FI900085L - Förfarande för framställning av terapeutiskt användbara N-(pyrimidin- och kondenserad pyrimidin-4-on)etyl-piperidin- och piperatzinderivat - Google Patents

Förfarande för framställning av terapeutiskt användbara N-(pyrimidin- och kondenserad pyrimidin-4-on)etyl-piperidin- och piperatzinderivat Download PDF

Info

Publication number: FI900085L
Authority: FI; Finland
Prior art keywords: pyrimidin; piperidine; ethyl; preparation; therapeutically useful
Prior art date: 1989-01-09

Application number

FI900085A

Other languages

English (en)

Finnish (fi)

Other versions

FI94525C (sv

FI94525B (sv

FI900085A0 (sv

Inventor

Ludo Edmond Josephine Kennis

Jan Vandenberk

Jozef Martin Boey

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-01-09

Filing date

1990-01-08

Publication date

1990-07-10

1990-01-08 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

1990-01-08 Publication of FI900085A0 publication Critical patent/FI900085A0/sv

1990-07-10 Publication of FI900085L publication Critical patent/FI900085L/sv

1995-06-15 Application granted granted Critical

1995-06-15 Publication of FI94525B publication Critical patent/FI94525B/sv

1995-09-25 Publication of FI94525C publication Critical patent/FI94525C/sv

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Anesthesiology (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

FI900085A 1989-01-09 1990-01-08 Förfarande för framställning av terapeutiskt användbara N-(pyrimidin- och kondenserad pyrimidin-4-on)etyl-piperidin- och piperatzinderivat FI94525C (sv)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB898900382A GB8900382D0 (en)	1989-01-09	1989-01-09	2-aminopyrimidinone derivatives
GB8900382		1989-01-09

Publications (4)

Publication Number	Publication Date
FI900085A0 FI900085A0 (sv)	1990-01-08
FI900085L true FI900085L (sv)	1990-07-10
FI94525B FI94525B (sv)	1995-06-15
FI94525C FI94525C (sv)	1995-09-25

Family

ID=10649779

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI900085A FI94525C (sv)	1989-01-09	1990-01-08	Förfarande för framställning av terapeutiskt användbara N-(pyrimidin- och kondenserad pyrimidin-4-on)etyl-piperidin- och piperatzinderivat

Country Status (25)

Country	Link
EP (1)	EP0378255B1 (sv)
JP (1)	JP2938492B2 (sv)
KR (1)	KR0159099B1 (sv)
CN (1)	CN1034865C (sv)
AT (1)	ATE104971T1 (sv)
AU (1)	AU617918B2 (sv)
CA (1)	CA2007200C (sv)
DE (1)	DE69008366T2 (sv)
DK (1)	DK0378255T3 (sv)
ES (1)	ES2055860T3 (sv)
FI (1)	FI94525C (sv)
GB (1)	GB8900382D0 (sv)
HU (1)	HU203747B (sv)
IE (1)	IE62874B1 (sv)
IL (1)	IL92730A (sv)
JO (1)	JO1605B1 (sv)
MA (1)	MA21722A1 (sv)
MY (1)	MY106259A (sv)
NO (1)	NO173139C (sv)
NZ (1)	NZ231788A (sv)
PT (1)	PT92806B (sv)
RU (1)	RU2028297C1 (sv)
TN (1)	TNSN90003A1 (sv)
ZA (1)	ZA90123B (sv)
ZW (1)	ZW290A1 (sv)

