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GB1309692A - N-substituted lactams - Google Patents

N-substituted lactams

Info

Publication number
GB1309692A
GB1309692A GB697870A GB697870A GB1309692A GB 1309692 A GB1309692 A GB 1309692A GB 697870 A GB697870 A GB 697870A GB 697870 A GB697870 A GB 697870A GB 1309692 A GB1309692 A GB 1309692A
Authority
GB
United Kingdom
Prior art keywords
formula
alkyl
alkenyl
hydrogen atom
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB697870A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UCB SA
Original Assignee
UCB SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UCB SA filed Critical UCB SA
Priority to GB697870A priority Critical patent/GB1309692A/en
Priority to FR7104195A priority patent/FR2081508B2/fr
Priority to NLAANVRAGE7101697,A priority patent/NL168830C/en
Priority to CS987A priority patent/CS167911B2/cs
Priority to ES388135A priority patent/ES388135A2/en
Priority to BE762728A priority patent/BE762728R/en
Priority to FI383/71A priority patent/FI54916C/en
Priority to DK59571AA priority patent/DK137451B/en
Priority to YU306/71A priority patent/YU34876B/en
Priority to DE2106418A priority patent/DE2106418C2/en
Priority to ZA710877A priority patent/ZA71877B/en
Priority to CH200171A priority patent/CH530395A/en
Priority to SU1621307A priority patent/SU508185A3/en
Priority to JP612471A priority patent/JPS535301B1/ja
Priority to SU1893858A priority patent/SU508186A3/en
Priority to CS140674A priority patent/CS167912B2/cs
Publication of GB1309692A publication Critical patent/GB1309692A/en
Priority to CY72774A priority patent/CY727A/en
Priority to MY197472A priority patent/MY7400072A/en
Priority to JP13335277A priority patent/JPS53130656A/en
Priority to YU01445/78A priority patent/YU144578A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

1309692 N-Amidoaldyllactams UCB SA 19 April 1971 [13 Feb 1970] 6978/70 Addition to 1039113 Heading C2C Novel compounds of Formula I wherein X is a hydrogen atom or an alkyl, alkenyl or alkynyl radical containing 1 to 6 carbon atoms, p is a whole number of from 1 to 6, Y is a hydrogen atom or an alkyl, alkenyl or alkynyl radical containing 1 to 6 carbon atoms or a cycloalkyl radical and R<SP>1</SP> and R<SP>11</SP>, which may be the same or different, are hydrogen atoms or alkyl, alkenyl, alkynyl, cycloalkyl or aryl radicals or R<SP>1</SP> and R<SP>11</SP>, together with the nitrogen atom to which they are attached, form a heterocyclic radical which may contain further heteroatoms, with the proviso that at least one of the symbols X and Y is other than a hydrogen atom are prepared by one of the following methods: (a) a compound of formula wherein M is an alkali metal atom is reacted with a compound of formula (b) an ester of Formula IV where Alk is alkyl or (c) an acid chloride of Formula VI is reacted with the amine H.N.R<SP>1</SP>R<SP>11</SP>, and (d) an ammonium salt of formula is heated. Esters of Formula IV above are prepared by reacting the sodium derivative of the appropriate pyrrolidin-2-one with the appropriate alkyl haloalkylcarboxylate and optionally hydrolysed to the corresponding acids which may be converted into their ammonium salts and acid chlorides by reaction with ammonia or thionyl chloride respectively. Pharmaceutical compositions in conventional forms for oral, parenteral or rectal administration to be used in treatment of motion sickness, hyperkinesia, hypertonia, epilepsy and mnesic conditions comprise an above novel compound and an excipient.
GB697870A 1964-08-06 1970-02-13 N-substituted lactams Expired GB1309692A (en)

Priority Applications (20)

