JP (1) JP4972081B2 (es)
KR (2) KR20130122988A (es)
CN (2) CN101132775A (es)
AR (2) AR053827A1 (es)
AU (1) AU2006223226B2 (es)
BR (1) BRPI0608464A2 (es)
CA (1) CA2602089C (es)
CR (1) CR9416A (es)
CY (1) CY1114504T1 (es)
DK (1) DK1858488T4 (es)
ES (1) ES2434944T5 (es)
GT (1) GT200600112A (es)
HN (1) HN2006011218A (es)
IL (1) IL185924A (es)
MX (1) MX2007010983A (es)
NO (1) NO20074278L (es)
PE (1) PE20061107A1 (es)
PL (1) PL1858488T5 (es)
PT (1) PT1858488E (es)
RU (1) RU2428190C2 (es)
TW (1) TW200700092A (es)
WO (1) WO2006099258A1 (es)
ZA (1) ZA200707831B (es)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GT200600112A (es) 2005-03-14 2006-11-29 Composiciiones de tigeciclina y metodos de preparacion
AR057649A1 (es) * 2005-05-27 2007-12-12 Wyeth Corp Formas solidas cristalinas de tigeciclina y metodos para preparar las mismas
PE20070072A1 (es) * 2005-06-16 2007-02-25 Wyeth Corp Proceso de manufactura para tigeciclina como polvo reconstituible
US7645789B2 (en) 2006-04-07 2010-01-12 Vertex Pharmaceuticals Incorporated Indole derivatives as CFTR modulators
CN101489987A (zh) * 2006-04-17 2009-07-22 特瓦制药工业有限公司 四环素衍生物的分离
PT2016045E (pt) * 2006-04-24 2015-02-05 Teva Pharma Forma cristalina de tigeciclina e processos para a sua preparação
US8198470B2 (en) * 2006-04-24 2012-06-12 Teva Pharmaceutical Industries Ltd. Crystalline form II of tigecycline and processes for preparation thereof
FR2910812B1 (fr) * 2006-12-29 2009-03-20 Pierre Fabre Medicament Sa Compositions pharmaceutiques injectables lyophilisees de derives hemi-synthetiques d'alcaloide de vinca stables a temperature ambiante
PT2271348T (pt) * 2008-03-28 2018-04-16 Paratek Pharm Innc Formulação de comprimido oral de composto de tetraciclina
US9107929B2 (en) 2008-05-01 2015-08-18 Ranbaxy Laboratories Limited Stable parenteral formulations of tigecycline
US20100035845A1 (en) * 2008-08-06 2010-02-11 Wyeth Tigecycline formulations
CN102138925B (zh) * 2010-01-29 2014-06-25 正大天晴药业集团股份有限公司 替加环素组合物及其制备方法
ES2715551T3 (es) * 2010-05-12 2019-06-04 The Medicines Company San Diego Llc Composiciones de tetraciclina
EP2719393B1 (en) * 2011-06-07 2020-10-21 Asahi Kasei Pharma Corporation Freeze-dried preparation containing high-purity pth and method for producing same
CN102391148B (zh) * 2011-10-24 2014-01-08 江苏奥赛康药业股份有限公司 一种高纯度替加环素的合成方法
CN103315947B (zh) 2012-03-22 2016-01-20 上海汇伦生命科技有限公司 一种注射用替加环素组合物
CN103356662B (zh) * 2012-03-27 2015-11-25 浙江医药股份有限公司新昌制药厂 注射用替加环素组合物及其制备方法
CN102641249A (zh) * 2012-05-06 2012-08-22 江苏奥赛康药业股份有限公司 一种替加环素组合物的制备方法
CN103417498B (zh) * 2012-05-18 2017-09-12 山东新时代药业有限公司 一种替加环素冻干粉针剂的制备方法
CN102697739B (zh) * 2012-05-31 2014-10-29 丽珠医药集团股份有限公司 一种减少替加环素差向异构体化的粉针剂制备方法
CN102911077B (zh) * 2012-11-12 2015-01-07 成都百裕科技制药有限公司 4r-替加环素的制备方法
IN2013MU01127A (es) 2013-03-26 2015-05-01 Astron Res Ltd
WO2014167575A2 (en) * 2013-03-26 2014-10-16 Astron Research Limited Stable tigecycline composition
