[go: up one dir, main page]

EE03952B1 - Tagasivoolu inhibiitorid - Google Patents

Tagasivoolu inhibiitorid

Info

Publication number
EE03952B1
EE03952B1 EEP199900095A EE9900095A EE03952B1 EE 03952 B1 EE03952 B1 EE 03952B1 EE P199900095 A EEP199900095 A EE P199900095A EE 9900095 A EE9900095 A EE 9900095A EE 03952 B1 EE03952 B1 EE 03952B1
Authority
EE
Estonia
Prior art keywords
reflux inhibitors
reflux
inhibitors
Prior art date
Application number
EEP199900095A
Other languages
English (en)
Other versions
EE9900095A (et
Inventor
L. R. Andrews Paul
Lehmann Anders
Original Assignee
Astra Aktiebolag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=20403936&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EE03952(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astra Aktiebolag filed Critical Astra Aktiebolag
Publication of EE9900095A publication Critical patent/EE9900095A/et
Publication of EE03952B1 publication Critical patent/EE03952B1/et

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G01N33/9406—Neurotransmitters
    • G01N33/9426—GABA, i.e. gamma-amino-butyrate
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
EEP199900095A 1996-09-18 1997-09-15 Tagasivoolu inhibiitorid EE03952B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9603408A SE9603408D0 (sv) 1996-09-18 1996-09-18 Medical use
PCT/SE1997/001555 WO1998011885A1 (en) 1996-09-18 1997-09-15 Reflux inhibitors

Publications (2)

Publication Number Publication Date
EE9900095A EE9900095A (et) 1999-10-15
EE03952B1 true EE03952B1 (et) 2003-02-17

Family

ID=20403936

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP199900095A EE03952B1 (et) 1996-09-18 1997-09-15 Tagasivoolu inhibiitorid

Country Status (34)

Country Link
US (2) US6117908A (et)
EP (2) EP0936906B1 (et)
JP (1) JP4098832B2 (et)
KR (2) KR100568659B1 (et)
CN (1) CN1117560C (et)
AR (1) AR007747A1 (et)
AT (2) ATE249212T1 (et)
AU (1) AU714370B2 (et)
BR (1) BR9711400A (et)
CA (1) CA2265615C (et)
CZ (1) CZ299997B6 (et)
DE (2) DE69736445T2 (et)
DK (2) DK1344524T3 (et)
EE (1) EE03952B1 (et)
ES (2) ES2206749T3 (et)
HU (1) HU224968B1 (et)
ID (1) ID19621A (et)
IL (1) IL128961A (et)
IS (2) IS2329B (et)
MY (1) MY122020A (et)
NO (1) NO326837B1 (et)
NZ (2) NZ334495A (et)
PL (1) PL190028B1 (et)
PT (2) PT936906E (et)
RU (1) RU2199316C2 (et)
SA (1) SA97180522B1 (et)
SE (1) SE9603408D0 (et)
SI (2) SI0936906T1 (et)
SK (1) SK285744B6 (et)
TR (1) TR199900591T2 (et)
TW (1) TW548104B (et)
UA (1) UA61081C2 (et)
WO (1) WO1998011885A1 (et)
ZA (1) ZA977969B (et)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12161695B2 (en) * 2018-02-22 2024-12-10 Diamyd Medical Ab GABA A receptor agonists for treatment of disorders influenced by dysfunction BETA cells

