EA199800404A1 - Производные 1-(1,2-дизамещенный пиперидинил)-4-замещенного пиперазина - Google Patents
Производные 1-(1,2-дизамещенный пиперидинил)-4-замещенного пиперазинаInfo
- Publication number
- EA199800404A1 EA199800404A1 EA199800404A EA199800404A EA199800404A1 EA 199800404 A1 EA199800404 A1 EA 199800404A1 EA 199800404 A EA199800404 A EA 199800404A EA 199800404 A EA199800404 A EA 199800404A EA 199800404 A1 EA199800404 A1 EA 199800404A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- alkyl
- het
- 6alkyl
- formula
- substituted
- Prior art date
Links
- -1 1-(1,2-Disubstituted piperidinyl)-4-substituted piperazine Chemical class 0.000 title 1
- 229940066771 systemic antihistamines piperazine derivative Drugs 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- QDZOEBFLNHCSSF-PFFBOGFISA-N (2S)-2-[[(2R)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-1-[(2R)-2-amino-5-carbamimidamidopentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-N-[(2R)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]pentanediamide Chemical compound C([C@@H](C(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)NC(=O)[C@@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](N)CCCNC(N)=N)C1=CC=CC=C1 QDZOEBFLNHCSSF-PFFBOGFISA-N 0.000 abstract 1
- 101100537937 Caenorhabditis elegans arc-1 gene Proteins 0.000 abstract 1
- 125000000815 N-oxide group Chemical group 0.000 abstract 1
- 102100024304 Protachykinin-1 Human genes 0.000 abstract 1
- 101800003906 Substance P Proteins 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 125000002618 bicyclic heterocycle group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Настоящее изобретение относится к соединениям формулы (I)их N-оксидным формам, фармацевтически приемлемым аддитивным солям и стереоизомерным формам, где n равно 0, 1 или 2; m равно 1 или 2, при условии, что если m равно 2, то n равно 1; p равно 1 или 2; =Q представляет =O или =NR; X представляет ковалентную связь или двухвалентный радикал формулы -O-, -S-, -NR-; Rпредставляет Ar, ArCалкил или ди(Ar)Cалкил, где каждая Cалкильная группа необязательно замещена гидрокси, Cалкилокси, оксо или кетализированным оксозаместителем, Rпредставляет Ar, ArCалкил, Hetили HetCалкил; Rпредставляет водород или Cалкил; L представляет водород; Ar; Cалкил; Cалкил, замещенный 1 или 2 заместителями, выбранными из гидрокси, Cалкилокси, Ar, ArCалкилокси и Het; Cалкенил; ArCалкенил; ди(Ar)Cалкенил или радикал формулы (а-1), (а-2), (а-3), (а-4) или (а-5); каждый из Ar, Arи Arпредставляет фенил или замещенный фенил; каждый из Hetи Hetпредставляет моноциклический или бициклический гетероцикл; в качестве антагонистов вещества P; их получению, композициям, содержащим их, и их использованию в качестве лекарственного средства.Международная заявка была опубликована вместе с отчетом о международном поиске.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP95202929 | 1995-10-30 | ||
| PCT/EP1996/004660 WO1997016440A1 (en) | 1995-10-30 | 1996-10-25 | 1-(1,2-disubstituted piperidinyl)-4-substituted piperazine derivatives |
