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FI881900A7 - Analogiförfarande för framställning av terapeutiskt användbara substituerade imidazolylalkylpiperazin- och -diazepinderivat - Google Patents

Analogiförfarande för framställning av terapeutiskt användbara substituerade imidazolylalkylpiperazin- och -diazepinderivat

Info

Publication number
FI881900A7
FI881900A7 FI881900A FI881900A FI881900A7 FI 881900 A7 FI881900 A7 FI 881900A7 FI 881900 A FI881900 A FI 881900A FI 881900 A FI881900 A FI 881900A FI 881900 A7 FI881900 A7 FI 881900A7
Authority
FI
Finland
Prior art keywords
imidazolylalkylpiperazine
preparation
therapeutically useful
analogous process
diazepine derivatives
Prior art date
Application number
FI881900A
Other languages
English (en)
Finnish (fi)
Other versions
FI881900A0 (sv
FI93104C (sv
FI93104B (sv
Inventor
Jean-Claude Pascal
Chi-Ho Lee
Brian J Alps
Henri Pinhas
Roger L Whiting
Serge Beranger
Original Assignee
Syntex Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex Pharma Ltd filed Critical Syntex Pharma Ltd
Publication of FI881900A0 publication Critical patent/FI881900A0/sv
Publication of FI881900A7 publication Critical patent/FI881900A7/sv
Application granted granted Critical
Publication of FI93104B publication Critical patent/FI93104B/sv
Publication of FI93104C publication Critical patent/FI93104C/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Pyridine Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Epoxy Resins (AREA)
FI881900A 1987-04-24 1988-04-22 Analogiförfarande för framställning av terapeutiskt användbara substituerade imidazolylalkylpiperazin- och -diazepinderivat FI93104C (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4218187 1987-04-24
US07/042,181 US4829065A (en) 1987-04-24 1987-04-24 Substituted imidazolyl-alkyl-piperazine and -diazepine derivatives

Publications (4)

Publication Number Publication Date
FI881900A0 FI881900A0 (sv) 1988-04-22
FI881900A7 true FI881900A7 (sv) 1988-10-25
FI93104B FI93104B (sv) 1994-11-15
FI93104C FI93104C (sv) 1995-02-27

Family

ID=21920487

Family Applications (1)

Application Number Title Priority Date Filing Date
FI881900A FI93104C (sv) 1987-04-24 1988-04-22 Analogiförfarande för framställning av terapeutiskt användbara substituerade imidazolylalkylpiperazin- och -diazepinderivat

Country Status (20)

Country Link
US (1) US4829065A (sv)
EP (1) EP0289227B1 (sv)
JP (1) JPH0737451B2 (sv)
KR (1) KR960007524B1 (sv)
AT (1) ATE74594T1 (sv)
AU (1) AU614282B2 (sv)
CA (1) CA1320199C (sv)
DE (1) DE3869821D1 (sv)
DK (1) DK220488A (sv)
ES (1) ES2038288T3 (sv)
FI (1) FI93104C (sv)
GR (1) GR3004317T3 (sv)
HU (2) HU199456B (sv)
IE (1) IE62106B1 (sv)
IL (1) IL86149A (sv)
MX (1) MX9203595A (sv)
NO (1) NO170018C (sv)
NZ (1) NZ224344A (sv)
PH (1) PH27325A (sv)
ZA (1) ZA882878B (sv)

