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GT199900056A - Nuevas dihidropirimidinas - Google Patents

Nuevas dihidropirimidinas

Info

Publication number
GT199900056A
GT199900056A GT199900056A GT199900056A GT199900056A GT 199900056 A GT199900056 A GT 199900056A GT 199900056 A GT199900056 A GT 199900056A GT 199900056 A GT199900056 A GT 199900056A GT 199900056 A GT199900056 A GT 199900056A
Authority
GT
Guatemala
Prior art keywords
dihydropyrimidines
new
new dihydropyrimidines
irmulas
precisely
Prior art date
Application number
GT199900056A
Other languages
English (en)
Inventor
Joern Stoelting
Juergen Stoltefub
Siegfried Goldmann
Thomas Dr Kraemer
Karl-Heinz Dr Schlemer
Ulrich Niewhoener
Arnold Dr Paebens
Erwin Dr Graef
Stefan Dr Lottmann
Olaf Weber
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GT199900056A publication Critical patent/GT199900056A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/20—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D239/22—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Saccharide Compounds (AREA)

Abstract

LA PRESENTE INVENCIÒN SE REFIERE A NUEVAS DIHIDROPIRIMIDINAS [INDICADAS ABAJO COMO FÒRMULAS (I) & (IA), DONDE LOS SÌMBOLOS "R" REPRESENTAN SUSTITUYENTES PREDILECTOS LISTADOS CON PRECISIÒN EN EL DOCUMENTO], A UN PROCEDIMIENTO PARA SU PREPARACIÒN Y SU USO COMO MEDICAMENTOS, ESPECIALMENTE PARA EL TRATAMIENTO Y
GT199900056A 1998-04-18 1999-04-16 Nuevas dihidropirimidinas GT199900056A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19817264A DE19817264A1 (de) 1998-04-18 1998-04-18 Neue Dihydropyrimidine

Publications (1)

Publication Number Publication Date
GT199900056A true GT199900056A (es) 2000-10-07

Family

ID=7864972

Family Applications (1)

Application Number Title Priority Date Filing Date
GT199900056A GT199900056A (es) 1998-04-18 1999-04-16 Nuevas dihidropirimidinas

Country Status (36)

Country Link
US (3) US6696451B1 (es)
EP (1) EP1080086B1 (es)
JP (2) JP4590097B2 (es)
KR (1) KR100636771B1 (es)
CN (1) CN1159311C (es)
AR (1) AR018187A1 (es)
AT (1) ATE223401T1 (es)
AU (1) AU740318B2 (es)
BG (1) BG64649B1 (es)
BR (2) BR9909730B1 (es)
CA (1) CA2328780C (es)
CO (1) CO5021127A1 (es)
CU (1) CU23049A3 (es)
CZ (1) CZ293482B6 (es)
DE (2) DE19817264A1 (es)
DK (1) DK1080086T3 (es)
ES (1) ES2183548T3 (es)
GT (1) GT199900056A (es)
HU (1) HUP0102372A3 (es)
ID (1) ID27263A (es)
IL (2) IL138584A0 (es)
MY (1) MY126527A (es)
NO (2) NO321985B1 (es)
NZ (1) NZ507569A (es)
PE (1) PE20000427A1 (es)
PL (1) PL193898B1 (es)
PT (1) PT1080086E (es)
RU (1) RU2245881C9 (es)
SI (1) SI1080086T1 (es)
SK (1) SK286407B6 (es)
SV (1) SV1999000047A (es)
TR (1) TR200003011T2 (es)
TW (1) TW548274B (es)
UA (1) UA63998C2 (es)
WO (1) WO1999054326A1 (es)
ZA (1) ZA200005136B (es)

