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ES8307743A1 - "un procedimiento para la preparacion de derivados de pirrolidina". - Google Patents

"un procedimiento para la preparacion de derivados de pirrolidina".

Info

Publication number
ES8307743A1
ES8307743A1 ES514267A ES514267A ES8307743A1 ES 8307743 A1 ES8307743 A1 ES 8307743A1 ES 514267 A ES514267 A ES 514267A ES 514267 A ES514267 A ES 514267A ES 8307743 A1 ES8307743 A1 ES 8307743A1
Authority
ES
Spain
Prior art keywords
hydrogen
formula
lower alkyl
pharmaceutical preparations
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES514267A
Other languages
English (en)
Other versions
ES514267A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH4849/81A external-priority patent/CH647234A5/de
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES8307743A1 publication Critical patent/ES8307743A1/es
Publication of ES514267A0 publication Critical patent/ES514267A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Electronic Switches (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicinal Preparation (AREA)

Abstract

UN PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE PIRROLIDINA. SE HACE REACCIONAR UN COMPUESTO DE FORMULA N<2NR>3 CON UN ACIDO CARBOXILICO (II) EN QUE R>1>1 ES HIDROGENO O ALCANOILO INFERIOR; O BIEN CON UN DERIVADO FUNCIONAL DEL MISMO. SE OBTIENE EL COMPUESTO (I) QUE SI SE DESEA, SE SEPARA EN LOS RACEMATOS CORRESPONDIENTES. R>1 ES HIDROGENO O ALCONOILO INFERIOR; R>2 ES HIDROGENO O ALQUILO INFERIOR; R>3 ES HIFROGENO, ALQUILO INFERIOR O UN GRUPO -(CH<2)<N-NR>4R>5; N ES UN ENTERO CUYO VALOR VA DE 2 A 4; R>4 Y R>5 SON HIDROGENO O ALQUILO INFERIOR.
ES514267A 1981-07-24 1982-07-23 "un procedimiento para la preparacion de derivados de pirrolidina". Granted ES514267A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH4849/81A CH647234A5 (en) 1981-07-24 1981-07-24 Pyrrolidine derivatives
CH276882 1982-05-05

Publications (2)

Publication Number Publication Date
ES8307743A1 true ES8307743A1 (es) 1983-08-16
ES514267A0 ES514267A0 (es) 1983-08-16

Family

ID=25691358

Family Applications (1)

Application Number Title Priority Date Filing Date
ES514267A Granted ES514267A0 (es) 1981-07-24 1982-07-23 "un procedimiento para la preparacion de derivados de pirrolidina".

Country Status (34)

