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ECSP11011243A - Agonistas y antagonistas de los receptores s1p5 y metodos de usos similares aplicaciones relacionadas - Google Patents

Agonistas y antagonistas de los receptores s1p5 y metodos de usos similares aplicaciones relacionadas

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Publication number
ECSP11011243A
ECSP11011243A EC2011011243A ECSP11011243A ECSP11011243A EC SP11011243 A ECSP11011243 A EC SP11011243A EC 2011011243 A EC2011011243 A EC 2011011243A EC SP11011243 A ECSP11011243 A EC SP11011243A EC SP11011243 A ECSP11011243 A EC SP11011243A
Authority
EC
Ecuador
Prior art keywords
methods
agonists
compounds
antagonists
receivers
Prior art date
Application number
EC2011011243A
Other languages
English (en)
Inventor
Christopher M Harris
Noel S Wilson
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of ECSP11011243A publication Critical patent/ECSP11011243A/es

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    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
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    • C07C215/10—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic with one amino group and at least two hydroxy groups bound to the carbon skeleton
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    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
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    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
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Abstract

Se revelan compuestos que son agonistas o antagonistas de los receptores S1P5, las composiciones que contienen los mencionados compuestos y métodos de uso de los mencionados compuestos y composiciones. En ciertas caracterizaciones, los mencionados compuestos son derivados de 1-bencilazetidina-3-carboxílico ácido. En ciertas caracterizaciones, los mencionados métodos se relacionan con el tratamiento del dolor neuropático y/o trastornos neurodegenerativos. En ciertas caracterizaciones, los mencionados compuestos pueden ser usados en combinación con un segundo agente terapéutico.
EC2011011243A 2009-02-10 2011-08-02 Agonistas y antagonistas de los receptores s1p5 y metodos de usos similares aplicaciones relacionadas ECSP11011243A (es)

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