| EP96937248A EP0862566B1 (en) | 1995-10-30 | 1996-10-25 | 1-(1,2-disubstituted piperidinyl)-4-substituted piperazine derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA199800404A1 true EA199800404A1 (ru) | 1998-10-29 |
| EA000909B1 EA000909B1 (ru) | 2000-06-26 |
Family
ID=8220780
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA199800404A EA000909B1 (ru) | 1995-10-30 | 1996-10-25 | Производные 1-(1,2-дизамещенный пиперидинил)-4-замещенного пиперазина |
Country Status (31)
| Country | Link |
|---|---|
| US (3) | US6197772B1 (ru) |
| EP (1) | EP0862566B1 (ru) |
| JP (1) | JP3073238B2 (ru) |
| KR (1) | KR100407067B1 (ru) |
| CN (2) | CN100415716C (ru) |
| AR (1) | AR004698A1 (ru) |
| AT (1) | ATE188691T1 (ru) |
| AU (1) | AU704155B2 (ru) |
| BR (1) | BR9611184B8 (ru) |
| CA (1) | CA2234096C (ru) |
| CY (1) | CY2177B1 (ru) |
| CZ (1) | CZ291794B6 (ru) |
| DE (1) | DE69606196T2 (ru) |
| DK (1) | DK0862566T3 (ru) |
| EA (1) | EA000909B1 (ru) |
| ES (1) | ES2143238T3 (ru) |
| GR (1) | GR3033154T3 (ru) |
| HR (1) | HRP960507B1 (ru) |
| HU (1) | HU227341B1 (ru) |
| IL (1) | IL123962A (ru) |
| MX (1) | MX9803407A (ru) |
| MY (1) | MY116575A (ru) |
| NO (1) | NO310232B1 (ru) |
| NZ (1) | NZ321575A (ru) |
| PL (1) | PL185029B1 (ru) |
| PT (1) | PT862566E (ru) |
| SI (1) | SI0862566T1 (ru) |
| TR (1) | TR199800756T2 (ru) |
| TW (1) | TW460473B (ru) |
| WO (1) | WO1997016440A1 (ru) |
| ZA (1) | ZA969090B (ru) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ321575A (en) * | 1995-10-30 | 1999-05-28 | Janssen Pharmaceutica Nv | 1-(1,2-disubstituted piperidinyl)-4- substituted piperazine derivatives |
| TW531537B (en) | 1995-12-27 | 2003-05-11 | Janssen Pharmaceutica Nv | 1-(1,2-disubstituted piperidinyl)-4-substituted piperidine derivatives |
| TW382017B (en) | 1995-12-27 | 2000-02-11 | Janssen Pharmaceutica Nv | 1-(1,2-disubstituted piperidinyl)-4-(fused imidazole)-piperidine derivatives |
| TW429256B (en) * | 1995-12-27 | 2001-04-11 | Janssen Pharmaceutica Nv | 1-(1,2-disubstituted piperidinyl)-4-(benzimidazolyl- and imidazopyridinyl)-piperidine derivatives |
| WO1999032486A1 (en) * | 1997-12-23 | 1999-07-01 | Alcon Laboratories, Inc. | Muscarinic agents and use thereof to treat glaucoma, myopia and various other conditions |
| US6391865B1 (en) | 1999-05-04 | 2002-05-21 | Schering Corporation | Piperazine derivatives useful as CCR5 antagonists |
| US6689765B2 (en) | 1999-05-04 | 2004-02-10 | Schering Corporation | Piperazine derivatives useful as CCR5 antagonists |
| USRE39921E1 (en) | 1999-10-07 | 2007-11-13 | Smithkline Beecham Corporation | Chemical compounds |
| GB9923748D0 (en) * | 1999-10-07 | 1999-12-08 | Glaxo Group Ltd | Chemical compounds |
| AU7788500A (en) * | 1999-10-25 | 2001-05-08 | Janssen Pharmaceutica N.V. | Use of substance p antagonists for influencing the circadian timing system |
| GB0025354D0 (en) | 2000-10-17 | 2000-11-29 | Glaxo Group Ltd | Chemical compounds |
| AR033452A1 (es) | 2001-03-29 | 2003-12-17 | Schering Corp | Antagonistas de ccr5 utiles para el tratamiento del sida |
| GB0108594D0 (en) * | 2001-04-05 | 2001-05-23 | Glaxo Group Ltd | Chemical compounds |
| GB0203022D0 (en) * | 2002-02-08 | 2002-03-27 | Glaxo Group Ltd | Chemical compounds |
