FI923527L - Förfarande för framställning av terapeutiskt användbara 3-piperidino-4-hydroxikromanderivat - Google Patents

Förfarande för framställning av terapeutiskt användbara 3-piperidino-4-hydroxikromanderivat Download PDF

Info

Publication number: FI923527L
Authority: FI; Finland
Prior art keywords: piperidino; preparation; therapeutically useful; hydroxychroman derivatives; hydroxychroman
Prior art date: 1990-02-06

Application number

FI923527A

Other languages

English (en)

Finnish (fi)

Other versions

FI94957C (sv

FI923527A0 (sv

FI94957B (sv

Inventor

Todd W Butler

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-02-06

Filing date

1992-08-05

Publication date

1992-08-05

1992-08-05 Application filed by Pfizer filed Critical Pfizer

1992-08-05 Publication of FI923527L publication Critical patent/FI923527L/sv

1992-08-05 Publication of FI923527A0 publication Critical patent/FI923527A0/sv

1995-08-15 Application granted granted Critical

1995-08-15 Publication of FI94957B publication Critical patent/FI94957B/sv

1995-11-27 Publication of FI94957C publication Critical patent/FI94957C/sv

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/48—Oxygen atoms attached in position 4 having an acyclic carbon atom attached in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

FI923527A 1990-02-06 1992-08-05 Förfarande för framställning av terapeutiskt användbara 3-piperidino-4-hydroxikromanderivat FI94957C (sv)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US9000674		1990-02-06
PCT/US1990/000674 WO1991012005A1 (en)	1990-02-06	1990-02-06	Neuroprotective 3-piperidino-4-hydroxychroman derivatives and analogs

Publications (4)

Publication Number	Publication Date
FI923527L true FI923527L (sv)	1992-08-05
FI923527A0 FI923527A0 (sv)	1992-08-05
FI94957B FI94957B (sv)	1995-08-15
FI94957C FI94957C (sv)	1995-11-27

Family

ID=22220666

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI923527A FI94957C (sv)	1990-02-06	1992-08-05	Förfarande för framställning av terapeutiskt användbara 3-piperidino-4-hydroxikromanderivat

Country Status (29)