Country Link
US (3) US4476308A (es)
EP (1) EP0071216B1 (es)
AT (2) ATE24488T1 (es)
AU (1) AU557651B2 (es)
BG (1) BG38334A3 (es)
CA (1) CA1176251A (es)
CS (1) CS226746B2 (es)
DD (1) DD202540A5 (es)
DE (2) DE3274851D1 (es)
DK (1) DK157848C (es)
EG (1) EG15921A (es)
ES (1) ES514267A0 (es)
FI (1) FI75158C (es)
FR (1) FR2515179A1 (es)
GB (2) GB2110207B (es)
HK (1) HK53788A (es)
HU (1) HU187777B (es)
IE (1) IE53428B1 (es)
IL (1) IL66341A (es)
IT (1) IT1152287B (es)
LU (1) LU84294A1 (es)
MC (1) MC1476A1 (es)
MT (1) MTP915B (es)
NL (1) NL8202922A (es)
NO (1) NO159592C (es)
NZ (1) NZ201297A (es)
OA (1) OA07151A (es)
PH (1) PH19149A (es)
PT (1) PT75314B (es)
RO (1) RO84097B (es)
SE (1) SE8204445L (es)
SG (1) SG22788G (es)
SU (1) SU1281172A3 (es)
ZW (1) ZW14482A1 (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2515179A1 (fr) * 1981-07-24 1983-04-29 Hoffmann La Roche Derives de pyrrolidine, leur procede de preparation, les intermediaires pour leur synthese et leur application therapeutique
IT1206699B (it) * 1984-02-27 1989-04-27 Isf Spa Procedimento per preparare derivati di pirrolidone.
IT1173763B (it) * 1984-03-30 1987-06-24 Proter Spa Derivati dell'acido 3-mercapto-2-oxo-1-pirrolidinacetico,procedimento di preparazione e composizioni farmaceutiche che li contengono
IT1190378B (it) * 1985-06-21 1988-02-16 Isf Spa Derivati pirrolidonici
US4758585A (en) * 1985-08-16 1988-07-19 Warner-Lambert Company Saturated cycloalkyl (B) pyrrol-1 (2H)- acetic acid amides and derivatives thereof
IT1224168B (it) * 1986-08-01 1990-09-26 Finanziaria R F Spa Ora Finanz Derivati del pirrolidin-2-one ad attivita' nootropa
CA1322199C (en) * 1987-07-15 1993-09-14 Masami Eigyo N-¬(2-oxopyrrolidin-1-yl) acetyl)| piperazine derivatives and drug for senile dementia
JPS6422883A (en) * 1987-07-17 1989-01-25 Sanwa Kagaku Kenkyusho Co 1-pyrrolidine acetamide derivative, its salt, production thereof and prophylactic and remedial agent for cereral dysfunction containing said derivative and salt as active ingredient
DE3813416A1 (de) * 1988-04-21 1989-11-02 Hoechst Ag 3,4-dihydroxypyrrolidin-2-on-derivate, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung sowie die bei der herstellung anfallenden neuen zwischenprodukte
US5021568A (en) * 1988-04-22 1991-06-04 Shipov Alexandr G Lactam-1-acetic acid carbalkoxymethyl esters and method for preparing same
IT1245870B (it) * 1991-06-05 1994-10-25 Sigma Tau Ind Farmaceuti 3-acilammino-2-pirrolidinoni quali attivatori dei processi di appremdimento e della memoria e composizioni farmaceutiche comprendenti tali composti
DE4127404A1 (de) * 1991-08-19 1993-02-25 Thomae Gmbh Dr K Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
CA2100641A1 (en) * 1992-07-23 1994-01-24 Hiromu Matsumura Novel piperidine derivatives and process for preparation thereof
ES2195803T1 (es) * 1996-11-22 2003-12-16 Mona Industries Inc Monomeros y oligomeros de silicona que tienen un grupo funcional carboxilo.
US5679798A (en) * 1996-11-22 1997-10-21 Mona Industries, Inc. Silicone monomers having a carboxyl functional group thereon
US6686477B2 (en) 2000-09-29 2004-02-03 Eastman Chemical Company Highly enantiomerically pure lactam-substituted propanoic acid derivatives and methods of making and using same
ES2637497T3 (es) 2008-10-16 2017-10-13 The Johns Hopkins University Procedimientos y composiciones para la mejora de la función cognitiva
CA2789014C (en) * 2010-02-09 2019-01-15 Michela Gallagher Methods and compositions for improving cognitive function
JP6440625B2 (ja) 2012-11-14 2018-12-19 ザ・ジョンズ・ホプキンス・ユニバーシティー 精神分裂病を処置するための方法および組成物
US11160785B2 (en) 2013-03-15 2021-11-02 Agenebio Inc. Methods and compositions for improving cognitive function
EP3827820A1 (en) 2013-03-15 2021-06-02 The Johns Hopkins University Brivaracetam for improving cognitive function
HK1251980B (en) 2015-05-22 2020-07-10 Agenebio, Inc. Extended release pharmaceutical compositions of levetiracetam

