EE04022B1 - Trombiini inhibiitorite eelravimid, nende valmistamise protsess, neid sisaldav ravimpreparaat ja nende kasutamine raviks - Google Patents

Trombiini inhibiitorite eelravimid, nende valmistamise protsess, neid sisaldav ravimpreparaat ja nende kasutamine raviks

Info

Publication number: EE04022B1
Authority: EE; Estonia
Prior art keywords: prodrugs; therapy; preparation; pharmaceutical formulation; formulation containing
Prior art date: 1995-12-21

Application number

EE9800187A

Other languages

English (en)

Other versions

EE9800187A (et

Inventor

Antonsson Thomas

Gustafsson David

Hoffmann Kurt-J�rgen

Nystr�m Jan-Erik

S�rensen Henrik

Sell�n Mikael

Original Assignee

Astra Aktiebolag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-12-21

Filing date

1996-12-17

Publication date

2003-04-15

1995-12-21 Priority claimed from GB9526273A external-priority patent/GB9526273D0/en

1996-02-15 Priority claimed from SE9600556A external-priority patent/SE9600556D0/xx

1996-12-17 Application filed by Astra Aktiebolag filed Critical Astra Aktiebolag

1998-12-15 Publication of EE9800187A publication Critical patent/EE9800187A/et

2003-04-15 Publication of EE04022B1 publication Critical patent/EE04022B1/et

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Diabetes (AREA)
Hematology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

EE9800187A 1995-12-21 1996-12-17 Trombiini inhibiitorite eelravimid, nende valmistamise protsess, neid sisaldav ravimpreparaat ja nende kasutamine raviks EE04022B1 (et)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB9526273A GB9526273D0 (en)	1995-12-21	1995-12-21	New prodrugs
SE9600556A SE9600556D0 (sv)	1996-02-15	1996-02-15	New prodrugs
PCT/SE1996/001680 WO1997023499A1 (en)	1995-12-21	1996-12-17	Prodrugs of thrombin inhibitors

Publications (2)

Publication Number	Publication Date
EE9800187A EE9800187A (et)	1998-12-15
EE04022B1 true EE04022B1 (et)	2003-04-15

Family

ID=26308368

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EE9800187A EE04022B1 (et)	1995-12-21	1996-12-17	Trombiini inhibiitorite eelravimid, nende valmistamise protsess, neid sisaldav ravimpreparaat ja nende kasutamine raviks

Country Status (29)

Country	Link
US (4)	US5965692A (et)
EP (3)	EP0869966B1 (et)
JP (1)	JP2000504313A (et)
KR (1)	KR100458545B1 (et)
AR (1)	AR005245A1 (et)
AT (2)	ATE291031T1 (et)
BR (1)	BR9612148A (et)
CA (1)	CA2238737A1 (et)
DE (3)	DE69634492T2 (et)
DK (2)	DK0869966T3 (et)
EE (1)	EE04022B1 (et)
ES (2)	ES2128283T3 (et)
HU (1)	HUP9900115A3 (et)
IL (1)	IL124857A0 (et)
IS (1)	IS1836B (et)
LU (1)	LU91172I2 (et)
MX (1)	MX9804623A (et)
MY (1)	MY121222A (et)
NL (1)	NL300179I2 (et)
NO (1)	NO982809L (et)
NZ (2)	NZ324902A (et)
PL (1)	PL187468B1 (et)
PT (1)	PT995755E (et)
RU (1)	RU2176644C2 (et)
SI (2)	SI0995755T1 (et)
SK (1)	SK285588B6 (et)
TR (1)	TR199801151T2 (et)
TW (2)	TWI238827B (et)
WO (1)	WO1997023499A1 (et)

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AR005245A1 (es)	1995-12-21	1999-04-28	Astrazeneca Ab	Prodrogas de inhibidores de trombina, una formulación farmaceutica que las comprende, el uso de dichas prodrogas para la manufactura de un medicamento y un procedimiento para su preparacion

