FR14C0033I2 - Derives de phenyl-piperazine en tant qu'inhibiteurs du recaptage de la serotonine - Google Patents

Derives de phenyl-piperazine en tant qu'inhibiteurs du recaptage de la serotonine

Info

Publication number: FR14C0033I2
Authority: FR; France
Prior art keywords: phenyl; serotonin reuptake; reuptake inhibitors; piperazine derivatives; piperazine
Prior art date: 2001-10-04
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Active

Application number

FR14C0033C

Other languages

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

H Lundbeck AS

Original Assignee

H Lundbeck AS

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-10-04

Filing date

2014-04-16

Publication date

2014-11-14

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8160750&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR14C0033(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2014-04-16 Application filed by H Lundbeck AS filed Critical H Lundbeck AS

2014-06-13 Publication of FR14C0033I1 publication Critical patent/FR14C0033I1/fr

2014-11-14 Application granted granted Critical

2014-11-14 Publication of FR14C0033I2 publication Critical patent/FR14C0033I2/fr

Status Active legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
- C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
- C07D295/033—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to carbocyclic rings

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

FR14C0033C 2001-10-04 2014-04-16 Derives de phenyl-piperazine en tant qu'inhibiteurs du recaptage de la serotonine Active FR14C0033I2 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DKPA200101466		2001-10-04
PCT/DK2002/000659 WO2003029232A1 (en)	2001-10-04	2002-10-02	Phenyl-piperazine derivatives as serotonin reuptake inhibitors

Publications (2)

Publication Number	Publication Date
FR14C0033I1 FR14C0033I1 (no)	2014-06-13
FR14C0033I2 true FR14C0033I2 (fr)	2014-11-14

Family

ID=8160750

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FR14C0033C Active FR14C0033I2 (fr)	2001-10-04	2014-04-16	Derives de phenyl-piperazine en tant qu'inhibiteurs du recaptage de la serotonine

Country Status (38)

Country	Link
US (10)	US7144884B2 (no)
EP (2)	EP1749818B1 (no)
JP (3)	JP3896116B2 (no)
KR (3)	KR100783346B1 (no)
CN (1)	CN1319958C (no)
AR (2)	AR036659A1 (no)
AT (2)	ATE441631T1 (no)
AU (2)	AU2002333220C1 (no)
BE (1)	BE2014C036I2 (no)
BR (3)	BR122012023120B8 (no)
CA (1)	CA2462110C (no)
CO (1)	CO5580746A2 (no)
CY (3)	CY1107924T1 (no)
DE (2)	DE60233608D1 (no)
DK (2)	DK1436271T6 (no)
EA (2)	EA007537B3 (no)
EG (1)	EG25095A (no)
ES (2)	ES2328725T3 (no)
FR (1)	FR14C0033I2 (no)
HR (1)	HRP20040220A2 (no)
HU (3)	HU230189B1 (no)
IL (1)	IL160655A0 (no)
IS (2)	IS2578B (no)
LT (1)	LTC1436271I2 (no)
LU (1)	LU92397I2 (no)
ME (1)	ME00039B (no)
MX (1)	MXPA04002959A (no)
MY (1)	MY140950A (no)
NL (1)	NL300652I2 (no)
NO (3)	NO326443B1 (no)
NZ (1)	NZ531556A (no)
PL (2)	PL209253B1 (no)
PT (2)	PT1436271E (no)
RS (2)	RS52326B (no)
SI (1)	SI1436271T1 (no)
UA (2)	UA81749C2 (no)
WO (1)	WO2003029232A1 (no)
ZA (1)	ZA200401583B (no)

