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FR2772615B1 - Comprime multicouche pour la liberation instantanee puis prolongee de substances actives - Google Patents

Comprime multicouche pour la liberation instantanee puis prolongee de substances actives

Info

Publication number
FR2772615B1
FR2772615B1 FR9716402A FR9716402A FR2772615B1 FR 2772615 B1 FR2772615 B1 FR 2772615B1 FR 9716402 A FR9716402 A FR 9716402A FR 9716402 A FR9716402 A FR 9716402A FR 2772615 B1 FR2772615 B1 FR 2772615B1
Authority
FR
France
Prior art keywords
active substances
multilayer tablet
instant release
prolonged active
prolonged
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9716402A
Other languages
English (en)
Other versions
FR2772615A1 (fr
Inventor
Olivier Saslawski
Laurence Orlando
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sante SAS
Original Assignee
LIPHA SAS
LIPHA Liyonnaise Industrielle Pharmaceutique
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LIPHA SAS, LIPHA Liyonnaise Industrielle Pharmaceutique filed Critical LIPHA SAS
Priority to FR9716402A priority Critical patent/FR2772615B1/fr
Priority to UA2000074216A priority patent/UA55503C2/uk
Priority to IDW20001144A priority patent/ID26313A/id
Priority to PCT/EP1998/008100 priority patent/WO1999033448A1/fr
Priority to CZ20002332A priority patent/CZ291884B6/cs
Priority to US09/581,992 priority patent/US6372255B1/en
Priority to JP2000526205A priority patent/JP4451563B2/ja
Priority to KR1020007007039A priority patent/KR100574207B1/ko
Priority to HU0100406A priority patent/HU226069B1/hu
Priority to PT98965814T priority patent/PT1041972E/pt
Priority to SK932-2000A priority patent/SK283236B6/sk
Priority to AT98965814T priority patent/ATE223207T1/de
Priority to CNB988124874A priority patent/CN1163220C/zh
Priority to DK98965814T priority patent/DK1041972T3/da
Priority to SI9830282T priority patent/SI1041972T1/xx
Priority to AU21606/99A priority patent/AU743195B2/en
Priority to EP98965814A priority patent/EP1041972B1/fr
Priority to PL98341228A priority patent/PL190599B1/pl
Priority to BR9814345-0A priority patent/BR9814345A/pt
Priority to DE69807747T priority patent/DE69807747T2/de
Priority to CA002316277A priority patent/CA2316277C/fr
Priority to RU2000120166/14A priority patent/RU2212885C2/ru
Priority to ES98965814T priority patent/ES2182397T3/es
Priority to ARP980106474A priority patent/AR017897A1/es
Priority to ZA9811799A priority patent/ZA9811799B/xx
Publication of FR2772615A1 publication Critical patent/FR2772615A1/fr
Priority to NO20003289A priority patent/NO20003289L/no
Application granted granted Critical
Publication of FR2772615B1 publication Critical patent/FR2772615B1/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
FR9716402A 1997-12-23 1997-12-23 Comprime multicouche pour la liberation instantanee puis prolongee de substances actives Expired - Fee Related FR2772615B1 (fr)

Priority Applications (26)

