[go: up one dir, main page]

FI834529L - Antikroppar med dubbel specificitet. - Google Patents

Antikroppar med dubbel specificitet. Download PDF

Info

Publication number
FI834529L
FI834529L FI834529A FI834529A FI834529L FI 834529 L FI834529 L FI 834529L FI 834529 A FI834529 A FI 834529A FI 834529 A FI834529 A FI 834529A FI 834529 L FI834529 L FI 834529L
Authority
FI
Finland
Prior art keywords
specificitet
antikroppar
dubbel
med
med dubbel
Prior art date
Application number
FI834529A
Other languages
English (en)
Other versions
FI834529A7 (fi
FI834529A0 (fi
Inventor
Joanne Martinis
Richard M Bartholomew
Gary S David
Thomas H Adams
James M Frincke
Original Assignee
Hybritech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hybritech Inc filed Critical Hybritech Inc
Publication of FI834529A7 publication Critical patent/FI834529A7/fi
Publication of FI834529A0 publication Critical patent/FI834529A0/fi
Publication of FI834529L publication Critical patent/FI834529L/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1084—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody the antibody being a hybrid immunoglobulin
    • A61K51/109—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody the antibody being a hybrid immunoglobulin immunoglobulins having two or more different antigen-binding sites or multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Optics & Photonics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
FI834529A 1982-04-12 1983-04-12 Antikroppar med dubbel specificitet. FI834529L (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36778482A 1982-04-12 1982-04-12
PCT/US1983/000525 WO1983003679A1 (en) 1982-04-12 1983-04-12 Antibodies having dual specificities, their preparation and uses therefor

Publications (3)

Publication Number Publication Date
FI834529A7 FI834529A7 (fi) 1983-12-09
FI834529A0 FI834529A0 (fi) 1983-12-09
FI834529L true FI834529L (fi) 1983-12-09

Family

ID=23448582

Family Applications (2)

Application Number Title Priority Date Filing Date
FI834529A FI834529L (fi) 1982-04-12 1983-04-12 Antikroppar med dubbel specificitet.
FI900212A FI900212A7 (fi) 1982-04-12 1983-04-12 Polydoomia, jotka tuottavat monoklonaalista hybridivasta-ainetta, joll a on kahdenlainen spesifisyys

Family Applications After (1)

Application Number Title Priority Date Filing Date
FI900212A FI900212A7 (fi) 1982-04-12 1983-04-12 Polydoomia, jotka tuottavat monoklonaalista hybridivasta-ainetta, joll a on kahdenlainen spesifisyys

Country Status (11)