| AU2003244455A1 (en) * | 2002-02-08 | 2003-09-02 | Glaxo Group Limited | Piperidylcarboxamide derivatives and their use in the treatment of tachykinim-mediated diseases |
| GB0203020D0 (en) * | 2002-02-08 | 2002-03-27 | Glaxo Group Ltd | Chemical compounds |
| US8541578B2 (en) | 2002-06-24 | 2013-09-24 | Janssen Pharmaceutica, N.V. | Process for the production of n-(2,6-dimethyl-phenyl)-2-piperazin-1-yl-acetamide |
| WO2004056772A1 (en) * | 2002-12-23 | 2004-07-08 | Janssen Pharmaceutica N.V. | Substituted 1,4-di-piperidin-4-yl-piperazine derivatives and their use as tachykinin antagonists |
| UA81918C2 (ru) * | 2002-10-08 | 2008-02-25 | Янссен Фармацевтика Н.В. | Замещенные производные 1,4-дипиперидин-4-илпиперазина и их применение в качестве нейрокининовых антагонистов |
| MY141736A (en) * | 2002-10-08 | 2010-06-15 | Elanco Animal Health Ireland | Substituted 1,4-di-piperidin-4-yi-piperazine derivatives and their use as neurokinin antagonists |
| EP1551811A1 (en) * | 2002-10-17 | 2005-07-13 | Amgen Inc. | Benzimidazole derivatives and their use as vanilloid receptor ligands |
| JO2485B1 (en) | 2002-12-23 | 2009-01-20 | شركة جانسين فارماسوتيكا ان. في | 1-Piperidine-3-Yl-4-Piperidine-4-Yl-Piperazine derivatives substituted and used as quinine antagonists |
| US7514424B2 (en) | 2002-12-23 | 2009-04-07 | Janssen Pharmaceutica N.V. | Substituted 4-(4-piperidin-4-yl-piperazin-1-yl)-azepane derivatives and their use as neurokinin antagonists |
| JO2696B1 (en) | 2002-12-23 | 2013-03-03 | شركة جانسين فارماسوتيكا ان. في | Derivatives of 1-piperdine-4-yl-4-biprolidine-3-yl-piperazine substituted and used as quinine antagonists |
| US7435736B2 (en) | 2002-12-23 | 2008-10-14 | Janssen Pharmaceutica, N.V. | Substituted 1-piperidin-4-yl-4-azetidin-3-yl-piperazine derivatives and their use as neurokinin antagonists |
| DE602004013772D1 (de) * | 2003-06-10 | 2008-06-26 | Janssen Pharmaceutica Nv | Kombination von opioiden und einem piperazin-derivat für die behandlung von schmerzen |
| EP1635811A2 (en) * | 2003-06-10 | 2006-03-22 | Janssen Pharmaceutica N.V. | Substituted 1, 4-di-piperidin-4-yl-piperazine derivative combined with an opioid analgesic and their use for the treatment of pain and side-effects associated with opioid-based treatments |
| AR047759A1 (es) * | 2003-09-26 | 2006-02-22 | Vertex Pharma | Derivados de fenil - piperazina como moduladores de receptores muscarnicos |
| JO2676B1 (en) * | 2004-04-06 | 2012-06-17 | جانسين فارماسوتيكا ان. في | Derivatives of second-aza-spiro- (5,4) -dikan and their use as antihistamines |
| JO2527B1 (en) * | 2004-04-06 | 2010-03-17 | شركة جانسين فارماسوتيكا ان. في | Derivatives of second-aza-Spiro- (5,5) -andecan and their use as antihistamines |
| JO2525B1 (en) * | 2004-04-08 | 2010-03-17 | شركة جانسين فارماسوتيكا ان. في | Derived 4-alkyl-and-4-canoelperidine derivatives and their use as anti-neroquin |
| AU2005234596B8 (en) | 2004-04-13 | 2011-06-16 | Incyte Holdings Corporation | Piperazinylpiperidine derivatives as chemokine receptor antagonists |