Country	Link
US (1)	US5356905A (sv)
EP (1)	EP0441506B1 (sv)
JP (1)	JPH0768214B2 (sv)
KR (1)	KR930011041B1 (sv)
CN (1)	CN1029960C (sv)
AT (1)	ATE108787T1 (sv)
AU (1)	AU626490B2 (sv)
BR (1)	BR9100490A (sv)
CA (1)	CA2035653C (sv)
CZ (1)	CZ286218B6 (sv)
DE (2)	DE69102893T4 (sv)
DK (1)	DK0441506T3 (sv)
EG (1)	EG19643A (sv)
ES (1)	ES2056571T3 (sv)
FI (1)	FI94957C (sv)
HU (1)	HU222726B1 (sv)
IE (1)	IE63836B1 (sv)
IL (1)	IL97100A (sv)
MX (1)	MX24433A (sv)
MY (1)	MY105293A (sv)
NO (1)	NO178399C (sv)
NZ (1)	NZ237025A (sv)
PH (1)	PH31061A (sv)
PL (1)	PL164866B1 (sv)
PT (1)	PT96664B (sv)
RU (1)	RU2099339C1 (sv)
SK (1)	SK281729B6 (sv)
WO (1)	WO1991012005A1 (sv)
ZA (1)	ZA91830B (sv)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5594007A (en) *	1991-04-18	1997-01-14	Pfizer Inc.	Method for treating spinal cord trauma with phenolic 2-piperidino-1-alkanols
DE9290042U1 (de) *	1991-04-18	1993-12-16	Pfizer Inc., New York, N.Y.	Pro-Arzneimittelester von phenolischen 2-Piperidino-1-alkanolen
US5436255A (en) *	1992-07-23	1995-07-25	Pfizer Inc.	Method of treating diseases susceptable to treatment by blocking NMDA-receptors
US5498610A (en) *	1992-11-06	1996-03-12	Pfizer Inc.	Neuroprotective indolone and related derivatives
CN1048247C (zh) *	1994-01-31	2000-01-12	美国辉瑞有限公司	神经保护的苯并二氢吡喃化合物
NZ284852A (en) *	1994-08-18	1998-06-26	Pfizer	3-(piperidin-1-yl)-chroman-4,7-diol and 1-(4-hydrophenyl)-2-(piperidin-1-yl) alkanol derivatives; medicaments; used as a neuroprotective agent
DK0828513T3 (da)	1995-05-26	2004-04-13	Pfizer	Kombinationspræparater til behandling af parkinsonisme, indeholdende selektive NMDA-antagonister
TW498067B (en) *	1996-07-19	2002-08-11	Hoffmann La Roche	4-hydroxy-piperidine derivatives
YU32700A (sh) *	1999-06-09	2002-03-18	Pfizer Products Inc.	Postupak za dobijanje sertralina iz hiralnog tetralona
US6369076B1 (en)	1999-10-29	2002-04-09	Merck & Co. Inc.	5-benzyl-octahydroindole and 6-benzyl-decahydroquinoline NMDA/NR2B antagonists
US6476041B1 (en)	1999-10-29	2002-11-05	Merck & Co., Inc.	1,4 substituted piperidinyl NMDA/NR2B antagonists
US6291499B1 (en)	1999-10-29	2001-09-18	Merck & Co., Inc.	2-cyclohexyl benzimidazole NMDA/NR2B antagonists
US6489477B1 (en)	1999-10-29	2002-12-03	Merck & Co., Inc.	2-aza-bicyclo[2.2.2]octane NMDA/NR2B antigonists
WO2001030330A2 (en)	1999-10-29	2001-05-03	Merck Sharp & Dohme Limited	Method to treat pain utilizing benzimidazole nmda/nr2b antagonists
US6495561B2 (en)	1999-10-29	2002-12-17	Merck & Co., Inc.	2-cyclohexyl imidazopyridine NMDA/NR2B antagonists
US6380205B1 (en)	1999-10-29	2002-04-30	Merck & Co., Inc.	2-cyclohexyl quinazoline NMDA/NR2B antagonists
US6316474B1 (en)	1999-10-29	2001-11-13	Merck & Co., Inc.	2-benzyl and 2-heteroaryl benzimidazole NMDA/NR2B antagonists
US6432976B1 (en)	1999-10-29	2002-08-13	Merck & Co., Inc.	8-aza-bicyclo[3.2.1]octane NMDA/NR2B antagonists
IL145209A0 (en)	2000-09-06	2002-06-30	Pfizer Prod Inc	Pharmaceutical combinations for the treatment of stroke and traumatic brain injury
EP1674087A1 (en)	2000-10-02	2006-06-28	Pfizer Products Inc.	Prophylactic use of n-methyl-d-aspartate (NMDA) antagonists
EA005974B1 (ru)	2001-02-23	2005-08-25	Мерк Энд Ко., Инк.	N-замещенные неарильные гетероциклические антагонисты nmda/nr2b
US7259157B2 (en)	2001-04-03	2007-08-21	Merck & Co., Inc.	N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists
CA2542077A1 (en) *	2003-10-08	2005-04-21	President And Fellows Of Harvard College	Pyrovalerone analogs and therapeutic uses thereof
WO2005051919A1 (en) *	2003-11-26	2005-06-09	Pfizer Products Inc.	Aminopyrazole derivatives as gsk-3 inhibitors

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3294804A (en) *	1961-01-27	1966-12-27	Sterling Drug Inc	1-(3-hydroxy-3-phenylpropyl)-4-phenyl-4-propionoxy-piperidine
FR5733M (sv) *	1966-09-27	1968-01-22
GB1495526A (en) *	1974-05-31	1977-12-21	Beecham Group Ltd	Chroman derivatives
DE2507782A1 (de) *	1975-02-22	1976-09-02	Merck Patent Gmbh	Tetralon- und indanon-derivate sowie verfahren zu ihrer herstellung
US4016281A (en) *	1975-02-22	1977-04-05	Merck Patent Gesellschaft Mit Beschrankter Haftung	Tetralone and indanone compounds
ATE23718T1 (de) *	1981-09-25	1986-12-15	Beecham Group Plc	Benzopyran-verbindungen mit pharmazeutischer wirkung.
EP0093534A1 (en) *	1982-04-28	1983-11-09	Beecham Group Plc	Novel chromanols
GB8308064D0 (en) *	1983-03-24	1983-05-05	Beecham Group Plc	Active compounds