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1039113A (en) * 1964-08-06 1966-08-17 Ucb Sa New n-substituted lactams
GB1309692A (en) * 1970-02-13 1973-03-14 Ucb Sa N-substituted lactams
IT1045043B (it) * 1975-08-13 1980-04-21 Isf Spa Derivati pirrolidinici
IT1075564B (it) * 1977-02-11 1985-04-22 Isf Spa Procedimento per la preparazione di derivati pirrolidinici
IT1075280B (it) * 1977-02-11 1985-04-22 Isf Spa Procedimento per la preparazione di derivati pirrolidinici
BE864269A (fr) * 1977-03-03 1978-06-16 Parke Davis & Co Nouveaux n-(aminoalkyl substitue)-2-oxo-1-pyrrolidine-acetamides et procedes pour les produire
DE2923975A1 (de) * 1979-06-13 1980-12-18 Nattermann A & Cie Pyrrolidinone, verfahren zu deren herstellung und diese enthaltende arzneimittel
IT1141287B (it) * 1979-06-13 1986-10-01 Nattermann A & Cie Ammidi di acidi pirrolidin-(2)-on-(1)-ilalchil-carbossilici,procedimento per la loro preparazione e prodotti medicinali che le contengono
DE2924011C2 (de) * 1979-06-13 1982-04-08 A. Nattermann & Cie GmbH, 5000 Köln Pyrrolidin-(2)-on-(1)-ylessigsäure-2,6,-dimethylanilid, Verfahren zur Herstellung und Arzneimittel, welche diese Verbindung enthalten
NL8004025A (nl) * 1979-08-09 1981-02-11 Hoffmann La Roche Pyrrolidinederivaten en werkwijze voor het bereiden daarvan alsmede geneesmiddel.
CH657527A5 (de) * 1980-02-13 1986-09-15 Ciba Geigy Ag Verwendung von zentralnervoes-wirksamen verbindungen in einem mittel, welches zur verhinderung oder linderung von nebenwirkungen bestimmt ist.
US4372960A (en) * 1980-12-12 1983-02-08 Warner-Lambert Company Quaternary derivatives of N-(substituted-aminoalkyl)-2-oxo-1-pyrrolidine-acetamides as cognition activators
CH646149A5 (de) * 1981-02-05 1984-11-15 Hoffmann La Roche Pyrrolidin-derivat.
FR2515179A1 (fr) * 1981-07-24 1983-04-29 Hoffmann La Roche Derives de pyrrolidine, leur procede de preparation, les intermediaires pour leur synthese et leur application therapeutique
BE892942A (fr) * 1982-04-23 1982-10-25 Ucb Sa Procede pour prevenir ou attenuer les psychoses iatrogenes causees par les medicaments a activite cytostatique.

Also Published As

Publication number Publication date
DE3227649A1 (de) 1983-02-10
BG38334A3 (en) 1985-11-15
IE53428B1 (en) 1988-11-09
GB2152038B (en) 1986-01-02
SU1281172A3 (ru) 1986-12-30
NO822222L (no) 1983-01-25
IT8222335A1 (it) 1984-01-09
CS226746B2 (en) 1984-04-16
DE3274851D1 (en) 1987-02-05
RO84097B (ro) 1984-06-30
GB8426076D0 (en) 1984-11-21
EG15921A (en) 1986-09-30
AU8615882A (en) 1983-01-27
NO159592C (no) 1989-01-18
DK157848C (da) 1990-07-23
SE8204445L (sv) 1983-01-25
GB2110207B (en) 1985-09-04
MC1476A1 (fr) 1983-06-17
RO84097A (ro) 1984-05-12
CA1176251A (en) 1984-10-16
FR2515179B1 (es) 1985-01-18
AT384424B (de) 1987-11-10
PH19149A (en) 1986-01-15
SE8204445D0 (sv) 1982-07-23
NO159592B (no) 1988-10-10
SG22788G (en) 1988-07-15
IT8222335A0 (it) 1982-07-09
IT1152287B (it) 1986-12-31
FI75158C (fi) 1988-05-09
HK53788A (en) 1988-07-22
FI822543L (fi) 1983-01-25
ZW14482A1 (en) 1983-02-09
GB2110207A (en) 1983-06-15
DD202540A5 (de) 1983-09-21
DK157848B (da) 1990-02-26
GB2152038A (en) 1985-07-31
FR2515179A1 (fr) 1983-04-29
ATA286382A (de) 1987-04-15
US5034402A (en) 1991-07-23
PT75314A (en) 1982-08-01
EP0071216B1 (de) 1986-12-30
ES514267A0 (es) 1983-08-16
NL8202922A (nl) 1983-02-16
ATE24488T1 (de) 1987-01-15
OA07151A (fr) 1984-03-31
IE821768L (en) 1983-01-24
FI822543A0 (fi) 1982-07-19
US4476308B1 (es) 1987-03-10
PT75314B (en) 1985-11-29
EP0071216A3 (en) 1983-09-07
IL66341A (en) 1986-12-31
EP0071216A2 (de) 1983-02-09
MTP915B (en) 1985-12-28
HU187777B (en) 1986-02-28
IL66341A0 (en) 1982-11-30
US4650878A (en) 1987-03-17
AU557651B2 (en) 1987-01-08
DK317382A (da) 1983-01-25
LU84294A1 (de) 1984-03-22
US4476308A (en) 1984-10-09
NZ201297A (en) 1985-12-13
FI75158B (fi) 1988-01-29

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20000201