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AU4289100A (en) * 1999-03-25 2000-10-16 Bayer Aktiengesellschaft Dihydropyrimidines and their use in the treatment of hepatitis
AU5568400A (en) 1999-06-23 2001-01-09 Ajinomoto Co., Inc. Novel dihydropyrimidine derivatives
AU3009801A (en) * 1999-12-22 2001-07-03 Bayer Aktiengesellschaft Combinations of medicaments for treating viral diseases
DE10012823A1 (de) 2000-03-16 2001-09-20 Bayer Ag Arzneimittel gegen virale Erkrankungen
DE10013126A1 (de) * 2000-03-17 2001-09-20 Bayer Ag Arzneimittel gegen virale Erkrankungen
DE10013125A1 (de) * 2000-03-17 2001-09-20 Bayer Ag Arzneimittel gegen virale Erkrankungen
DE10125131A1 (de) 2001-05-23 2002-12-05 Bayer Ag Verfahren zur Spaltung des Methyl 4-(2-chlor-4-fluorphenyl)-2-(3,5-difluor-2-pyridinyl)-6-methyl-1,4-dihydro-5-pyrmidincarboxylat-Racemats
US20040092735A1 (en) * 2002-11-08 2004-05-13 Orchid Chemicals & Pharmaceuticals Limited Process for the preparation of cefuroxime sodium
CN101104617B (zh) * 2006-07-10 2010-06-23 北京摩力克科技有限公司 二氢嘧啶类化合物及其用于制备治疗和预防病毒性疾病的药物的用途
CN101104604B (zh) * 2006-07-10 2011-03-02 北京摩力克科技有限公司 光学纯二氢嘧啶类化合物及其用于制备治疗和预防病毒性疾病的药物的用途
RU2452733C2 (ru) * 2007-04-27 2012-06-10 Пэдью Фарма Л.П. Антагонисты trpv1 и их применение
RU2443703C2 (ru) 2007-06-18 2012-02-27 Саншайн Лейк Фарма Ко., Лтд Бром-фенил замещенные тиазолилдигидропиримидины
EP2178503A1 (en) 2007-07-12 2010-04-28 Novartis Ag Oral pharmaceutical solutions containing telbivudine
US20130267517A1 (en) 2012-03-31 2013-10-10 Hoffmann-La Roche Inc. Novel 4-methyl-dihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection
CA2876690C (en) 2012-08-24 2020-06-09 Sunshine Lake Pharma Co., Ltd. Dihydropyrimidine compounds and their application in pharmaceuticals
EP2892893B2 (en) 2012-09-10 2019-10-16 F.Hoffmann-La Roche Ag 6-amino acid heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection
CN103664899B (zh) * 2012-09-11 2017-06-16 广东东阳光药业有限公司 杂芳基取代的二氢嘧啶类化合物及其在药物中的应用
JP2016502519A (ja) * 2012-11-09 2016-01-28 インディアナ・ユニバーシティ・リサーチ・アンド・テクノロジー・コーポレーション Ｈｂｖ集合エフェクターの代替的使用
TW201609652A (zh) * 2013-11-12 2016-03-16 陶氏農業科學公司 用於氟化化合物之過程（三）
MX2016006564A (es) 2013-11-19 2017-09-12 Sunshine Lake Pharma Co Ltd Compuestos dihidropirimidina y su aplicacion en productos farmaceuticos.
RU2688193C1 (ru) 2013-11-27 2019-05-21 Саншайн Лейк Фарма Ко., Лтд. Процессы приготовления производных дигидропиримидина и их промежуточных соединений
EP3122747B1 (en) 2014-03-28 2020-05-20 North & South Brother Pharmacy Investment Company Limited Dihydropyrimidine compounds and their application in pharmaceuticals
CN105153164B (zh) * 2014-05-30 2018-10-30 齐鲁制药有限公司 作为hbv抑制剂的二氢嘧啶并环衍生物
RU2693897C2 (ru) * 2014-05-30 2019-07-05 Килу Фармасьютикал Ко., Лтд. Производное на основе дигидропиримидо-кольца в качестве ингибитора hbv
US10098889B2 (en) 2015-02-07 2018-10-16 Sunshine Lake Pharma Co., Ltd. Complexes and salts of dihydropyrimidine derivatives and their application in pharmaceuticals
WO2019001420A1 (en) * 2017-06-27 2019-01-03 Janssen Pharmaceutica Nv HETEROARYLDIHYDROPYRIMIDINE DERIVATIVES AND METHODS OF TREATING INFECTIONS WITH HEPATITIS B VIRUS
US10759774B2 (en) 2017-09-28 2020-09-01 The Curators Of The University Of Missouri Inhibitors of hepatitis B virus targeting capsid assembly
WO2019086142A1 (en) 2017-11-02 2019-05-09 Aicuris Gmbh & Co. Kg Novel, highly active pyrazolo-piperidine substituted indole-2-carboxamides active against the hepatitis b virus (hbv)
CN111448199A (zh) 2017-11-02 2020-07-24 艾库里斯有限及两合公司 具有抗乙型肝炎病毒(hbv)活性的新的高活性的氨基-噻唑取代的吲哚-2-甲酰胺
MA52586A (fr) * 2018-05-08 2021-03-17 Janssen Sciences Ireland Unlimited Co Dérivés de dihydropyrimidine et leurs utilisations dans le traitement d'une infection par le virus de l'hépatite b ou de maladies induites par le virus de l'hépatite b
US11053235B2 (en) 2018-08-09 2021-07-06 Janssen Sciences Ireland Unlimited Company Substituted 1,4-dihydropyrimidines for the treatment of HBV infection or HBV-induced diseases
UY38434A (es) 2018-11-02 2020-05-29 Aicuris Gmbh & Co Kg Nuevas 6,7-dihidro-4h-pirazolo[1,5-a]pirazin indol-2-carboxamidas activas contra el virus de la hepatitis b (hbv)
AR117188A1 (es) 2018-11-02 2021-07-21 Aicuris Gmbh & Co Kg Derivados de urea 6,7-dihidro-4h-pirazolo[1,5-a]pirazinas activas contra el virus de la hepatitis b (vhb)
AR116948A1 (es) 2018-11-02 2021-06-30 Aicuris Gmbh & Co Kg Derivados de urea 6,7-dihidro-4h-pirazolo[1,5-a]pirazinas activas contra el virus de la hepatitis b (vhb)
AR116947A1 (es) 2018-11-02 2021-06-30 Aicuris Gmbh & Co Kg Derivados de urea 6,7-dihidro-4h-pirazolo[1,5-a]pirazinas-indol-2-carboxamidas activas contra el virus de la hepatitis b (vhb)
US20220009945A1 (en) * 2018-11-02 2022-01-13 Aicuris Gmbh & Co. Kg Novel urea 6,7-dihydro-4h-thiazole[5,4-c]pyridines active against the hepatitis b virus (hbv)
AR116946A1 (es) 2018-11-02 2021-06-30 Aicuris Gmbh & Co Kg Derivados de urea 6,7-dihidro-4h-pirazolo[4,3-c]piridinas activas contra el virus de la hepatitis b (vhb)
CN113227090A (zh) 2018-12-20 2021-08-06 詹森药业有限公司 杂芳基二氢嘧啶衍生物和治疗乙型肝炎感染的方法
CU20210089A7 (es) 2019-04-30 2022-06-06 Aicuris Gmbh & Co Kg Compuestos derivados de fenil y piridil ureas activas contra el virus de la hepatitis b (vhb)
AU2020266258A1 (en) 2019-04-30 2021-12-23 Aicuris Gmbh & Co. Kg Novel oxalyl piperazines active against the hepatitis B virus (HBV)
AU2020267015A1 (en) 2019-04-30 2021-12-23 Aicuris Gmbh & Co. Kg Novel indole-2-carboxamides active against the hepatitis B virus (HBV)
WO2020221824A1 (en) 2019-04-30 2020-11-05 Aicuris Gmbh & Co. Kg Novel indolizine-2-carboxamides active against the hepatitis b virus (hbv)
WO2020255016A1 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Combination of hepatitis b virus (hbv) vaccines and dihydropyrimidine derivatives as capsid assembly modulators