Country Link
EP (1) EP0105360A4 (fi)
JP (2) JPH0753119B2 (fi)
AT (1) AT394577B (fi)
AU (1) AU550486B2 (fi)
CA (1) CA1213229A (fi)
CH (1) CH672796A5 (fi)
ES (7) ES521370A0 (fi)
FI (2) FI834529L (fi)
GB (4) GB2128631B (fi)
IT (1) IT1219778B (fi)
WO (1) WO1983003679A1 (fi)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3177776B2 (ja) * 1988-09-27 2001-06-18 武田薬品工業株式会社 ハイブリッドモノクローナル抗体，抗体産生ポリドーマおよび抗体含有薬剤
US5292668A (en) * 1981-12-21 1994-03-08 Boston Biomedical Research Institute, Inc. Bispecific antibody determinants
CA1214123A (en) * 1983-01-20 1986-11-18 Masashi Matsui Cell lines for use in the preparation of hybridoma cells
GB2148299B (en) * 1983-09-01 1988-01-06 Hybritech Inc Antibody compositions of therapeutic agents having an extended serum half-life
EP0467416A1 (en) * 1983-09-01 1992-01-22 Hybritech Incorporated Antibody compositions of therapeutic agents having an extended serum half-life
JPH0617909B2 (ja) * 1984-04-23 1994-03-09 ボストン バイオメディカル リサーチ インスティテュート，インコーポレイテッド 双特異性抗体決定子
NL8501219A (nl) * 1985-04-29 1986-11-17 Stichting Vrienden Van De Stic Immunologisch complex, de bereiding en toepassing daarvan.
JP2635343B2 (ja) 1986-04-14 1997-07-30 ザ・ジェネラル・ホスピタル・コーポレーション ヘテロ二官能性抗体および利用方法
US5453269A (en) * 1986-04-14 1995-09-26 The General Hospital Corporation Heterobifunctional antibodies having dual specificity for fibrin and thrombolylic agents and methods of use
FR2604092B1 (fr) * 1986-09-19 1990-04-13 Immunotech Sa Immunoreactifs destines a cibler les cellules animales pour leur visualisation ou leur destruction in vivo
GB8626413D0 (en) * 1986-11-05 1986-12-03 Gilliland L K Antibodies
GB8626412D0 (en) * 1986-11-05 1986-12-03 Clark M R Antibodies
US5053226A (en) * 1987-07-15 1991-10-01 Board Of Regents, The University Of Texas System Monoclonal antibodies binding platinum complexes
CA1338518C (en) * 1987-09-23 1996-08-13 Joyce M. Zarling Antibody heteroconjugates for the killing of hiv-infected cells
GB2218100A (en) * 1988-03-02 1989-11-08 Erling Sundrehagen Conjugates for the detection and/or quantification of antigenic substances in body fluids
US4892824A (en) * 1988-03-15 1990-01-09 Synbiotics Corporation Fast track method for producing monoclonal bi-specific immunoglobulins
US5582862A (en) 1988-04-04 1996-12-10 General Hospital Corporation Antibodies that bind to α2-antiplasmin crosslinked to fibrin which do not inhibit plasma α2-antiplasmin
US5372812A (en) * 1988-04-04 1994-12-13 The General Hospital Corporation Composition and method for acceleration of clot lysis
JPH02196799A (ja) * 1988-04-08 1990-08-03 Agency Of Ind Science & Technol 抗ヒト癌蛋白複合体
US5851527A (en) * 1988-04-18 1998-12-22 Immunomedics, Inc. Method for antibody targeting of therapeutic agents
IT1235349B (it) * 1988-12-23 1992-06-30 Biodata Spa Saggio immunologico per determinazioni in fase omogenea
CA2006408A1 (en) * 1988-12-27 1990-06-27 Susumu Iwasa Bispecific monoclonal antibody, its production and use
US5217713A (en) * 1988-12-27 1993-06-08 Takeda Chemical Industries, Ltd. Cytotoxic bispecific monoclonal antibody, its production and use
WO1990012109A1 (en) * 1989-03-30 1990-10-18 Board Of Regents, The University Of Texas System Monoclonal antibodies binding platinum complexes
FR2652004B1 (fr) * 1989-09-21 1994-10-28 Immunotech Partners Nouveaux derives hydrophiles, application au diagnostic et a la therapeutique, kits diagnostiques ou therapeutiques et reactifs immunologiques.
EP0515571B1 (en) * 1990-02-16 1998-12-02 Boston Biomedical Research Institute Hybrid reagents capable of selectively releasing molecules into cells
TW212184B (fi) * 1990-04-02 1993-09-01 Takeda Pharm Industry Co Ltd
WO1992019973A1 (en) * 1991-04-26 1992-11-12 Surface Active Limited Novel antibodies, and methods for their use
GB9316369D0 (en) * 1993-08-06 1993-09-22 Surface Active Ltd Diagnostic method
US5541110A (en) 1994-05-17 1996-07-30 Bristol-Myers Squibb Cloning and expression of a gene encoding bryodin 1 from Bryonia dioica
GB9421468D0 (en) * 1994-10-18 1994-12-07 Surface Active Ltd Biosensor