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0934061B3 (en) 1996-07-24 2015-01-21 Warner-Lambert Company LLC Isobutylgaba and its derivatives for the treatment of pain
WO1999008670A1 (en) 1997-08-20 1999-02-25 Guglietta, Antonio Gaba analogs to prevent and treat gastrointestinal damage
US6127418A (en) * 1997-08-20 2000-10-03 Warner-Lambert Company GABA analogs to prevent and treat gastrointestinal damage
EP0974351A3 (en) * 1998-04-24 2000-12-13 Jouveinal Medicament for preventing and treating gastrointestinal damage
US7164034B2 (en) 1999-06-10 2007-01-16 Pfizer Inc. Alpha2delta ligands for fibromyalgia and other disorders
US20080207755A1 (en) * 2000-05-31 2008-08-28 Pfizer Inc Alpha 2 Delta Ligands For Fibromyalgia and Other Disorders
SE9904507D0 (sv) 1999-12-09 1999-12-09 Astra Ab New compounds
US7319095B2 (en) 1999-12-09 2008-01-15 Astrazeneca Ab Use of GABAB receptor agonists
SE9904508D0 (sv) 1999-12-09 1999-12-09 Astra Ab New compounds
TWI256314B (en) * 2000-02-09 2006-06-11 Mitsubishi Pharma Corp Preventive-therapeutical medicament for gastroesophageal reflux disease
EP1401423A4 (en) * 2001-05-29 2006-08-16 Depomed Dev Ltd METHOD FOR THE TREATMENT OF GASTROÖSOPHAGEAL REFLUX DISEASE AND NURSING ACID BREAKDOWN
AR033779A1 (es) 2001-06-08 2004-01-07 Astrazeneca Ab Compuestos utiles en la enfermedad de reflujo
SE0102058D0 (sv) * 2001-06-08 2001-06-08 Astrazeneca Ab New Salts II
SE0102057D0 (sv) * 2001-06-08 2001-06-08 Astrazeneca Ab New Salts I
SE0102055D0 (sv) * 2001-06-08 2001-06-08 Astrazeneca Ab New Compounds
GB0209481D0 (en) * 2002-04-24 2002-06-05 Novartis Ag Organic compounds
SE0201939D0 (sv) * 2002-06-20 2002-06-20 Astrazeneca Ab New combination
SE0201940D0 (sv) * 2002-06-20 2002-06-20 Astrazeneca Ab New combination II
SE0201943D0 (sv) * 2002-06-20 2002-06-20 Astrazeneca Ab New use
US7964609B2 (en) * 2002-06-20 2011-06-21 Astrazeneca Ab Use of mGluR5 antagonists for the treatment of gerd
GB0226434D0 (en) * 2002-11-13 2002-12-18 Astrazeneca Ab Combination product
WO2004054566A1 (en) * 2002-12-13 2004-07-01 Warner-Lambert Company Llc Pregabalin derivatives for the treatment of fibromyalgia and other disorders
MXPA06001876A (es) * 2003-08-20 2006-05-17 Xenoport Inc Prodrogas de aciloxialquil carbamato, metodos de sintesis y uso.
NZ545719A (en) * 2003-08-20 2010-03-26 Xenoport Inc Prodrugs of the GABA analog baclofen, methods of synthesis and use
EP2354120A1 (en) 2003-08-20 2011-08-10 XenoPort, Inc. Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
CN1849336A (zh) * 2003-09-12 2006-10-18 詹森药业有限公司 嵌合gabab受体
ATE516801T1 (de) * 2003-10-14 2011-08-15 Xenoport Inc Kristalline form eines gamma-aminobuttersäure- analogons
GB0327186D0 (en) * 2003-11-21 2003-12-24 Novartis Ag Organic compounds
US20050220873A1 (en) * 2004-04-02 2005-10-06 Chien-Hsuan Han Pharmaceutical dosage forms having immediate and controlled release properties that contain a GABAB receptor agonist
US20050220863A1 (en) * 2004-04-02 2005-10-06 Chien-Hsuan Han Pharmaceutical dosage forms having controlled release properties that contain a GABAB receptor agonist
US8007827B2 (en) * 2004-04-02 2011-08-30 Impax Laboratories, Inc. Pharmaceutical dosage forms having immediate release and/or controlled release properties
US20050226927A1 (en) * 2004-04-02 2005-10-13 Impax Laboratories, Inc. Pharmaceutical dosage forms having immediate release and/or controlled release properties that contain a GABAB receptor agonist
SE0401653D0 (sv) 2004-06-24 2004-06-24 Astrazeneca Ab New compounds