Application Number Priority Date Filing Date Title
GB697870A GB1309692A (en) 1970-02-13 1970-02-13 N-substituted lactams
FR7104195A FR2081508B2 (en) 1970-02-13 1971-02-08
NLAANVRAGE7101697,A NL168830C (en) 1970-02-13 1971-02-09 PROCESS FOR PREPARING THERAPEUTIC PREPARATIONS AND PROCESS FOR PREPARING AMIDS SUITABLE FOR THESE
CS987A CS167911B2 (en) 1970-02-13 1971-02-10
ES388135A ES388135A2 (en) 1970-02-13 1971-02-10 PROCEDURE FOR OBTAINING NITROGEN SUBSTITUTED LACTAMS.
BE762728A BE762728R (en) 1970-02-13 1971-02-10 NEW LACTAMES N-SUBSTITUTES
FI383/71A FI54916C (en) 1970-02-13 1971-02-10 FRAMEWORK FOR THERAPEUTIC TREATMENT OF NUTRITIONAL N-SUBSTITUTE 2-PYRROLIDONER
DK59571AA DK137451B (en) 1970-02-13 1971-02-10 Analogous process for the preparation of derivatives of 2-oxo-pyrrolidine.
YU306/71A YU34876B (en) 1970-02-13 1971-02-10 Process for obtaining novel n-substituted pyrrolidines
DE2106418A DE2106418C2 (en) 1970-02-13 1971-02-11 N-substituted 2-pyrrolidone derivatives, processes for their preparation and pharmaceuticals containing them
ZA710877A ZA71877B (en) 1970-02-13 1971-02-11 New n-substituted lactams
CH200171A CH530395A (en) 1970-02-13 1971-02-11 Process for the preparation of new N-substituted lactams
SU1621307A SU508185A3 (en) 1970-02-13 1971-02-12 The method of obtaining-substituted lactams
JP612471A JPS535301B1 (en) 1970-02-13 1971-02-12
SU1893858A SU508186A3 (en) 1970-02-13 1971-02-12 The method of obtaining-substituted lactams
CS140674A CS167912B2 (en) 1970-02-13 1971-12-10
CY72774A CY727A (en) 1964-08-06 1974-03-01 New n-substituted lactams
MY197472A MY7400072A (en) 1970-02-13 1974-12-31 New n-substituted lactams
JP13335277A JPS53130656A (en) 1970-02-13 1977-11-07 Method of producing novel nnsubstituted lactams
YU01445/78A YU144578A (en) 1970-02-13 1978-06-19 Process for obtaining new n-substituted pyrrolidones

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB697870A GB1309692A (en) 1970-02-13 1970-02-13 N-substituted lactams

Publications (1)

Publication Number Publication Date
GB1309692A true GB1309692A (en) 1973-03-14

Family

ID=9824325

Family Applications (1)

Application Number Title Priority Date Filing Date
GB697870A Expired GB1309692A (en) 1964-08-06 1970-02-13 N-substituted lactams

Country Status (15)

Country Link
JP (2) JPS535301B1 (en)
BE (1) BE762728R (en)
CH (1) CH530395A (en)
CS (2) CS167911B2 (en)
DE (1) DE2106418C2 (en)
DK (1) DK137451B (en)
ES (1) ES388135A2 (en)
FI (1) FI54916C (en)
FR (1) FR2081508B2 (en)
GB (1) GB1309692A (en)
MY (1) MY7400072A (en)
NL (1) NL168830C (en)
SU (2) SU508185A3 (en)
YU (2) YU34876B (en)
ZA (1) ZA71877B (en)