CA2266341A1 (en) * 1996-09-20 1998-03-26 The General Hospital Corporation Composition and method for enhancing fibrinolysis using antibodies to alpha-2-antiplasmin
US20020132274A1 (en) 2001-01-17 2002-09-19 Nevalainen Marja T. Diagnostic and monitorings methods for cancer
EP2353611B1 (en) 2002-07-31 2015-05-13 Seattle Genetics, Inc. Drug conjugates and their use for treating cancer, an autoimmune disease or an infectious disease
PT2489364E (pt) 2003-11-06 2015-04-16 Seattle Genetics Inc Compostos de monometilvalina conjugados com anticorpos
US7932242B2 (en) 2004-03-16 2011-04-26 Temple University - Of The Commonwealth System Of Higher Education Substituted phenoxy-and phenylthio-derivatives for treating proliferative disorders
CA2586909A1 (en) 2004-11-12 2006-12-14 Seattle Genetics, Inc. Auristatins having an aminobenzoic acid unit at the n terminus
EP2511299A1 (en) 2005-04-19 2012-10-17 Seattle Genetics, Inc. Humanized anti-CD70 binding agents and uses thereof
WO2007011968A2 (en) 2005-07-18 2007-01-25 Seattle Genetics, Inc. Beta-glucuronide-linker drug conjugates
PT2099823E (pt) 2006-12-01 2014-12-22 Seattle Genetics Inc Agentes de ligação ao alvo variantes e suas utilizações
WO2008091740A2 (en) 2007-01-22 2008-07-31 Genentech, Inc. Polyelectrolyte precipitation and purification of antibodies
EP2282773B2 (en) 2008-05-02 2025-03-05 Seagen Inc. Methods and compositions for making antibodies and antibody derivatives with reduced core fucosylation
WO2011133658A1 (en) 2010-04-22 2011-10-27 Boston Medical Center Corporation Compositions and methods for targeting and delivering therapeutics into cells
US9353150B2 (en) 2012-12-04 2016-05-31 Massachusetts Institute Of Technology Substituted pyrazino[1′,2′:1 ,5]pyrrolo[2,3-b]-indole-1,4-diones for cancer treatment
US10201614B2 (en) 2013-03-15 2019-02-12 Zymeworks Inc. Cytotoxic and anti-mitotic compounds, and methods of using the same
JP6473418B2 (ja) 2013-10-10 2019-02-20 幸成 加藤 抗ポドプラニン抗体
EP3086815B1 (en) 2013-12-27 2022-02-09 Zymeworks Inc. Sulfonamide-containing linkage systems for drug conjugates
US10450378B2 (en) 2014-09-17 2019-10-22 Zymeworks Inc. Cytotoxic and anti-mitotic compounds, and methods of using the same
TWI618697B (zh) 2015-11-03 2018-03-21 財團法人工業技術研究院 化合物、連接子－藥物、及配體－藥物耦合體
CN109843919A (zh) 2016-03-25 2019-06-04 西雅图基因公司 用于制备聚乙二醇化的药物-接头及其中间体的方法
US10918627B2 (en) 2016-05-11 2021-02-16 Massachusetts Institute Of Technology Convergent and enantioselective total synthesis of Communesin analogs
CN110430901B (zh) 2017-03-24 2024-08-16 西雅图基因公司 制备葡糖苷酸药物-接头及其中间体的方法
US11932650B2 (en) 2017-05-11 2024-03-19 Massachusetts Institute Of Technology Potent agelastatin derivatives as modulators for cancer invasion and metastasis
US10640508B2 (en) 2017-10-13 2020-05-05 Massachusetts Institute Of Technology Diazene directed modular synthesis of compounds with quaternary carbon centers
US10869888B2 (en) 2018-04-17 2020-12-22 Innovative Cellular Therapeutics CO., LTD. Modified cell expansion and uses thereof
US12240915B2 (en) 2018-08-30 2025-03-04 Innovative Cellular Therapeutics Holdings, Ltd. Chimeric antigen receptor cells for treating solid tumor
WO2020047306A1 (en) 2018-08-30 2020-03-05 Innovative Cellular Therapeutics CO., LTD. Chimeric antigen receptor cells for treating solid tumor
CN119770674A (zh) 2019-05-10 2025-04-08 武田药品工业株式会社 抗体药物缀合物
TWI877278B (zh) 2019-12-30 2025-03-21 美商思進公司 以非海藻糖苷化抗－ｃｄ７０抗體治療癌症之方法
US12076343B2 (en) 2020-02-19 2024-09-03 Innovative Cellular Therapeutics Holdings, Ltd. Engineered safety in cell therapy
US12043654B2 (en) 2020-06-02 2024-07-23 Innovative Cellular Therapeutics Holdings, Ltd. Anti-GCC antibody and CAR thereof for treating digestive system cancer
IL302390A (en) 2020-11-09 2023-06-01 Takeda Pharmaceuticals Co Drug antibody conjugates
WO2022182415A1 (en) 2021-02-24 2022-09-01 Massachusetts Institute Of Technology Himastatin derivatives, and processes of preparation thereof, and uses thereof
EP4362977A1 (en) 2021-06-29 2024-05-08 Seagen Inc. Methods of treating cancer with a combination of a nonfucosylated anti-cd70 antibody and a cd47 antagonist