WO2006050472A2 (en) * 2004-11-03 2006-05-11 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphonous and -phosphinic acids
WO2006050471A2 (en) * 2004-11-03 2006-05-11 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs of sulfinic acids, methods of synthesis, and use
WO2006071186A1 (en) * 2004-12-27 2006-07-06 Astrazeneca Ab Use of gabab receptor agonists
EP1966154A4 (en) * 2005-12-23 2011-01-26 Astrazeneca Ab IMIDAZOLE DERIVATIVES FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS
KR20080090449A (ko) * 2005-12-23 2008-10-08 아스트라제네카 아베 Ｇｅｒｄ 및 ｉｂｓ의 치료를 위한 피라졸
WO2007073300A1 (en) * 2005-12-23 2007-06-28 Astrazeneca Ab Gaba-b receptor modulators
AU2006327313A1 (en) * 2005-12-23 2007-06-28 Astrazeneca Ab Heterocyclic GABA-B modulators
BRPI0620373A2 (pt) * 2005-12-23 2011-11-08 Astrazeneca Ab composto e sais farmaceuticamente e farmacologicamente aceitáveis dos mesmos, e enantiÈmeros do composto e sais dos mesmos, uso dos mesmos, opcionalmente em combinação com um agonista do receptor de gabab,e , composição farmaceutica
US7585996B2 (en) * 2006-09-15 2009-09-08 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs, methods of synthesis and use
PL2124884T3 (pl) * 2006-12-22 2020-01-31 Ironwood Pharmaceuticals, Inc. Metody i kompozycje do leczenia zaburzeń przełyku
CA2674610C (en) * 2007-01-11 2013-06-18 Xenoport, Inc. Sustained release oral dosage forms of a prodrug of r-baclofen and methods of treatment
KR20100015648A (ko) * 2007-04-18 2010-02-12 아스트라제네카 아베 양성 알로스테릭 ｇａｂａｂ 수용체 조절제 효과를 갖는 크산틴 화합물
TW200908957A (en) * 2007-06-15 2009-03-01 Xenoport Inc Use of prodrugs of GABA analogs, antispasticity agents, and prodrugs of GABAB receptor agonists for treating spasticity
EP2217245A4 (en) * 2007-07-25 2011-01-12 Astrazeneca Ab USE OF (3-AMINO-2-FLUOROPROPYL) -PHOSPHIC ACID FOR THE TREATMENT OF NERD
US20090118365A1 (en) * 2007-11-06 2009-05-07 Xenoport, Inc Use of Prodrugs of GABA B Agonists for Treating Neuropathic and Musculoskeletal Pain
EP2250148B1 (en) 2008-01-25 2016-08-17 XenoPort, Inc. Crystalline form of calcium-salts of (3s)-aminomethyl-5-methyl-hexanoic acids and methods of use
TWI380812B (zh) * 2008-01-25 2013-01-01 Xenoport Inc （３ｓ）-胺甲基-５-甲基己酸前藥之晶形及使用方法
WO2009094577A2 (en) 2008-01-25 2009-07-30 Xenoport, Inc. Mesophasic forms of (3s)-aminomethyl-5-methyl-hexanoic acid prodrugs and methods of use
US20100137442A2 (en) * 2008-02-01 2010-06-03 Xenoport, Inc. Sustained Release Particulate Oral Dosage Forms of (R)-Baclofen and Methods of Treatment
US8993639B2 (en) * 2008-03-20 2015-03-31 Burt Shulman Compound and method for treatment of gastroesophageal reflux
US7989641B2 (en) 2008-08-07 2011-08-02 Xenoport, Inc. Methods of synthesizing N-hydroxysuccinimidyl carbonates
US8299291B2 (en) * 2008-08-07 2012-10-30 Xenoport, Inc. Methods of synthesizing 1-(acyloxy)-alkyl carbamate prodrugs
JP2012519212A (ja) 2009-03-03 2012-08-23 ゼノポート，インコーポレイティド Ｒ−バクロフェンプロドラッグの持効性放出経口投与形
EP2419401A2 (en) * 2009-04-17 2012-02-22 XenoPort, Inc. GAMMA-AMINO-BUTYRIC ACID DERIVATIVES AS GABAb RECEPTOR LIGANDS
WO2011113904A1 (en) 2010-03-17 2011-09-22 INSERM (Institut National de la Santé et de la Recherche Médicale) Medicaments for the prevention and treatment of a disease associated with retinal ganglion cell degeneration
US8580850B2 (en) 2011-08-11 2013-11-12 Xenoport, Inc. Anhydrous and hemihydrate crystalline forms of an (R)-baclofen prodrug, methods of synthesis and methods of use
WO2013180796A1 (en) 2012-06-01 2013-12-05 Lynn Health Science Institute, Inc. Methods for treating insomnia
TW202412754A (zh) * 2022-06-07 2024-04-01 瑞士商意梭凱普公司 應用於食道黏膜的包含逆流抑制劑的藥物傳遞系統