Families Citing this family (107)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
UA81749C2 (uk)	2001-10-04	2008-02-11	Х. Луннбек А/С	Фенілпіперазинові похідні як інгібітори зворотного захоплення серотоніну
GB0305575D0 (en) *	2003-03-11	2003-04-16	Glaxo Group Ltd	Novel compounds
UA81300C2 (en) *	2003-04-04	2007-12-25	Lundbeck & Co As H	Derivates of 4-(2-fenilsulfanilfenil)-1,2,3,6-tetrahydropiridin as retarding agents of serotonin recapture
CL2004000726A1 (es) *	2003-04-04	2005-05-20	Lundbeck & Co As H	Compuestos derivados de 4-[2-(feniloxi sustituido)fenil]piperidina o -1,2,3,6-tetrahidropiridina; composcion farmaceutica que los contiene; y su uso para el tratamiento de trastornos afectivos, tales como la depresion, trastornos de ansiedad, de ansi
ES2303062T3 (es) *	2003-04-04	2008-08-01	H. Lundbeck A/S	Derivados de 4-(2-feniloxifenil)-piperidina o 1,2,3,6-tetrahidropiridina como inhibidores de la recaptura de serotonina.
JP4667366B2 (ja) *	2003-04-04	2011-04-13	ハー・ルンドベック・アクチエゼルスカベット	セロトニン再取り込み阻害剤としての４−（２−フェニルスルファニル−フェニル）−ピペリジン誘導体
UA81472C2 (en) *	2003-04-04	2008-01-10	Lundbeck & Co As H	4-(2-phenylsulfanyl-phenyl)-piperidine derivatives as serotonin reuptake inhibitors
AU2004303461B2 (en)	2003-12-23	2011-04-28	H. Lundbeck A/S	2-(1H-indolylsulfanyl)-benzyl amine derivatives as SSRI
AR052308A1 (es) *	2004-07-16	2007-03-14	Lundbeck & Co As H	Derivados de 2-(1h-indolilsulfanil)-arilamina y una composicion farmaceutica que contiene al compuesto
EP1851207B1 (en) *	2005-02-10	2009-07-01	Neurosearch A/S	Alkyl substituted homopiperazine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
US7629473B2 (en)	2005-06-17	2009-12-08	H. Lundbeck A/S	2-(1H-indolylsulfanyl)-aryl amine derivatives
AR054394A1 (es) *	2005-06-17	2007-06-20	Lundbeck & Co As H	Derivados de 2- (1h-indolilsulfanil)-aril amina
AR054393A1 (es) *	2005-06-17	2007-06-20	Lundbeck & Co As H	Derivados de benzo(b)furano y benzo(b)tiofeno, composiciones farmaceuticas que los contienen y su uso en la fabricacion de un medicamento para el tratamiento de enfermedades mediadas por la inhibicion de la reabsorcion de neurotransmisores de amina biogenicos.
JP2007106746A (ja) *	2005-09-13	2007-04-26	Tosoh Corp	新規アリールホモピペラジン類、またはその塩と製造方法
AU2007260355B2 (en)	2006-06-16	2013-08-15	H. Lundbeck A/S	1- [2- (2, 4-dimethylphenylsulfanyl) -phenyl] piperazine as a compound with combined serotonin reuptake, 5-HT3 and 5-HT1A activity for the treatment of cognitive impairment
HRP20110412T1 (hr) *	2006-06-16	2011-06-30	H. Lundbeck A/S	Kristalni oblici 4-[2-4-(4-metilfenilsulfanil)fenil]piperidina sa kombiniranom inhibicijom reapsorpcije serotonina i norepinefrina za liječenje neuropatskih bolova
CN101472891B (zh) *	2006-06-16	2013-08-21	H.隆德贝克有限公司	有神经病痛治疗用血清素和去甲肾上腺素再摄取综合抑制作用的4-[2-(4-甲基苯硫基)苯基]哌啶的结晶形式
MY150698A (en) *	2006-06-16	2014-02-28	Lundbeck & Co As H	Crystalline forms of 4- [2- (-methylphenylsulfanyl) -phenyl] piperidine with combined serotonin and norepinephrine reuptake inhibition for the treatment of neuropathic pain
JP7179035B2 (ja) *	2006-06-16	2022-11-28	ハー・ルンドベック・アクチエゼルスカベット	認識機能障害（ｃｏｇｎｉｔｉｖｅｉｍｐａｉｒｍｅｎｔ）を治療するための、組み合わされたセロトニン再取り込み、５－ＨＴ３および５－ＨＴ１Ａ活性を有する化合物としての１－［２－（２，４－ジメチルフェニルスルファニル）－フェニル］ピペラジン
TWI432194B (zh) *	2007-03-20	2014-04-01	Lundbeck & Co As H	４-〔２-（４-甲基苯硫基）苯基〕哌啶之新穎治療用途
TW200848411A (en) *	2007-03-20	2008-12-16	Lundbeck & Co As H	Novel therapeutic uses of 1-[2-(2, 4-dimethylphenylsulfanyl)phenyl]-piperazine