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US5091428A (en) * 1987-04-24 1992-02-25 Syntex Pharmaceuticals, Ltd. Substituted imidazolyl-alkyl-piperazine and -diazepine derivatives
US5043447A (en) * 1987-04-24 1991-08-27 Syntex Pharmaceuticals, Ltd. Substituted imidazolyl-alkyl-piperazine and -diazepine derivatives
US4973591A (en) * 1988-10-21 1990-11-27 Syntex Pharmaceuticals, Ltd. Parenteral formulations of 1-diphenylmethyl-4-((2-(4-methylphenyl)-5-methyl-1H-imidazol-4-yl)methyl)piperazine
US5106845A (en) * 1990-01-10 1992-04-21 Merrell Dow Pharmaceuticals Inc. Calcium antagonists
US5159083A (en) * 1990-12-28 1992-10-27 Neurogen Corporation Certain aminomethyl phenylimidazole derivatives; a class of dopamine receptor subtype specific ligands
US5681956A (en) * 1990-12-28 1997-10-28 Neurogen Corporation 4-aryl substituted piperazinylmethyl phenylimidazole derivatives; a new class of dopamine receptor subtype specific ligands
US5646281A (en) 1990-12-28 1997-07-08 Neurogen Corporation Certain 4-piperidino- and piperazinomethyl-2-phenyl imidazole derivatives; dopamine receptor subtype specific ligands
EP0579754A1 (en) * 1991-04-09 1994-01-26 The Upjohn Company Use of amines to sensitize multidrug-resistant cells
EP0618905B1 (en) * 1991-12-18 1995-10-04 Schering Corporation Imidazolyl-alkyl-piperazine and -diazepine derivatives as histamine h3 agonists/antagonists
US5633250A (en) * 1991-12-18 1997-05-27 Schering Corporation Imidazoylalkyl substituted with a six or seven membered heterocyclic ring containing two nitrogen atoms
US5296609A (en) * 1993-04-09 1994-03-22 Syntex Pharmaceuticals, Ltd. Process for the preparation of 1,2,4-substituted imidazoles and related aminoalkylimidazole derivatives
US5428037A (en) * 1993-04-09 1995-06-27 Syntex Pharmaceuticals, Ltd. Heterocyclic derivatives in the treatment of Ischaemia and related diseases
US5478934A (en) * 1994-11-23 1995-12-26 Yuan; Jun Certain 1-substituted aminomethyl imidazole and pyrrole derivatives: novel dopamine receptor subtype specific ligands
SE9504662D0 (sv) * 1995-12-22 1995-12-22 Astra Pharma Inc New compounds
SE9504661D0 (sv) * 1995-12-22 1995-12-22 Astra Pharma Inc New compounds
US5869682A (en) * 1996-04-03 1999-02-09 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US5885995A (en) * 1996-04-03 1999-03-23 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
JP2000507579A (ja) * 1996-04-03 2000-06-20 メルク エンド カンパニー インコーポレーテッド ファルネシル―タンパク質トランスフェラーゼ阻害剤
US5972942A (en) * 1997-03-27 1999-10-26 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US6166205A (en) * 1998-09-02 2000-12-26 Neurogen Corporation 2-Aryl-4-(1-[4-heteroaryl]piperazin-1-yl)methylimidazoles: dopamine . D.sub4 receptor subtype ligands
CA2362493A1 (en) 1999-03-03 2000-09-08 Merck & Co., Inc. Inhibitors of prenyl-protein transferase
EP1158983A4 (en) 1999-03-03 2003-05-21 Merck & Co Inc Prenyl protein transferase inhibitors
JP2003524618A (ja) 1999-03-03 2003-08-19 メルク エンド カムパニー インコーポレーテッド プレニル蛋白トランスフェラーゼ阻害剤
CA2362778A1 (en) 1999-03-03 2000-09-08 Merck & Co., Inc. Inhibitors of prenyl-protein transferase
EP1196395A1 (en) * 1999-07-06 2002-04-17 Vertex Pharmaceuticals Incorporated Cyclized amino acid derivatives
SE9904674D0 (sv) 1999-12-20 1999-12-20 Astra Pharma Inc Novel compounds
SE9904673D0 (sv) 1999-12-20 1999-12-20 Astra Pharma Inc Novel compounds
SE0001209D0 (sv) 2000-04-04 2000-04-04 Astrazeneca Canada Inc Novel compounds
AR032894A1 (es) * 2000-09-20 2003-12-03 Schering Corp Compuestos imidazoles sustituidos, composicion farmaceutica, metodo para su preparacion y el uso de los mismos para la manufactura de medicamentos como agonistas o antagonistas de h1 y h3 de histamina.
AR035974A1 (es) 2001-05-18 2004-07-28 Astrazeneca Ab Derivados de diarilmetil piperazina, procesos para su preparacion, uso de estos derivados para la elaboracion de medicamentos y composicion farmaceutica
SE0203302D0 (sv) 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
SE0203303D0 (sv) 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
SE0203300D0 (sv) 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
HRP20120343T1 (hr) 2004-08-02 2012-05-31 Astrazeneca Ab Derivati diarilmetil piperazina, njihovi pripravci i njihova uporaba
CN114349745B (zh) * 2022-01-14 2023-12-08 黑龙江中医药大学 一种用于治疗心肌缺血的药物及其制备方法

