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ES2008359A6 - Procedimiento para preparar nuevos derivados de catecol farmacologicamente activos. - Google Patents

Procedimiento para preparar nuevos derivados de catecol farmacologicamente activos.

Info

Publication number
ES2008359A6
ES2008359A6 ES8703401A ES8703401A ES2008359A6 ES 2008359 A6 ES2008359 A6 ES 2008359A6 ES 8703401 A ES8703401 A ES 8703401A ES 8703401 A ES8703401 A ES 8703401A ES 2008359 A6 ES2008359 A6 ES 2008359A6
Authority
ES
Spain
Prior art keywords
alkyl
optionally substituted
cyano
acyl
nitro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8703401A
Other languages
English (en)
Inventor
Johannes Backstrom
Kalevi Evert Heinola
Erkki Juhani Honkanen
Seppo Kalevi Kaakkola
Pekka Juhani Kairisalo
Yvonne Linden
Pekka Topias Mannisto
Erkki Aarne Ola Nissinen
Pentti Pohto
Aino Kylliki Pippuri
Jarmo Johan Pystynen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Orion Oyj
Original Assignee
Orion Yhtyma Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26158050&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2008359(A6) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from FI864875A external-priority patent/FI864875A0/fi
Application filed by Orion Yhtyma Oy filed Critical Orion Yhtyma Oy
Publication of ES2008359A6 publication Critical patent/ES2008359A6/es
Expired legal-status Critical Current

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    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/333—Radicals substituted by oxygen or sulfur atoms
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07C45/562—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with nitrogen as the only hetero atom
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    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
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    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
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Abstract

PROCEDIMIENTO PARA PREPARAR NUEVOS DERIVADOS DE CATECOL FARMACOLOGICAMENTE ACTIVOS DE FORMULA (I) EN DONDE LOS DISTINTOS RADICALES TIENEN LOS SIGNIFICADOS INDICADOS EN LA DESCRIPCION. ENTRE OTRAS SINTESIS, EL PROCEDIMIENTO COMPRENDE CONDENSAR UN COMPUESTO DE FORMULA (II), EN PRESENCIA DE UN CATALIZADOR ACIDO O BASICO, CON UN COMPUESTO DE FORMULA (III). LOS COMPUESTOS (I) SON FARMACOLOGICAMENTE ACTIVOS Y SE PUEDEN APLICAR COMO MEDICAMENTOS PARA EL TRATAMIENTO DE LA ENFERMEDAD DE PARKINSON, DE ESTADOS DEPRESIVOS Y DE FALLOS CARDIACOS.
ES8703401A 1986-11-28 1987-11-27 Procedimiento para preparar nuevos derivados de catecol farmacologicamente activos. Expired ES2008359A6 (es)

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FI864875A FI864875A0 (fi) 1986-11-28 1986-11-28 Nya farmakologiskt aktiva foereningar, dessa innehaollande kompositioner samt foerfarande och mellanprodukter foer anvaendning vid framstaellning av dessa.
GB878712437A GB8712437D0 (en) 1986-11-28 1987-05-27 Pharmacologically active compounds

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ES2008359A6 true ES2008359A6 (es) 1989-07-16

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NO874966L (no) 1988-05-30
PL269091A1 (en) 1988-12-08
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PT86236B (pt) 1990-11-07
JPH085781B2 (ja) 1996-01-24
US4963590A (en) 1990-10-16
DE3740383A1 (de) 1988-06-01
NO171450C (no) 1993-03-17
YU48020B (sh) 1996-10-09
CS276263B6 (en) 1992-05-13
HU206073B (en) 1992-08-28
CS843988A3 (en) 1992-01-15
YU2189A (en) 1989-12-31
FR2607493A1 (fr) 1988-06-03
DK175394B1 (da) 2004-09-20
AR243491A1 (es) 1993-08-31
SE503434C2 (sv) 1996-06-17
AU621036B2 (en) 1992-03-05
SE8704751L (sv) 1988-05-29
FR2607493B1 (fr) 1994-08-12
IS1753B (is) 2000-07-21
CA1334967C (en) 1995-03-28
YU47790B (sr) 1996-01-09
PH26145A (en) 1992-03-18
CS277018B6 (en) 1992-11-18
LV10236B (en) 1995-06-20
NO171450B (no) 1992-12-07
JP2735834B2 (ja) 1998-04-02
IT1225762B (it) 1990-11-26
HUT45473A (en) 1988-07-28
LV10236A (lv) 1994-10-20
PT86236A (en) 1987-12-01
NZ222729A (en) 1990-04-26
CN1040062C (zh) 1998-10-07
JPS63170311A (ja) 1988-07-14
YU2289A (en) 1989-12-31
RU2014319C1 (ru) 1994-06-15
GR871817B (en) 1988-03-24
BE1003279A5 (fr) 1992-02-18
NL8702857A (nl) 1988-06-16
DK623087D0 (da) 1987-11-27
AU8187987A (en) 1988-06-02
IS3290A7 (is) 1988-05-29
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PL152642B1 (en) 1991-01-31
GB8727854D0 (en) 1987-12-31
NL194821C (nl) 2003-04-03
ATA312987A (de) 1995-10-15
SE8704751D0 (sv) 1987-11-27
DK623087A (da) 1988-05-29
IE60320B1 (en) 1994-06-29
CS844088A3 (en) 1992-05-13
BG60407B2 (bg) 1995-02-28
CA1289078C (en) 1991-09-17
HK75594A (en) 1994-08-12
EG18338A (en) 1992-09-30
LU87050A1 (fr) 1988-05-03
DE19975025I2 (de) 2000-08-24
YU213587A (en) 1989-06-30
NO874966D0 (no) 1987-11-27
CN87108011A (zh) 1988-06-08
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MA21120A1 (fr) 1988-07-01
JPS63150237A (ja) 1988-06-22
DE3740383C2 (de) 1997-09-25
GB2200109A (en) 1988-07-27
NL194821B (nl) 2002-12-02
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NL300136I2 (nl) 2004-02-02
GB2200109B (en) 1991-07-03

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