ES8205770A1 - Procedimiento para la preparacion de derivados de 2,3-indo- lediona - Google Patents
Procedimiento para la preparacion de derivados de 2,3-indo- ledionaInfo
- Publication number
- ES8205770A1 ES8205770A1 ES497530A ES497530A ES8205770A1 ES 8205770 A1 ES8205770 A1 ES 8205770A1 ES 497530 A ES497530 A ES 497530A ES 497530 A ES497530 A ES 497530A ES 8205770 A1 ES8205770 A1 ES 8205770A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- derivatives
- lediona
- indo
- procedure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE 2,3 INDOLEDIONA Y DE SUS SALES FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE R ES ISOPROPILO O T-BUTILO, R1 ES HIDROGENO O ALQUILO INFERIOR Y R2 ES ALQUILO O ARALQUILO INFERIOORES. CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (II) CON UNA AMINA DE FORMULA R-NH2, EN LAS QUE R3 ES HIDROXILO Y R4 ES CLORO O BROMO, O JUNTOS REPRESENTAN UN ATOMO DE OXIGENO, Y R, R1 Y R2 TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO EN UN DISOLVENTE ORGANICO INERTE TAL COMO METANOL O ETANOL O UN EXCESO DE LA AMINA Y UNA TEMPERATURA ENTRE O C Y LA AMBIENTE. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE LA ANGINA DE PECHO Y ARRITMIAS CARDIACAS Y COMO AGENTES ANTIHIPERTENSIVOS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7942324 | 1979-12-07 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8205770A1 true ES8205770A1 (es) | 1982-07-01 |
| ES497530A0 ES497530A0 (es) | 1982-07-01 |
Family
ID=10509706
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES497530A Granted ES497530A0 (es) | 1979-12-07 | 1980-12-06 | Procedimiento para la preparacion de derivados de 2,3-indo- lediona |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US4395559A (es) |
| EP (1) | EP0030380A1 (es) |
| JP (1) | JPS5695167A (es) |
| AR (1) | AR226869A1 (es) |
| AU (1) | AU6494680A (es) |
| DK (1) | DK522180A (es) |
| ES (1) | ES497530A0 (es) |
| FI (1) | FI803727L (es) |
| GR (1) | GR72136B (es) |
| HU (1) | HU180620B (es) |
| IL (1) | IL61603A0 (es) |
| MC (1) | MC1357A1 (es) |
| NO (1) | NO803693L (es) |
| NZ (1) | NZ195702A (es) |
| PT (1) | PT72176B (es) |
| ZA (1) | ZA807494B (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4593106A (en) * | 1984-06-04 | 1986-06-03 | Smithkline Beckman Corporation | 4-[2-(dialkylamino)ethyl]-7-hydroxyisatins |
| US4847863A (en) * | 1985-10-03 | 1989-07-11 | Watson Bruce W | Expandable modular data modem |
| AR016384A1 (es) | 1997-07-30 | 2001-07-04 | Smithkline Beecham Corp | Inhibidores de caspasas, composiciones farmaceuticas que comprenden dichos inhibidores de caspasas y uso de los inhibidores de caspasas para prepararun medicamento util para el tratamiento de apoptosis y desordenes asociados con excesiva actividad de la convertosa il-1 beta. |
| EP1079859B1 (en) | 1998-05-22 | 2010-07-14 | The Board Of Trustees Of The Leland Stanford Junior University | Bifunctional molecules and therapies based thereon |
| DE60234057D1 (de) | 2001-07-25 | 2009-11-26 | Raptor Pharmaceutical Inc | Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke |
| EP3827747A1 (en) | 2005-04-28 | 2021-06-02 | Otsuka Pharmaceutical Co., Ltd. | Pharma-informatics system |
| KR20090071598A (ko) | 2006-09-18 | 2009-07-01 | 랩터 파마슈티컬 인코포레이티드 | 수용체 결합 단백질(ｒａｐ)-접합체 투여에 의한 간 질환의 치료 |
| ES2728225T3 (es) | 2009-02-20 | 2019-10-23 | 2 Bbb Medicines B V | Sistema de administración de fármacos a base de glutatión |
| KR20190116576A (ko) | 2009-05-06 | 2019-10-14 | 라보라토리 스킨 케어, 인크. | 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법 |
| US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1778174A (en) * | 1926-05-30 | 1930-10-14 | Gen Aniline Works Inc | Substituted isatins and process of preparing them |
| GB1069343A (en) * | 1963-09-10 | 1967-05-17 | Ici Ltd | Propanolamine derivatives |
| CH472404A (de) * | 1966-03-04 | 1969-05-15 | Sandoz Ag | Verfahren zur Herstellung neuer Indolderivate |
| SE379196B (es) * | 1971-06-24 | 1975-09-29 | Sandoz Ag | |
| US4137331A (en) * | 1974-06-19 | 1979-01-30 | Sandoz Ltd. | 3-Piperidino-2-hydroxypropoxy substituted-2-indolinones |
| US4212804A (en) * | 1978-12-04 | 1980-07-15 | Sandoz, Inc. | Process for the preparation of optionally substituted 2,3-indolinediones |
-
1980
- 1980-11-26 MC MC801482A patent/MC1357A1/fr unknown
- 1980-12-01 IL IL61603A patent/IL61603A0/xx unknown
- 1980-12-01 AU AU64946/80A patent/AU6494680A/en not_active Abandoned
- 1980-12-01 US US06/211,883 patent/US4395559A/en not_active Expired - Lifetime
- 1980-12-01 ZA ZA00807494A patent/ZA807494B/xx unknown
- 1980-12-01 NZ NZ195702A patent/NZ195702A/en unknown
- 1980-12-01 FI FI803727A patent/FI803727L/fi not_active Application Discontinuation
- 1980-12-03 HU HU80802878A patent/HU180620B/hu unknown
- 1980-12-04 AR AR283480A patent/AR226869A1/es active
- 1980-12-05 GR GR63552A patent/GR72136B/el unknown
- 1980-12-05 DK DK522180A patent/DK522180A/da unknown
- 1980-12-05 EP EP80107669A patent/EP0030380A1/de not_active Withdrawn
- 1980-12-05 JP JP17109080A patent/JPS5695167A/ja active Pending
- 1980-12-05 PT PT72176A patent/PT72176B/pt unknown
- 1980-12-05 NO NO803693A patent/NO803693L/no unknown
- 1980-12-06 ES ES497530A patent/ES497530A0/es active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| MC1357A1 (fr) | 1981-08-10 |
| EP0030380A1 (de) | 1981-06-17 |
| ZA807494B (en) | 1981-11-25 |
| FI803727A7 (fi) | 1981-06-08 |
| DK522180A (da) | 1981-06-08 |
| HU180620B (en) | 1983-03-28 |
| JPS5695167A (en) | 1981-08-01 |
| US4395559A (en) | 1983-07-26 |
| AU6494680A (en) | 1981-06-11 |
| NO803693L (no) | 1981-06-09 |
| AR226869A1 (es) | 1982-08-31 |
| PT72176A (en) | 1981-01-01 |
| FI803727L (fi) | 1981-06-08 |
| NZ195702A (en) | 1984-09-28 |
| GR72136B (es) | 1983-09-20 |
| PT72176B (en) | 1982-07-05 |
| ES497530A0 (es) | 1982-07-01 |
| IL61603A0 (en) | 1981-01-30 |
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