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EP1578910A4 - Nitrilasen - Google Patents

Nitrilasen

Info

Publication number
EP1578910A4
EP1578910A4 EP02780877A EP02780877A EP1578910A4 EP 1578910 A4 EP1578910 A4 EP 1578910A4 EP 02780877 A EP02780877 A EP 02780877A EP 02780877 A EP02780877 A EP 02780877A EP 1578910 A4 EP1578910 A4 EP 1578910A4
Authority
EP
European Patent Office
Prior art keywords
nitrilases
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP02780877A
Other languages
English (en)
French (fr)
Other versions
EP1578910A2 (de
Inventor
Grace Desantis
Jennifer Ann Chaplin
David Paul Weiner
Aileen Milan
Ellen Chi
Jay M Short
Mark Madden
Mark Burk
Dan Robertson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF Enzymes LLC
Original Assignee
Verenium Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Verenium Corp filed Critical Verenium Corp
Priority to EP10190401.9A priority Critical patent/EP2319919B1/de
Priority to EP10189100.0A priority patent/EP2327765B1/de
Priority to EP20100190399 priority patent/EP2327767B1/de
Priority to EP08075753A priority patent/EP2039762A3/de
Priority to EP10190397.9A priority patent/EP2327766B1/de
Publication of EP1578910A2 publication Critical patent/EP1578910A2/de
Publication of EP1578910A4 publication Critical patent/EP1578910A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00Preparation of nitrogen-containing organic compounds
    • C12P13/002Nitriles (-CN)
    • C12P13/004Cyanohydrins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/78Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00Preparation of nitrogen-containing organic compounds
    • C12P13/04Alpha- or beta- amino acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/006Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/40Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42Hydroxy-carboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Processing Of Solid Wastes (AREA)
  • Treatment Of Sludge (AREA)
EP02780877A 2001-06-21 2002-05-15 Nitrilasen Withdrawn EP1578910A4 (de)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP10190401.9A EP2319919B1 (de) 2001-06-21 2002-05-15 Nitralasen
EP10189100.0A EP2327765B1 (de) 2001-06-21 2002-05-15 Nitralasen
EP20100190399 EP2327767B1 (de) 2001-06-21 2002-05-15 Nitralasen
EP08075753A EP2039762A3 (de) 2001-06-21 2002-05-15 Nitralasen
EP10190397.9A EP2327766B1 (de) 2001-06-21 2002-05-15 Nitralasen

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US30018901P 2001-06-21 2001-06-21
US300189P 2001-06-21
US30900601P 2001-07-30 2001-07-30
US309006P 2001-07-30
US35133602P 2002-01-22 2002-01-22
US351336P 2002-01-22
PCT/US2002/015983 WO2003000840A2 (en) 2001-06-21 2002-05-15 Nitrilases

Related Child Applications (5)

Application Number Title Priority Date Filing Date
EP08075753A Division EP2039762A3 (de) 2001-06-21 2002-05-15 Nitralasen
EP10190401.9A Division EP2319919B1 (de) 2001-06-21 2002-05-15 Nitralasen
EP10189100.0A Division EP2327765B1 (de) 2001-06-21 2002-05-15 Nitralasen
EP20100190399 Division EP2327767B1 (de) 2001-06-21 2002-05-15 Nitralasen
EP10190397.9A Division EP2327766B1 (de) 2001-06-21 2002-05-15 Nitralasen

Publications (2)

Publication Number Publication Date
EP1578910A2 EP1578910A2 (de) 2005-09-28
EP1578910A4 true EP1578910A4 (de) 2008-06-04

Family

ID=27404717

Family Applications (6)

Application Number Title Priority Date Filing Date
EP10190397.9A Expired - Lifetime EP2327766B1 (de) 2001-06-21 2002-05-15 Nitralasen
EP08075753A Withdrawn EP2039762A3 (de) 2001-06-21 2002-05-15 Nitralasen
EP10189100.0A Expired - Lifetime EP2327765B1 (de) 2001-06-21 2002-05-15 Nitralasen
EP02780877A Withdrawn EP1578910A4 (de) 2001-06-21 2002-05-15 Nitrilasen
EP20100190399 Expired - Lifetime EP2327767B1 (de) 2001-06-21 2002-05-15 Nitralasen
EP10190401.9A Expired - Lifetime EP2319919B1 (de) 2001-06-21 2002-05-15 Nitralasen

Family Applications Before (3)