WO2008151632A1 (en)	2007-06-15	2008-12-18	H.Lundbeck A/S	4- [2- (4-methylphenylsulfanyl) phenyl] piperidine for the treatment of irritable bowel syndrome (ibs)
TWI405588B (zh) *	2007-03-20	2013-08-21	Lundbeck & Co As H	４-〔２-（４-甲苯基硫基）-苯基〕哌啶之鹽類的液體調配物
TW200932233A (en)	2007-11-13	2009-08-01	Lundbeck & Co As H	Therapeutic uses of compounds having combined SERT, 5-HT3 and 5-HT1a activity
AU2014200364B2 (en) *	2007-11-13	2015-09-17	H. Lundbeck A/S	Therapeutic uses of compounds having combined SERT, 5-HT3 and 5-HT1A activity
TW200932225A (en) *	2007-12-14	2009-08-01	Lundbeck & Co As H	4-[2,3-difluoro-6-(2-fluoro-4-methyl-phenylsulfanyl)-phenyl]-piperidine
TW200938194A (en) *	2007-12-14	2009-09-16	Lundbeck & Co As H	Therapeutic uses of compounds having affinity to the serotonin transporter, serotonin receptors and noradrenalin transporter
WO2009081259A1 (en) *	2007-12-21	2009-07-02	Pfizer Inc.	Phenoxy-pyridyl derivatives
UA98698C2 (en)	2008-03-03	2012-06-11	Х. Луннбек А/С	Phenylsulfanylphenyl-piperidines and process for the preparation thereof
ES2401224T3 (es)	2008-11-14	2013-04-17	Theravance, Inc.	Procedimiento para la preparación de compuestos de 4-[2-(2-fluorofenoximetil)fenil]piperidina
TW201033181A (en)	2009-02-17	2010-09-16	Lundbeck & Co As H	Purification of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine
RS53539B1 (sr)	2009-04-24	2015-02-27	H. Lundbeck A/S	Tečne formulacije soli 1-[2-(2,4-dimetilfenilsulfanil)fenil] piperazina
EA021321B1 (ru) *	2009-08-24	2015-05-29	Х. Лундбекк А/С	Новые композиции 1-[2-(2,4-диметилфенилсульфанил)фенил]пиперазина
CA2779108C (en) *	2009-10-30	2018-01-02	Janssen Pharmaceutica Nv	4-substituted-2-phenoxy-phenylamine delta opioid receptor modulators
WO2011085291A1 (en)	2010-01-11	2011-07-14	Theravance, Inc.	1 - (2 - phenoxymethylphenyl) piperazine compounds as serotonin and norepinephrine reuptake inhibitors
EP2550252B1 (en) *	2010-03-22	2015-05-06	Theravance Biopharma R&D IP, LLC	1-(2-phenoxymethylheteroaryl)piperidine and piperazine compounds
PH12012502153A1 (en)	2010-04-30	2013-02-04	Takeda Pharmaceuticals Co	Enteric tablet
EP2564837B1 (en)	2010-04-30	2019-01-30	Takeda Pharmaceutical Company Limited	Enteric tablet
EP2407467A1 (de)	2010-07-14	2012-01-18	Sandoz Ag	Kristalline Verbindung von 1-[4-(2-azepan-1-yl-ethoxy)-benzyl]-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol und Milchsäure
TW201212918A (en) *	2010-08-23	2012-04-01	Lundbeck & Co As H	Therapeutic uses of 1-[2-(2,4-dimethyl-phenylsulfanyl)phenyl]piperazine
DK3135656T3 (en)	2011-06-20	2019-04-23	H Lundbeck As	DEUTERATED 1-PIPERAZINO-3-PHENYL INDANES FOR TREATMENT OF schizophrenia
EP2780467B1 (en)	2011-11-14	2018-10-17	Alfasigma S.p.A.	Assays and methods for selecting a treatment regimen for a subject with depression and methods for treatment
EP2800746B1 (en) *	2012-01-03	2019-04-17	H. Lundbeck A/S	Process for the manufacture of 1-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-piperazine
BR112015006075B1 (pt)	2012-09-19	2022-10-04	Sandoz Ag	Composto cristalino, composição farmacêutica, uso do composto cristalino, hidrato cristalino do bromidrato de vortioxetina, método para a preparação do hidrato cristalino de bromidrato de vortioxetina, método para a preparação do composto cristalino e uso do hidrato cristalino de bromidrato de vortioxetina
EA028300B1 (ru)	2012-12-13	2017-10-31	Х. Лундбекк А/С	Композиции, содержащие вортиоксетин и донепезил
MX362355B (es)	2013-02-22	2019-01-14	H Lundbeck As	Proceso de fabricacion de vortioxetina.