Cited By (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2368275A1 (en) * 1976-10-19 1978-05-19 Ucb Sa 2- (2-OXO-PYRROLIDINO) -ALKYLAMIDES FOR THE TREATMENT OF VASCULAR DISORDERS
DE2808067A1 (en) * 1977-03-03 1978-09-07 Parke Davis & Co N- (SUBSTITUTED AMINOALKYL) -2-OXO-1- PYRROLIDINE ACETAMIDE AND METHOD FOR THE PREPARATION
US4221789A (en) 1978-05-08 1980-09-09 Ucb, Societe Anonyme Lactam-N-acetic acids and their amides
EP0089900A1 (en) * 1982-03-24 1983-09-28 Prodes S.A. New N-((2-oxo-1-pyrrolidinyl)acetyl)piperazines, the methods of producing such new compounds and their salts as well as pharmaceutical preparations for therapeutic use containing these compounds or salts
JPS60252461A (en) * 1984-05-15 1985-12-13 ユセベ　ソシエテ　アノニム Antihypoxic and ischemic pharmacological composition
JPS60255764A (en) * 1984-05-15 1985-12-17 ユセベ　ソシエテ　アノニム (r)-alpha-ethyl-2-oxo-1-pyridineacetamide, manufacture and pharmaceutical composition
EP0071216B1 (en) * 1981-07-24 1986-12-30 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft 3-hydroxypyrrolidin-2-one derivatives, process and intermediates for their preparation and pharmaceutical preparations containing them
US4670456A (en) * 1984-05-30 1987-06-02 Boehringer Ingelheim Kg 4-Aminocarbonylaminomethyl-1-benzylpyrrolidin-2-ones as nootropic agents and as agents for treating cerebral insufficiency
US4929272A (en) * 1986-09-12 1990-05-29 Ciba-Geigy Corporation N-phenyl-maleimides and N-phenyl-succinimides and their use in a herbicidal and/or plant growth regulating action
GB2225322A (en) * 1988-11-23 1990-05-30 Ucb Sa The preparation of S-alpha-ethyl-2-oxo-1-pyrrolidineacetamide
WO2001062726A3 (en) * 2000-02-23 2002-01-17 Ucb Sa 2-oxo-1-pyrrolidine derivatives, processes for preparing them and their uses
WO2002026705A3 (en) * 2000-09-29 2002-07-11 Eastman Chem Co Highly enantiomerically pure lactam-substituted propanoic acid derivatives and their preparation
WO2002094787A1 (en) * 2001-05-23 2002-11-28 Ucb, S.A. 2-oxo-piperidinyl- and 2-oxo-azepanyl alkanoic acid derivativ es for the treatment of epilepsy and other neurological disorders
WO2003014080A3 (en) * 2001-08-10 2003-11-06 Ucb Sa Oxopyrrolidine compounds, preparation of said compounds and their use in the manufacturing of levetiracetam and analogues
WO2003030899A3 (en) * 2001-10-08 2004-01-08 Ucb Sa Use of 2-oxo-1-pyrrolidine derivatives for the treatment of dyskinesia and movement disorders
ES2214147A1 (en) * 2003-02-28 2004-09-01 Farma-Lepori S.A. PROCEDURE FOR OBTAINING AN ANTIEPILEPTIC AGENT.
EP1566376A1 (en) 2004-02-18 2005-08-24 Dr. Reddy's Laboratories Limited Preparation of amino acid amides
WO2006053441A1 (en) 2004-11-22 2006-05-26 Apotex Pharmachem Inc. Improved process for the preparation of (s)-alpha-etyl-2-oxo-1-pyrrolidineacetamide and (r)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide
WO2006095362A1 (en) * 2005-03-10 2006-09-14 Rubamin Limited Process for preparing levetiracetam
US7132552B2 (en) 2003-02-03 2006-11-07 Teva Pharmaceutical Industries, Ltd. Process for producing levetiracetam
EP2147911A1 (en) 2008-07-24 2010-01-27 ZaCh System S.p.A. Process for the preparation of levetiracetam
EP2308867A2 (en) 2005-06-01 2011-04-13 UCB Pharma S.A. 2-oxo-1-pyrrolidine deriatives, processes for preparing them and their uses
US7939676B2 (en) 2009-09-17 2011-05-10 Zach System S.P.A. Process for the preparation of levetiracetam
WO2011100373A1 (en) 2010-02-09 2011-08-18 The Johns Hopkins University Methods and compositions for improving cognitive function
US8604075B2 (en) 2008-10-16 2013-12-10 The Johns Hopkins University Methods and compositions for improving cognitive function
US8785661B2 (en) 2009-05-13 2014-07-22 Nektar Therapeutics Oligome-containing pyrrolidine compounds
WO2014144801A1 (en) 2013-03-15 2014-09-18 Agenebio Inc. Methods and compositions for improving cognitive function
CN104059010A (en) * 2014-06-12 2014-09-24 浙江华海药业股份有限公司 Preparation method of 2-(2-oxopyrrolidine-1-yl)-butyrate
WO2015110435A1 (en) 2014-01-21 2015-07-30 Janssen Pharmaceutica Nv Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use
US10154988B2 (en) 2012-11-14 2018-12-18 The Johns Hopkins University Methods and compositions for treating schizophrenia
EP3827820A1 (en) 2013-03-15 2021-06-02 The Johns Hopkins University Brivaracetam for improving cognitive function
CN113979911A (en) * 2021-11-12 2022-01-28 汤斌 Method for extracting etiracetam from giant salamander peptide
US11369606B2 (en) 2014-01-21 2022-06-28 Janssen Pharmaceutica Nv Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use
US11384050B1 (en) 2021-02-03 2022-07-12 Vitaworks Ip, Llc Method for preparing levetiracetam and intermediates thereof
WO2024039886A1 (en) 2022-08-19 2024-02-22 Agenebio, Inc. Benzazepine derivatives, compositions, and methods for treating cognitive impairment
US12528770B2 (en) 2023-06-12 2026-01-20 Suzhou Brighthope Pharmatech Co., Ltd. Process for the production of levetiracetam and intermediates thereof