1990
- 1990-02-06 HU HU9202568A patent/HU222726B1/hu active IP Right Grant
- 1990-02-06 WO PCT/US1990/000674 patent/WO1991012005A1/en not_active Ceased
- 1990-02-06 US US07/916,130 patent/US5356905A/en not_active Expired - Lifetime
- 1990-02-06 MX MX2443391A patent/MX24433A/es unknown
- 1990-02-06 RU SU5053040/04A patent/RU2099339C1/ru not_active IP Right Cessation
1991
- 1991-01-21 PH PH41875A patent/PH31061A/en unknown
- 1991-01-24 DK DK91300549.2T patent/DK0441506T3/da active
- 1991-01-24 ES ES91300549T patent/ES2056571T3/es not_active Expired - Lifetime
- 1991-01-24 AT AT91300549T patent/ATE108787T1/de not_active IP Right Cessation
- 1991-01-24 DE DE69102893A patent/DE69102893T4/de not_active Expired - Fee Related
- 1991-01-24 EP EP91300549A patent/EP0441506B1/en not_active Expired - Lifetime
- 1991-01-30 IL IL9710091A patent/IL97100A/en not_active IP Right Cessation
- 1991-02-01 CZ CS1991250A patent/CZ286218B6/cs not_active IP Right Cessation
- 1991-02-01 SK SK250-91A patent/SK281729B6/sk unknown
- 1991-02-04 CA CA002035653A patent/CA2035653C/en not_active Expired - Fee Related
- 1991-02-04 PT PT96664A patent/PT96664B/pt not_active IP Right Cessation
- 1991-02-04 PL PL91288949A patent/PL164866B1/pl not_active IP Right Cessation
- 1991-02-05 AU AU70293/91A patent/AU626490B2/en not_active Ceased
- 1991-02-05 NZ NZ237025A patent/NZ237025A/en unknown
- 1991-02-05 JP JP3014569A patent/JPH0768214B2/ja not_active Expired - Fee Related
- 1991-02-05 ZA ZA91830A patent/ZA91830B/xx unknown
- 1991-02-05 CN CN91100705A patent/CN1029960C/zh not_active Expired - Fee Related
- 1991-02-05 MY MYPI91000171A patent/MY105293A/en unknown
- 1991-02-05 IE IE37291A patent/IE63836B1/en not_active IP Right Cessation
- 1991-02-06 DE DE9101346U patent/DE9101346U1/de not_active Expired - Lifetime
- 1991-02-06 BR BR919100490A patent/BR9100490A/pt not_active Application Discontinuation
- 1991-02-06 EG EG7291A patent/EG19643A/xx active
- 1991-02-06 KR KR1019910002022A patent/KR930011041B1/ko not_active Expired - Fee Related
1992
- 1992-08-05 NO NO923081A patent/NO178399C/no not_active IP Right Cessation
- 1992-08-05 FI FI923527A patent/FI94957C/sv active

Also Published As

Publication number	Publication date
KR910015568A (ko)	1991-09-30
NZ237025A (en)	1992-11-25
AU7029391A (en)	1991-09-05
HU222726B1 (hu)	2003-09-29
FI94957C (sv)	1995-11-27
DE69102893T2 (de)	1994-11-03
DE69102893T4 (de)	1995-08-10
MY105293A (en)	1994-09-30
EP0441506A3 (en)	1991-11-21
PT96664A (pt)	1991-10-31
JPH0768214B2 (ja)	1995-07-26
ES2056571T3 (es)	1994-10-01
DK0441506T3 (da)	1994-09-05
ZA91830B (en)	1992-09-30
IL97100A0 (en)	1992-03-29
US5356905A (en)	1994-10-18
DE9101346U1 (de)	1991-06-06
ATE108787T1 (de)	1994-08-15
WO1991012005A1 (en)	1991-08-22
JPH04211058A (ja)	1992-08-03
FI923527A0 (sv)	1992-08-05
BR9100490A (pt)	1991-10-29
NO178399B (no)	1995-12-11
PT96664B (pt)	1998-07-31
IE63836B1 (en)	1995-06-14
CA2035653A1 (en)	1991-08-07
SK281729B6 (sk)	2001-07-10
RU2099339C1 (ru)	1997-12-20
PH31061A (en)	1998-02-05
NO178399C (no)	1996-03-20
FI94957B (sv)	1995-08-15
PL288949A1 (en)	1991-07-29
IL97100A (en)	1996-06-18
MX24433A (es)	1993-05-01
EG19643A (en)	1995-09-30
AU626490B2 (en)	1992-07-30
CN1053923A (zh)	1991-08-21
PL164866B1 (pl)	1994-10-31
CN1029960C (zh)	1995-10-11
EP0441506B1 (en)	1994-07-20
NO923081D0 (no)	1992-08-05
CZ286218B6 (cs)	2000-02-16
IE910372A1 (en)	1991-08-14
CA2035653C (en)	1999-12-21
CS25091A3 (en)	1991-09-15
KR930011041B1 (ko)	1993-11-20
DE69102893D1 (de)	1994-08-25
NO923081L (no)	1992-08-05
EP0441506A2 (en)	1991-08-14