Application Number Title Priority Date Filing Date
EP10190397.9A Expired - Lifetime EP2327766B1 (de) 2001-06-21 2002-05-15 Nitralasen
EP08075753A Withdrawn EP2039762A3 (de) 2001-06-21 2002-05-15 Nitralasen
EP10189100.0A Expired - Lifetime EP2327765B1 (de) 2001-06-21 2002-05-15 Nitralasen

Family Applications After (2)

Application Number Title Priority Date Filing Date
EP20100190399 Expired - Lifetime EP2327767B1 (de) 2001-06-21 2002-05-15 Nitralasen
EP10190401.9A Expired - Lifetime EP2319919B1 (de) 2001-06-21 2002-05-15 Nitralasen

Country Status (6)

Country Link
EP (6) EP2327766B1 (de)
JP (2) JP4405258B2 (de)
AU (2) AU2006252258B2 (de)
CA (2) CA2445046C (de)
DK (3) DK2327767T3 (de)
WO (1) WO2003000840A2 (de)

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US7521216B2 (en) 1999-12-29 2009-04-21 Verenium Corporation Nitrilases and methods for making and using them
US7300775B2 (en) 1999-12-29 2007-11-27 Verenium Corporation Methods for producing α-substituted carboxylic acids using nitrilases and strecker reagents
US20040002147A1 (en) * 1999-12-29 2004-01-01 Desantis Grace Nitrilases
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US7932064B2 (en) 2002-06-13 2011-04-26 Verenium Corporation Processes for making (R)-ethyl 4-cyano-3-hydroxybutyric acid
CN100445375C (zh) * 2003-02-27 2008-12-24 巴斯福股份公司 经修饰的腈水解酶及它们在产生羧酸的方法中的用途
TW200519106A (en) 2003-05-02 2005-06-16 Novartis Ag Organic compounds
US7198926B2 (en) 2003-05-08 2007-04-03 E. I. Du Pont De Nemours And Company Preparation of (E)- and (Z)-2-methyl-2-butenoic acids
GB0401334D0 (en) 2004-01-21 2004-02-25 Novartis Ag Organic compounds
GB0411056D0 (en) 2004-05-18 2004-06-23 Novartis Ag Organic compounds
GT200500281A (es) 2004-10-22 2006-04-24 Novartis Ag Compuestos organicos.
EP1817413B1 (de) 2004-11-11 2012-01-04 Modular Genetics, Inc. Oligonukleotid-leiterkonstruktion und system zur erzeugung von molekularer vielfalt
GB0426164D0 (en) 2004-11-29 2004-12-29 Novartis Ag Organic compounds
GB0507577D0 (en) 2005-04-14 2005-05-18 Novartis Ag Organic compounds
GB0510390D0 (en) 2005-05-20 2005-06-29 Novartis Ag Organic compounds
KR20080049113A (ko) 2005-10-21 2008-06-03 노파르티스 아게 Il-13에 대항한 인간 항체 및 치료적 용도
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GB0601951D0 (en) 2006-01-31 2006-03-15 Novartis Ag Organic compounds
CA2649215A1 (en) 2006-04-21 2007-11-01 Novartis Ag 2,6,9-trisubstituted purine compounds as adenosine aza receptor modulators
CN100500832C (zh) * 2006-04-29 2009-06-17 浙江工业大学 枯草芽孢杆菌zjb-063及其应用
KR20090073121A (ko) 2006-09-29 2009-07-02 노파르티스 아게 Pi3k 지질 키나제 억제제로서의 피라졸로피리미딘
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JP5165393B2 (ja) * 2008-01-10 2013-03-21 旭化成ケミカルズ株式会社 グリコール酸又はグリコール酸アンモニウムの製造方法
PT2231642E (pt) 2008-01-11 2014-03-12 Novartis Ag Pirimidinas como inibidores de quinase
US8268834B2 (en) 2008-03-19 2012-09-18 Novartis Ag Pyrazine derivatives that inhibit phosphatidylinositol 3-kinase enzyme
ES2535736T3 (es) 2008-06-10 2015-05-14 Novartis Ag Derivados de pirazina como bloqueadores de los canales de sodio epitelial
US20110281917A1 (en) 2009-01-29 2011-11-17 Darrin Stuart Substituted Benzimidazoles for the Treatment of Astrocytomas
US8389526B2 (en) 2009-08-07 2013-03-05 Novartis Ag 3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives
WO2011018454A1 (en) 2009-08-12 2011-02-17 Novartis Ag Heterocyclic hydrazone compounds and their uses to treat cancer and inflammation
IN2012DN01961A (de) 2009-08-17 2015-08-21 Intellikine Llc
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US8247436B2 (en) 2010-03-19 2012-08-21 Novartis Ag Pyridine and pyrazine derivative for the treatment of CF
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US8372845B2 (en) 2010-09-17 2013-02-12 Novartis Ag Pyrazine derivatives as enac blockers
WO2012107500A1 (en) 2011-02-10 2012-08-16 Novartis Ag [1, 2, 4] triazolo [4, 3 -b] pyridazine compounds as inhibitors of the c-met tyrosine kinase
WO2012116237A2 (en) 2011-02-23 2012-08-30 Intellikine, Llc Heterocyclic compounds and uses thereof
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GB201111639D0 (en) * 2011-07-07 2011-08-24 Waterford Inst Technology A process for producing amides and acids using a nitrile-metabolising enzyme
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US8883819B2 (en) 2011-09-01 2014-11-11 Irm Llc Bicyclic heterocycle derivatives for the treatment of pulmonary arterial hypertension
US9062045B2 (en) 2011-09-15 2015-06-23 Novartis Ag Triazolopyridine compounds
WO2013038373A1 (en) 2011-09-16 2013-03-21 Novartis Ag Pyridine amide derivatives
WO2013038378A1 (en) 2011-09-16 2013-03-21 Novartis Ag Pyridine amide derivatives
WO2013038381A1 (en) 2011-09-16 2013-03-21 Novartis Ag Pyridine/pyrazine amide derivatives
CN103946221B (zh) 2011-09-16 2016-08-03 诺华股份有限公司 用于治疗囊性纤维化的杂环化合物
JP6165733B2 (ja) 2011-09-16 2017-07-19 ノバルティス アーゲー N−置換ヘテロシクリルカルボキサミド類
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CN102363775B (zh) * 2011-11-30 2014-04-02 重庆大学 一种纯化腈水解酶的方法
US8809340B2 (en) 2012-03-19 2014-08-19 Novartis Ag Crystalline form
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US10004732B2 (en) 2014-04-24 2018-06-26 Novartis Ag Amino pyrazine derivatives as phosphatidylinositol 3-kinase inhibitors
WO2015162456A1 (en) 2014-04-24 2015-10-29 Novartis Ag Amino pyridine derivatives as phosphatidylinositol 3-kinase inhibitors
WO2016011658A1 (en) 2014-07-25 2016-01-28 Novartis Ag Combination therapy
MX373272B (es) 2014-07-31 2020-04-16 Novartis Ag Terapia de combinacion.
CN104774825B (zh) * 2015-03-23 2017-11-07 浙江工业大学 腈水解酶突变体及其应用
CN108368033B (zh) * 2015-11-19 2021-05-04 Gsp作物科学有限公司 一种用于制备肟菌酯的方法
CN106854673B (zh) * 2016-12-23 2020-05-15 枣庄市杰诺生物酶有限公司 利用腈水解酶工程菌制备r-邻氯扁桃酸的方法
CN109111043B (zh) * 2018-09-16 2021-11-09 苏州渭中科技发展有限公司 一种高盐高cod废水的处理方法
WO2020152104A2 (en) * 2019-01-22 2020-07-30 Basf Se Method for production of 4-cyano benzoic acid or salts thereof
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Citations (1)

