[go: up one dir, main page]

EE05400B1 - Prasoolderivaadid, neid v?i nende farmatseutiliselt vastuv?etavaid sooli, solvaate v?i derivaate sisaldavad farmatseutilised kompositsioonid, nende kasutamine ning meetodid nende valmistamiseks - Google Patents

Prasoolderivaadid, neid v?i nende farmatseutiliselt vastuv?etavaid sooli, solvaate v?i derivaate sisaldavad farmatseutilised kompositsioonid, nende kasutamine ning meetodid nende valmistamiseks

Info

Publication number
EE05400B1
EE05400B1 EEP200300497A EEP200300497A EE05400B1 EE 05400 B1 EE05400 B1 EE 05400B1 EE P200300497 A EEP200300497 A EE P200300497A EE P200300497 A EEP200300497 A EE P200300497A EE 05400 B1 EE05400 B1 EE 05400B1
Authority
EE
Estonia
Prior art keywords
derivatives
solvates
preparation
methods
pharmaceutically acceptable
Prior art date
Application number
EEP200300497A
Other languages
English (en)
Inventor
Howard Jones Lyn
Eric Mowbray Charles
Anthony Price David
Duncan Selby Matthew
Anthony Stupple Paul
Original Assignee
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0108999A external-priority patent/GB0108999D0/en
Priority claimed from GB0127426A external-priority patent/GB0127426D0/en
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Publication of EE200300497A publication Critical patent/EE200300497A/et
Publication of EE05400B1 publication Critical patent/EE05400B1/et

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C07D231/20—One oxygen atom attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
EEP200300497A 2001-04-10 2002-04-04 Prasoolderivaadid, neid v?i nende farmatseutiliselt vastuv?etavaid sooli, solvaate v?i derivaate sisaldavad farmatseutilised kompositsioonid, nende kasutamine ning meetodid nende valmistamiseks EE05400B1 (et)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0108999A GB0108999D0 (en) 2001-04-10 2001-04-10 Pyrazole derivatives
GB0127426A GB0127426D0 (en) 2001-11-15 2001-11-15 Pyrazole derivatives
PCT/IB2002/001234 WO2002085860A1 (en) 2001-04-10 2002-04-04 Pyrazole derivatives for treating hiv

Publications (2)

Publication Number Publication Date
EE200300497A EE200300497A (et) 2004-02-16
EE05400B1 true EE05400B1 (et) 2011-04-15

Family

ID=26245955

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200300497A EE05400B1 (et) 2001-04-10 2002-04-04 Prasoolderivaadid, neid v?i nende farmatseutiliselt vastuv?etavaid sooli, solvaate v?i derivaate sisaldavad farmatseutilised kompositsioonid, nende kasutamine ning meetodid nende valmistamiseks

Country Status (42)