| WO2005123081A2 (en) * | 2004-06-22 | 2005-12-29 | Janssen Pharmaceutica N.V. | (2-benzyl-4-{4-[1-(tetrahydrofuran-3-carbonyl)-pyrrolidin-3-yl]-piperazin-1-yl}-piperidin-1-yl)-(3,5-trifluoromethyl-phenyl))-methanone for the treatment of schizophrenia |
| US20060024481A1 (en) * | 2004-07-29 | 2006-02-02 | Eastman Kodak Company | Jet printing of patterned metal |
| ATE415819T1 (de) | 2004-08-19 | 2008-12-15 | Monsanto Technology Llc | Herbizide glyphosatsalzusammensetzung |
| US7635698B2 (en) * | 2004-12-29 | 2009-12-22 | Millennium Pharmaceuticals, Inc. | Compounds useful as chemokine receptor antagonists |
| CN101137657B (zh) | 2005-03-08 | 2011-02-02 | 詹森药业有限公司 | 作为神经激肽（nk1）拮抗剂的二氮杂-螺-[4.4]-壬烷衍生物 |
| CN101190330A (zh) | 2006-11-30 | 2008-06-04 | 深圳市鼎兴生物医药技术开发有限公司 | 胆碱酯酶在拮抗速激肽药物中的应用 |
| AU2008208920A1 (en) | 2007-01-24 | 2008-07-31 | Glaxo Group Limited | Pharmaceutical compositions comprising 3, 5-diamin0-6- (2, 3-dichl0phenyl) -l, 2, 4-triazine or R(-) -2, 4-diamino-5- (2, 3-dichlorophenyl) -6-fluoromethyl pyrimidine and an NK1 |
| WO2010081851A1 (en) | 2009-01-14 | 2010-07-22 | Genoscience Pharma | Piperidin-4-ylpiperazine compounds for the treatment of hcv infection |
| GB201106817D0 (en) | 2011-04-21 | 2011-06-01 | Astex Therapeutics Ltd | New compound |
| GB201218864D0 (en) | 2012-10-19 | 2012-12-05 | Astex Therapeutics Ltd | Bicyclic heterocycle compounds and their uses in therapy |
| GB201218850D0 (en) | 2012-10-19 | 2012-12-05 | Astex Therapeutics Ltd | Bicyclic heterocycle compounds and their uses in therapy |
| US9980973B2 (en) | 2012-10-19 | 2018-05-29 | Astex Therapeutics Limited | Bicyclic heterocycle compounds and their uses in therapy |
| GB201218862D0 (en) | 2012-10-19 | 2012-12-05 | Astex Therapeutics Ltd | Bicyclic heterocycle compounds and their uses in therapy |
| BR112015018847A2 (pt) | 2013-02-08 | 2017-07-18 | Gen Mills Inc | produtos alimentícios reduzidos em sódio |
| LT3083616T (lt) | 2013-12-20 | 2021-09-10 | Astex Therapeutics Limited | Bicikinių heterociklų junginiai ir jų panaudojimas terapijoje |
| PT3377064T (pt) * | 2016-01-08 | 2019-07-23 | Nerre Therapeutics Ltd | Orvepitante para o tratamento da tosse crónica |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2676055B1 (fr) * | 1991-05-03 | 1993-09-03 | Sanofi Elf | Composes polycycliques amines et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant. |
| MY110227A (en) * | 1991-08-12 | 1998-03-31 | Ciba Geigy Ag | 1-acylpiperindine compounds. |
| CN1042335C (zh) * | 1993-01-03 | 1999-03-03 | 诺瓦提斯公司 | 1－酰基哌啶化合物、其制备方法、药物组合物及用途 |
| ES2105003T3 (es) * | 1993-05-12 | 1997-10-16 | Heumann Pharma Gmbh & Co | Forma estable y cristalina del bezafibrato. |
| GB9310066D0 (en) * | 1993-05-17 | 1993-06-30 | Zeneca Ltd | Alkyl substituted heterocycles |
| WO1995011895A1 (en) * | 1993-10-26 | 1995-05-04 | Ciba-Geigy Ag | N-benzoyl-4-oxy/thio-2-substituted piperidines as substance-p receptor antagonists |
| IL111730A (en) * | 1993-11-29 | 1998-12-06 | Fujisawa Pharmaceutical Co | Piperazine derivatives processes for the preparation thereof and pharmaceutical compositions containing the same |
| EP0721941A4 (en) * | 1994-07-15 | 1996-09-25 | Meiji Seika Co | NOVEL COMPOUNDS HAVING AN INHIBITING EFFECT ON PLATELET AGGREGATION |