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DE68908786T2 (de) *	1988-06-16	1994-03-17	Smith Kline French Lab	Condensierte Pyrimidinderivate, Verfahren und Zwischenprodukte zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen.
GB9008850D0 (en) *	1990-04-19	1990-06-13	Janssen Pharmaceutica Nv	Novel 2,9-disubstituted-4h-pyridol(1,2-a)pyrimidin-4-ones
US5075315A (en) *	1990-05-17	1991-12-24	Mcneilab, Inc.	Antipsychotic hexahydro-2H-indeno[1,2-c]pyridine derivatives
US5143923B1 (en) *	1991-04-29	1993-11-02	Hoechst-Roussel Pharmaceuticals Incorporated	Benzoisothiazole-and benzisoxazole-3-carboxamides
DE69330283T2 (de) *	1992-07-13	2002-01-10	Janssen Pharmaceutica N.V., Beerse	Neue 4-(3-benzofuranyl) piperidinyl und 4-(3-benzothienyl) piperidinyl-derivate und diese enthaltende pharmazeutische zusammenstellungen
CN1050604C (zh) *	1993-02-04	2000-03-22	明治制果株式会社	具有抗精神病作用的化合物
GB9305623D0 (en) *	1993-03-18	1993-05-05	Merck Sharp & Dohme	Therapeutic agents
US5521196A (en) *	1994-10-05	1996-05-28	Eli Lilly And Company	5-HT1F agonists for the treatment of migraine
US5521197A (en) *	1994-12-01	1996-05-28	Eli Lilly And Company	3-<1-alkylenearyl>-4-<1,2,3,6-tetrahydropyridinyl>-and 3-<1-alkylenearyl>-4-piperidinyl-1h-indoles: new 5-HT1F agonists
TW421649B (en) *	1995-01-31	2001-02-11	Janssen Pharmaceutica Nv	4-(1H-indol-1yl)-1-piperidinyl derivatives
KR19980703048A (ko) *	1995-03-20	1998-09-05	피터쥐.스트링거	5-치환-3-(1,2,3,6-테트라히드로피리딘-4-일)- 및 3-(피페리딘-4-일)-1ｈ-인돌: 신규한 5-ｈｔ1ｆ 아고니스트
ZA979781B (en)	1996-11-14	1998-06-08	Akzo Nobel Nv	Piperidine derivatives.
ES2165274B1 (es) *	1999-06-04	2003-04-01	Almirall Prodesfarma Sa	Nuevos derivados de indolilpiperidina como agentes antihistaminicos y antialergicos.
US6995144B2 (en)	2002-03-14	2006-02-07	Eisai Co., Ltd.	Nitrogen containing heterocyclic compounds and medicines containing the same
ES2201907B1 (es)	2002-05-29	2005-06-01	Almirall Prodesfarma, S.A.	Nuevos derivados de indolilpiperidina como potentes agentes antihistaminicos y antialergicos.
KR20050122220A (ko)	2003-03-25	2005-12-28	다케다 샌디에고, 인코포레이티드	디펩티딜 펩티다제 억제제
BRPI0413452A (pt)	2003-08-13	2006-10-17	Takeda Pharmaceutical	composto, composição farmacêutica, kit, artigo de fabricação, e, métodos de inibir dpp-iv, terapêutico e de tratar um estado de doença, cáncer, distúrbios autoimunes, uma condição einfecção por hiv
EP1911754B1 (en) *	2003-08-13	2013-10-09	Takeda Pharmaceutical Company Limited	Dipeptidyl peptidase inhibitors
WO2005026148A1 (en) *	2003-09-08	2005-03-24	Takeda San Diego, Inc.	Dipeptidyl peptidase inhibitors
CN102079743B (zh)	2004-03-15	2020-08-25	武田药品工业株式会社	二肽基肽酶抑制剂
US7371769B2 (en)	2004-12-07	2008-05-13	Solvay Pharmaceuticals B.V.	Tetrahydropyridin-4-yl indoles with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites
TW200626575A (en) *	2004-12-07	2006-08-01	Solvay Pharm Bv	Tetrahydropyridin-4-yl indoles with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites
US20060122247A1 (en)	2004-12-08	2006-06-08	Solvay Pharmaceuticals B.V.	Aryloxyethylamine and phenylpiperazine derivatives with a combination of partial dopamine-D2 receptor agonism and serotonin reuptake inhibition
WO2006068978A2 (en)	2004-12-21	2006-06-29	Takeda Pharmaceutial Company Limited	Dipeptidyl peptidase inhibitors
GEP20135838B (en)	2005-09-14	2013-06-10	Takeda Pharmaceutical	Dipeptidyl peptidase inhibitors usage at diabetes treatment
CA2622642C (en)	2005-09-16	2013-12-31	Takeda Pharmaceutical Company Limited	Dipeptidyl peptidase inhibitors
TW200813015A (en)	2006-03-15	2008-03-16	Mitsubishi Pharma Corp	2-(cyclic amino)-pyrimidone derivatives
US8324383B2 (en)	2006-09-13	2012-12-04	Takeda Pharmaceutical Company Limited	Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile
TW200838536A (en)	2006-11-29	2008-10-01	Takeda Pharmaceutical	Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor
US8093236B2 (en)	2007-03-13	2012-01-10	Takeda Pharmaceuticals Company Limited	Weekly administration of dipeptidyl peptidase inhibitors
PE20091236A1 (es) *	2007-11-22	2009-09-16	Astrazeneca Ab	Derivados de pirimidina como immunomoduladores de tlr7
BR102012024778A2 (pt) *	2012-09-28	2014-08-19	Cristalia Prod Quimicos Farm	Compostos heteroaromáticos; processo para preparar os compostos, composições farmacêuticas, usos e método de tratamento para as dores aguda e crônica
WO2015064714A1 (ja) *	2013-10-31	2015-05-07	国立大学法人東京大学	オートタキシン阻害活性を有する１－置換イミダゾピリミジノン誘導体
ES2747768T3 (es)	2017-03-20	2020-03-11	Forma Therapeutics Inc	Composiciones de pirrolopirrol como activadores de quinasa de piruvato (PKR)
ES2924359T3 (es) *	2017-04-11	2022-10-06	Sunshine Lake Pharma Co Ltd	Compuestos de indazol sustituidos con flúor y usos de los mismos
WO2020061378A1 (en)	2018-09-19	2020-03-26	Forma Therapeutics, Inc.	Treating sickle cell disease with a pyruvate kinase r activating compound
WO2020061255A1 (en)	2018-09-19	2020-03-26	Forma Therapeutics, Inc.	Activating pyruvate kinase r
US20220378756A1 (en)	2019-09-19	2022-12-01	Forma Therapeutics, Inc.	Activating pyruvate kinase r
US12128035B2 (en)	2021-03-19	2024-10-29	Novo Nordisk Health Care Ag	Activating pyruvate kinase R

