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EE200300327A - Uurea derivaadid, nende valmistamismeetodid, kasutamine ja farmatseutiline kompositsioon - Google Patents

Uurea derivaadid, nende valmistamismeetodid, kasutamine ja farmatseutiline kompositsioon

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Publication number
EE200300327A
EE200300327A EEP200300327A EEP200300327A EE200300327A EE 200300327 A EE200300327 A EE 200300327A EE P200300327 A EEP200300327 A EE P200300327A EE P200300327 A EEP200300327 A EE P200300327A EE 200300327 A EE200300327 A EE 200300327A
Authority
EE
Estonia
Prior art keywords
processes
preparation
pharmaceutical composition
urea derivatives
urea
Prior art date
Application number
EEP200300327A
Other languages
English (en)
Estonian (et)
Inventor
Miguel Jimenez Mayorga Juan
Bach Tana Jordi
Maria Ontoria Ontoria Jesus
Navarro Romero Eloisa
Original Assignee
Almirall Prodesfarma, S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Almirall Prodesfarma, S.A. filed Critical Almirall Prodesfarma, S.A.
Publication of EE200300327A publication Critical patent/EE200300327A/xx

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    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/54—Sulfur atoms
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
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    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
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    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/40—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
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    • C07C275/42—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
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EEP200300327A 2001-01-19 2002-01-15 Uurea derivaadid, nende valmistamismeetodid, kasutamine ja farmatseutiline kompositsioon EE200300327A (et)

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Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6960597B2 (en) 2000-06-30 2005-11-01 Orth-Mcneil Pharmaceutical, Inc. Aza-bridged-bicyclic amino acid derivatives as α4 integrin antagonists
ES2219177B1 (es) * 2003-05-05 2006-02-16 Almirall Prodesfarma, S.A. Derivados de n-(2-feniletil) sulfamida como antagonistas de la integrina alfa4.
WO2005019193A2 (en) * 2003-08-20 2005-03-03 Smithkline Beecham Corporation Phenylurea derivatives useful in the treatment of conditions mediated by polo-like kinases (plk)
CA2813757C (en) 2005-08-18 2014-04-08 Nissan Chemical Industries, Ltd. Thiophene compound having sulfonyl group and process for producing the same
WO2007060409A1 (en) * 2005-11-23 2007-05-31 Astrazeneca Ab L-alanine derivatives
KR100588821B1 (ko) * 2006-01-06 2006-06-12 모악개발 주식회사 균일 팽창이 가능한 패커를 구비하는 하수관로 부분보수장치
US20080045521A1 (en) * 2006-06-09 2008-02-21 Astrazeneca Ab Phenylalanine derivatives
WO2008093065A1 (en) * 2007-01-29 2008-08-07 Astrazeneca Ab L-ALANINE DERIVATIVES AS α5βL ANTAGONISTS
WO2008094992A2 (en) 2007-01-31 2008-08-07 Vertex Pharmaceuticals Incorporated 2-aminopyridine derivatives useful as kinase inhibitors
ES2320955B1 (es) 2007-03-02 2010-03-16 Laboratorios Almirall S.A. Nuevos derivados de 3-((1,2,4)triazolo(4,3-a)piridin-7-il)benzamida.
WO2008125811A1 (en) * 2007-04-11 2008-10-23 Astrazeneca Ab N-[HETEROARYLCARBONYL]-S-THIENYL-L-ALANINE DERIVATIVES AS α5β1 ANTAGONISTS
EP2108641A1 (de) 2008-04-11 2009-10-14 Laboratorios Almirall, S.A. Neue substituierte Spiro[Cycloalkyl-1,3'-indo]-2'(1'H)-on-Derivate und ihre Verwendung als p38 mitogen-activated Kinase Inhibitoren
EP2113503A1 (de) 2008-04-28 2009-11-04 Laboratorios Almirall, S.A. Neue substituierte Indolin-2-on- Derivate und ihre Verwendung als p39 mitogen-activated Kinase Inhibitoren
EP2328896B1 (de) 2008-07-23 2013-10-23 Vertex Pharmaceuticals Incorporated Tricyclische pyrazolopyridine als kinaseinhibitoren
AU2009274011B2 (en) 2008-07-23 2014-12-18 Vertex Pharmaceuticals Incorporated Pyrazolopyridine kinase inhibitors
US8569337B2 (en) 2008-07-23 2013-10-29 Vertex Pharmaceuticals Incorporated Tri-cyclic pyrazolopyridine kinase inhibitors
EP2313372B1 (de) * 2008-08-06 2013-04-10 Vertex Pharmaceuticals Incorporated Aminopyridine als kinaseinhibitoren
KR101038486B1 (ko) * 2008-09-03 2011-06-01 쌍용건설 주식회사 패커를 이용한 비굴착식 하수관로 보수 장치 및 방법
TW201034689A (en) * 2008-12-05 2010-10-01 Molecular Insight Pharm Inc CA-IX specific radiopharmaceuticals for the treatment and imaging of cancer
CN102459259A (zh) 2009-05-06 2012-05-16 沃泰克斯药物股份有限公司 吡唑并吡啶类
FI20095678A0 (fi) * 2009-06-16 2009-06-16 Biotie Therapies Oy Ureasubstituoituja sulfoniamidijohdannaisia
EP2322176A1 (de) 2009-11-11 2011-05-18 Almirall, S.A. Neue 7-Phenyl-[1,2,4]triazol[4,3-a]pyridin-3(2H)on-Derivate
EP2550272A1 (de) 2010-01-27 2013-01-30 Vertex Pharmaceuticals Incorporated Pyrazolopyrazinkinasehemmer
JP2013518114A (ja) 2010-01-27 2013-05-20 バーテックス ファーマシューティカルズ インコーポレイテッド ピラゾロピリミジンキナーゼ阻害剤
CA2787315A1 (en) 2010-01-27 2011-08-04 Vertex Pharmaceuticals Incorporated Pyrazolopyridine kinase inhibitors
EP2611777B1 (de) * 2010-09-03 2016-05-11 Forma TM, LLC. 4- {[(pyridin- 3 -yl-methyl) aminocarbonyl] amino}-benzolsulfonderivate als nampt-inhibitoren zur behandlung von krankheiten wie krebs
US10266488B2 (en) 2013-10-10 2019-04-23 Eastern Virginia Medical School 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase
EP3873897B1 (de) 2018-10-30 2024-08-14 Gilead Sciences, Inc. N-benzoyl-phenylalanin-derivate als alpha4beta7 integrin-inhibitoren zur behandlung von entzündlichen erkrankungen
PL3873900T3 (pl) 2018-10-30 2025-06-02 Gilead Sciences, Inc. Imidazo[1,2-a]pirydynowe pochodne jako inhibitory integryny alpha4beta7 do leczenia chorób zapalnych
LT3873884T (lt) 2018-10-30 2025-03-10 Gilead Sciences, Inc. 3-(chinolin-8-il)-1,4-dihidropirido[3,4-d]pirimidin-2,4-diono dariniai kaip alfa4beta7 integrino inhibitoriai, skirti uždegiminių ligų gydymui
KR102659859B1 (ko) 2018-10-30 2024-04-25 길리애드 사이언시즈, 인코포레이티드 알파4β7 인테그린의 억제를 위한 화합물
EP4013499A1 (de) 2019-08-14 2022-06-22 Gilead Sciences, Inc. Verbindungen zur inhibierung von alpha-4-beta-7-integrin
WO2022093552A2 (en) * 2020-10-16 2022-05-05 Saint Louis Univeristy Rev-erb agonists