PL2981520T3 (pl)	2013-04-04	2019-09-30	Lek Pharmaceuticals D.D.	Nowy sposób syntezy 1-(2-((2,4-dimetylofenylo)tio)fenylo)piperazyny
CN104109135B (zh) *	2013-04-22	2018-10-26	江苏豪森药业集团有限公司	1-[2-(2,4-二甲基苯基硫烷基)-苯基]哌嗪的制备方法
US10414741B2 (en)	2013-09-30	2019-09-17	Cadila Healthcare Limited	Amorphous vortioxetine and salts thereof
EP2878596A1 (en) *	2013-11-29	2015-06-03	LEK Pharmaceuticals d.d.	Synthesis of vortioxetine via (2-(piperazine-1-yl)phenyl)lithium intermediates
CN104710345B (zh) *	2013-12-17	2017-09-05	江苏恩华药业股份有限公司	用于制备4‑（2‑（4‑甲基苯基硫基））苯基哌啶的化合物、其制备方法及应用
MX368870B (es)	2013-12-20	2019-10-21	H Lundbeck As	Uso de un antagonista de receptores de opioides con actividad kappa y vortioxetina para el tratamiento de trastorno depresivo con características melancólicas.
EP2894154A1 (en)	2014-01-14	2015-07-15	LEK Pharmaceuticals d.d.	Synthesis of vortioxetine via (2-(piperazine-1-yl)phenyl)aniline intermediates
CN103788019B (zh) *	2014-01-22	2015-10-07	苏州明锐医药科技有限公司	沃替西汀的制备方法
EP3099669A1 (en)	2014-01-31	2016-12-07	Egis Gyógyszergyár Zrt.	Process for the preparation of vortioxetine salts
EP2930171A1 (en)	2014-04-07	2015-10-14	LEK Pharmaceuticals d.d.	Synthesis of vortioxetine via (2,4-dimethylphenyl)(2-iodophenyl)sulfane intermediate
CN104059030B (zh) *	2014-05-30	2016-05-04	镇江圣安医药有限公司	[(苯硫烷基)-苯基]哌嗪的衍生物及其药物组合物和用途
FR3023320B1 (fr) *	2014-07-03	2017-03-10	Ifp Energies Now	Systeme et procede de stockage et de recuperation d'energie par gaz comprime avec stockage de la chaleur au moyen d'un echangeur radial
CZ2014471A3 (cs)	2014-07-08	2016-01-20	Zentiva, K.S.	Způsob přípravy vortioxetinu
US9687484B2 (en)	2014-07-18	2017-06-27	Dipharma Francis S.R.L.	Crystalline forms of an antidepressant compound
CN104146953A (zh) *	2014-07-24	2014-11-19	李雪梅	一种氢溴酸沃替西汀注射液
CN104292183B (zh) *	2014-09-29	2016-01-06	杨献美	一种抗抑郁药物沃替西汀的制备方法
WO2016079751A2 (en)	2014-11-17	2016-05-26	Megafine Pharma (P) Ltd.	A process for preparation of vortioxetine and polymorphs thereof
ES2634496T3 (es)	2014-11-21	2017-09-28	Dipharma Francis S.R.L.	Proceso para la preparación de un antidepresivo y los intermedios del mismo
CN104447622B (zh) *	2014-11-28	2017-01-04	郑州大明药物科技有限公司	氢溴酸沃替西汀β晶型的制备方法
CN104586756A (zh) *	2015-01-05	2015-05-06	万特制药(海南)有限公司	一种含沃替西汀的口服溶液及其制备方法
CZ201531A3 (cs)	2015-01-21	2016-08-03	Zentiva, K.S.	Polymerem stabilizované amorfní formy vortioxetinu
CN104610195B (zh) *	2015-01-30	2017-06-27	上虞京新药业有限公司	沃替西汀的天冬氨酸盐或其水合物及其制备方法和用途
WO2016125191A2 (en)	2015-02-04	2016-08-11	Mylan Laboratories Limited	Processes for the preparation of vortioxetine hydrobromide
WO2016125190A2 (en)	2015-02-04	2016-08-11	Mylan Laboratories Limited	Novel crystalline forms of vortioxetine, premixes, and processes for the preparation thereof
WO2016135636A1 (en)	2015-02-25	2016-09-01	Lupin Limited	Process for the preparation of vortioxetine
EP3274330A1 (en)	2015-03-26	2018-01-31	Cipla Limited	Method for making serotonin reuptake inhibitors
CN104829557B (zh) *	2015-04-23	2017-06-27	山东百诺医药股份有限公司	一种新化合物1‑[2‑（2,4‑二甲基苯基硫基）苯基]‑2‑氧哌嗪及其制备方法和在沃替西汀合成中的应用
JO3456B1 (ar)	2015-05-13	2020-07-05	H Lundbeck As	فيروتيوكسيتين بيروجلوتامات
CA2992161A1 (en) *	2015-07-17	2017-01-26	Institut Pasteur	5-hydroxytryptamine 1b receptor-stimulating agent for use as a promoter of satellite cells self-renewal and/or differentiation
US20180237386A1 (en) *	2015-08-19	2018-08-23	Amneal Pharmaceuticals Company Gmbh	Process For Preparation Of Vortioxetine Hydrobromide