| ATE212981T1 (de) * | 1994-09-30 | 2002-02-15 | Novartis Erfind Verwalt Gmbh | 1-acyl-4-aliphatische aminopiperidin verbindungen |
| NZ321575A (en) * | 1995-10-30 | 1999-05-28 | Janssen Pharmaceutica Nv | 1-(1,2-disubstituted piperidinyl)-4- substituted piperazine derivatives |
-
1994
- 1994-02-24 NZ NZ321575A patent/NZ321575A/xx not_active IP Right Cessation
-
1996
- 1996-10-24 TW TW085113017A patent/TW460473B/zh not_active IP Right Cessation
- 1996-10-25 WO PCT/EP1996/004660 patent/WO1997016440A1/en not_active Ceased
- 1996-10-25 CN CNB021574278A patent/CN100415716C/zh not_active Expired - Lifetime
- 1996-10-25 SI SI9630141T patent/SI0862566T1/xx unknown
- 1996-10-25 CA CA002234096A patent/CA2234096C/en not_active Expired - Lifetime
- 1996-10-25 KR KR10-1998-0702659A patent/KR100407067B1/ko not_active Expired - Lifetime
- 1996-10-25 CN CN96199225A patent/CN1117744C/zh not_active Expired - Lifetime
- 1996-10-25 CZ CZ19981322A patent/CZ291794B6/cs not_active IP Right Cessation
- 1996-10-25 DK DK96937248T patent/DK0862566T3/da active
- 1996-10-25 EA EA199800404A patent/EA000909B1/ru not_active IP Right Cessation
- 1996-10-25 AU AU74932/96A patent/AU704155B2/en not_active Expired
- 1996-10-25 TR TR1998/00756T patent/TR199800756T2/xx unknown
- 1996-10-25 PL PL96327406A patent/PL185029B1/pl unknown
- 1996-10-25 PT PT96937248T patent/PT862566E/pt unknown
- 1996-10-25 JP JP09517050A patent/JP3073238B2/ja not_active Expired - Lifetime
- 1996-10-25 HU HU9802985A patent/HU227341B1/hu unknown
- 1996-10-25 EP EP96937248A patent/EP0862566B1/en not_active Expired - Lifetime
- 1996-10-25 BR BRPI9611184-4B8A patent/BR9611184B8/pt not_active IP Right Cessation
- 1996-10-25 DE DE69606196T patent/DE69606196T2/de not_active Expired - Lifetime
- 1996-10-25 AT AT96937248T patent/ATE188691T1/de active
- 1996-10-25 IL IL12396296A patent/IL123962A/xx not_active IP Right Cessation
- 1996-10-25 ES ES96937248T patent/ES2143238T3/es not_active Expired - Lifetime
- 1996-10-28 AR ARP960104941A patent/AR004698A1/es active IP Right Grant
- 1996-10-29 ZA ZA9609090A patent/ZA969090B/xx unknown
- 1996-10-29 MY MYPI96004500A patent/MY116575A/en unknown
- 1996-10-30 HR HR960507A patent/HRP960507B1/xx not_active IP Right Cessation
-
1998
- 1998-04-03 NO NO19981534A patent/NO310232B1/no not_active IP Right Cessation
- 1998-04-03 US US09/054,963 patent/US6197772B1/en not_active Ceased
- 1998-04-29 MX MX9803407A patent/MX9803407A/es unknown
-
2000
- 2000-04-04 GR GR20000400847T patent/GR3033154T3/el unknown
- 2000-06-16 CY CY0000030A patent/CY2177B1/xx unknown
- 2000-12-22 US US09/745,513 patent/US6521621B1/en not_active Expired - Lifetime
-
2001
- 2001-08-23 US US09/935,698 patent/USRE37886E1/en not_active Expired - Lifetime
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EA199800404A1 (ru) | Производные 1-(1,2-дизамещенный пиперидинил)-4-замещенного пиперазина | |
| EA199800604A1 (ru) | Производные 1-(1,2-дизамещенный пиперидинил)-4-замещенного пиперидинина как антагонисты рецепторов тахикинина | |
| ATE230729T1 (de) | Benzamid-derivate und ihre verwendung als vasopressin-antagonisten | |