CN104107170A (zh) * 2013-04-22 2014-10-22 上海汇伦生命科技有限公司 一种替加环素组合物
US20140323443A1 (en) * 2013-04-30 2014-10-30 Fresenius Kabi Usa, Llc Tigecycline formulations
EP3068370A2 (en) 2013-11-12 2016-09-21 Galenicum Health S.L. Stable pharmaceutical compositions
NO2723977T3 (es) 2014-03-19 2018-03-10
CN105079816B (zh) * 2015-08-17 2018-09-07 江苏豪森药业集团有限公司 替加环素药物组合物及其制备方法
CN108653216B (zh) * 2018-05-28 2020-12-18 福安药业集团湖北人民制药有限公司 注射用替加环素
WO2021063468A1 (en) * 2019-10-02 2021-04-08 Anfarm Hellas S.A. Stable parenteral pharmaceutical composition containing tigecycline and process for the preparation thereof
CN113582870A (zh) * 2020-05-01 2021-11-02 复旦大学附属华山医院 一种恢复替加环素抗菌活性的方法
IT202100031133A1 (it) 2021-12-13 2023-06-13 Zambon Spa Composizione farmaceutica comprendente tigeciclina

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH225704A (de) 1942-01-06 1943-02-15 Schlotterbeck Automobile Aktie Holzgasgenerator.
GB901107A (en) 1959-06-29 1962-07-11 Pfizer Therapeutic composition and method of preparing same
US3026248A (en) * 1959-09-11 1962-03-20 Pfizer & Co C Thioglycerol and formaldehyde sulfoxylate stabilized tetracycline antibiotics in polyhydric alcohol solvents
US3106512A (en) * 1961-07-19 1963-10-08 Olin Mathieson Stabilization of tetracycline base in dry form with glucono delta lactone
US3145228A (en) * 1962-09-06 1964-08-18 Pfizer & Co C 5-alkoxy-and 5-benzyloxy-tetracycline, derivatives and analogues thereof
US3219529A (en) * 1962-10-04 1965-11-23 American Cyanamid Co Stable tetracycline solutions
US4038315A (en) * 1972-05-11 1977-07-26 American Cyanamid Company Isolation and recovery of calcium chloride complex of 7-dimethylamino-6-dimethyl l-6-deoxytetracycline hydrochloride
DE2748132A1 (de) 1977-10-27 1979-05-03 Behringwerke Ag Stabilisator fuer polysaccharid
US4457916A (en) 1982-08-31 1984-07-03 Asahi Kasei Kogyo Kabushiki Kaisha Method for stabilizing Tumor Necrosis Factor and a stable aqueous solution or powder containing the same
US4678812A (en) 1986-05-30 1987-07-07 E. I. Du Pont De Nemours And Company Trehalose as stabilizer and tableting excipient
US5122519A (en) * 1989-06-27 1992-06-16 American Cyanamid Company Stable, cosmetically acceptable topical gel formulation and method of treatment for acne
EP0779603B1 (en) † 1990-06-22 2002-03-27 Canon Kabushiki Kaisha Image processing apparatus
US5494903A (en) * 1991-10-04 1996-02-27 American Cyanamid Company 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
US5538954A (en) * 1994-06-24 1996-07-23 A/S Dumex (Dumex Ltd.) Salts of tetracyclines
US5675030A (en) † 1994-11-16 1997-10-07 American Cyanamid Company Method for selective extracting a 7-(hydrogen or substituted amino)-9- (substituted glycyl) amido!-6-demethyl-6-deoxytetracycline compound