US20180303772A1 (en) *	2015-10-14	2018-10-25	Institut Pasteur	5-hydroxytryptamine 1b receptor-stimulating agent for the treatment of myocardial infarction
CN105348204B (zh) *	2015-11-18	2018-09-14	乳源瑶族自治县大众药品贸易有限公司	1-杂环基-2-(杂芳基硫基)苯衍生物及其使用方法和用途
CN105461635B (zh) *	2015-11-18	2018-06-08	乳源瑶族自治县大众药品贸易有限公司	苯基哌嗪衍生物及其使用方法和用途
US11013830B2 (en) *	2015-11-20	2021-05-25	Institut Pasteur	5-hydroxytryptamine 1B receptor-stimulating agent for enhancing in vivo engraftment potential
WO2017162536A1 (en)	2016-03-21	2017-09-28	H. Lundbeck A/S	Vortioxetine prodrugs
MX2018015759A (es)	2016-07-01	2019-03-21	H Lundbeck As	Regimenes de dosificacion de vortioxetina para el rapido inicio del efecto antidepresivo.
BR112019000706A8 (pt)	2016-07-15	2022-12-06	Pasteur Institut	Agente de estímulo do receptor 1b de 5-hidroxitriptamina para reparo de pele e/ou cabelo
CN109890799A (zh) *	2016-07-22	2019-06-14	江苏恩华络康药物研发有限公司	沃替西汀类似物及其用途和制备
US20190224192A1 (en)	2016-08-29	2019-07-25	Cipla Limited	Stable Pharmaceutical Composition of Vortioxetine Hydrobromide
CN106349132B (zh) *	2016-08-30	2018-02-02	重庆植恩药业有限公司	沃替西汀中间体杂质及其制备方法和用途
US10519121B2 (en)	2016-12-30	2019-12-31	Apicore Us Llc	Process and novel polymorphic form of vortioxetine and its pharmaceutically acceptable salts
CN108409729B (zh) *	2017-02-09	2020-11-24	广东东阳光药业有限公司	苯基八氢-1H-吡啶并[1,2-a]吡嗪衍生物及其用途
CN108409728B (zh) *	2017-02-09	2020-11-24	广东东阳光药业有限公司	苯基八氢-1H-吡啶并[1,2-a]吡嗪衍生物及其用途
US10428033B2 (en)	2017-02-15	2019-10-01	Piramal Enterprises Limited	Process for the preparation of vortioxetine and salts thereof
US11020390B2 (en)	2017-02-17	2021-06-01	Unichem Laboratories Ltd	Bioequivalent pharmaceutical composition of vortioxetine hydrobromide
US10836730B2 (en)	2017-02-23	2020-11-17	Unichem Laboratories Ltd.	Process for preparation and purification of vortioxetine hydrobromide
BR112018076411A2 (pt) *	2017-04-25	2019-04-09	H. Lundbeck A/S	processo para a preparação de hbr de vortioxetina na forma alfa
EP3412661A1 (en)	2017-06-08	2018-12-12	Enantia, S.L.	Cocrystals of vortioxetine hydrobromide and resorcinol
KR102026337B1 (ko)	2017-07-07	2019-09-27	영진약품 주식회사	1-[2-(2,4-디메틸페닐설파닐)페닐]피페라진의 신규염 및 이의 제조방법
CN107915685A (zh) *	2017-12-11	2018-04-17	重庆植恩药业有限公司	一种氢溴酸沃替西汀中间体的制备方法
CN108017595A (zh) *	2017-12-20	2018-05-11	安徽源久源科技有限公司	一种1-[2-(2,5-二甲基苯硫基)苯基]哌嗪的制备方法
EP3810582B1 (en)	2018-06-20	2024-01-03	Vio Ag Pharmaceuticals S.A.	A one-pot organo-pseudocatalytic c-h activation approach for the preparation of vortioxetine and vortioxetine intermediate
CN108727393B (zh) *	2018-08-06	2019-10-29	广东东阳光药业有限公司	苯基二氮杂双环衍生物及其用途
CN108863986B (zh) *	2018-08-06	2020-01-21	广东东阳光药业有限公司	二氟甲基取代的苯基哌嗪衍生物及其用途
WO2020087031A1 (en)	2018-10-26	2020-04-30	The Research Foundation For The State University Of New York	Combination serotonin specific reuptake inhibitor and serotonin 1a receptor partial agonist for reducing l-dopa-induced dyskinesia
KR20220163997A (ko)	2020-04-03	2022-12-12	하. 룬드벡 아크티에셀스카브	정서적 둔마의 예방 또는 치료를 위한 1-[2-(2,4-디메틸페닐설파닐)-페닐]피페라진
WO2022052391A1 (zh)	2020-09-10	2022-03-17	苏州富德兆丰生化科技有限公司	伏硫西汀的合成方法
GB2622880A (en)	2022-09-30	2024-04-03	Alkaloid Ad Skopje	Palatable orodispersible formulation of vortioxetine
WO2025132869A1 (en)	2023-12-21	2025-06-26	H. Lundbeck A/S	Method for the preparation of vortioxetine pharmaceutical compositions with low amounts of nitrosamine impurities
CN120774863A (zh) *	2024-04-02	2025-10-14	王春刚	一种烷基二胺取代双芳杂环基硫醚类化合物及其制备和在制备治疗和/或预防肿瘤药物中的应用
EP4681702A1 (en)	2024-07-16	2026-01-21	PharmaPath S.A.	Oral solution comprising vortioxetine hydrobromide