1996
- 1996-12-09 AR ARP960105567A patent/AR005245A1/es active IP Right Grant
- 1996-12-09 TW TW091115525A patent/TWI238827B/zh active
- 1996-12-09 TW TW085115209A patent/TW541316B/zh active
- 1996-12-17 SI SI9630364T patent/SI0995755T1/xx unknown
- 1996-12-17 DE DE69634492T patent/DE69634492T2/de not_active Expired - Lifetime
- 1996-12-17 JP JP9523571A patent/JP2000504313A/ja active Pending
- 1996-12-17 DE DE69614579T patent/DE69614579T2/de not_active Expired - Lifetime
- 1996-12-17 PT PT99120315T patent/PT995755E/pt unknown
- 1996-12-17 CA CA002238737A patent/CA2238737A1/en not_active Abandoned
- 1996-12-17 EP EP96943446A patent/EP0869966B1/en not_active Expired - Lifetime
- 1996-12-17 NZ NZ324902A patent/NZ324902A/en not_active IP Right Cessation
- 1996-12-17 WO PCT/SE1996/001680 patent/WO1997023499A1/en not_active Ceased
- 1996-12-17 ES ES96943446T patent/ES2128283T3/es not_active Expired - Lifetime
- 1996-12-17 ES ES99120315T patent/ES2163916T3/es not_active Expired - Lifetime
- 1996-12-17 DE DE122004000046C patent/DE122004000046I2/de active Active
- 1996-12-17 AT AT96943446T patent/ATE291031T1/de active
- 1996-12-17 DK DK96943446T patent/DK0869966T3/da active
- 1996-12-17 NZ NZ504245A patent/NZ504245A/en not_active IP Right Cessation
- 1996-12-17 AT AT99120315T patent/ATE204292T1/de active
- 1996-12-17 IL IL12485796A patent/IL124857A0/xx unknown
- 1996-12-17 US US08/776,231 patent/US5965692A/en not_active Expired - Lifetime
- 1996-12-17 PL PL96327569A patent/PL187468B1/pl not_active IP Right Cessation
- 1996-12-17 DK DK99120315T patent/DK0995755T3/da active
- 1996-12-17 RU RU98111148/04A patent/RU2176644C2/ru not_active IP Right Cessation
- 1996-12-17 BR BR9612148A patent/BR9612148A/pt active Search and Examination
- 1996-12-17 HU HU9900115A patent/HUP9900115A3/hu unknown
- 1996-12-17 EE EE9800187A patent/EE04022B1/et not_active IP Right Cessation
- 1996-12-17 TR TR1998/01151T patent/TR199801151T2/xx unknown
- 1996-12-17 EP EP05000116A patent/EP1533318A1/en not_active Withdrawn
- 1996-12-17 KR KR10-1998-0704728A patent/KR100458545B1/ko not_active Expired - Fee Related
- 1996-12-17 SK SK821-98A patent/SK285588B6/sk not_active IP Right Cessation
- 1996-12-17 EP EP99120315A patent/EP0995755B1/en not_active Expired - Lifetime
- 1996-12-17 SI SI9630712T patent/SI0869966T1/xx unknown
- 1996-12-19 MY MYPI96005362A patent/MY121222A/en unknown
1998
- 1998-05-26 IS IS4756A patent/IS1836B/is unknown
- 1998-06-09 MX MX9804623A patent/MX9804623A/es not_active IP Right Cessation
- 1998-06-18 NO NO982809A patent/NO982809L/no not_active Application Discontinuation
1999
- 1999-07-15 US US09/353,644 patent/US6262028B1/en not_active Expired - Fee Related
2002
- 2002-02-14 US US10/074,008 patent/US20020142968A1/en not_active Abandoned
2004
- 2004-02-12 US US10/776,245 patent/US7354905B2/en not_active Expired - Fee Related
2005
- 2005-03-03 NL NL300179C patent/NL300179I2/nl unknown
- 2005-05-11 LU LU91172C patent/LU91172I2/fr unknown

Also Published As

Publication number	Publication date
NZ504245A (en)	2004-11-26
CA2238737A1 (en)	1997-07-03
SI0869966T1 (en)	2005-08-31
LU91172I2 (fr)	2005-07-11
IL124857A0 (en)	1999-01-26
AU706350B2 (en)	1999-06-17
DK0869966T3 (da)	2005-06-20
RU2176644C2 (ru)	2001-12-10
US7354905B2 (en)	2008-04-08
AR005245A1 (es)	1999-04-28
DE69614579T2 (de)	2002-06-27
PT995755E (pt)	2002-02-28
US6262028B1 (en)	2001-07-17
NL300179I2 (nl)	2005-06-01
US5965692A (en)	1999-10-12
EP0869966B1 (en)	2005-03-16
IS4756A (is)	1998-05-26
DE69634492T2 (de)	2006-04-13
ES2163916T3 (es)	2002-02-01
BR9612148A (pt)	1999-07-13
EP0995755A1 (en)	2000-04-26
US20020142968A1 (en)	2002-10-03
KR100458545B1 (ko)	2005-01-15
NO982809D0 (no)	1998-06-18
KR19990076624A (ko)	1999-10-15
MX9804623A (es)	1998-10-31
JP2000504313A (ja)	2000-04-11
EP0995755B1 (en)	2001-08-16
HK1026214A1 (en)	2000-12-08
TW541316B (en)	2003-07-11
NL300179I1 (nl)	2005-05-02
SK82198A3 (en)	1998-12-02
ES2128283T3 (es)	2005-09-01
SI0995755T1 (en)	2002-02-28
ATE204292T1 (de)	2001-09-15
HUP9900115A2 (hu)	1999-05-28
EP1533318A1 (en)	2005-05-25
WO1997023499A1 (en)	1997-07-03
DK0995755T3 (da)	2001-11-12
DE69634492D1 (de)	2005-04-21
HUP9900115A3 (en)	1999-11-29
AU1217897A (en)	1997-07-17
DE122004000046I2 (de)	2011-06-16
TWI238827B (en)	2005-09-01
US20040162410A1 (en)	2004-08-19
ATE291031T1 (de)	2005-04-15
IS1836B (is)	2002-11-25
DE69614579D1 (de)	2001-09-20
ES2128283T1 (es)	1999-05-16
DE122004000046I1 (de)	2005-04-21
TR199801151T2 (xx)	1998-08-21
HK1016610A1 (en)	1999-11-05
NZ324902A (en)	2000-06-23
MY121222A (en)	2006-01-28
PL187468B1 (pl)	2004-07-30
EE9800187A (et)	1998-12-15
SK285588B6 (sk)	2007-04-05
EP0869966A1 (en)	1998-10-14
NO982809L (no)	1998-08-20
PL327569A1 (en)	1998-12-21