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JPS60185764A (ja) 1984-03-05 1985-09-21 Wako Pure Chem Ind Ltd ピリジン誘導体の新規な製造法
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Also Published As

Publication number Publication date
SK15652000A3 (sk) 2001-04-09
NZ507569A (en) 2002-04-26
JP2002512243A (ja) 2002-04-23
HK1039119A1 (en) 2002-04-12
DE19817264A1 (de) 1999-10-21
NO20005215D0 (no) 2000-10-17
ID27263A (id) 2001-03-22
JP2010241837A (ja) 2010-10-28
KR20010042788A (ko) 2001-05-25
EP1080086B1 (de) 2002-09-04
PE20000427A1 (es) 2000-06-25
NO321985B1 (no) 2006-07-31
US20070117812A1 (en) 2007-05-24
SI1080086T1 (en) 2003-02-28
CU23049A3 (es) 2005-06-24
BRPI9917862A2 (es) 2010-12-07
DE59902573D1 (en) 2002-10-10
CA2328780C (en) 2008-09-23
PL343481A1 (en) 2001-08-27
NO329020B1 (no) 2010-07-26
CZ20003871A3 (cs) 2001-01-17
SV1999000047A (es) 2000-06-23
AU3813399A (en) 1999-11-08
US20040167135A1 (en) 2004-08-26
RU2245881C9 (ru) 2006-02-10
AR018187A1 (es) 2001-10-31
PT1080086E (pt) 2002-12-31
WO1999054326A8 (de) 1999-12-29
PL193898B1 (pl) 2007-03-30
MY126527A (en) 2006-10-31
CO5021127A1 (es) 2001-03-27
BR9909730B1 (pt) 2012-09-04
ES2183548T3 (es) 2003-03-16
KR100636771B1 (ko) 2006-10-23
ZA200005136B (en) 2001-03-02
AU740318B2 (en) 2001-11-01
DK1080086T3 (da) 2002-12-23
BG104812A (en) 2001-06-29
UA63998C2 (uk) 2004-02-16
BR9909730A (pt) 2000-12-19
CZ293482B6 (cs) 2004-05-12
BRPI9917862B1 (pt) 2013-05-07
HUP0102372A2 (hu) 2001-12-28
IL138584A (en) 2006-09-05
US6696451B1 (en) 2004-02-24
NO20005215L (no) 2000-12-13
HUP0102372A3 (en) 2003-01-28
NO20045259L (no) 2000-12-13
CA2328780A1 (en) 1999-10-28
ATE223401T1 (de) 2002-09-15
RU2245881C2 (ru) 2005-02-10
JP4590097B2 (ja) 2010-12-01
TW548274B (en) 2003-08-21
BG64649B1 (bg) 2005-10-31
CN1305471A (zh) 2001-07-25
IL138584A0 (en) 2001-10-31
US7514565B2 (en) 2009-04-07
BRPI9917862B8 (pt) 2021-05-25
CN1159311C (zh) 2004-07-28
WO1999054326A1 (de) 1999-10-28
EP1080086A1 (de) 2001-03-07
TR200003011T2 (tr) 2001-01-22
SK286407B6 (sk) 2008-09-05
JP5237332B2 (ja) 2013-07-17

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