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CS151755B1 (no)	1971-04-13	1973-11-19
CS151752B1 (no)	1971-04-13	1973-11-19
CS151753B1 (no)	1971-04-13	1973-11-19
CS151751B1 (no)	1971-04-13	1973-11-19
YU163075A (en)	1975-07-21	1982-05-31	Science Union & Cie	Process for preparing new phenoxy derivatives
US4241071A (en) *	1977-01-27	1980-12-23	American Hoechst Corporation	Antidepressant (α-phenyl-2-tolyl)azacycloalkanes
US4198417A (en) *	1979-01-10	1980-04-15	American Hoechst Corporation	Phenoxyphenylpiperidines
US4198419A (en) *	1979-01-10	1980-04-15	American Hoechst Corporation	Phenylthiophenylpiperidines
ES2004809A6 (es)	1987-07-29	1989-02-01	Ferrer Int	Procedimiento de obtencion de nuevas 1-(2-(fenilmetil)fenil)piperazinas
GB9126311D0 (en)	1991-12-11	1992-02-12	Wellcome Found	Substituted diphenylsulfides
ES2239766T3 (es) *	1995-01-23	2005-10-01	Daiichi Suntory Pharma Co., Ltd.	Alivio o remedio para sintomas causados por enfermedades isquemicas y compuestos de fenilpiperidina utilizados para ello.
CZ293595A3 (cs)	1995-11-09	1999-12-15	Farmak A. S.	Deriváty N,N-dimethyl-2-(arylthio)benzylaminu, jejich soli, způsoby jejich přípravy a jejich použití v léčivých přípravcích
FR2757160B1 (fr) *	1996-12-13	1999-03-12	Sanofi Sa	1-phenylalkyl-1,2,3,6-tetrahydropyridines
US6297239B1 (en)	1997-10-08	2001-10-02	Merck & Co., Inc.	Inhibitors of prenyl-protein transferase
CA2276373C (en) *	1997-10-31	2010-01-12	Suntory Limited	Arylpiperidinopropanol and arylpiperazinopropanol derivatives and pharmaceuticals containing the same
MXPA01009915A (es)	1999-04-02	2003-08-20	Icos Corp	Inhibidores de lfa-1 que se unen a los icam y usos de los mismos.
WO2001010842A2 (en)	1999-08-04	2001-02-15	Millennium Pharmaceuticals, Inc.	Melanocortin-4 receptor binding compounds and methods of use thereof
EP1220780A4 (en) *	1999-09-14	2004-03-24	Pharmacopeia Inc	ARTICLE COMPRISING A DISPENSING HEAD COMPRISING MULTIPLE CHANNELS
PT1246816E (pt) *	1999-12-30	2004-08-31	Lundbeck & Co As H	Derivados de fenilpiperazina substituidos sua preparacao e utilizacao
EP1246819A1 (en) *	1999-12-30	2002-10-09	H. Lundbeck A/S	A method for the preparation of substituted benzene derivatives
US6813639B2 (en)	2000-01-26	2004-11-02	Viaclix, Inc.	Method for establishing channel-based internet access network
DE10033548C2 (de)	2000-07-11	2002-05-16	Wolfgang Papenbrock	Verfahren zur Vorschau von Internetseiten
JP2004523530A (ja) *	2001-01-23	2004-08-05	イーライ・リリー・アンド・カンパニー	メラノコルチン受容体アゴニストとしてのピペラジンおよびピペリジン誘導体
EP1363890A4 (en)	2001-02-07	2009-06-10	Ore Pharmaceuticals Inc	MELANOCORTIN-4-RECEPTOR BINDING COMPOUNDS AND METHOD FOR THEIR APPLICATION
UA81749C2 (uk)	2001-10-04	2008-02-11	Х. Луннбек А/С	Фенілпіперазинові похідні як інгібітори зворотного захоплення серотоніну
EP1458689B1 (en) *	2001-12-20	2007-04-11	H. Lundbeck A/S	Aryloxyphenyl and arylsulfanylphenyl derivatives
TW200505902A (en)	2003-03-20	2005-02-16	Schering Corp	Cannabinoid receptor ligands
JP4667366B2 (ja) *	2003-04-04	2011-04-13	ハー・ルンドベック・アクチエゼルスカベット	セロトニン再取り込み阻害剤としての４−（２−フェニルスルファニル−フェニル）−ピペリジン誘導体
WO2005000309A2 (en)	2003-06-27	2005-01-06	Ionix Pharmaceuticals Limited	Chemical compounds
AU2007260355B2 (en) *	2006-06-16	2013-08-15	H. Lundbeck A/S	1- [2- (2, 4-dimethylphenylsulfanyl) -phenyl] piperazine as a compound with combined serotonin reuptake, 5-HT3 and 5-HT1A activity for the treatment of cognitive impairment