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0250572A1 (en) * 1986-01-03 1988-01-07 The University Of Melbourne Gastro-oesophageal reflux composition
NO882881L (no) * 1988-06-29 1990-01-02 Trond Nilsen Anordning for lengdekorrugering av metallplater.
GB8820266D0 (en) * 1988-08-26 1988-09-28 Smith Kline French Lab Compounds
AU5106790A (en) * 1989-02-03 1990-09-05 Cambridge Neuroscience Research, Inc. Method of screening and classifying compounds
GB9117716D0 (en) * 1991-08-16 1991-10-02 Lynxvale Ltd Gaba derivatives and their therapeutic application
ATE215365T1 (de) * 1992-01-22 2002-04-15 Glaxo Group Ltd Medizinische verwendung von atypischen beta- adrenoceptor agonisten
GB9408064D0 (en) * 1994-04-22 1994-06-15 Merck Sharp & Dohme Nucleic acids
US5491134A (en) * 1994-09-16 1996-02-13 Bristol-Myers Squibb Company Sulfonic, phosphonic or phosphiniic acid β3 agonist derivatives
US5656730A (en) * 1995-04-07 1997-08-12 Enzon, Inc. Stabilized monomeric protein compositions

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12161695B2 (en) * 2018-02-22 2024-12-10 Diamyd Medical Ab GABA A receptor agonists for treatment of disorders influenced by dysfunction BETA cells

Also Published As

Publication number Publication date
CN1237105A (zh) 1999-12-01
BR9711400A (pt) 1999-08-17
SK30599A3 (en) 2000-01-18
EE9900095A (et) 1999-10-15
ID19621A (id) 1998-07-23
ZA977969B (en) 1998-03-18
IL128961A (en) 2004-08-31
NO326837B1 (no) 2009-02-23
KR20050101237A (ko) 2005-10-20
ES2206749T3 (es) 2004-05-16
PT1344524E (pt) 2006-11-30
JP2001501604A (ja) 2001-02-06
IS2538B (is) 2009-09-15
SE9603408D0 (sv) 1996-09-18
EP1344524A1 (en) 2003-09-17
PL332497A1 (en) 1999-09-13
RU2199316C2 (ru) 2003-02-27
IS5001A (is) 1999-03-15
NO991287L (no) 1999-03-17
US6117908A (en) 2000-09-12
HK1057004A1 (en) 2004-03-12
US6664069B1 (en) 2003-12-16
EP0936906A1 (en) 1999-08-25
HK1022100A1 (en) 2000-07-28
EP0936906B1 (en) 2003-09-10
ATE249212T1 (de) 2003-09-15
AR007747A1 (es) 1999-11-10
SI1344524T1 (sl) 2006-12-31
CA2265615A1 (en) 1998-03-26
NO991287D0 (no) 1999-03-17
NZ334495A (en) 2000-09-29
WO1998011885A1 (en) 1998-03-26
KR100553294B1 (ko) 2006-02-22
TR199900591T2 (xx) 1999-07-21
SI0936906T1 (en) 2004-02-29
DK1344524T3 (da) 2006-10-30
AU4406497A (en) 1998-04-14
ES2268227T3 (es) 2007-03-16
IS8623A (is) 2007-03-19
TW548104B (en) 2003-08-21
HUP9903825A2 (hu) 2001-05-28
IS2329B (is) 2008-01-15
IL128961A0 (en) 2000-02-17
CZ299997B6 (cs) 2009-01-14
DE69724809T2 (de) 2004-07-15
DE69736445T2 (de) 2007-03-15
DK0936906T3 (da) 2003-11-24
NZ504244A (en) 2000-09-29
CN1117560C (zh) 2003-08-13
HUP9903825A3 (en) 2001-06-28
KR100568659B1 (ko) 2006-04-07
EP1344524B1 (en) 2006-08-02
PT936906E (pt) 2003-12-31
AU714370B2 (en) 1999-12-23
CA2265615C (en) 2007-01-30
CZ93099A3 (cs) 1999-09-15
DE69724809D1 (de) 2003-10-16
SK285744B6 (sk) 2007-07-06
SA97180522B1 (ar) 2006-04-04
HU224968B1 (en) 2006-04-28
JP4098832B2 (ja) 2008-06-11
UA61081C2 (uk) 2003-11-17
PL190028B1 (pl) 2005-10-31
KR20000036185A (ko) 2000-06-26
MY122020A (en) 2006-03-31
ATE334700T1 (de) 2006-08-15
DE69736445D1 (de) 2006-09-14