Country Link
US (4) US7109228B2 (et)
EP (2) EP1377556B1 (et)
JP (1) JP3806090B2 (et)
KR (1) KR100569324B1 (et)
CN (1) CN100408564C (et)
AR (2) AR037319A1 (et)
AT (2) ATE358669T1 (et)
AU (1) AU2002242926B2 (et)
BG (1) BG66349B1 (et)
BR (1) BRPI0208811B8 (et)
CA (1) CA2443449C (et)
CR (1) CR7069A (et)
CY (2) CY1107626T1 (et)
CZ (1) CZ305099B6 (et)
DE (1) DE60219292T2 (et)
DK (2) DK1377556T3 (et)
DO (1) DOP2002000378A (et)
EA (1) EA007184B1 (et)
EE (1) EE05400B1 (et)
ES (2) ES2283532T3 (et)
GE (1) GEP20053619B (et)
HR (1) HRP20030783B1 (et)
HU (1) HU229025B1 (et)
IL (2) IL157875A0 (et)
IS (1) IS2734B (et)
MA (1) MA27009A1 (et)
ME (1) ME00558A (et)
MX (1) MXPA03009380A (et)
MY (1) MY146669A (et)
NO (1) NO326518B1 (et)
NZ (1) NZ529403A (et)
OA (1) OA12501A (et)
PA (1) PA8543601A1 (et)
PE (1) PE20021056A1 (et)
PL (3) PL217629B1 (et)
PT (2) PT1377556E (et)
RS (1) RS51166B (et)
SI (2) SI1762567T1 (et)
SK (1) SK287858B6 (et)
TW (1) TWI333488B (et)
UY (1) UY27248A1 (et)
WO (1) WO2002085860A1 (et)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA007184B1 (ru) * 2001-04-10 2006-08-25 Пфайзер Инк. Производные пиразола для лечения инфекции вируса иммунодефицита человека (вич)
EP1465871A1 (en) * 2001-12-28 2004-10-13 Bayer Corporation Pyrazole derivatives for use in diseases associated with the 5-ht2c receptor
JP4228587B2 (ja) * 2002-05-22 2009-02-25 昭和電工株式会社 アミノメチル基含有ベンズアミド化合物の製造方法
US20040132793A1 (en) * 2002-09-16 2004-07-08 Pfizer Inc. Pyrazole derivatives
GB0221477D0 (en) * 2002-09-16 2002-10-23 Pfizer Ltd Chemical compounds
US6933312B2 (en) 2002-10-07 2005-08-23 Agouron Pharmaceuticals, Inc. Pyrazole derivatives
GB0223234D0 (en) * 2002-10-07 2002-11-13 Pfizer Ltd Chemical compounds
GB0223232D0 (en) * 2002-10-07 2002-11-13 Pfizer Ltd Chemical compounds
TW200423930A (en) * 2003-02-18 2004-11-16 Hoffmann La Roche Non-nucleoside reverse transcriptase inhibitors
CN100469769C (zh) 2003-03-24 2009-03-18 弗·哈夫曼-拉罗切有限公司 作为逆转录酶抑制剂的苄基-哒嗪酮
WO2005013888A2 (en) * 2003-05-14 2005-02-17 Cytokinetics, Inc. Compounds, compositions and methods
US7220772B2 (en) 2003-09-05 2007-05-22 Pfizer, Inc. Pyrazole derivatives
US7102001B2 (en) * 2003-12-12 2006-09-05 Bristol-Myers Squibb Company Process for preparing pyrrolotriazine
WO2005080320A1 (en) 2004-02-13 2005-09-01 Warner-Lambert Company Llc Androgen receptor modulators
CA2563291A1 (en) 2004-04-13 2005-10-27 Warner-Lambert Company Llc 4-cyano-phenoxy-alkyl carboxyl derivatives as androgen modulators
JP2007533726A (ja) 2004-04-22 2007-11-22 ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー アンドロゲンモジュレーター
AR048650A1 (es) * 2004-05-04 2006-05-10 Tibotec Pharm Ltd Derivados de (1,10b-dihidro-2-(aminocarbonil-fenil)-5h-pirazolo[1,5 c][1,3]benzoxazin-5-il)fenil metanona como inhibidores de la replicacion viral del vih
BRPI0513020A (pt) 2004-07-08 2008-04-22 Warner Lambert Co moduladores de andrÈgenio, seus usos, composição farmacêutica, formulação farmacêutica tópica e artigo de fabricação
CA2604218A1 (en) 2005-04-20 2006-10-26 Pfizer Limited Pyrazole derivatives as progesterone receptor antagonists
TW200724139A (en) 2005-05-05 2007-07-01 Warner Lambert Co Androgen modulators
AR057455A1 (es) * 2005-07-22 2007-12-05 Merck & Co Inc Inhibidores de la transcriptasa reversa de vih y composicion farmaceutica
UA90763C2 (ru) * 2005-11-08 2010-05-25 Пфайзер Лимитед Производные пиразола, способ их получения, фармацевтический состав на их основе и их применение
DK2010493T3 (en) 2006-04-12 2016-05-02 Merck Sharp & Dohme PYRIDYLAMIDE T-TYPE CALCIUM CHANNEL ANTAGONISTS