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US3362956A (en) * 1965-08-19 1968-01-09 Sterling Drug Inc 1-[(heterocyclyl)-lower-alkyl]-4-substituted-piperazines
GB1184714A (en) * 1965-12-16 1970-03-18 Science Union & Cie Di- and Tri-Phenylpropyl Piperazine Derivatives
US3491098A (en) * 1967-05-29 1970-01-20 Sterling Drug Inc 1-((imidazolyl)-lower-alkyl)-4-substituted-piperazines
DE1795314A1 (de) * 1968-09-11 1972-01-05 Merck Patent Gmbh N-(Thiazolyl-2)-piperazine
US3927011A (en) * 1973-05-10 1975-12-16 Yoshitomi Pharmaceutical 2-Aminoalkyl-1-(pyridylcarbonylphenyl)imidazole compounds
IT1056055B (it) * 1974-03-01 1982-01-30 Malesci Sas Inst Farmaco Bilog Derivati eterocicli della 4 fenil riperazina i alchil sostituita ad azione farmacologica e relativo procedimento di preparazione
US4022783A (en) * 1975-10-29 1977-05-10 Usv Pharmaceutical Corporation Piperazinyl-imidazolines
GB1551993A (en) * 1976-09-21 1979-09-05 Malesci Sas Pharmacologiclly active derivatives of 1 alkyl 4-phenylpiperazines and the preparation thereof
IT1159698B (it) * 1978-05-29 1987-03-04 Rotta Research Lab Derivati 5-nitro-imidazolici della piperazina ad attivita' antiprotozoica
US4243806A (en) * 1979-06-13 1981-01-06 Janssen Pharmaceutica N.V. 5-[4-(Diarylmethyl)-1-piperazinylalkyl]benzimidazole derivatives
US4404382A (en) * 1980-09-17 1983-09-13 The Upjohn Company Piperazinyl-substituted imidazoles
CA1162540A (en) * 1980-12-24 1984-02-21 Ikutaro Saji Imidazolylpropanol compounds and their acid addition salts, and production and use thereof
US4435399A (en) * 1981-07-18 1984-03-06 Pfizer Inc. 2-Aryl-1-(imidazol-1-yl)-8-(4-piperazin-1-ylphenoxy) octan-2-ol antifungal agents

Also Published As

Publication number Publication date
US4829065A (en) 1989-05-09
MX9203595A (es) 1992-09-01
FI881900A0 (sv) 1988-04-22
NO170018B (no) 1992-05-25
KR880012589A (ko) 1988-11-28
ATE74594T1 (de) 1992-04-15
NO881789L (no) 1988-10-25
KR960007524B1 (ko) 1996-06-05
EP0289227A1 (en) 1988-11-02
DE3869821D1 (de) 1992-05-14
JPS63280081A (ja) 1988-11-17
HU210720A9 (en) 1995-06-28
PH27325A (en) 1993-06-08
ZA882878B (en) 1989-12-27
ES2038288T3 (es) 1993-07-16
IE881209L (en) 1988-10-24
EP0289227B1 (en) 1992-04-08
NO881789D0 (no) 1988-04-22
NZ224344A (en) 1991-01-29
HUT46690A (en) 1988-11-28
DK220488D0 (da) 1988-04-22
IL86149A0 (en) 1988-11-15
DK220488A (da) 1988-10-25
IL86149A (en) 1993-01-14
JPH0737451B2 (ja) 1995-04-26
IE62106B1 (en) 1994-12-14
NO170018C (no) 1992-09-02
HU199456B (en) 1990-02-28
FI93104C (sv) 1995-02-27
AU1510288A (en) 1988-10-27
GR3004317T3 (sv) 1993-03-31
FI93104B (sv) 1994-11-15
AU614282B2 (en) 1991-08-29
CA1320199C (en) 1993-07-13

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Legal Events

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MM Patent lapsed
MM Patent lapsed

Owner name: SYNTEX PHARMACEUTICALS LIMITED