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ES8205410A1 - Un procedimiento para preparar una pirazolo-piridinona - Google Patents

Un procedimiento para preparar una pirazolo-piridinona

Info

Publication number
ES8205410A1
ES8205410A1 ES500395A ES500395A ES8205410A1 ES 8205410 A1 ES8205410 A1 ES 8205410A1 ES 500395 A ES500395 A ES 500395A ES 500395 A ES500395 A ES 500395A ES 8205410 A1 ES8205410 A1 ES 8205410A1
Authority
ES
Spain
Prior art keywords
alkyl
halo
addition salts
pyridinylnicotinates
pyrazolopyridinones
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES500395A
Other languages
English (en)
Other versions
ES500395A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
STWB Inc
Original Assignee
Sterling Drug Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/130,623 external-priority patent/US4265895A/en
Priority claimed from US06/130,628 external-priority patent/US4264612A/en
Application filed by Sterling Drug Inc filed Critical Sterling Drug Inc
Publication of ES8205410A1 publication Critical patent/ES8205410A1/es
Publication of ES500395A0 publication Critical patent/ES500395A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/53—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/50—Ketonic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
    • C07D213/85—Nitriles in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE UNA PIRAZOLOIPIRIDINA Y DE SUS SALES DE ADICION DE ACIDO, DE FORMULA (I), EN LA QUE Q ES HIDROGENO O ALQUILO INFERIOR; PY ES 4- / 3-PIRIDINILO CON UNO O DOS SUSTITUYENTES ALQUILO INFERIORA ENTRE 15 Y 200 G Y R PUEDE SER UNO DE VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DEL A LQUILO INFERIOR 2-HALO-5-PY-6-Q-NICOTINATO CON UNA 1-R-HIDRAZINA, EN LOS QUE TODOS LOS SIMBOLOS TIENEN EL MISMO SIGNIFICDO QUE EN LA FORMULA (I), Y HALO ES CLORO O BROMO. LA REACCION SE LLEVA A CABO EN UN DISOLVENTE TAL COMO ETANOL O MET ANOLM, A UNA TEMPERATURA DE RAFLUJO EL MEDIO DE REACCION.
ES500395A 1980-03-17 1981-03-16 Un procedimiento para preparar una pirazolo-piridinona Granted ES500395A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/130,623 US4265895A (en) 1980-03-17 1980-03-17 1,2-Dihydro-5-pyridinyl-3H-pyrazolo[3,4-b]pyridin-3-ones and their use as cardiotonics
US06/130,628 US4264612A (en) 1980-03-17 1980-03-17 Lower-alkyl 2-halo-5-(pyridinyl)nicotinates, their preparation and use as cardiotonics

Publications (2)

Publication Number Publication Date
ES8205410A1 true ES8205410A1 (es) 1982-06-01
ES500395A0 ES500395A0 (es) 1982-06-01

Family

ID=26828659

Family Applications (1)

Application Number Title Priority Date Filing Date
ES500395A Granted ES500395A0 (es) 1980-03-17 1981-03-16 Un procedimiento para preparar una pirazolo-piridinona

Country Status (16)

Country Link
AU (1) AU6813881A (es)
DE (1) DE3110313A1 (es)
DK (1) DK117081A (es)
ES (1) ES500395A0 (es)
FI (1) FI810779L (es)
FR (1) FR2478098A1 (es)
GB (1) GB2073179A (es)
IL (1) IL62306A0 (es)
IT (1) IT1141999B (es)
LU (1) LU83221A1 (es)
NL (1) NL8101269A (es)
NO (1) NO810833L (es)
NZ (1) NZ196453A (es)
PH (1) PH15978A (es)
PT (1) PT72674B (es)
SE (1) SE8101592L (es)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2953571A (en) * 1957-12-13 1960-09-20 Gen Aniline & Film Corp Pyrazolopyridines
AU454992B2 (en) * 1970-06-03 1974-10-28 Euclid Inc Exhaust diverting valve for dumpable vehicles having heated dump bodies
DE2232038A1 (de) * 1972-06-30 1974-01-10 Hoechst Ag 3-amino-1h-pyrazolo eckige klammer auf 3,4-b eckige klammer zu pyridine, ihre herstellung und verwendung
US4081451A (en) * 1975-03-20 1978-03-28 Schering Corporation Process for preparing 2-halogeno nicotinic acids
US4072746A (en) * 1975-10-14 1978-02-07 Sterling Drug Inc. 3-Amino-5-(pyridinyl)-2(1H)-pyridinones

Also Published As

Publication number Publication date
DK117081A (da) 1981-09-18
PT72674B (en) 1982-03-22
IT8120272A0 (it) 1981-03-10
FR2478098A1 (fr) 1981-09-18
PH15978A (en) 1983-05-16
FI810779A7 (fi) 1981-09-18
GB2073179A (en) 1981-10-14
PT72674A (en) 1981-04-01
SE8101592L (sv) 1981-09-18
NL8101269A (nl) 1981-10-16
IT1141999B (it) 1986-10-08
FI810779L (fi) 1981-09-18
AU6813881A (en) 1981-09-24
NZ196453A (en) 1983-12-16
LU83221A1 (fr) 1981-10-30
NO810833L (no) 1981-09-18
DE3110313A1 (de) 1981-12-24
ES500395A0 (es) 1982-06-01
IL62306A0 (en) 1981-05-20

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