Family Cites Families (5)

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Publication number	Priority date	Publication date	Assignee	Title
US4443451A (en) *	1981-07-15	1984-04-17	Janssen Pharmaceutica N.V.	Bicyclic pyrimidin-5-one derivatives
US4485107A (en) *	1982-11-01	1984-11-27	Janssen Pharmaceutica N.V.	[[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones
FR2537764A1 (fr) *	1982-12-08	1984-06-15	Framatome Sa	Dispositif de commande de deux grappes de crayons de reglage deplacables verticalement dans un meme assemblage combustible du coeur d'un reacteur nucleaire
US4804663A (en) *	1985-03-27	1989-02-14	Janssen Pharmaceutica N.V.	3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
GB8900380D0 (en) *	1989-01-09	1989-03-08	Janssen Pharmaceutica Nv	2-aminopyrimidinone derivatives

1989
- 1989-01-09 GB GB898900382A patent/GB8900382D0/en active Pending
- 1989-12-14 NZ NZ231788A patent/NZ231788A/en unknown
- 1989-12-15 IL IL92730A patent/IL92730A/xx not_active IP Right Cessation
1990
- 1990-01-02 JO JO19901605A patent/JO1605B1/en active
- 1990-01-03 DK DK90200005.8T patent/DK0378255T3/da active
- 1990-01-03 ES ES90200005T patent/ES2055860T3/es not_active Expired - Lifetime
- 1990-01-03 DE DE69008366T patent/DE69008366T2/de not_active Expired - Fee Related
- 1990-01-03 AT AT9090200005T patent/ATE104971T1/de not_active IP Right Cessation
- 1990-01-03 EP EP90200005A patent/EP0378255B1/en not_active Expired - Lifetime
- 1990-01-05 CA CA002007200A patent/CA2007200C/en not_active Expired - Fee Related
- 1990-01-06 MY MYPI90000016A patent/MY106259A/en unknown
- 1990-01-08 IE IE6990A patent/IE62874B1/en not_active IP Right Cessation
- 1990-01-08 RU SU904742788A patent/RU2028297C1/ru not_active IP Right Cessation
- 1990-01-08 FI FI900085A patent/FI94525C/sv not_active IP Right Cessation
- 1990-01-08 ZW ZW2/90A patent/ZW290A1/xx unknown
- 1990-01-08 NO NO900071A patent/NO173139C/no not_active IP Right Cessation
- 1990-01-08 MA MA21982A patent/MA21722A1/fr unknown
- 1990-01-08 PT PT92806A patent/PT92806B/pt not_active IP Right Cessation
- 1990-01-08 HU HU9064A patent/HU203747B/hu not_active IP Right Cessation
- 1990-01-08 AU AU47779/90A patent/AU617918B2/en not_active Ceased
- 1990-01-08 ZA ZA90123A patent/ZA90123B/xx unknown
- 1990-01-09 TN TNTNSN90003A patent/TNSN90003A1/fr unknown
- 1990-01-09 KR KR1019900000188A patent/KR0159099B1/ko not_active Expired - Fee Related
- 1990-01-09 CN CN90100075A patent/CN1034865C/zh not_active Expired - Fee Related
- 1990-01-09 JP JP2002415A patent/JP2938492B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
PT92806B (pt)	1995-11-30
JPH02225482A (ja)	1990-09-07
IL92730A (en)	1993-06-10
ZA90123B (en)	1991-09-25
IL92730A0 (en)	1990-09-17
TNSN90003A1 (fr)	1991-03-05
FI94525C (sv)	1995-09-25
IE62874B1 (en)	1995-03-08
HU900064D0 (en)	1990-03-28
KR0159099B1 (ko)	1998-12-01
ZW290A1 (en)	1991-09-11
ATE104971T1 (de)	1994-05-15
CA2007200A1 (en)	1990-07-09
FI94525B (sv)	1995-06-15
NO173139C (no)	1993-11-03
MY106259A (en)	1995-04-29
EP0378255B1 (en)	1994-04-27
NZ231788A (en)	1990-12-21
JP2938492B2 (ja)	1999-08-23
EP0378255A3 (en)	1991-01-09
EP0378255A2 (en)	1990-07-18
AU617918B2 (en)	1991-12-05
IE900069L (en)	1990-07-09
PT92806A (pt)	1990-07-31
GB8900382D0 (en)	1989-03-08
CN1034865C (zh)	1997-05-14
KR900011755A (ko)	1990-08-02
NO173139B (no)	1993-07-26
HU203747B (en)	1991-09-30
RU2028297C1 (ru)	1995-02-09
FI900085A0 (sv)	1990-01-08
ES2055860T3 (es)	1994-09-01
MA21722A1 (fr)	1990-10-01
JO1605B1 (en)	1990-07-01
DE69008366D1 (de)	1994-06-01
NO900071D0 (no)	1990-01-08
CA2007200C (en)	1999-07-20
AU4777990A (en)	1990-07-12
DE69008366T2 (de)	1994-08-25
NO900071L (no)	1990-07-10
HUT52770A (en)	1990-08-28
DK0378255T3 (da)	1994-05-24
CN1044094A (zh)	1990-07-25