US6503881B2 (en) * 1996-08-21 2003-01-07 Micrologix Biotech Inc. Compositions and methods for treating infections using cationic peptides alone or in combination with antibiotics
US5908838A (en) * 1998-02-19 1999-06-01 Medics Pharmaceutical Corporation Method for the treatment of acne
WO2001019362A2 (en) 1999-09-14 2001-03-22 Orapharma, Inc. Formulations for treating or preventing mucositis
AU2000265203A1 (en) 2000-08-04 2002-02-18 Trustees Of Tufts College 8-substituted tetracycline compounds
AU2002241849A1 (en) 2001-01-11 2002-07-24 Board Of Regents, The University Of Texas System Dosage adjustement for antibiotics
CA2449002C (en) 2001-05-29 2011-08-16 Tap Pharmaceutical Products Inc. Enhancement of oral bioavailability of non-emulsified formulation of prodrug esters with lecithin
US20040063674A1 (en) 2001-07-13 2004-04-01 Levy Stuart B. Tetracycline compounds having target therapeutic activities
US20030171340A1 (en) 2002-02-07 2003-09-11 Jenefir Isbister Methods of disease treatment using metal-complexed tetracycline antibiotics
CN1390550A (zh) * 2002-07-25 2003-01-15 于航 盐酸米诺环素冻干粉针剂及其制备方法
CA2503446C (en) 2002-10-24 2012-12-18 Paratek Pharmaceuticals, Inc. Methods of using substituted tetracycline compounds to modulate rna
WO2004078111A2 (en) 2003-03-06 2004-09-16 Ranbaxy Laboratories Limited Extended release minocycline compositions and processes for their preparation
CN1568999A (zh) † 2003-07-14 2005-01-26 南宁枫叶药业有限公司 稳定的医药用河豚毒素冷冻干燥制剂
US20050148553A1 (en) * 2003-09-05 2005-07-07 Testa Raymond T. Use of tigecycline, alone, or in combination with rifampin to treat osteomyelitis and/or septic arthritis
GB2414668B (en) 2004-06-03 2009-07-29 Dexcel Ltd Tetracycline modified release delivery system
ATE415973T1 (de) * 2004-10-28 2008-12-15 Wyeth Corp Gemeinsame gabe von tigecyclin und digoxin
GT200600112A (es) * 2005-03-14 2006-11-29 Composiciiones de tigeciclina y metodos de preparacion
AR057034A1 (es) 2005-05-27 2007-11-14 Wyeth Corp Metodos para purificar tigeciclina
WO2014191552A1 (en) † 2013-05-31 2014-12-04 Xellia Pharmaceuticals Aps A method for stabilizing tigecycline

Also Published As

Publication number Publication date
KR20080002828A (ko) 2008-01-04
US9694078B2 (en) 2017-07-04
WO2006099258A1 (en) 2006-09-21
BRPI0608464A2 (pt) 2010-01-05
CN101132775A (zh) 2008-02-27
US7879828B2 (en) 2011-02-01
PT1858488E (pt) 2013-11-18
US20110118216A1 (en) 2011-05-19
DK1858488T4 (da) 2022-09-12
AU2006223226A1 (en) 2006-09-21
EP1858488A1 (en) 2007-11-28
TW200700092A (en) 2007-01-01
US20160144036A1 (en) 2016-05-26
CN102512429A (zh) 2012-06-27
WO2006099258A8 (en) 2007-10-04
ZA200707831B (en) 2011-02-23
AR053827A1 (es) 2007-05-23
CA2602089C (en) 2013-04-30
CR9416A (es) 2008-03-06
US8975242B2 (en) 2015-03-10
RU2428190C2 (ru) 2011-09-10
US9254328B2 (en) 2016-02-09
DK1858488T3 (da) 2013-11-04
AR109500A2 (es) 2018-12-19
MX2007010983A (es) 2007-09-19
IL185924A0 (en) 2008-01-06
EP1858488B2 (en) 2022-07-20