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1045043B (en) * 1975-08-13 1980-04-21 Isf Spa PYROLIDINE DERIVATIVES
IT1141287B (en) * 1979-06-13 1986-10-01 Nattermann A & Cie PYROLIDIN ACIDS AMIDS- (2) -ON- (1) -ILALKYL-CARBOXYLS, PROCEDURE FOR THEIR PREPARATION AND MEDICINAL PRODUCTS CONTAINING THEM
TW544311B (en) * 1998-08-06 2003-08-01 Daiichi Seiyaku Co Therapeutic or preventive agent for intractable epilepsies
CN106591179B (en) * 2016-12-05 2018-07-03 长兴制药股份有限公司 Methyl packing bacterium and its prepare the application on (S)-α-ethyl -2- oxygen -1- pyrrolidine acetic acid salt in selective fractionation
RU2663899C1 (en) * 2017-07-19 2018-08-13 Федеральное государственное унитарное предприятие "Государственный научный центр "Научно-исследовательский институт органических полупродуктов и красителей" Process for the preparation of 1-carbamoylmethyl-4-phenyl-2-pyrrolidone

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1039113A (en) * 1964-08-06 1966-08-17 Ucb Sa New n-substituted lactams

Cited By (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4115579A (en) 1976-10-19 1978-09-19 U C B, Societe Anonyme Process for inhibiting blood platelet aggregation
FR2368275A1 (en) * 1976-10-19 1978-05-19 Ucb Sa 2- (2-OXO-PYRROLIDINO) -ALKYLAMIDES FOR THE TREATMENT OF VASCULAR DISORDERS
DE2808067A1 (en) * 1977-03-03 1978-09-07 Parke Davis & Co N- (SUBSTITUTED AMINOALKYL) -2-OXO-1- PYRROLIDINE ACETAMIDE AND METHOD FOR THE PREPARATION
US4221789A (en) 1978-05-08 1980-09-09 Ucb, Societe Anonyme Lactam-N-acetic acids and their amides
EP0071216B1 (en) * 1981-07-24 1986-12-30 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft 3-hydroxypyrrolidin-2-one derivatives, process and intermediates for their preparation and pharmaceutical preparations containing them
US5034402A (en) * 1981-07-24 1991-07-23 Hoffmann-La Roche Inc. Methods and pharmaceutical compositions using pyrrolidine derivatives
EP0089900A1 (en) * 1982-03-24 1983-09-28 Prodes S.A. New N-((2-oxo-1-pyrrolidinyl)acetyl)piperazines, the methods of producing such new compounds and their salts as well as pharmaceutical preparations for therapeutic use containing these compounds or salts
AU574465B2 (en) * 1984-05-15 1988-07-07 Ucb (s)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide
US4696942A (en) * 1984-05-15 1987-09-29 Ucb Societe Anonyme Treatment of memory impairment using (R)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide
US4696943A (en) * 1984-05-15 1987-09-29 U C B Societe Anonyme (S)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide
AU574175B2 (en) * 1984-05-15 1988-06-30 Ucb (r)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide
JPS60255764A (en) * 1984-05-15 1985-12-17 ユセベ　ソシエテ　アノニム (r)-alpha-ethyl-2-oxo-1-pyridineacetamide, manufacture and pharmaceutical composition
JPS60252461A (en) * 1984-05-15 1985-12-13 ユセベ　ソシエテ　アノニム Antihypoxic and ischemic pharmacological composition
JPH0629186B2 (en) 1984-05-15 1994-04-20 ユセベ ソシエテ アノニム Anti-hypoxia and ischemia pharmacological composition
US4670456A (en) * 1984-05-30 1987-06-02 Boehringer Ingelheim Kg 4-Aminocarbonylaminomethyl-1-benzylpyrrolidin-2-ones as nootropic agents and as agents for treating cerebral insufficiency