Similar Documents

Publication Publication Date Title
ATE334700T1 (de) Refluxinhibitoren
FI963597A7 (fi) Isoprenyylitransferaasi-inhibiittoreita
NO972930D0 (no) Fibronectin-adhesjonsinhibitorer
FI972160A0 (fi) Matriisimetalloproteaasi-inhibiittorit
ID19198A (id) Inhibitor metaloprotease heterosiklik
DK1004669T3 (da) Hidtil ukendte differentieringsinhibitor
NO20002121D0 (no) Benzotiazol-protein-tyrosin-kinaseinhibitorer
DK1027332T3 (da) Hidtil ukendte lactametalloproteaseinhibitorer
ID18416A (id) Inhibitor metaloprotease diheterosiklik
DK0958287T3 (da) Sulfamidmetalloprotease-inhibitorer
ID18141A (id) Inhibitor metaloprotease 1,3-diheterosiklik
LV12150A (lv) Farneziltransferazes inhibitori
ID18995A (id) Amida-amida inhibitor apo b-sekresi/mtp
ATE268781T1 (de) Thrombininhibitoren
NO20003256D0 (no) ACE inhibitor-MMP inhibitor kombinasjoner
ID18417A (id) Inhibitor ditentat metaloprotease
FI971156A0 (fi) 5alfa-reduktaasi-inhibiittoreita
PT948483E (pt) Inibidores da farnesil-transferase
ATE252547T1 (de) Matrixmetalloproteinaseinhibitoren
DE69733263D1 (de) Markierte elastase-inhibitoren
FI964781A7 (fi) Uusia elastaasi-inhibiittoreita
ATE282629T1 (de) Thrombininhibitoren
DE69720957T2 (de) Ace-hemmer
BR9610514A (pt) Inibidores cicloantihelmínticos
EP1007548A4 (en) THROMBIN INHIBITOR FROM TSE-TSE FLY

Legal Events

Date Code Title Description
KB4A Valid patent at the end of a year

Effective date: 20031231

KB4A Valid patent at the end of a year

Effective date: 20041231

KB4A Valid patent at the end of a year

Effective date: 20051231

KB4A Valid patent at the end of a year

Effective date: 20061231

KB4A Valid patent at the end of a year

Effective date: 20071231

KB4A Valid patent at the end of a year

Effective date: 20081231

KB4A Valid patent at the end of a year

Effective date: 20091231

KB4A Valid patent at the end of a year

Effective date: 20101231

MM4A Lapsed by not paying the annual fees

Effective date: 20120915