Application Number Priority Date Filing Date Title
FR9716402A FR2772615B1 (fr) 1997-12-23 1997-12-23 Comprime multicouche pour la liberation instantanee puis prolongee de substances actives
UA2000074216A UA55503C2 (uk) 1997-12-23 1998-11-12 Таблетка з миттєвим і в подальшому пролонгованим вивільненням діючих речовин та спосіб одержання таблетки
EP98965814A EP1041972B1 (fr) 1997-12-23 1998-12-11 Comprime a liberation instantanee et prolongee d'un ou de plusieurs principes actifs
CZ20002332A CZ291884B6 (cs) 1997-12-23 1998-12-11 Několikavrstvová tableta pro okamžité a prodloužené uvolňování jedné nebo několika účinných látek
US09/581,992 US6372255B1 (en) 1997-12-23 1998-12-11 Tablet for instant and prolonged release of one or more active substances
JP2000526205A JP4451563B2 (ja) 1997-12-23 1998-12-11 １種以上の活性物質を即時的ならびに持続的に放出するための錠剤
KR1020007007039A KR100574207B1 (ko) 1997-12-23 1998-12-11 하나 이상의 활성 물질의 즉각적 및 장기적 방출을 위한정제
HU0100406A HU226069B1 (en) 1997-12-23 1998-12-11 Tablet for instant and prolonged release of one or more active substances
PT98965814T PT1041972E (pt) 1997-12-23 1998-12-11 Comprimido para a libertacao instantanea e prolongada de uma ou mais substancias activas
SK932-2000A SK283236B6 (sk) 1997-12-23 1998-12-11 Niekoľkovrstvová tableta na okamžité a predĺžené uvoľňovanie jednej alebo niekoľkých účinných látok a spôsob jej prípravy
AT98965814T ATE223207T1 (de) 1997-12-23 1998-12-11 Tablette mit instant- und verzögerte freisetzung von einen oder mehrere wirkstoffe
CNB988124874A CN1163220C (zh) 1997-12-23 1998-12-11 用于立即和延长释放一种或多种活性物质的片剂
DK98965814T DK1041972T3 (da) 1997-12-23 1998-12-11 Tablet til øjeblikkelig og prolongeret release af ét eller flere aktive stoffer
SI9830282T SI1041972T1 (en) 1997-12-23 1998-12-11 Tablet for instant and prolonged release of one or more active substances
IDW20001144A ID26313A (id) 1997-12-23 1998-12-11 Tablet untuk pembebasan dengan segera dan yang diperlambat dari satu atau lebih substansi aktif
BR9814345-0A BR9814345A (pt) 1997-12-23 1998-12-11 Comprimido para liberação imediata e prolongada de uma ou mais substâncias ativas
RU2000120166/14A RU2212885C2 (ru) 1997-12-23 1998-12-11 Таблетка для очень быстрого и пролонгированного высвобождения действующих веществ
PL98341228A PL190599B1 (pl) 1997-12-23 1998-12-11 Tabletka o natychmiastowym i przedłużonym uwalnianiu jednej lub większej liczby substancji aktywnych oraz sposób jej otrzymywania
DE69807747T DE69807747T2 (de) 1997-12-23 1998-12-11 Tablette mit instant- und verzögerte freisetzung von einen oder mehrere wirkstoffe
CA002316277A CA2316277C (fr) 1997-12-23 1998-12-11 Comprime a liberation instantanee et prolongee d'un ou de plusieurs principes actifs
PCT/EP1998/008100 WO1999033448A1 (fr) 1997-12-23 1998-12-11 Comprime a liberation instantanee et prolongee d'un ou de plusieurs principes actifs
ES98965814T ES2182397T3 (es) 1997-12-23 1998-12-11 Comprimido para la liberacion instantanea y prolongada de una o mas substancias activas.
AU21606/99A AU743195B2 (en) 1997-12-23 1998-12-11 Tablet for instant and prolonged release of one or more active substances
ARP980106474A AR017897A1 (es) 1997-12-23 1998-12-18 Un comprimido de capas multiples para la liberacion instantanea y prolongada de sustancias activas que contiene al menos dos capas superpuestas, y un procedimiento para su preparacion
ZA9811799A ZA9811799B (en) 1997-12-23 1998-12-22 Solid galenic form of the controlled release tablet type for the instant and then prolonged release of one or more active substances
NO20003289A NO20003289L (no) 1997-12-23 2000-06-22 Tablett for omgÕende og langvarig frigjørelse av ett eller flere aktive stoffer

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9716402A FR2772615B1 (fr) 1997-12-23 1997-12-23 Comprime multicouche pour la liberation instantanee puis prolongee de substances actives

Publications (2)

Publication Number Publication Date
FR2772615A1 FR2772615A1 (fr) 1999-06-25
FR2772615B1 true FR2772615B1 (fr) 2002-06-14

Family

ID=9515042

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9716402A Expired - Fee Related FR2772615B1 (fr) 1997-12-23 1997-12-23 Comprime multicouche pour la liberation instantanee puis prolongee de substances actives

Country Status (24)

Country Link
US (1) US6372255B1 (fr)
EP (1) EP1041972B1 (fr)
JP (1) JP4451563B2 (fr)
KR (1) KR100574207B1 (fr)
CN (1) CN1163220C (fr)
AR (1) AR017897A1 (fr)
AT (1) ATE223207T1 (fr)
AU (1) AU743195B2 (fr)
BR (1) BR9814345A (fr)
CA (1) CA2316277C (fr)
CZ (1) CZ291884B6 (fr)
DE (1) DE69807747T2 (fr)
DK (1) DK1041972T3 (fr)
ES (1) ES2182397T3 (fr)
FR (1) FR2772615B1 (fr)
HU (1) HU226069B1 (fr)
ID (1) ID26313A (fr)
NO (1) NO20003289L (fr)
PT (1) PT1041972E (fr)
RU (1) RU2212885C2 (fr)
SK (1) SK283236B6 (fr)
UA (1) UA55503C2 (fr)
WO (1) WO1999033448A1 (fr)
ZA (1) ZA9811799B (fr)

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DK1041972T3 (da) 2003-01-06
DE69807747D1 (de) 2002-10-10
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FR2772615A1 (fr) 1999-06-25
KR20010033532A (ko) 2001-04-25
ES2182397T3 (es) 2003-03-01
CZ20002332A3 (cs) 2000-10-11
ATE223207T1 (de) 2002-09-15
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UA55503C2 (uk) 2003-04-15
US6372255B1 (en) 2002-04-16
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ZA9811799B (en) 1999-06-22
HUP0100406A2 (hu) 2001-08-28
KR100574207B1 (ko) 2006-04-27
PT1041972E (pt) 2003-01-31
ID26313A (id) 2000-12-14
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AU743195B2 (en) 2002-01-24
AU2160699A (en) 1999-07-19
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RU2212885C2 (ru) 2003-09-27
EP1041972A1 (fr) 2000-10-11
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DE69807747T2 (de) 2003-06-12
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SK283236B6 (sk) 2003-04-01
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