Publication	Publication Date	Title
EE04022B1 (et)	2003-04-15	Trombiini inhibiitorite eelravimid, nende valmistamise protsess, neid sisaldav ravimpreparaat ja nende kasutamine raviks
EE04399B1 (et)	2004-12-15	Spiroasabitsüklilised heterotsüklilised ühendid, nende valmistamise protsess, neid sisaldavad ravimkoostised ja nende kasutamine ravis
EE04463B1 (et)	2005-04-15	3-arüülpropaanhappe derivaadid ja nende analoogid, nende valmistamise meetod, neid sisaldavad ravimkoostised ja ühendid kasutamiseks ravis
EE04021B1 (et)	2003-04-15	7a-( -aminoalküül)östratrieenid, nende valmistamise meetod, 7a-( -aminoalküül)östratrieene sisaldavad farmatseutilised preparaadid ja nende kasutamine ravimite valmistamiseks
EE05134B1 (et)	2009-02-16	Adamantaani derivaadid, meetod nende valmistamiseks, neid sisaldavad ravimkoostised ja nende kasutamine ravis
EE04273B1 (et)	2004-04-15	Bensotsüklohepteenid, nende valmistamise meetod, neid sisaldavad farmatseutilised preparaadid ja nende kasutamine ravimite valmistamiseks
FI973278A0 (fi)	1997-08-08	Uudet farnesyylitransferaasin inhibiittorit, niiden valmistus ja niitä sisältävät farmaseuttiset valmisteet
EE9800028A (et)	1998-08-17	Iprotroopiumsoolad, neid sisaldavad ravimkompositsioonid ja nende kasutamine
IS2156B (is)	2006-11-15	Settar bensensúlfonamíðafleiður sem forlyf fyrir COX-2 tálma, aðferð til þess að búa þær til, lyfjasamsetningar sem innihalda þær og notkun þeirra við framleiðslu lyfja
EE04238B1 (et)	2004-02-16	Asendatud 1,2,3,4-tetrahüdronaftaleeni derivaadid, meetod selle valmistamiseks, nimetatud terapeutilise toimega aineid sisaldavad ravimkoostised ja nimetatud aktiivsete ühendite kasutamine teraapias
EE9700141A (et)	1997-12-15	Piperasiinderivaadid, neid sisaldavad ravimid, nende kasutamine ja valmistamise meetod
EE9700145A (et)	1998-02-16	Tsükloalkaanpüridiinid, nende valmistamismeetod, kasutamine ravimite tootmiseks ja nimetatud ühendeid sisaldavad ravimid
FI964028L (fi)	1996-10-08	Uusi farmaseuttinen formulaatio ja menetelmä
FI973039A7 (fi)	1997-07-17	Uusia farnesyylitransferaasin inhibiittoreita, niiden valmistus ja niitä sisältäviä farmaseuttisia koostumuksia
FI973279A0 (fi)	1997-08-08	Uudet farnesyylitransferaasin inhibiittorit, niiden valmistus ja niitä sisältävät farmaseuttiset koostumukset
FI964920A7 (fi)	1996-12-09	Uudet farnesyylitransferaasin inhibiittorit, niiden valmistus ja niitä sisältävät farmaseuttiset valmisteet
NO20016198D0 (no)	2001-12-18	Orale farmasöytiske sammensetninger som inneholder taxaner og fremgangsmåter for anvendelse av samme i behandling
EE9700060A (et)	1997-10-15	2-arüül-asendatud püridiinid,nende valmistamismeetod, kasutamine ravimite valmistamiseks ja nimetatud ühendeid sisaldavad ravimid
EE9700153A (et)	1998-02-16	Heterotsükliga kondenseerunud püridiinid, nende valmistamismeetod, kasutamine ravimite valmistamiseks ja nimetatud ühendeid sisaldavad ravimid
EE03399B1 (et)	2001-04-16	Teraapias kasutatavad spiro-asabitsüklilised ühendid ja nende valmistamise protsess
FI953898L (fi)	1996-02-20	Glysiiniamidijohdannaisia, menetelmiä niiden valmistamiseksi ja niitä sisältäviä lääkeaineita
BR9611137A (pt)	1999-03-30	Composições e métodos para distribuição bucal de agentes farmacêuticos
EE9700061A (et)	1997-08-15	Farmatseutiline aerosoolpreparaat ja selle valmistamismeetod
HUP9802315A3 (en)	1999-03-01	Thrombin inhibitors, process for producing them and use of them for producing pharmaceutical compositions
IL119466A (en)	2001-08-26	Thrombin inhibitors, their preparation and pharmaceutical compositions containing them

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