US4929272A (en) * 1986-09-12 1990-05-29 Ciba-Geigy Corporation N-phenyl-maleimides and N-phenyl-succinimides and their use in a herbicidal and/or plant growth regulating action
GB2225322A (en) * 1988-11-23 1990-05-30 Ucb Sa The preparation of S-alpha-ethyl-2-oxo-1-pyrrolidineacetamide
GB2225322B (en) * 1988-11-23 1992-03-25 Ucb Sa A process for the preparation of (s)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide
CZ304420B6 (en) * 2000-02-23 2014-04-30 Ucb Pharma S.A. 2-Oxo-1-pyrrolidine derivatives, process of their preparation and their use
US6806287B2 (en) 2000-02-23 2004-10-19 Ucb, S.A. 2-oxo-1-pyrrolidine derivatives, process for preparing them and their uses
CN1303066C (en) * 2000-02-23 2007-03-07 Ucb公司 2-oxo-1-pyrrolidine derivatives, their preparation methods and uses
US8492416B2 (en) 2000-02-23 2013-07-23 Ucb Pharma, S.A. 2-oxo-1-pyrrolidine derivatives, processes for preparing them and their uses
US8034958B2 (en) 2000-02-23 2011-10-11 UOB Pharma, S.A. 2-oxo-1-pyrrolidine derivatives, processes for preparing them and their uses
WO2001062726A3 (en) * 2000-02-23 2002-01-17 Ucb Sa 2-oxo-1-pyrrolidine derivatives, processes for preparing them and their uses
EP1447399A1 (en) * 2000-02-23 2004-08-18 Ucb, S.A. "2-oxo-1-pyrrolidine derivative and its pharmaceutical uses"
US6784197B2 (en) * 2000-02-23 2004-08-31 Ucb S.A. 2-oxo-1-pyrrolidine derivatives, processes for preparing them and their uses
EP1452524A1 (en) 2000-02-23 2004-09-01 Ucb, S.A. "2-oxo-1-pyrrolidine derivative and its pharmaceutical uses"
BG65923B1 (en) * 2000-02-23 2010-05-31 Ucb S.A. 2-oxo-1-pyrrolidine derivatives, processes for preparing them and their uses
US7692028B2 (en) 2000-02-23 2010-04-06 Ucb Pharma, S.A. 2-oxo-1-pyrrolidine derivatives, processes for preparing them and their uses
CZ304702B6 (en) * 2000-02-23 2014-09-03 Ucb Pharma S.A. (4R) and (4S) Diastereoisomers of (2S)-2-[2-oxo-4-propylpyrrolidinyl] butanamide, pharmaceutical composition containing thereof and their use
AU2001252144B2 (en) * 2000-02-23 2005-04-28 Ucb Biopharma Sprl 2-oxo-1-pyrrolidine derivatives, processes for preparing them and their uses
MY139420A (en) * 2000-02-23 2009-09-30 Ucb Sa 2-oxo-1-pyrrolidine derivatives, processes for preparing them and their uses
US6911461B2 (en) 2000-02-23 2005-06-28 Ucb, S.A. 2-oxo-1-pyrrolidine derivatives, processes for preparing them and their uses
US7358276B2 (en) 2000-02-23 2008-04-15 Ucb, S.A. 2-Oxo-1-pyrrolidine derivatives, processes for preparing them and their uses
EP1577296A1 (en) * 2000-02-23 2005-09-21 Ucb S.A. 2-oxo-1-pyrrolidine derivatives, processes for preparing them and their use
AU2001252144C1 (en) * 2000-02-23 2008-03-20 Ucb Biopharma Sprl 2-oxo-1-pyrrolidine derivatives, processes for preparing them and their uses
EP1604979A1 (en) * 2000-02-23 2005-12-14 UCB Farchim S.A. 2-oxo-1-pyrrolidine derivative and its pharmaceutical uses
KR100720784B1 (en) 2000-02-23 2007-05-23 유씨비 소시에떼아노님 2-oxo-1-pyrrolidine derivatives, processes for preparing them and their uses
