AR025068A1 - Pirazinas sustituidas y piridazinas fusionadas, composicion farmaceutica que las comprenden, uso de dichos compuestos para la manufactura de un medicamentocon actividad inhibidora de angiogenesis - Google Patents
Pirazinas sustituidas y piridazinas fusionadas, composicion farmaceutica que las comprenden, uso de dichos compuestos para la manufactura de un medicamentocon actividad inhibidora de angiogenesisInfo
- Publication number
- AR025068A1 AR025068A1 ARP000104073A ARP000104073A AR025068A1 AR 025068 A1 AR025068 A1 AR 025068A1 AR P000104073 A ARP000104073 A AR P000104073A AR P000104073 A ARP000104073 A AR P000104073A AR 025068 A1 AR025068 A1 AR 025068A1
- Authority
- AR
- Argentina
- Prior art keywords
- substituted
- alkylamino
- alkyl
- alkyl substituted
- bridge
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 150000004892 pyridazines Chemical class 0.000 title abstract 2
- 230000033115 angiogenesis Effects 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 10
- 125000000217 alkyl group Chemical group 0.000 abstract 9
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
- 125000004429 atom Chemical group 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000005236 alkanoylamino group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000003739 carbamimidoyl group Chemical group C(N)(=N)* 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 125000002795 guanidino group Chemical group C(N)(=N)N* 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003216 pyrazines Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Pirazinas sustituidas y piridazinas fusionadas, que comprenden un compuesto que tiene la formula estructural generalizada (1) en la cual R1 y R2:i) representan independientemente H o alquilo inferior; ii) conjuntamente forman un puente que tiene la estructura (2) donde la adhesion se logra a través delos átomos de carbono terminales; iii) conjuntamente forman un puente que tiene la estructura (3) donde la adhesion se logra a través de los átomos de carbonoterminales o; iv) conjuntamente forman un puente que tiene la estructura (4) donde uno o dos miembros del anillo T1 y N y los otros son CH, y la adicion selogra a través de los átomos terminales; y donde m es 0 un numero entero de 1-4 y G1 es un sustituyente independientemente seleccionadodel grupo que consisteen: . -N(R6)2; . -NR3COR6; . halogeno; . alquilo; . cicloalquilo; . alquenilo inferior; . cicloalquenilo inferior; . alquilo sustituido con halogeno; . alquilosustituido con amino; . alquilo sustituido con N-alquilamino inferior; . alquilo sustituido con N,N-dialquilamino inferior; . alquilo sustituido conN-alcoilamino inferior; . alquilo sustituido con hidroxi; . alquilo sustituido con ciano; . alquilo sustituido con carboxi; . alquilo sustituido conalcoxicarbonilo inferior; . alquilo sustituido con fenilalcoxicarbonilo inferior; . alquilamino sustituido con halogeno; . alquilamino sustituido con amino;. alquilamino sustituido con N-alquilamino inferior; alquilamino sustituido con N,N-dialquilamino inferior; . aquilamino sustituido con N-alcanoilaminoinferior; . alquilamino sustituido con hidroxi; . alquilamino sustituido con ciano; . alquilamino sustituido con carboxi; . alquilamino sustituido conalcoxicarbonilo inferior; . alquilamino sustituido con fenilalcoxicarbonilo inferior; . -OR6; . -SR6; . -S(O)R6; . -S(O)2R6; . alcoxi inferior halogenado;. alquiltio inferior halogenado; . alquilsulfonilo inferior halogenado; . -OCOR6; -COR6; . -CO2R6; . -CON(R6)2; . -CH2OR3; . -NO2; . -CN; . amidino;. guanidino;. sulfo; . -B(OH)2; . arilo opcionalmente sustituido; . heteroarilo opcionalmente sustituido; . heterociclilo saturado opcionalmente sustituido