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4130634A (en) * 1974-03-15 1978-12-19 University Of Illinois Foundation Method for detecting and quantifying antigens
US4331647A (en) * 1980-03-03 1982-05-25 Goldenberg Milton David Tumor localization and therapy with labeled antibody fragments specific to tumor-associated markers
US4376110A (en) * 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
US4474893A (en) * 1981-07-01 1984-10-02 The University of Texas System Cancer Center Recombinant monoclonal antibodies

Also Published As

Publication number Publication date
ES8603080A1 (es) 1985-12-01
ES527963A0 (es) 1985-02-16
GB2168998A (en) 1986-07-02
GB8530308D0 (en) 1986-01-22
JP2562002B2 (ja) 1996-12-11
ES8503441A1 (es) 1985-02-16
FI900212A0 (fi) 1990-01-15
GB8332646D0 (en) 1984-01-11
ES538727A0 (es) 1986-02-01
IT1219778B (it) 1990-05-24
ES8504461A1 (es) 1985-04-16
WO1983003679A1 (en) 1983-10-27
JPH0753119B2 (ja) 1995-06-07
ES537257A0 (es) 1986-04-01
FI834529A7 (fi) 1983-12-09
GB2168998B (en) 1987-03-04
AT394577B (de) 1992-05-11
FI834529A0 (fi) 1983-12-09
GB2169921A (en) 1986-07-23
GB2169921B (en) 1987-03-04
GB2128631B (en) 1987-02-25
ATA901883A (de) 1991-10-15
CA1213229A (en) 1986-10-28
ES533930A0 (es) 1985-12-01
GB8530309D0 (en) 1986-01-22
ES8607386A1 (es) 1986-05-16
GB2167086B (en) 1987-03-04
JPS6312276A (ja) 1988-01-19
ES521370A0 (es) 1985-04-16
ES8604424A1 (es) 1986-02-01
GB2128631A (en) 1984-05-02
EP0105360A1 (en) 1984-04-18
EP0105360A4 (en) 1986-07-08
ES8606655A1 (es) 1986-04-01
AU1555983A (en) 1983-11-04
CH672796A5 (fi) 1989-12-29
AU550486B2 (en) 1986-03-20
FI900212A7 (fi) 1990-01-15
ES533931A0 (es) 1985-06-16
ES8506091A1 (es) 1985-06-16
IT8320548A0 (it) 1983-04-12
JPH0753600A (ja) 1995-02-28
GB8530310D0 (en) 1986-01-22
GB2167086A (en) 1986-05-21
ES545247A0 (es) 1986-05-16

Similar Documents

Publication Publication Date Title
FI834529L (fi) Antikroppar med dubbel specificitet.
FI851075A0 (fi) Kompinerad enkel/dubbel ortodontisk kantstaellning.
FI834326L (fi) Engaongsbloeja med elastiskt hopdragbart midjeband.
FI834747A7 (fi) Kationfoereningar innehaollande tvaettmedelskompositioner med lersmuts avlaegsnings-/aoterutfaellning foerhindrande egenskaper.
FI841522A7 (fi) Processtyrsystem med felsoekning.
FI834361L (fi) Teledatasystem med publikterminaler.
FI834199A7 (fi) Med sjaelvdraeneringsanordning foersedd dispenserings- och maetningsfoerpackning foer en vaetskeprodukt.
FI842562A7 (fi) Fiberoptisk laegesgivare med inbyggd referens.
FI73523B (fi) Tryck- eller tryckdifferensmaetare med en mot oeverbelastning skyddad tryckavkaenningsanordning.
FI73534B (fi) Bandkassett.
FI73505B (fi) Faestelement.
EP0108151A4 (en) VOICE ENCODER.
FI834693L (fi) Tryckanordning med elektrostatisk tryckhjaelp.
FI77050B (fi) Gelatinkomposition foer sprutgjutning.
FI834240A0 (fi) Faergtelevisionsmottagare med digitalt behandlingssystem, vilket bildar digitala informationssignaler foer bildroeret
FI834311L (fi) Med samlingsroer foersedd sz- tvinnmaskin.
FI841976A0 (fi) Plasmider med villkorligt okontrollerat replikeringsuppfoerande.
DE3381054D1 (de) Immunoessay.
FI834474L (fi) Cyklonavskiljare med filterenhet.
FI833831L (fi) Spridaranordning i lagerbehaollare foer jaemn fyllning av behaollaren med kornformig lagervara.
FI823573A0 (fi) Spritsroer med dysor, saerskilt flatstraoldysor
FI834327A7 (fi) Draeneringsanordning med avboejd gasstroemningsvaeg.
FI73520B (fi) Maolanordning.
FI834886L (fi) Hydrocyklon med vattentroeskel i oeverstroemningskanalen.
FI842788L (fi) Taktisk kompass foer segeljolle.

Legal Events

Date Code Title Description
FD Application lapsed

Owner name: HYBRITECH INCORPORATED