EP2057125B1 (en) 2006-08-16 2011-03-30 F. Hoffmann-La Roche AG Non-nucleoside reverse transcriptase inhibitors
US20080096950A1 (en) * 2006-10-19 2008-04-24 Karl Richard Gibson Compounds Useful In Therapy
US9280685B2 (en) * 2006-12-08 2016-03-08 Johnnie R. Jackson System and method for portable medical records
WO2008135824A1 (en) * 2007-05-02 2008-11-13 Pfizer Limited Oxyalkylpyrazole compounds useful in therapy
KR20100039348A (ko) 2007-06-22 2010-04-15 에프. 호프만-라 로슈 아게 비-뉴클레오사이드 역 전사효소 억제제로서 우레아 및 카바메이트 유도체
EP2212293A4 (en) * 2007-10-24 2010-12-01 Merck Sharp & Dohme HETEROCYCLIC AMID CALCIUM CHANNEL ANTAGONISTS OF TYPE T
BRPI0818244A2 (pt) 2007-10-24 2015-06-16 Merck Sharp & Dohme Composto, composição farmacêutica, uso de um composto, e, método para tratamento de um distúrbio ou doença
KR101610415B1 (ko) 2007-12-21 2016-04-07 에프. 호프만-라 로슈 아게 헤테로사이클릭 항바이러스 화합물
LT3494972T (lt) 2010-01-27 2024-03-12 Viiv Healthcare Company Dolutegraviro ir lamivudino kompozicija živ infekcijai gydyti
WO2011129893A1 (en) * 2010-04-13 2011-10-20 Sentreheart, Inc. Methods and devices for treating atrial fibrillation
CN103517990A (zh) 2010-10-07 2014-01-15 通用医疗公司 癌症生物标志物
CA2820408C (en) * 2010-12-06 2018-03-06 Glaxo Group Limited Pyrimidinone compounds for use in the treatment of diseases or conditions mediated by lp-pla2
WO2013050884A1 (en) 2011-10-07 2013-04-11 Phivco Uk Limited Process for the preparation of lersivirine
WO2013057593A1 (en) 2011-10-07 2013-04-25 Phivco Uk Limited Process for the preparation of lersivirine
WO2013050873A1 (en) 2011-10-07 2013-04-11 Phivco Uk Limited Process for the preparation of lersivirine
EP2716632A1 (en) * 2012-10-05 2014-04-09 Laboratoire Biodim Inhibitors of viral replication, their process of preparation and their therapeutical uses
WO2014074628A1 (en) * 2012-11-08 2014-05-15 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Compounds for treating hiv and methods for using the compounds
US10026064B2 (en) 2013-09-13 2018-07-17 Microsoft Technology Licensing, Llc Automatically recommending updates based on stored lifecycle information
WO2015060348A1 (ja) * 2013-10-23 2015-04-30 大日本住友製薬株式会社 縮合ピラゾール誘導体
CN106458925A (zh) * 2014-05-06 2017-02-22 杜邦公司 杀真菌吡唑类
US10301624B2 (en) 2014-06-25 2019-05-28 The General Hospital Corporation Targeting human satellite II (HSATII)
WO2016066664A1 (en) * 2014-10-31 2016-05-06 F. Hoffmann-La Roche Ag New pyridinyloxy- and phenyloxy-pyrazolyl compounds
US9925190B2 (en) 2015-02-16 2018-03-27 University of Pittsburgh—of the Commonwealth System of Higher Education Small molecules targeting HIV-1 Nef
JOP20180092A1 (ar) * 2017-10-13 2019-04-13 Gilead Sciences Inc مثبطات hiv بروتياز
AU2019217875A1 (en) 2018-02-06 2020-08-20 Icahn School Of Medicine At Mount Sinai Repeat RNA as biomarkers of tumor immune response
KR102114389B1 (ko) * 2018-05-02 2020-05-25 이화여자대학교 산학협력단 신규 소듐채널 저해 화합물, 이의 제조방법, 및 이를 포함하는 소듐채널 관련 질환의 예방 또는 치료용 약학적 조성물
WO2020056564A1 (zh) 2018-09-17 2020-03-26 南通纺织丝绸产业技术研究院 基于金属氢化物/钯化合物体系制备1,3-二羰基化合物的方法
JP2022504982A (ja) * 2018-10-18 2022-01-13 南京聖和薬業股▲ふん▼有限公司 ＴＧＦ－βＲ１阻害剤としての化合物及びその応用
CN113527304B (zh) * 2020-04-17 2025-08-12 南京圣和药物研发有限公司 喹啉类TGF-β1抑制剂的制备方法
CN113527306B (zh) * 2020-04-17 2025-06-24 南京圣和药物研发有限公司 喹啉类TGF-β1抑制剂的晶型
EP4541790A1 (en) 2022-06-15 2025-04-23 Nissan Chemical Corporation Pyrazole compound, production intermediate thereof, and pest control agent
CN120981445A (zh) 2023-03-31 2025-11-18 日产化学株式会社 吡唑化合物及有害生物防除剂

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3303200A (en) * 1963-11-05 1967-02-07 American Home Prod Pyrazole-1-ethanol derivatives
US3963742A (en) * 1974-07-12 1976-06-15 American Cyanamid Company 1,2-Dialkyl-3,4,5-trisubstituted pyrazolium salts as herbicidal agents
US4009277A (en) * 1975-01-17 1977-02-22 American Cyanamid Company 1,2-Dialkyl-3,4,5-trisubstituted pyrazolium salts as fungicidal agents
US4041046A (en) 1975-06-06 1977-08-09 American Cyanamid Company 1,2-Dialkyl-3,4,5-trisubstituted pyrazole compounds
US4000301A (en) 1975-11-14 1976-12-28 American Cyanamid Company Fungicidal use of 4-alkoxypyrazoles
US5376645A (en) 1990-01-23 1994-12-27 University Of Kansas Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
KR0166088B1 (ko) 1990-01-23 1999-01-15 . 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
JPH0565237A (ja) 1991-09-10 1993-03-19 Mitsubishi Heavy Ind Ltd メタノールを媒体としたエネルギ供給方法
FR2682379B1 (fr) 1991-10-09 1994-02-11 Rhone Poulenc Agrochimie Nouveaux phenylpyrazoles fongicides.
WO1994022830A1 (en) 1993-03-31 1994-10-13 Smithkline Beecham Corporation Chemical compounds
FR2707295A1 (fr) 1993-06-07 1995-01-13 Rhone Poulenc Agrochimie Fongicides pyrazoles substitués en position 3 par un hétérocycle.
EP0658547B1 (en) 1993-12-14 1998-03-11 Mitsubishi Chemical Corporation N-pyrazolyl carbamate derivative, agricultural/horticultural fungicide containing the same as active ingredient and production intermediate thereof
FR2722369B1 (fr) 1994-07-13 1998-07-10 Rhone Poulenc Agrochimie Compositions fongicides a base de derives 3-phenyl-pyrazoles pour le traitement du materiel vegetal de multiplication, nouveaux derives 3-phenyl-pyrazoles et leurs applications fongicides
HUT77357A (hu) 1994-09-26 1998-03-30 Shionogi & Co. Ltd. AIDS-ellenes imidazolszármazékok és ilyen vegyületeket tartalmazó gyógyászati készítmények
TW343232B (en) * 1994-10-13 1998-10-21 Chisso Corp Difluorooxymethane derivative and liquid crystal composition
GB9711643D0 (en) 1997-06-05 1997-07-30 Janssen Pharmaceutica Nv Glass thermoplastic systems
KR100840816B1 (ko) * 2000-05-12 2008-06-23 젠자임 코포레이션 ＴＮＦ-α시그널링의 조절물질
GB0016787D0 (en) 2000-07-07 2000-08-30 Pfizer Ltd Compounds useful in therapy
EA007184B1 (ru) * 2001-04-10 2006-08-25 Пфайзер Инк. Производные пиразола для лечения инфекции вируса иммунодефицита человека (вич)

Also Published As

Publication number Publication date
HRP20030783A2 (en) 2005-08-31
ES2385659T3 (es) 2012-07-27
PA8543601A1 (es) 2002-10-31
BG66349B1 (bg) 2013-08-30
EP1377556B1 (en) 2007-04-04
PL217224B1 (pl) 2014-06-30
US20060020012A1 (en) 2006-01-26
WO2002085860A1 (en) 2002-10-31
BG108244A (bg) 2005-04-30
IS2734B (is) 2011-04-15
SI1762567T1 (sl) 2012-08-31
HUP0303735A2 (hu) 2004-03-01
EA007184B1 (ru) 2006-08-25
SI1377556T1 (sl) 2007-08-31
CA2443449C (en) 2008-11-04
OA12501A (en) 2006-05-26
EP1377556A1 (en) 2004-01-07
CN1514828A (zh) 2004-07-21
CY1107626T1 (el) 2013-04-18
PL396946A1 (pl) 2012-01-02
PT1762567E (pt) 2012-07-16
JP3806090B2 (ja) 2006-08-09
HK1063781A1 (zh) 2005-01-14
SK12442003A3 (sk) 2004-12-01
EE200300497A (et) 2004-02-16
EP1762567B1 (en) 2012-05-02
AR037319A1 (es) 2004-11-03
ATE556059T1 (de) 2012-05-15
DE60219292T2 (de) 2008-04-10
KR20040007496A (ko) 2004-01-24
DE60219292D1 (de) 2007-05-16
ES2283532T3 (es) 2007-11-01
NO20034523L (no) 2003-12-09
AU2002242926B2 (en) 2007-10-11
MA27009A1 (fr) 2004-12-20
ME00558A (en) 2011-12-20
BRPI0208811B1 (pt) 2018-03-13
HUP0303735A3 (en) 2004-07-28
PL217629B1 (pl) 2014-08-29
BR0208811A (pt) 2004-03-09
BRPI0208811B8 (pt) 2021-05-25
PE20021056A1 (es) 2002-12-03
PT1377556E (pt) 2007-06-06
SK287858B6 (sk) 2012-01-04
NZ529403A (en) 2005-06-24
EP1762567A1 (en) 2007-03-14
NO20034523D0 (no) 2003-10-09
DK1377556T3 (da) 2007-07-16
IL157875A0 (en) 2004-03-28
MXPA03009380A (es) 2004-04-21
TWI333488B (en) 2010-11-21
NO326518B1 (no) 2008-12-22
GEP20053619B (en) 2005-09-26
HU229025B1 (en) 2013-07-29
EA200300943A1 (ru) 2004-08-26
CA2443449A1 (en) 2002-10-31
CZ305099B6 (cs) 2015-05-06
DK1762567T3 (da) 2012-06-25
US8063044B2 (en) 2011-11-22
PL365026A1 (en) 2004-12-27
DOP2002000378A (es) 2002-10-15
CR7069A (es) 2007-12-17
KR100569324B1 (ko) 2006-04-07
IL157875A (en) 2010-05-17
IS6939A (is) 2003-09-04
MY146669A (en) 2012-09-14
US7109228B2 (en) 2006-09-19
US20030100554A1 (en) 2003-05-29
ATE358669T1 (de) 2007-04-15
CY1113515T1 (el) 2016-06-22
UY27248A1 (es) 2002-11-29
JP2004531535A (ja) 2004-10-14
CN100408564C (zh) 2008-08-06
US7435728B2 (en) 2008-10-14
CZ20032676A3 (cs) 2004-11-10
YU77503A (sh) 2006-05-25
US20120029192A1 (en) 2012-02-02
PL216985B1 (pl) 2014-06-30
PL398536A1 (pl) 2012-06-04
RS51166B (sr) 2010-10-31
AR076259A2 (es) 2011-06-01
US20090215712A1 (en) 2009-08-27
HRP20030783B1 (hr) 2011-11-30

Similar Documents

Publication Publication Date Title
EE05400B1 (et) Prasoolderivaadid, neid v?i nende farmatseutiliselt vastuv?etavaid sooli, solvaate v?i derivaate sisaldavad farmatseutilised kompositsioonid, nende kasutamine ning meetodid nende valmistamiseks
EE05081B1 (et) Farmatseutilised kompositsioonid, mis sisaldavad 3-aminoasetidiini derivaate, 3-aminoasetidiini derivaadid ja nende valmistamise meetodid
EE04779B1 (et) 1,3-dihüdro-2H-indool-2-ooni derivaadid, nende valmistamismeetod ja neid sisaldavad farmatseutilised kompositsioonid
IL192937A0 (en) Pharmaceutical compositions containing beta-lapachone or derivatives or analogs thereof, and methods of using same
EE04613B1 (et) Sahhariidijääkidega asendatud 1,4-bensotiasepiin-1,1-dioksiidi derivaadid, meetod nende valmistamiseks, ühendite kasutamine ning neid sisaldav ravim
EE05181B1 (et) Prasolo[4,3-d]primidiini derivaadid, neid sisaldavad farmatseutilised kompositsioonid, nende kasutamine ja meetodid nende valmistamiseks
IL154965A0 (en) Sulfonamide derivatives, their preparation and pharmaceutical compositions containing them
EE05034B1 (et) Bitsüklilised heterotsüklilised ühendid, neid ühendeid sisaldavad farmatseutilised kompositsioonid ja nende valmistamise meetodid
EE200300054A (et) Kinaasi inhibiitoritena toimivad bitsüklopürasoolid, nende valmistamismeetod, kasutamine ja neid sisaldavad farmatseutilised kompositsioonid
EE05104B1 (et) Asetidiini derivaadid, nende valmistamise meetodid ja farmatseutiline kompositsioon
EE04673B1 (et) Kinoliini derivaadid, nende valmistamine ja kasutamine ravimina ning neid sisaldavad farmatseutilised kompositsioonid
EE05001B1 (et) Heterotsüklilised ühendid, meetod nende valmistamiseks, neid sisaldav ravimkoostis ning nende kasutamine ravis
HUP0401642A3 (en) Use of staurosporine derivatives for the preparation of pharmaceutical compositions
HUP0303529A3 (en) New quinuclidine carbamate derivatives, process for their preparation and pharmaceutical compositions containing them and their use
EE200300207A (et) Heterotsüklüülalküülpiperidiini derivaadid, nendevalmistamismeetodid ja farmatseutiline kompositsioon
EE05424B1 (et) Asendatud asaindooloksoatseetpiperasiini derivaadid, neid sisaldav ravimpreparaat ning nende kasutamine ravis
EE200200138A (et) Kinolüülpropüülpiperidiini derivaadid, nende valmistamine ja neid sisaldavad kompositsioonid
HU228253B1 (en) Substituted cyclohexane-1,4-diamine derivatives, process for their preparation and pharmaceutical compositions containing them
IL161582A0 (en) Use of oxindole hydrazide derivatives for the preparation of pharmaceutical compositions, certain such new derivatives and their preparation
EE04276B1 (et) Kinoliini derivaadid, nende valmistamine ja kasutamine ravimina ning neid sisaldavad farmatseutilised kompositsioonid
HUP0302327A3 (en) Ecteinascidin derivatives their use, pharmaceutical compositions containing them
PT1210119E (pt) Composicoes farmaceuticas para administracao oral e topica
EE200100711A (et) Naftüridiini derivaadid, nende valmistamismeetod ning neid sisaldav farmatseutiline kompositsioon
EE200300574A (et) Aminokinoliini derivaadid, nende valmistamine, neid sisaldavad ravimkoostised ja nende kasutamine adenosiini A3-retseptori ligandidena
EE200200292A (et) Asendatud norbornüülaminoderivaadid, nende valmistamine ja kasutamine ravimitena või diagnostilisteainetena ning neid sisaldav ravim

Legal Events

Date Code Title Description
HC1A Change of owner name