2002
- 2002-02-10 UA UA2004032271A patent/UA81749C2/uk unknown
- 2002-09-30 AR ARP020103689A patent/AR036659A1/es active IP Right Grant
- 2002-10-02 IL IL16065502A patent/IL160655A0/xx active Protection Beyond IP Right Term
- 2002-10-02 DK DK02800051.1T patent/DK1436271T6/da active
- 2002-10-02 EG EG2002101084A patent/EG25095A/xx active
- 2002-10-02 PL PL368442A patent/PL209253B1/pl unknown
- 2002-10-02 HU HU1300028A patent/HU230189B1/hu unknown
- 2002-10-02 RS YU27704A patent/RS52326B/sr unknown
- 2002-10-02 RS RS20120158A patent/RS52865B/sr unknown
- 2002-10-02 SI SI200230678T patent/SI1436271T1/sl unknown
- 2002-10-02 HU HU0402313A patent/HU228956B1/hu active Protection Beyond IP Right Term
- 2002-10-02 PT PT02800051T patent/PT1436271E/pt unknown
- 2002-10-02 AT AT06016609T patent/ATE441631T1/de active
- 2002-10-02 PT PT06016609T patent/PT1749818E/pt unknown
- 2002-10-02 UA UAA200612495A patent/UA93857C2/uk unknown
- 2002-10-02 JP JP2003532482A patent/JP3896116B2/ja not_active Expired - Lifetime
- 2002-10-02 ES ES06016609T patent/ES2328725T3/es not_active Expired - Lifetime
- 2002-10-02 PL PL392184A patent/PL210551B1/pl unknown
- 2002-10-02 WO PCT/DK2002/000659 patent/WO2003029232A1/en not_active Ceased
- 2002-10-02 BR BR122012023120A patent/BR122012023120B8/pt active IP Right Grant
- 2002-10-02 DE DE60233608T patent/DE60233608D1/de not_active Expired - Lifetime
- 2002-10-02 EP EP06016609A patent/EP1749818B1/en not_active Expired - Lifetime
- 2002-10-02 ME MEP-2008-65A patent/ME00039B/me unknown
- 2002-10-02 AU AU2002333220A patent/AU2002333220C1/en active Active
- 2002-10-02 AT AT02800051T patent/ATE386730T1/de active
- 2002-10-02 US US10/488,280 patent/US7144884B2/en active Active
- 2002-10-02 MX MXPA04002959A patent/MXPA04002959A/es active IP Right Grant
- 2002-10-02 EA EA200400498A patent/EA007537B3/ru active Protection Beyond IP Right Term
- 2002-10-02 DE DE60225162.1T patent/DE60225162T3/de not_active Expired - Lifetime
- 2002-10-02 DK DK06016609T patent/DK1749818T3/da active
- 2002-10-02 CN CNB028190254A patent/CN1319958C/zh not_active Expired - Lifetime
- 2002-10-02 ES ES02800051T patent/ES2298425T7/es active Active
- 2002-10-02 BR BR122012009534D patent/BR122012009534C8/pt not_active IP Right Cessation
- 2002-10-02 NZ NZ531556A patent/NZ531556A/en not_active IP Right Cessation
- 2002-10-02 KR KR1020067022562A patent/KR100783346B1/ko not_active Expired - Lifetime
- 2002-10-02 KR KR1020077022025A patent/KR100842702B1/ko not_active Expired - Lifetime
- 2002-10-02 EA EA200601269A patent/EA011096B1/ru not_active IP Right Cessation
- 2002-10-02 EP EP02800051.1A patent/EP1436271B3/en not_active Expired - Lifetime
- 2002-10-02 BR BRPI0212733A patent/BRPI0212733B8/pt active IP Right Grant
- 2002-10-02 KR KR1020047004897A patent/KR100770194B1/ko not_active Expired - Lifetime
- 2002-10-02 CA CA2462110A patent/CA2462110C/en not_active Expired - Lifetime
- 2002-10-02 HR HR20040220A patent/HRP20040220A2/hr not_active Application Discontinuation
- 2002-10-03 MY MYPI20023705A patent/MY140950A/en unknown
2004
- 2004-02-26 IS IS7164A patent/IS2578B/is unknown
- 2004-02-26 ZA ZA2004/01583A patent/ZA200401583B/en unknown
- 2004-04-21 NO NO20041628A patent/NO326443B1/no active IP Right Maintenance
- 2004-04-30 CO CO04039958A patent/CO5580746A2/es not_active Application Discontinuation
2005
- 2005-12-06 US US11/296,835 patent/US7138407B2/en not_active Expired - Lifetime
- 2005-12-06 US US11/296,836 patent/US7148238B2/en not_active Expired - Lifetime
2006
- 2006-09-14 AU AU2006215994A patent/AU2006215994B2/en not_active Ceased
- 2006-10-03 JP JP2006271762A patent/JP3955614B2/ja not_active Expired - Lifetime
- 2006-10-03 JP JP2006271758A patent/JP3955613B2/ja not_active Expired - Lifetime
- 2006-10-19 US US11/551,188 patent/US7683053B2/en not_active Expired - Fee Related
2008
- 2008-04-18 CY CY20081100436T patent/CY1107924T1/el unknown
- 2008-05-06 AR ARP080101915A patent/AR066460A2/es active IP Right Grant
- 2008-08-06 NO NO20083446A patent/NO332355B1/no not_active IP Right Cessation
2009
- 2009-03-10 IS IS8806A patent/IS2732B/is unknown
- 2009-10-14 CY CY20091101068T patent/CY1110064T1/el unknown
2010
- 2010-02-04 US US12/700,521 patent/US8110567B2/en not_active Expired - Fee Related
2012
- 2012-02-06 US US13/367,065 patent/US8476279B2/en not_active Expired - Fee Related
2013
- 2013-06-26 US US13/927,678 patent/US9090575B2/en not_active Expired - Fee Related
2014
- 2014-03-07 NL NL300652C patent/NL300652I2/nl unknown
- 2014-03-12 LU LU92397C patent/LU92397I2/fr unknown
- 2014-03-12 HU HUS1400012C patent/HUS1400012I1/hu unknown
- 2014-03-13 LT LTPA2014013C patent/LTC1436271I2/lt unknown
- 2014-04-16 FR FR14C0033C patent/FR14C0033I2/fr active Active
- 2014-05-13 NO NO2014011C patent/NO2014011I2/no not_active IP Right Cessation
- 2014-06-03 BE BE2014C036C patent/BE2014C036I2/nl unknown
- 2014-06-11 CY CY2014022C patent/CY2014022I2/el unknown
2015
- 2015-06-19 US US14/744,197 patent/US9708280B2/en not_active Expired - Fee Related
2017
- 2017-06-15 US US15/624,417 patent/US10844029B2/en not_active Expired - Fee Related
2020
- 2020-10-22 US US17/078,055 patent/US20210276966A1/en not_active Abandoned