Publication	Publication Date	Title
FI900085L (sv)	1990-07-10	Förfarande för framställning av terapeutiskt användbara N-(pyrimidin- och kondenserad pyrimidin-4-on)etyl-piperidin- och piperatzinderivat
FI905941A0 (sv)	1990-12-03	Förfarande för framställning av terapeutiskt användbara heterocykliska 2-acylaminotiazolderivat
FI892787L (sv)	1989-12-11	Analogiförfarande för framställning av terapeutiskt användbara 1-indolylalkyl-4-(substituerat pyridinyl)piperaziner
FI881900A7 (sv)	1988-10-25	Analogiförfarande för framställning av terapeutiskt användbara substituerade imidazolylalkylpiperazin- och -diazepinderivat
FI96861C (sv)	1996-09-10	Förfarande för framställning av terapeutiskt aktiva substituerade indolylpyrrolderivat
FI944704L (sv)	1994-10-07	Förfarande för framställning av farmakologiskt aktiva tricykliskt kondenserade kinolinaminer
FI914905L (sv)	1992-04-19	Förfarande för framställning av nya terapeutiskt användbara merkaptoacetylamidopyrrolo- och -pyridobensazepinderivat
FI875660L (sv)	1987-12-22	Förfarande för framställning av terapeutiskt användbara 5-fenyl-2-pyrimidinonderivat
FI905444A0 (sv)	1990-11-02	Förfarande för framställning av terapeutiskt användbara aromatiskt substituerade piperidin- och piperazinderivat
FI875024A7 (sv)	1988-05-15	Förfarande för framställning av terapeutiskt användbara 1-alkyl-6-halogentetrahydronaftalenderivat
FI925737A7 (sv)	1993-06-20	Förfarande för framställning av nya terapeutiskt användbara indol-3-ylalkylpiperazinderivat
FI883739A7 (sv)	1989-02-15	Förfarande för framställning av terapeutiskt aktiva fenoxiindanmetylaminderivat
PT87754A (pt)	1988-07-01	Process for the preparation of new amino acid derivatives
FI890072A0 (sv)	1989-01-06	Förfarande för framställning av farmaceutiskt användbara isokinolinderivat
FI923527L (sv)	1992-08-05	Förfarande för framställning av terapeutiskt användbara 3-piperidino-4-hydroxikromanderivat
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Date	Code	Title	Description
1995-05-16	BB	Publication of examined application
2004-08-31	MM	Patent lapsed	Owner name: JANSSEN PHARMACEUTICA N.V.