KR20130122988A (ko) 2013-11-11
PL1858488T3 (pl) 2014-01-31
KR101354093B1 (ko) 2014-01-24
JP2008533146A (ja) 2008-08-21
IL185924A (en) 2014-05-28
ES2434944T3 (es) 2013-12-18
HN2006011218A (es) 2008-09-17
CA2602089A1 (en) 2006-09-21
NO20074278L (no) 2007-11-20
CY1114504T1 (el) 2016-10-05
RU2007131396A (ru) 2009-04-20
JP4972081B2 (ja) 2012-07-11
ES2434944T5 (es) 2022-10-20
US20060247181A1 (en) 2006-11-02
US20150141379A1 (en) 2015-05-21
PE20061107A1 (es) 2006-12-08
AU2006223226B2 (en) 2012-03-15
US20170266290A1 (en) 2017-09-21
US10588975B2 (en) 2020-03-17
PL1858488T5 (pl) 2024-01-03
EP1858488B1 (en) 2013-09-11

Similar Documents

Publication Publication Date Title
GT200600112A (es) Composiciiones de tigeciclina y metodos de preparacion
ECSP099296A (es) Inmuno-reguladores, preparaciones y composiciones que incluyen los inmuno-reguladores, pruebas para evaluar la actividad de los inmuno-reguladores y preparaciones y composiciones que incluyen los mismos y métodos
CY1117721T1 (el) Κυτταρα προελευσης αμνιακου υγρου
MX373050B (es) Antagonistas de activina-actrii y usos para incrementar los niveles de globulos rojos.
CY1110860T1 (el) Αναστροφη μεταγραφαση τελομερασης πτηνου
ECSP10010344A (es) Azolilmetiloxiranos, su uso y agentes que los contienen
MX2020003168A (es) Pirimidinas modificadas en la posicion 5 y su uso.
GT200600035A (es) Aminopiridinas como inhibidores de beta-secretasa
AR053066A1 (es) Arabinofuranosidasas
CO6470854A2 (es) Variantes de celulasa con expresión, actividad y/o estabilidad mejoradas, y uso de las mismas
BR112012031071A2 (pt) 8-proteínas de ligação à il-1
MX339624B (es) Composiciones mejoradas de celulas y metodos para preparar las mismas.
MX2012009088A (es) Anticuerpos que se enlazan a lisil oxidasa-tipo2 (loxl2) y metodos de uso para los mismos.
MX2011011942A (es) Metodos para el diagnostico de trastornos oncologicos usando intercambiadores epimetabolicos, moleculas intracelulares multidimensionales, o influyentes ambientales.
GT200600316A (es) Sales de 4-metilo-n-(3-(4-metilo-imidazol-1-ilo)-5-trifluorometilo-fenilo)-3-(4-piridina-3-ilo-pirimidina-2-iloamino)- benzamida.
ATE548050T1 (de) Diagnoseverfahren
GT200600227A (es) Formas solidas cristalinas de tigeciclina y metodos para preparar las mismas
PA8671301A1 (es) Pirrolopiridinas sustituidas, composiciones que las contienen, proceso de fabricación y utilización
CR20110660A (es) Mezclas fungicidas
PA8845301A1 (es) Polipéptidos que tienen actividad antimicrobiana
CR9853A (es) Compuestos de exemestano (s)-6-metiloxaalquilo y metodos relacionados con su utilizacion
ATE549638T1 (de) 13c-mr-bildgebung oder spektroskopie von zelltod
UY29857A1 (es) Derivados de la 4-amino-quinazolina, su preparación y su aplicación en terapéutica.
ATE524482T1 (de) Ionische flüssigkeiten mit niedriger viskosität
EP4509835A3 (en) Utility of protein in the prediction of in vivo effects