Also Published As

Publication number	Publication date
CY1107924T1 (el)	2013-09-04
JP2007031447A (ja)	2007-02-08
JP2007051149A (ja)	2007-03-01
NZ531556A (en)	2005-12-23
RS52326B (sr)	2012-12-31
PT1436271E (pt)	2008-04-10
NO20083446L (no)	2004-04-21
BR0212733B1 (pt)	2014-05-13
JP3896116B2 (ja)	2007-03-22
EP1436271A1 (en)	2004-07-14
CA2462110A1 (en)	2003-04-10
BR122012023120B1 (pt)	2017-03-21
US7144884B2 (en)	2006-12-05
NL300652I1 (no)	2016-01-18
MXPA04002959A (es)	2004-07-05
UA93857C2 (uk)	2011-03-25
EG25095A (en)	2011-08-17
IS8806A (is)	2009-03-10
NO2014011I1 (no)	2014-05-13
IS2578B (is)	2010-02-15
RS52865B (sr)	2013-12-31
CO5580746A2 (es)	2005-11-30
DE60225162T2 (de)	2009-02-12
WO2003029232A1 (en)	2003-04-10
CA2462110E (en)	2003-04-10
EP1749818A2 (en)	2007-02-07
MEP6508A (xx)	2010-02-10
AR036659A1 (es)	2004-09-22
DE60233608D1 (de)	2009-10-15
HU230189B1 (hu)	2015-09-28
EA011096B1 (ru)	2008-12-30
ATE441631T1 (de)	2009-09-15
ES2328725T3 (es)	2009-11-17
HRP20040220A2 (en)	2005-02-28
RS27704A (sr)	2006-10-27
EA200601269A1 (ru)	2007-02-27
US7683053B2 (en)	2010-03-23
AU2002333220A2 (en)	2003-04-14
KR20040047886A (ko)	2004-06-05
DK1436271T6 (da)	2022-06-27
EP1436271B1 (en)	2008-02-20
PL209253B1 (pl)	2011-08-31
CY2014022I1 (el)	2015-12-09
US7148238B2 (en)	2006-12-12
UA81749C2 (uk)	2008-02-11
BR122012009534C8 (pt)	2021-05-25
KR20060118020A (ko)	2006-11-17
KR100770194B1 (ko)	2007-10-25
EA007537B3 (ru)	2015-02-27
HUP0402313A2 (hu)	2005-02-28
US20050014740A1 (en)	2005-01-20
US20110009423A1 (en)	2011-01-13
FR14C0033I1 (no)	2014-06-13
AU2002333220C1 (en)	2023-10-05
CY2014022I2 (el)	2015-12-09
US20120302553A1 (en)	2012-11-29
LTPA2014013I1 (lt)	2014-04-25
US20060084662A1 (en)	2006-04-20
BR122012009534B1 (pt)	2018-02-27
NO332355B1 (no)	2012-09-03
RS20120158A2 (sr)	2012-10-31
HU228956B1 (en)	2013-07-29
IS7164A (is)	2004-02-26
JP3955614B2 (ja)	2007-08-08
NO326443B1 (no)	2008-12-08
US9708280B2 (en)	2017-07-18
EP1749818B1 (en)	2009-09-02
AU2006215994A2 (en)	2006-10-05
ZA200401583B (en)	2005-05-25
ATE386730T1 (de)	2008-03-15
CA2462110C (en)	2010-05-11
SI1436271T1 (sl)	2008-06-30
LTC1436271I2 (lt)	2016-09-12
BR122012009534B8 (pt)	2019-01-29
US8476279B2 (en)	2013-07-02
EA007537B1 (ru)	2006-10-27
ES2298425T7 (es)	2022-06-27
BE2014C036I2 (no)	2021-11-22
CN1561336A (zh)	2005-01-05
AU2002333220B2 (en)	2008-02-07
KR100783346B1 (ko)	2007-12-07
IS2732B (is)	2011-04-15
LU92397I2 (fr)	2014-05-12
US8110567B2 (en)	2012-02-07
RS20120158A3 (en)	2013-10-31
DK1749818T3 (da)	2009-10-12
NO20041628L (no)	2004-04-21
DE60225162D1 (de)	2008-04-03
PL368442A1 (pl)	2005-03-21
CY1110064T1 (el)	2015-01-14
HUP0402313A3 (en)	2010-03-29
PL210551B1 (pl)	2012-02-29
AU2006215994B2 (en)	2008-11-13
US9090575B2 (en)	2015-07-28
EA200400498A1 (ru)	2004-08-26
IL160655A0 (en)	2004-07-25
HK1072600A1 (zh)	2005-09-02
BR0212733A (pt)	2004-11-16
AR066460A2 (es)	2009-08-19
EP1749818A3 (en)	2008-04-02
AU2006215994A1 (en)	2006-10-05
US10844029B2 (en)	2020-11-24
PT1749818E (pt)	2009-10-06
MY140950A (en)	2010-02-12
BRPI0212733B8 (pt)	2021-05-25
ES2298425T3 (es)	2008-05-16
BR122012023120B8 (pt)	2022-01-18
KR20070103515A (ko)	2007-10-23
JP2005505585A (ja)	2005-02-24
US20060089368A1 (en)	2006-04-27
ME00039B (me)	2010-06-10
HUS1400012I1 (hu)	2020-12-28
US20210276966A1 (en)	2021-09-09
US20160137620A1 (en)	2016-05-19
NL300652I2 (no)	2016-01-18
DK1436271T3 (da)	2008-06-09
JP3955613B2 (ja)	2007-08-08
KR100842702B1 (ko)	2008-07-01
CN1319958C (zh)	2007-06-06
US20070060574A1 (en)	2007-03-15
DE60225162T3 (de)	2022-08-11
US20140163043A1 (en)	2014-06-12
NO2014011I2 (no)	2015-08-31
EP1436271B3 (en)	2022-04-20
US7138407B2 (en)	2006-11-21
AU2006215994A9 (en)	2006-10-05
US20180127389A1 (en)	2018-05-10

Publication	Publication Date	Title
FR14C0033I2 (fr)	2014-11-14	Derives de phenyl-piperazine en tant qu'inhibiteurs du recaptage de la serotonine
NO20034307D0 (no)	2003-09-26	Cyklopropylindol-derivater som selektive serotonin- gjenopptaksinhibitorer
FR15C0086I2 (fr)	2016-06-03	Derives d'hydroxamate en tant qu'inhibiteurs de desacetylase
FR18C1024I2 (fr)	2019-05-17	Derives d'heterocyclocarboxamide
FR15C0068I2 (fr)	2016-04-22	Derives de diamine
NO20043022L (no)	2004-07-15	5,6-diaryl-pyrazin-2-amid-derivater som CB1-antagonister
EP1415974A4 (en)	2005-07-27	PROCESS FOR THE PREPARATION OF FLUOROUS NORBORENE DERIVATIVES
NO20030842L (no)	2003-04-28	Fenoksybenzylaminderivater som selektive serotonin- gjenopptaksinhibitorer
EP1577361A4 (en)	2009-04-08	spray composition
NO20034525D0 (no)	2003-10-09	Fenyl heterocyklyleterderivater som serotonin re- opptaksinhibitorer
DZ3489A1 (fr)	2002-08-29	Procede de preparation de mesylates de derives de piperazine
FR2833596B1 (fr)	2005-02-18	Procede de preparation de derives d'echinocandine
EP1829864A4 (en)	2010-09-15	ISOCHINOLINE DERIVATIVES AS CALPAININHIBITORS
EP1192128A4 (en)	2003-07-02	THIOLE DERIVATIVES AS METALLO-BETA-LACTAMASE INHIBITORS
ITMI20011718A0 (it)	2001-08-03	Processo per la preparazione del sale sodico dell'acido-6(d-(-)-alpha-(4-etil-2,3-diosso-1-piperazinocarbonilammino)fenilacetammido)penicill
DE60321724D1 (de)	2008-07-31	1,2-diaza-dibenzoazulene als inhibitoren der produfür deren herstellung
HK1060563A (en)	2004-08-13	Cyclopropylindole derivatives as selective serotonin reuptake inhibitors