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37132299A | 1999-08-10 | 1999-08-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR025068A1 true AR025068A1 (es) | 2002-11-06 |
Family
ID=23463486
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP000104073A AR025068A1 (es) | 1999-08-10 | 2000-08-07 | Pirazinas sustituidas y piridazinas fusionadas, composicion farmaceutica que las comprenden, uso de dichos compuestos para la manufactura de un medicamentocon actividad inhibidora de angiogenesis |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP1208096B1 (es) |
| JP (1) | JP2003506447A (es) |
| KR (1) | KR20020019969A (es) |
| CN (1) | CN1378543A (es) |
| AR (1) | AR025068A1 (es) |
| AT (1) | ATE265448T1 (es) |
| AU (1) | AU775237B2 (es) |
| BR (1) | BR0013113A (es) |
| CA (1) | CA2381621A1 (es) |
| CO (1) | CO5180637A1 (es) |
| DE (1) | DE60010280T2 (es) |
| ES (1) | ES2219382T3 (es) |
| IL (1) | IL147885A0 (es) |
| MX (1) | MXPA02001324A (es) |
| NO (1) | NO20020569L (es) |
| NZ (1) | NZ517087A (es) |
| PE (1) | PE20010494A1 (es) |
| WO (1) | WO2001010859A1 (es) |
| ZA (1) | ZA200200691B (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6689883B1 (en) | 1999-09-28 | 2004-02-10 | Bayer Pharmaceuticals Corporation | Substituted pyridines and pyridazines with angiogenesis inhibiting activity |
| CO5200835A1 (es) * | 1999-09-28 | 2002-09-27 | Bayer Corp | Piridinas y piridacinas sustituidas con actividad de inhibicion de angiogenesis |
| US7977333B2 (en) | 2000-04-20 | 2011-07-12 | Bayer Healthcare Llc | Substituted pyridines and pyridazines with angiogenesis inhibiting activity |
| GB0111078D0 (en) | 2001-05-04 | 2001-06-27 | Novartis Ag | Organic compounds |
| SI1427420T1 (sl) * | 2001-09-12 | 2006-12-31 | Novartis Ag | Uporaba kombinacije, ki vsebuje 4-piridilmetilftalazine za zdravljenje raka |
| MXPA04005561A (es) * | 2001-12-21 | 2004-12-06 | Bayer Pharmaceuticals Corp | Terapias de combinacion anti-angiogenesis que comprenden derivados de piridazina o piridina. |
| US7015227B2 (en) | 2002-06-21 | 2006-03-21 | Cgi Pharmaceuticals, Inc. | Certain amino-substituted monocycles as kinase modulators |
| WO2004028542A1 (en) * | 2002-09-24 | 2004-04-08 | Novartis Ag | Use of 4-pyridylmethyl-phthalazine derivatives for the manufacture of a medicament for the treatment of myelodysplastic syndromes |
| US20060058313A1 (en) * | 2002-11-12 | 2006-03-16 | Hohneker John A | Treatment of mesothelioma |
| GB0612721D0 (en) | 2006-06-27 | 2006-08-09 | Novartis Ag | Organic compounds |
| EP2137177B1 (en) | 2007-04-05 | 2014-05-07 | Amgen, Inc | Aurora kinase modulators and method of use |
| PL2167549T3 (pl) | 2007-06-19 | 2013-03-29 | Rynel Inc | Materiały zawierające cząstki polimeru rozpuszczalnego w wodzie oraz sposoby ich wytwarzania i stosowania |
| MX2010010151A (es) | 2008-03-20 | 2010-10-25 | Amgen Inc | Moduladores de cinasa aurora y metodo de uso. |
| AU2009279760B2 (en) * | 2008-08-04 | 2012-07-12 | Amgen Inc. | Aurora kinase modulators and methods of use |