| FI882081A0 (fi) | 2-substituerade e-fusionerade (1,2,4) triazolo(1,5-c) pyrimidiner, farmaceutiska kompositioner och deras anvaendning. | |
| EA200100553A1 (ru) | Замещенные бициклические производные, полезные в качестве противораковых агентов | |
| BG103983A (en) | Gastrokinetic bicyclic benzamides of 3- or 4-substuituted 4-(aminomethyl)-piperidine derivatives | |
| NO986055D0 (no) | Nye heterocykliske forbindelser, deres fremstilling, farmas÷ytiske preparat | |
| ES2044836T3 (es) | Derivado de la piperidina, su utilizacion y compuesto farmaceutico que lo contiene. | |
| EA199800603A1 (ru) | Производные 1-(1,2-дизамещенный пиперидинил)-4-(конденсированный имидазол)-пиперидина | |
| IL77452A0 (en) | Derivatives of arylcyclobutylalkylamines,their preparation and pharmaceutical compositions containing them | |
| MX9306310A (es) | Compuestos antagonistas del receptor de 5-ht4, procedimiento para su preparacion y composiciones farmaceuticas que los contienen | |
| TR199801218T2 (xx) | Takikinin antagonistleri olarak N-asil-2-ikameli-4-(Benzimidazolil-ya da imidazopiridinil-ikameli art�klar)-piperidinler. | |
| UA41295C2 (ru) | Триазолилзамещенные третичные аминные соединения или их соли как ингибитор ароматазы и фармацевтическая композиция на их основе | |
| DE69133295D1 (de) | 3,9-diazabicyclo-[3.3.1]-nonanylderivate, verfahren und intermediate für ihre darstellung und sie enthaltende pharmazeutische zusammensetzungen | |
| AR007108A1 (es) | Agentes antitumorales y antivirales alquilantes, procedimiento para su preparacion, utilizacion de los mismos para la fabricacion de un medicamento y composicion farmaceutica que contiene a dichos agentes. | |
| NO892295L (no) | Fremgangsmaate for fremstilling av nye cefemforbindelser. | |
| AR008168A1 (es) | Compuestos etilamino arilamida aril substituidos de pirrolidinilo y pirrolinilo, composicion farmaceutica que lo contiene, compuesto util para susintesis, procedimiento para su preparacion | |
| RU96102842A (ru) | Применение кумаринов и карбостирилов в качестве pla2-ингибиторов, новые кумарины и карбостирилы, способ их получения и лекарственные средства | |
| NO960441L (no) | Benzopyraner og farmasöytiske forbindelser inneholdende dem | |
| SE8303913L (sv) | Heterocykliska foreningar | |
| AR027454A1 (es) | Derivados de beta-alanina, utiles como antagonistas de receptores, las composiciones farmaceuticas que las contienen y el uso de los mismos para lapreparacion de medicamentos | |
| FR2778404B1 (fr) | Derives du dihydro ou tetrahydronaphtalene, et les compositions pharmaceutiques les renfermant | |
| NO165593C (no) | Analogifremgangsmaate ved fremstilling av nye tetracykliske indolderivater. | |
| NO982549L (no) | 5-naftalen-1-yl-1,3-dioksan-derivater, fremstilling og terapeutisk anvendelse derav | |
| ECSP972156A (es) | Inhibidores de metaloproteinasas, composiciones farmaceuticas que los contienen y sus usos farmaceuticos y los metodos e intermedios utiles para su preparacion |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK4A | Patent expired |
Designated state(s): AM AZ BY KZ KG MD TJ TM RU |