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Also Published As

Publication number Publication date
EP2327767B1 (de) 2015-04-29
EP2327765B1 (de) 2015-04-01
DK2327766T3 (en) 2016-03-07
JP4405258B2 (ja) 2010-01-27
AU2010212259B2 (en) 2012-11-29
EP2327765A1 (de) 2011-06-01
AU2006252258A1 (en) 2007-01-25
DK2327765T3 (en) 2015-07-13
EP2327767A1 (de) 2011-06-01
AU2010212259A1 (en) 2010-09-02
CA2445046A1 (en) 2003-01-03
EP2039762A2 (de) 2009-03-25
JP2005509407A (ja) 2005-04-14
EP2039762A3 (de) 2009-07-29
JP2007252382A (ja) 2007-10-04
WO2003000840A3 (en) 2007-11-15
EP2327766B1 (de) 2015-12-02
CA2677781A1 (en) 2003-01-03
EP2319919B1 (de) 2015-08-12
JP4405528B2 (ja) 2010-01-27
CA2677781C (en) 2013-01-29
EP1578910A2 (de) 2005-09-28
EP2319919A1 (de) 2011-05-11
EP2327766A1 (de) 2011-06-01
CA2445046C (en) 2009-11-24
AU2006252258B2 (en) 2010-07-22
WO2003000840A2 (en) 2003-01-03
DK2327767T3 (en) 2015-07-27

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