| US9126935B2 (en) | 2008-08-14 | 2015-09-08 | Amgen Inc. | Aurora kinase modulators and methods of use |
| JP2024505256A (ja) * | 2021-01-28 | 2024-02-05 | ユニバーシティ オブ フロリダ リサーチファウンデーション インコーポレイティッド | 神経変性、変性及び代謝性障害の処置のための化合物並びにその使用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1293565A (en) * | 1969-05-03 | 1972-10-18 | Aspro Nicholas Ltd | Aminophthalazines and pharmaceutical compositions thereof |
| JPH03106875A (ja) * | 1989-09-20 | 1991-05-07 | Morishita Pharmaceut Co Ltd | １―（３―ピリジルメチル）フタラジン誘導体 |
| JPH0673022A (ja) * | 1992-08-27 | 1994-03-15 | Kumiai Chem Ind Co Ltd | ピリミジンまたはトリアジン誘導体及び除草剤 |
| HU219864B (hu) * | 1994-08-09 | 2001-08-28 | Eisai Co., Ltd. | cGMP-PDE inhibitor kondenzált piridazinszármazékok és alkalmazásuk |
| JP3919835B2 (ja) * | 1994-08-09 | 2007-05-30 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 縮合ピリダジン系化合物 |
| CO4950519A1 (es) * | 1997-02-13 | 2000-09-01 | Novartis Ag | Ftalazinas, preparaciones farmaceuticas que las comprenden y proceso para su preparacion |
| DE60028740T2 (de) * | 1999-03-30 | 2007-05-24 | Novartis Ag | Phthalazinderivate zur behandlung von entzündlichen erkrankungen |
-
2000
- 2000-08-07 AR ARP000104073A patent/AR025068A1/es unknown
- 2000-08-08 NZ NZ517087A patent/NZ517087A/en unknown
- 2000-08-08 CO CO00059237A patent/CO5180637A1/es unknown
- 2000-08-08 ES ES00957317T patent/ES2219382T3/es not_active Expired - Lifetime
- 2000-08-08 JP JP2001515668A patent/JP2003506447A/ja active Pending
- 2000-08-08 EP EP00957317A patent/EP1208096B1/en not_active Expired - Lifetime
- 2000-08-08 DE DE60010280T patent/DE60010280T2/de not_active Expired - Lifetime
- 2000-08-08 AT AT00957317T patent/ATE265448T1/de not_active IP Right Cessation
- 2000-08-08 BR BR0013113-0A patent/BR0013113A/pt not_active IP Right Cessation
- 2000-08-08 AU AU68954/00A patent/AU775237B2/en not_active Ceased
- 2000-08-08 KR KR1020027001797A patent/KR20020019969A/ko not_active Ceased
- 2000-08-08 IL IL14788500A patent/IL147885A0/xx unknown
- 2000-08-08 WO PCT/US2000/021579 patent/WO2001010859A1/en not_active Ceased
- 2000-08-08 CN CN00814059A patent/CN1378543A/zh active Pending
- 2000-08-08 PE PE2000000799A patent/PE20010494A1/es not_active Application Discontinuation
- 2000-08-08 CA CA002381621A patent/CA2381621A1/en not_active Abandoned
- 2000-08-08 MX MXPA02001324A patent/MXPA02001324A/es active IP Right Grant
-
2002
- 2002-01-25 ZA ZA200200691A patent/ZA200200691B/en unknown
- 2002-02-05 NO NO20020569A patent/NO20020569L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO20020569D0 (no) | 2002-02-05 |
| MXPA02001324A (es) | 2002-07-22 |
| EP1208096A1 (en) | 2002-05-29 |
| ES2219382T3 (es) | 2004-12-01 |
| DE60010280T2 (de) | 2009-10-15 |
| AU775237B2 (en) | 2004-07-22 |
| NO20020569L (no) | 2002-04-10 |
| IL147885A0 (en) | 2002-08-14 |
| WO2001010859A1 (en) | 2001-02-15 |
| ATE265448T1 (de) | 2004-05-15 |
| JP2003506447A (ja) | 2003-02-18 |
| KR20020019969A (ko) | 2002-03-13 |
| CO5180637A1 (es) | 2002-07-30 |
| CN1378543A (zh) | 2002-11-06 |
| ZA200200691B (en) | 2003-10-29 |
| CA2381621A1 (en) | 2001-02-15 |
| BR0013113A (pt) | 2002-04-30 |
| NZ517087A (en) | 2004-05-28 |
| AU6895400A (en) | 2001-03-05 |
| DE60010280D1 (de) | 2004-06-03 |
| EP1208096B1 (en) | 2004-04-28 |
| PE20010494A1 (es) | 2001-06-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |