ME00558A - Pyrazole derivatives for treating hiv - Google Patents

Pyrazole derivatives for treating hiv

Info

Publication number: ME00558A
Authority: ME; Montenegro
Prior art keywords: derivatives; present; pyrazole derivatives; disorders; compounds
Prior art date: 2001-04-10

Application number

MEP-758/08A

Other languages

Bosnian (bs)

English (en)

Inventor

Lyn Howard Ones

Charles Eric Mowbray

Davis Anthony Price

Matthew Duncan Selby

Paul Anthony Stupple

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-04-10

Filing date

2002-04-04

Publication date

2011-12-20

2001-04-10 Priority claimed from GB0108999A external-priority patent/GB0108999D0/en

2001-11-15 Priority claimed from GB0127426A external-priority patent/GB0127426D0/en

2002-04-04 Application filed filed Critical

2011-12-20 Publication of ME00558A publication Critical patent/ME00558A/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
- C07D231/20—One oxygen atom attached in position 3 or 5
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Immunology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

MEP-758/08A 2001-04-10 2002-04-04 Pyrazole derivatives for treating hiv ME00558A (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GB0108999A GB0108999D0 (en)	2001-04-10	2001-04-10	Pyrazole derivatives
GB0127426A GB0127426D0 (en)	2001-11-15	2001-11-15	Pyrazole derivatives
YUP-775/03A RS51166B (sr)	2001-04-10	2002-04-04	Derivati pirazola za tretiranje hiv
PCT/IB2002/001234 WO2002085860A1 (en)	2001-04-10	2002-04-04	Pyrazole derivatives for treating hiv

Publications (1)

Publication Number	Publication Date
ME00558A true ME00558A (en)	2011-12-20

Family

ID=26245955

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MEP-758/08A ME00558A (en)	2001-04-10	2002-04-04	Pyrazole derivatives for treating hiv

Country Status (42)

Country	Link
US (4)	US7109228B2 (xx)
EP (2)	EP1377556B1 (xx)
JP (1)	JP3806090B2 (xx)
KR (1)	KR100569324B1 (xx)
CN (1)	CN100408564C (xx)
AR (2)	AR037319A1 (xx)
AT (2)	ATE358669T1 (xx)
AU (1)	AU2002242926B2 (xx)
BG (1)	BG66349B1 (xx)
BR (1)	BRPI0208811B8 (xx)
CA (1)	CA2443449C (xx)
CR (1)	CR7069A (xx)
CY (2)	CY1107626T1 (xx)
CZ (1)	CZ305099B6 (xx)
DE (1)	DE60219292T2 (xx)
DK (2)	DK1377556T3 (xx)
DO (1)	DOP2002000378A (xx)
EA (1)	EA007184B1 (xx)
EE (1)	EE05400B1 (xx)
ES (2)	ES2283532T3 (xx)
GE (1)	GEP20053619B (xx)
HR (1)	HRP20030783B1 (xx)
HU (1)	HU229025B1 (xx)
IL (2)	IL157875A0 (xx)
IS (1)	IS2734B (xx)
MA (1)	MA27009A1 (xx)
ME (1)	ME00558A (xx)
MX (1)	MXPA03009380A (xx)
MY (1)	MY146669A (xx)
NO (1)	NO326518B1 (xx)
NZ (1)	NZ529403A (xx)
OA (1)	OA12501A (xx)
PA (1)	PA8543601A1 (xx)
PE (1)	PE20021056A1 (xx)
PL (3)	PL216985B1 (xx)
PT (2)	PT1377556E (xx)
RS (1)	RS51166B (xx)
SI (2)	SI1762567T1 (xx)
SK (1)	SK287858B6 (xx)
TW (1)	TWI333488B (xx)
UY (1)	UY27248A1 (xx)
WO (1)	WO2002085860A1 (xx)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP3806090B2 (ja) *	2001-04-10	2006-08-09	ファイザー・インク	Ｈｉｖ関連疾患治療用のピラゾール誘導体
CA2471880A1 (en) *	2001-12-28	2003-07-17	Bayer Pharmaceuticals Corporation	1h-pyrazolyl derivative compounds, for use in diseases associated with the 5-ht2c receptor
JP4228587B2 (ja)	2002-05-22	2009-02-25	昭和電工株式会社	アミノメチル基含有ベンズアミド化合物の製造方法
GB0221477D0 (en) *	2002-09-16	2002-10-23	Pfizer Ltd	Chemical compounds
US20040132793A1 (en) *	2002-09-16	2004-07-08	Pfizer Inc.	Pyrazole derivatives
GB0223232D0 (en) *	2002-10-07	2002-11-13	Pfizer Ltd	Chemical compounds
GB0223234D0 (en) *	2002-10-07	2002-11-13	Pfizer Ltd	Chemical compounds
US6933312B2 (en)	2002-10-07	2005-08-23	Agouron Pharmaceuticals, Inc.	Pyrazole derivatives
TW200423930A (en)	2003-02-18	2004-11-16	Hoffmann La Roche	Non-nucleoside reverse transcriptase inhibitors
MXPA05010081A (es)	2003-03-24	2005-11-23	Hoffmann La Roche	Bencil-piridazinonas como inhibidores de transcriptasa inversa.
WO2005013888A2 (en) *	2003-05-14	2005-02-17	Cytokinetics, Inc.	Compounds, compositions and methods
US7220772B2 (en)	2003-09-05	2007-05-22	Pfizer, Inc.	Pyrazole derivatives
US7102001B2 (en) *	2003-12-12	2006-09-05	Bristol-Myers Squibb Company	Process for preparing pyrrolotriazine
JP3997255B2 (ja)	2004-02-13	2007-10-24	ワーナー−ランバートカンパニーリミテッドライアビリティーカンパニー	アンドロゲンレセプターモジュレーター
WO2005100305A1 (en)	2004-04-13	2005-10-27	Warner-Lambert Company Llc	Androgen modulators
WO2005102990A1 (en)	2004-04-22	2005-11-03	Warner-Lambert Company Llc	Androgen modulators
AR048650A1 (es) *	2004-05-04	2006-05-10	Tibotec Pharm Ltd	Derivados de (1,10b-dihidro-2-(aminocarbonil-fenil)-5h-pirazolo[1,5 c][1,3]benzoxazin-5-il)fenil metanona como inhibidores de la replicacion viral del vih
BRPI0513020A (pt)	2004-07-08	2008-04-22	Warner Lambert Co	moduladores de andrÈgenio, seus usos, composição farmacêutica, formulação farmacêutica tópica e artigo de fabricação
CA2604218A1 (en) *	2005-04-20	2006-10-26	Pfizer Limited	Pyrazole derivatives as progesterone receptor antagonists
TW200724139A (en)	2005-05-05	2007-07-01	Warner Lambert Co	Androgen modulators
AR057455A1 (es) *	2005-07-22	2007-12-05	Merck & Co Inc	Inhibidores de la transcriptasa reversa de vih y composicion farmaceutica
PL1948615T3 (pl) *	2005-11-08	2012-04-30	Pfizer Ltd	Pochodne pirazolu przydatne w leczeniu chorób ginekologicznych
US7875636B2 (en) *	2006-04-12	2011-01-25	Merck Sharp & Dohme Corp.	Pyridyl amide T-type calcium channel antagonists
CN101501002B (zh)	2006-08-16	2012-06-27	弗·哈夫曼-拉罗切有限公司	非核苷逆转录酶抑制剂
US20080096950A1 (en) *	2006-10-19	2008-04-24	Karl Richard Gibson	Compounds Useful In Therapy
US9280685B2 (en) *	2006-12-08	2016-03-08	Johnnie R. Jackson	System and method for portable medical records
WO2008135824A1 (en) *	2007-05-02	2008-11-13	Pfizer Limited	Oxyalkylpyrazole compounds useful in therapy
JP2010530863A (ja)	2007-06-22	2010-09-16	エフ．ホフマン−ラロシュアーゲー	非ヌクレオシド逆転写酵素阻害剤としての尿素及びカルバマート誘導体
CA2702126A1 (en) *	2007-10-24	2009-04-30	Merck Sharp & Dohme Corp.	Heterocycle amide t-type calcium channel antagonists
CA2701594C (en)	2007-10-24	2014-02-18	Merck Sharp & Dohme Corp.	Heterocycle phenyl amide t-type calcium channel antagonists
WO2009080534A1 (en)	2007-12-21	2009-07-02	F. Hoffmann-La Roche Ag	Heterocyclic antiviral compounds
PH12012501537A1 (en)	2010-01-27	2018-02-07	Viiv Healthcare Co	Antiviral therapy
AU2011241103A1 (en) *	2010-04-13	2012-11-08	Sentreheart, Inc.	Methods and devices for treating atrial fibrillation
EP2625292B1 (en)	2010-10-07	2018-12-05	The General Hospital Corporation	Biomarkers of cancer
UY33766A (es) *	2010-12-06	2012-06-29	Glaxo Group Ltd	COMPUESTOS CON ESTRUCTURA DE PIRIMIDINONA PARA USO EN EL TRATAMIENTO DE ENFERMEDADES MEDIADAS POR Lp-PLA2
WO2013050873A1 (en)	2011-10-07	2013-04-11	Phivco Uk Limited	Process for the preparation of lersivirine
WO2013057593A1 (en)	2011-10-07	2013-04-25	Phivco Uk Limited	Process for the preparation of lersivirine
WO2013050884A1 (en)	2011-10-07	2013-04-11	Phivco Uk Limited	Process for the preparation of lersivirine
EP2716632A1 (en)	2012-10-05	2014-04-09	Laboratoire Biodim	Inhibitors of viral replication, their process of preparation and their therapeutical uses
US9695127B2 (en)	2012-11-08	2017-07-04	University of Pittsburgh—of the Commonwealth System of Higher Education	Compounds for treating HIV and methods for using the compounds
US10026064B2 (en)	2013-09-13	2018-07-17	Microsoft Technology Licensing, Llc	Automatically recommending updates based on stored lifecycle information
JPWO2015060348A1 (ja) *	2013-10-23	2017-03-09	大日本住友製薬株式会社	縮合ピラゾール誘導体
EP3140289A1 (en) *	2014-05-06	2017-03-15	E. I. du Pont de Nemours and Company	Fungicidal pyrazoles
EP3161159B1 (en)	2014-06-25	2020-08-05	The General Hospital Corporation	Targeting human satellite ii (hsatii)
ES2968785T3 (es) *	2014-10-31	2024-05-14	Hoffmann La Roche	Nuevos compuestos de piridiniloxi- y feniloxipirazolilo
US9925190B2 (en)	2015-02-16	2018-03-27	University of Pittsburgh—of the Commonwealth System of Higher Education	Small molecules targeting HIV-1 Nef
JOP20180092A1 (ar) *	2017-10-13	2019-04-13	Gilead Sciences Inc	مثبطات hiv بروتياز
AU2019217875A1 (en)	2018-02-06	2020-08-20	Icahn School Of Medicine At Mount Sinai	Repeat RNA as biomarkers of tumor immune response
KR102114389B1 (ko) *	2018-05-02	2020-05-25	이화여자대학교 산학협력단	신규 소듐채널 저해 화합물, 이의 제조방법, 및 이를 포함하는 소듐채널 관련 질환의 예방 또는 치료용 약학적 조성물
WO2020056564A1 (zh) *	2018-09-17	2020-03-26	南通纺织丝绸产业技术研究院	基于金属氢化物/钯化合物体系制备1,3-二羰基化合物的方法
JP2022504982A (ja) *	2018-10-18	2022-01-13	南京聖和薬業股▲ふん▼有限公司	ＴＧＦ－βＲ１阻害剤としての化合物及びその応用
CN113527306B (zh) *	2020-04-17	2025-06-24	南京圣和药物研发有限公司	喹啉类TGF-β1抑制剂的晶型
CN113527304B (zh) *	2020-04-17	2025-08-12	南京圣和药物研发有限公司	喹啉类TGF-β1抑制剂的制备方法
EP4541790A1 (en)	2022-06-15	2025-04-23	Nissan Chemical Corporation	Pyrazole compound, production intermediate thereof, and pest control agent
KR20250164815A (ko)	2023-03-31	2025-11-25	닛산 가가쿠 가부시키가이샤	피라졸 화합물 및 유해 생물 방제제

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3303200A (en) *	1963-11-05	1967-02-07	American Home Prod	Pyrazole-1-ethanol derivatives
US3963742A (en) *	1974-07-12	1976-06-15	American Cyanamid Company	1,2-Dialkyl-3,4,5-trisubstituted pyrazolium salts as herbicidal agents
US4009277A (en) *	1975-01-17	1977-02-22	American Cyanamid Company	1,2-Dialkyl-3,4,5-trisubstituted pyrazolium salts as fungicidal agents
US4041046A (en)	1975-06-06	1977-08-09	American Cyanamid Company	1,2-Dialkyl-3,4,5-trisubstituted pyrazole compounds
US4000301A (en)	1975-11-14	1976-12-28	American Cyanamid Company	Fungicidal use of 4-alkoxypyrazoles
KR0166088B1 (ko)	1990-01-23	1999-01-15	.	수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
US5376645A (en) *	1990-01-23	1994-12-27	University Of Kansas	Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
JPH0565237A (ja)	1991-09-10	1993-03-19	Mitsubishi Heavy Ind Ltd	メタノールを媒体としたエネルギ供給方法
FR2682379B1 (fr) *	1991-10-09	1994-02-11	Rhone Poulenc Agrochimie	Nouveaux phenylpyrazoles fongicides.
WO1994022830A1 (en)	1993-03-31	1994-10-13	Smithkline Beecham Corporation	Chemical compounds
FR2707295A1 (fr)	1993-06-07	1995-01-13	Rhone Poulenc Agrochimie	Fongicides pyrazoles substitués en position 3 par un hétérocycle.
DE69408950T2 (de)	1993-12-14	1998-10-15	Mitsubishi Chem Corp	N-Pyrazolylcarbamatderivate und Fungizide für Landwirtschaft und Gartenbau, die diese als aktive Bestandteile erhalten, Produktion und Zwischenprodukte
FR2722369B1 (fr)	1994-07-13	1998-07-10	Rhone Poulenc Agrochimie	Compositions fongicides a base de derives 3-phenyl-pyrazoles pour le traitement du materiel vegetal de multiplication, nouveaux derives 3-phenyl-pyrazoles et leurs applications fongicides
MX9702030A (es)	1994-09-26	1997-06-28	Shionogi & Co	Derivado de imidazol.
TW343232B (en) *	1994-10-13	1998-10-21	Chisso Corp	Difluorooxymethane derivative and liquid crystal composition
GB9711643D0 (en)	1997-06-05	1997-07-30	Janssen Pharmaceutica Nv	Glass thermoplastic systems
CA2876779A1 (en) *	2000-05-12	2001-11-22	Genzyme Corporation	Modulators of tnf-.alpha. signaling
GB0016787D0 (en) *	2000-07-07	2000-08-30	Pfizer Ltd	Compounds useful in therapy
JP3806090B2 (ja) *	2001-04-10	2006-08-09	ファイザー・インク	Ｈｉｖ関連疾患治療用のピラゾール誘導体

2002
- 2002-04-04 JP JP2002583387A patent/JP3806090B2/ja not_active Expired - Lifetime
- 2002-04-04 SK SK1244-2003A patent/SK287858B6/sk unknown
- 2002-04-04 ES ES02708600T patent/ES2283532T3/es not_active Expired - Lifetime
- 2002-04-04 AU AU2002242926A patent/AU2002242926B2/en not_active Expired
- 2002-04-04 CZ CZ2003-2676A patent/CZ305099B6/cs not_active IP Right Cessation
- 2002-04-04 EP EP02708600A patent/EP1377556B1/en not_active Expired - Lifetime
- 2002-04-04 ES ES06126433T patent/ES2385659T3/es not_active Expired - Lifetime
- 2002-04-04 DK DK02708600T patent/DK1377556T3/da active
- 2002-04-04 PL PL365026A patent/PL216985B1/pl unknown
- 2002-04-04 PL PL396946A patent/PL217224B1/pl unknown
- 2002-04-04 KR KR1020037013352A patent/KR100569324B1/ko not_active Expired - Fee Related
- 2002-04-04 MX MXPA03009380A patent/MXPA03009380A/es active IP Right Grant
- 2002-04-04 OA OA1200300258A patent/OA12501A/en unknown
- 2002-04-04 BR BR0208811-8 patent/BRPI0208811B8/pt not_active IP Right Cessation
- 2002-04-04 PT PT02708600T patent/PT1377556E/pt unknown
- 2002-04-04 AT AT02708600T patent/ATE358669T1/de active
- 2002-04-04 DE DE60219292T patent/DE60219292T2/de not_active Expired - Lifetime
- 2002-04-04 IL IL15787502A patent/IL157875A0/xx unknown
- 2002-04-04 EA EA200300943A patent/EA007184B1/ru not_active IP Right Cessation
- 2002-04-04 RS YUP-775/03A patent/RS51166B/sr unknown
- 2002-04-04 NZ NZ529403A patent/NZ529403A/en not_active IP Right Cessation
- 2002-04-04 HR HR20030783A patent/HRP20030783B1/xx not_active IP Right Cessation
- 2002-04-04 CN CNB028116259A patent/CN100408564C/zh not_active Expired - Lifetime
- 2002-04-04 EE EEP200300497A patent/EE05400B1/xx unknown
- 2002-04-04 HU HU0303735A patent/HU229025B1/hu unknown
- 2002-04-04 CA CA002443449A patent/CA2443449C/en not_active Expired - Lifetime
- 2002-04-04 WO PCT/IB2002/001234 patent/WO2002085860A1/en not_active Ceased
- 2002-04-04 ME MEP-758/08A patent/ME00558A/xx unknown
- 2002-04-04 SI SI200230986T patent/SI1762567T1/sl unknown
- 2002-04-04 EP EP06126433A patent/EP1762567B1/en not_active Expired - Lifetime
- 2002-04-04 DK DK06126433.9T patent/DK1762567T3/da active
- 2002-04-04 GE GE5299A patent/GEP20053619B/en unknown
- 2002-04-04 SI SI200230529T patent/SI1377556T1/sl unknown
- 2002-04-04 PL PL398536A patent/PL217629B1/pl unknown
- 2002-04-04 AT AT06126433T patent/ATE556059T1/de active
- 2002-04-04 PT PT06126433T patent/PT1762567E/pt unknown
- 2002-04-05 US US10/118,512 patent/US7109228B2/en not_active Expired - Lifetime
- 2002-04-08 AR ARP020101281A patent/AR037319A1/es active IP Right Grant
- 2002-04-08 MY MYPI20021264A patent/MY146669A/en unknown
- 2002-04-09 TW TW091107115A patent/TWI333488B/zh not_active IP Right Cessation
- 2002-04-09 UY UY27248A patent/UY27248A1/es not_active IP Right Cessation
- 2002-04-10 PE PE2002000297A patent/PE20021056A1/es active IP Right Grant
- 2002-04-10 DO DO2002000378A patent/DOP2002000378A/es unknown
- 2002-04-10 PA PA20028543601A patent/PA8543601A1/es unknown
2003
- 2003-09-04 IS IS6939A patent/IS2734B/is unknown
- 2003-09-09 CR CR7069A patent/CR7069A/es unknown
- 2003-09-11 IL IL157875A patent/IL157875A/en active IP Right Grant
- 2003-10-06 MA MA27336A patent/MA27009A1/fr unknown
- 2003-10-08 BG BG108244A patent/BG66349B1/bg unknown
- 2003-10-09 NO NO20034523A patent/NO326518B1/no not_active IP Right Cessation
2005
- 2005-06-20 US US11/157,340 patent/US7435728B2/en not_active Expired - Lifetime
2007
- 2007-05-10 CY CY20071100627T patent/CY1107626T1/el unknown
2008
- 2008-08-25 US US12/197,655 patent/US8063044B2/en not_active Expired - Fee Related
2010
- 2010-03-19 AR ARP100100890A patent/AR076259A2/es active IP Right Grant
2011
- 2011-10-07 US US13/269,278 patent/US20120029192A1/en not_active Abandoned
2012
- 2012-06-27 CY CY20121100571T patent/CY1113515T1/el unknown

Also Published As

Publication number	Publication date
PL398536A1 (pl)	2012-06-04
EP1762567B1 (en)	2012-05-02
DOP2002000378A (es)	2002-10-15
EP1377556B1 (en)	2007-04-04
DE60219292D1 (de)	2007-05-16
NO20034523D0 (no)	2003-10-09
CN100408564C (zh)	2008-08-06
DK1377556T3 (da)	2007-07-16
EE200300497A (et)	2004-02-16
IL157875A (en)	2010-05-17
YU77503A (sh)	2006-05-25
HK1063781A1 (zh)	2005-01-14
IL157875A0 (en)	2004-03-28
EP1762567A1 (en)	2007-03-14
KR100569324B1 (ko)	2006-04-07
US20120029192A1 (en)	2012-02-02
UY27248A1 (es)	2002-11-29
US8063044B2 (en)	2011-11-22
PL396946A1 (pl)	2012-01-02
WO2002085860A1 (en)	2002-10-31
SK12442003A3 (sk)	2004-12-01
HRP20030783A2 (en)	2005-08-31
ES2283532T3 (es)	2007-11-01
EP1377556A1 (en)	2004-01-07
US20030100554A1 (en)	2003-05-29
EA007184B1 (ru)	2006-08-25
SI1377556T1 (sl)	2007-08-31
HU229025B1 (en)	2013-07-29
JP2004531535A (ja)	2004-10-14
AR076259A2 (es)	2011-06-01
BRPI0208811B1 (pt)	2018-03-13
CZ305099B6 (cs)	2015-05-06
CY1113515T1 (el)	2016-06-22
US20060020012A1 (en)	2006-01-26
CZ20032676A3 (cs)	2004-11-10
CA2443449A1 (en)	2002-10-31
CA2443449C (en)	2008-11-04
BG66349B1 (bg)	2013-08-30
GEP20053619B (en)	2005-09-26
EE05400B1 (et)	2011-04-15
HRP20030783B1 (hr)	2011-11-30
PL217224B1 (pl)	2014-06-30
PT1377556E (pt)	2007-06-06
US7109228B2 (en)	2006-09-19
DK1762567T3 (da)	2012-06-25
MA27009A1 (fr)	2004-12-20
PE20021056A1 (es)	2002-12-03
SK287858B6 (sk)	2012-01-04
MY146669A (en)	2012-09-14
AU2002242926B2 (en)	2007-10-11
PL216985B1 (pl)	2014-06-30
RS51166B (sr)	2010-10-31
KR20040007496A (ko)	2004-01-24
AR037319A1 (es)	2004-11-03
HUP0303735A3 (en)	2004-07-28
US7435728B2 (en)	2008-10-14
BG108244A (bg)	2005-04-30
DE60219292T2 (de)	2008-04-10
PL365026A1 (en)	2004-12-27
IS2734B (is)	2011-04-15
CY1107626T1 (el)	2013-04-18
CR7069A (es)	2007-12-17
MXPA03009380A (es)	2004-04-21
ATE556059T1 (de)	2012-05-15
OA12501A (en)	2006-05-26
PT1762567E (pt)	2012-07-16
HUP0303735A2 (hu)	2004-03-01
NZ529403A (en)	2005-06-24
PL217629B1 (pl)	2014-08-29
TWI333488B (en)	2010-11-21
US20090215712A1 (en)	2009-08-27
JP3806090B2 (ja)	2006-08-09
CN1514828A (zh)	2004-07-21
NO20034523L (no)	2003-12-09
ATE358669T1 (de)	2007-04-15
IS6939A (is)	2003-09-04
EA200300943A1 (ru)	2004-08-26
NO326518B1 (no)	2008-12-22
ES2385659T3 (es)	2012-07-27
BR0208811A (pt)	2004-03-09
BRPI0208811B8 (pt)	2021-05-25
SI1762567T1 (sl)	2012-08-31
PA8543601A1 (es)	2002-10-31

Publication	Publication Date	Title
ME00558A (en)	2011-12-20	Pyrazole derivatives for treating hiv
DK1353911T3 (da)	2011-07-18	Antivirale midler
YU45095A (sh)	1999-03-04	Derivati benzimidazola, postupci za njihovo prirpremanje i primena tih derivata u medicinskoj terapiji, naročito za lečenje ili sprečavanje virusnih infekcija
ATE383339T1 (de)	2008-01-15	Amin-derivate zur behandlung von apoptosis
EA200900358A1 (ru)	2009-10-30	Энантиомерно чистые фосфоиндолы в качестве ингибиторов hiv
EA200600225A1 (ru)	2006-08-25	Производные пиперазина для лечения вич инфекций
BRPI0108395B8 (pt)	2021-05-25	derivados de pirrolopirimidinona, processos de preparação e uso
HRP20041137B1 (hr)	2014-11-21	Indolni, azaindolni i srodni heterocikliäśni 4-alkenil piperidinski amidi
ES2165269A1 (es)	2002-03-01	Derivados de alfa-cetoamidas.
BR0314860A (pt)	2005-08-02	Derivados de pirazol
ATE386741T1 (de)	2008-03-15	Pyrazolamide zur behandlung von hiv-infektionen
AR043271A1 (es)	2005-07-27	Compuestos de dihidropironas con heterociclos unidos y su uso en composicines farmaceuticas que poseen actividad inhibidora de hiv proteasa
BG98238A (bg)	1995-02-28	Заместени бензотиазолови производни,получаванетоим и приложението им като хербициди
BR0314709A (pt)	2005-07-26	Derivados de pirazol
DK0944618T3 (da)	2004-02-02	Nye N-benzensulfonyl-L-prolin-derivater, fremgangsmåde til deres fremstilling og deres anvendelse til terapeutiske formål
EA200500287A1 (ru)	2005-10-27	Производные 4-(3, 5-дицианофенокси)пиразола для применения в качестве модуляторов обратной транскриптазы в лечении, в числе прочего, вич-инфекции
BR0314930A (pt)	2005-08-02	Derivados de pirazol e seu uso como agentes terapêuticos para doenças mediadas por hiv