Publication	Publication Date	Title
FI914905L (sv)	1992-04-19	Förfarande för framställning av nya terapeutiskt användbara merkaptoacetylamidopyrrolo- och -pyridobensazepinderivat
FI925737A7 (sv)	1993-06-20	Förfarande för framställning av nya terapeutiskt användbara indol-3-ylalkylpiperazinderivat
FI905941A0 (sv)	1990-12-03	Förfarande för framställning av terapeutiskt användbara heterocykliska 2-acylaminotiazolderivat
FI914174A7 (sv)	1992-03-06	Förfarande för framställning av piperidylalkylaminer
FI875660L (sv)	1987-12-22	Förfarande för framställning av terapeutiskt användbara 5-fenyl-2-pyrimidinonderivat
FI875024A7 (sv)	1988-05-15	Förfarande för framställning av terapeutiskt användbara 1-alkyl-6-halogentetrahydronaftalenderivat
FI923527L (sv)	1992-08-05	Förfarande för framställning av terapeutiskt användbara 3-piperidino-4-hydroxikromanderivat
FI96861C (sv)	1996-09-10	Förfarande för framställning av terapeutiskt aktiva substituerade indolylpyrrolderivat
FI92934B (sv)	1994-10-14	Analogiförfarande för framställning av terapeutiskt användbara 1-deoxinojirimycinderivat
NO179448C (no)	1996-10-09	Analogifremgangsmåte for fremstilling av terapeutisk aktive forbindelser
NO175528C (no)	1994-10-26	Analogifremgangsmåte for fremstilling av terapeutisk aktive fenylacetamid-derivater
FI930723L (sv)	1993-02-18	Förfarande för framställning av terapeutiskt aktiva tiazolidinderivat
FI891003A7 (sv)	1989-09-04	Förfarande för framställning av terapeutiskt användbara 6-substituerade purinylpiperazinderivat
FI925871L (sv)	1992-12-23	Förfarande för framställning av terapeutiskt aktiva fenylguanidinderivat
FI906408L (sv)	1991-06-29	Förfarande för framställning av terapeutiskt användbara 2-aminopyrimidin-4-karboxamidderivat
FI884553A7 (sv)	1989-04-06	Analogiförfarande för framställning av terapeutiskt användbara 9-aminotetrahydroakridinderivat
FI911701A0 (sv)	1991-04-09	Förfarande för framställning av terapeutiskt användbara 2-substituerade-3-karboxikarbapenemer
FI911420A0 (sv)	1991-03-25	Förfarande för framställning av terapeutiskt användbara föreningar
FI892946A7 (sv)	1989-12-16	Förfarande för framställning av nya terapeutiskt användbara 2,3,4,5-tetrahydro-1H-3-bensazepinderivat
EE03027B1 (et)	1997-08-15	Meetod 8-klorokinolooni derivaatide valmistamiseks
FI893682L (sv)	1990-02-14	Förfarande för framställning av en terapeutiskt användbar 1,2,5-ditiazocinderivat
FI922835L (sv)	1992-06-17	Förfarande för framställning av terapeutiskt aktiva piperidinderivat
FI913464A7 (sv)	1992-01-21	Förfarande för framställning av 1-hydroximetylpyrazoler
FI893434A7 (sv)	1990-01-16	Förfarande för framställning av nya terapeutiskt användbara cykloalkyltiazolderivat
FI910159A7 (sv)	1991-01-11	Förfarande för framställning av nya terapeutiskt användbara 9a-hydroxi -3-oxo-4,24(25)-stigmastadien-26-syraderivat

Legal Events

Date	Code	Title	Description
1995-07-17	BB	Publication of examined application