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4740611A (en) * 1986-10-30 1988-04-26 The Standard Oil Company N,N'-disubstituted ureas
US4705864A (en) * 1986-11-10 1987-11-10 The Standard Oil Company Aryl oxime derivatives of hydantoins
WO1992008464A1 (en) * 1990-11-15 1992-05-29 Tanabe Seiyaku Co. Ltd. Substituted urea and related cell adhesion modulation compounds
GB9310713D0 (en) * 1993-05-24 1993-07-07 Zeneca Ltd Aryl substituted heterocycles
DK0900211T3 (da) * 1996-04-23 2003-10-27 Upjohn Co Thiadiazolyl(thio)urinstoffer, der er nyttige som matrixmetalloproteaseinhibitorer
ES2271971T3 (es) 1996-07-25 2007-04-16 Biogen Idec Ma Inc. Inhibidores de la adhesion celular.
NZ333038A (en) * 1996-08-22 2000-10-27 Warner Lambert Co Non-peptide bombesin receptor antagonists
AU728435B2 (en) 1997-05-29 2001-01-11 Merck & Co., Inc. Sulfonamides as cell adhesion inhibitors
ATE249421T1 (de) 1997-06-23 2003-09-15 Tanabe Seiyaku Co Inhibitoren der alpha4-beta1 vermittelten zelladhäsion
US6353023B1 (en) 1997-08-28 2002-03-05 Pharmacia & Upjohn Company Inhibitors of protein tyrosine phosphatase
WO1999020617A1 (en) * 1997-10-21 1999-04-29 Active Biotech Ab Antiinflammatory thiadiazolyl ureas which act as lfa-1 and mac-1 inhibitors
TR200001312T2 (tr) 1997-11-10 2000-09-21 Bristol-Myers Squibb Company Benzotiyazol protein tirozin kinaz önleyicileri.
US6645939B1 (en) 1997-11-24 2003-11-11 Merck & Co., Inc. Substituted β-alanine derivatives as cell adhesion inhibitors
JP2001524465A (ja) 1997-11-24 2001-12-04 メルク エンド カムパニー インコーポレーテッド 細胞接着阻害剤としての置換β−アラニン誘導体
ATE298338T1 (de) 1997-12-17 2005-07-15 Merck & Co Inc Integrin-rezeptor-antagonisten
EP0975589A2 (de) 1998-01-21 2000-02-02 ZymoGenetics, Inc. Dialkylharnstoffe als calcitoninmimetika
DE69927050T2 (de) * 1998-12-16 2006-06-29 Bayer Healthcare Ag Biphenylverbindungen und biphenyl-analoge als intergrin-antagonisten
CA2359114A1 (en) 1999-01-25 2000-07-27 Elan Pharmaceuticals, Inc. Compounds which inhibit leukocyte adhesion mediated by vla-4
WO2000051974A1 (en) 1999-03-01 2000-09-08 Elan Pharmaceuticals, Inc. Alpha-aminoacetic acid derivatives useful as alpha 4 beta 7 - receptor antagonists
DE19909979A1 (de) 1999-03-06 2000-09-07 Bayer Ag Verfahren zur Herstellung von Glycokonjugaten von 20(S)-Camptothecin
CZ303312B6 (cs) 1999-05-07 2012-07-25 Texas Biotechnology Corporation Deriváty karboxylové kyseliny, které inhibují vazbu integrinu na jejich receptory
US6518283B1 (en) 1999-05-28 2003-02-11 Celltech R&D Limited Squaric acid derivatives
AU6909300A (en) * 1999-08-20 2001-03-19 Merck & Co., Inc. Substituted ureas as cell adhesion inhibitors

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