AU2005200717B2 (en) * 2000-02-23 2007-05-17 Ucb Farchim S.A. (Ag-Ltd) 2-oxo-1-pyrrolidine derivatives, process for preparing them and their uses
US7217826B2 (en) 2000-02-23 2007-05-15 Ucb Farchim S.A. 2-oxo-1-pyrrolidine derivatives, process for preparing them and their uses
US6686477B2 (en) 2000-09-29 2004-02-03 Eastman Chemical Company Highly enantiomerically pure lactam-substituted propanoic acid derivatives and methods of making and using same
US6977303B2 (en) 2000-09-29 2005-12-20 Eastman Chemical Company Highly enantiomerically pure lactam-substituted propanoic acid derivatives and methods of making and using same
US6897323B2 (en) 2000-09-29 2005-05-24 Eastman Chemical Company Highly enantiomerically pure lactam-substituted propanoic acid derivatives and methods of making and using same
US7214803B2 (en) 2000-09-29 2007-05-08 Eastman Chemical Company Highly enantiomerically pure lactam-substituted propanoic acid derivatives and methods of making and using same
WO2002026705A3 (en) * 2000-09-29 2002-07-11 Eastman Chem Co Highly enantiomerically pure lactam-substituted propanoic acid derivatives and their preparation
US7473697B2 (en) 2001-05-23 2009-01-06 Ucb S.A. 2-Oxo-piperidinyl- and 2-oxo-azepanyl alkanoic acid derivatives for the treatment of epilepsy and other neurological disorders
WO2002094787A1 (en) * 2001-05-23 2002-11-28 Ucb, S.A. 2-oxo-piperidinyl- and 2-oxo-azepanyl alkanoic acid derivativ es for the treatment of epilepsy and other neurological disorders
US7087596B2 (en) 2001-05-23 2006-08-08 Ucb, S.A. 2-oxo-piperidinyl- and 2-oxo-azepanyl alkanoic acid derivatives for the treatment of epilepsy and other neurological disorders
WO2003014080A3 (en) * 2001-08-10 2003-11-06 Ucb Sa Oxopyrrolidine compounds, preparation of said compounds and their use in the manufacturing of levetiracetam and analogues
AU2002329233B2 (en) * 2001-08-10 2007-08-16 Ucb Pharma Oxopyrrolidine compounds, preparation of said compounds and their use in the manufacturing of levetiracetam and analogues
US7122682B2 (en) 2001-08-10 2006-10-17 Ucb, S.A. Oxopyrrolidine compounds, preparation of said compounds and their use in the manufacturing of levetiracetam and analogues
US7563912B2 (en) 2001-08-10 2009-07-21 Ucb Pharma, S.A. Oxopyrrolidine compounds, preparation of said compounds and their use in the manufacturing of Levetiracetam and analogues
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YU30671A (en) 1979-10-31
FR2081508A2 (en) 1971-12-03
ES388135A2 (en) 1973-05-01
BE762728R (en) 1971-08-10
FI54916C (en) 1979-04-10
SU508185A3 (en) 1976-03-25
NL7101697A (en) 1971-08-17
FI54916B (en) 1978-12-29
DE2106418C2 (en) 1983-12-22
DK137451B (en) 1978-03-06
YU34876B (en) 1980-04-30
FR2081508B2 (en) 1975-06-06
NL168830C (en) 1982-05-17
JPS53130656A (en) 1978-11-14
CH530395A (en) 1972-11-15
DK137451C (en) 1978-07-24
YU144578A (en) 1982-10-31
CS167911B2 (en) 1976-05-28
CS167912B2 (en) 1976-05-28
JPS535301B1 (en) 1978-02-25
SU508186A3 (en) 1976-03-25
NL168830B (en) 1981-12-16
MY7400072A (en) 1974-12-31
ZA71877B (en) 1971-10-27
DE2106418A1 (en) 1971-08-19
JPS5420491B2 (en) 1979-07-23

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