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MX2011008450A - Agonistas y antagonistas del receptor s1p5, y metodos de uso de los mismos. - Google Patents

Agonistas y antagonistas del receptor s1p5, y metodos de uso de los mismos.

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Publication number
MX2011008450A
MX2011008450A MX2011008450A MX2011008450A MX2011008450A MX 2011008450 A MX2011008450 A MX 2011008450A MX 2011008450 A MX2011008450 A MX 2011008450A MX 2011008450 A MX2011008450 A MX 2011008450A MX 2011008450 A MX2011008450 A MX 2011008450A
Authority
MX
Mexico
Prior art keywords
compounds
methods
agonists
antagonists
receptor
Prior art date
Application number
MX2011008450A
Other languages
English (en)
Inventor
Adrian D Hobson
Christopher M Harris
Noel S Wilson
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of MX2011008450A publication Critical patent/MX2011008450A/es

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    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
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Abstract

Se describen compuestos que son agonistas o antagonistas del receptor S1P5, composiciones que comprenden dichos compuestos, y métodos para utilizar dichos compuestos y composiciones. En ciertas modalidades, dichos compuestos son derivados de ácido 1- bencilazetidin-3-carboxílico. En ciertas modalidades, dichos métodos se refieren al tratamiento de dolor neuropático y/o trastorno neurodegenerativo. En ciertas modalidades, dichos compuestos pueden ser utilizados en combinación con un segundo agente terapéutico.
MX2011008450A 2009-02-10 2010-02-10 Agonistas y antagonistas del receptor s1p5, y metodos de uso de los mismos. MX2011008450A (es)

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Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ590474A (en) 2008-07-23 2012-10-26 Arena Pharm Inc SUBSTITUTED 1,2,3,4- TETRAHYDROCYCLOPENTA[b]INDOL-3-YL) ACETIC ACID DERIVATIVES USEFUL IN THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISORDERS
JP5726737B2 (ja) 2008-08-27 2015-06-03 アリーナ ファーマシューティカルズ， インコーポレイテッド 自己免疫障害および免疫性障害の治療において有用なｓ１ｐ１受容体のアゴニストとしての置換三環式酸誘導体
EP4148045A1 (en) 2010-01-27 2023-03-15 Arena Pharmaceuticals, Inc. Intermediate compounds for the preparation of (r)-2-(7-(4-cyclopentyl-3- (trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b] indol-3-yl)acetic acid and salts thereof
WO2011109471A1 (en) 2010-03-03 2011-09-09 Arena Pharmaceuticals, Inc. Processes for the preparation of s1p1 receptor modulators and crystalline forms thereof
EP2646415A1 (en) 2010-12-03 2013-10-09 Allergan, Inc. Novel azetidine derivatives as sphingosine 1-phosphate (s1p) receptor modulators
CA2819624A1 (en) 2010-12-03 2012-06-07 Allergan, Inc. Alkyne and alkene derivatives as sphingosine 1-phosphate-1 receptor modulators
US8975235B2 (en) 2011-03-20 2015-03-10 Intermune, Inc. Lysophosphatidic acid receptor antagonists
US8507686B2 (en) * 2011-04-14 2013-08-13 Allergan, Inc. Substituted bicyclic methyl azetidines as sphingosine-1 phosphate receptors modulators
CA2833305A1 (en) 2011-04-14 2012-10-18 Allergan, Inc. Phenyl bicyclic methyl azetidine derivatives as sphingosine-1 phosphate receptors modulators
WO2014018881A1 (en) 2012-07-27 2014-01-30 Biogen Idec Ma Inc. Atx modulating agents
EP2925721B1 (en) 2012-11-20 2017-06-07 Biogen MA Inc. S1p and/or atx modulating agents
US8871755B2 (en) 2013-02-12 2014-10-28 Allergan, Inc. Alkene azetidine derivatives as sphingosine 1-phosphate (S1P) receptor modulators
WO2014127033A1 (en) * 2013-02-13 2014-08-21 Allergan, Inc. Azetidine derivatives as sphingosine 1-phosphate (s1p) receptor modulators
US20150045341A1 (en) * 2013-08-08 2015-02-12 Allergan, Inc. Disubstituted aryl azetidine derivatives as sphingosine-1 phosphate receptors modulators
JPWO2015129859A1 (ja) 2014-02-28 2017-03-30 キッセイ薬品工業株式会社 新規なアニリン誘導体、それを含有する医薬組成物およびそれらの用途
EP4445956A3 (en) 2015-01-06 2024-12-04 Arena Pharmaceuticals, Inc. Compound for use in treating conditions related to the s1p1 receptor
PL3310760T3 (pl) 2015-06-22 2023-03-06 Arena Pharmaceuticals, Inc. Krystaliczna sól L-argininy kwasu (R)-2-(7-(4-cyklopentylo-3-(trifluorometylo)benzyloksy)- 1,2,3,4-tetrahydrocyklo-penta[b]indol-3-ilo)octowego do zastosowania w zaburzeniach związanych z receptorem S1P1
JP2018526371A (ja) * 2015-08-27 2018-09-13 ジェネンテック， インコーポレイテッド 治療化合物及びその使用方法
EP3500308A4 (en) * 2016-08-18 2020-04-22 Memorial Sloan Kettering Cancer Center INHIBITION OF THE SPHINGOSIN-1-PHOSPHATE RECEPTOR FOR TREATING AND PREVENTING LYMPHEDEMES
CN110520124A (zh) 2017-02-16 2019-11-29 艾尼纳制药公司 用于治疗原发性胆汁性胆管炎的化合物和方法
AU2018222747A1 (en) 2017-02-16 2019-09-05 Arena Pharmaceuticals, Inc. Compounds and methods for treatment of inflammatory bowel disease with extra-intestinal manifestations
IL270251B2 (en) 2017-05-15 2025-01-01 Cognition Therapeutics Inc 1-Phenyl-1,1-dimethyl-2-(piperidinyl/pyrrolidinyl/piperazinyl)ethane derivatives and pharmaceutical preparations containing them
EP3655392A1 (en) * 2017-07-17 2020-05-27 Abbvie Deutschland GmbH & Co. KG 1,2,3,4-substituted quinoline compounds as s1p modulators
US11046646B2 (en) 2017-08-09 2021-06-29 Bristol-Myers Squibb Company Alkylphenyl compounds
WO2019032631A1 (en) 2017-08-09 2019-02-14 Bristol-Myers Squibb Company Oxime ether compounds
CA3102136A1 (en) 2018-06-06 2019-12-12 Arena Pharmaceuticals, Inc. Methods of treating conditions related to the s1p1 receptor
EP3847158A1 (en) 2018-09-06 2021-07-14 Arena Pharmaceuticals, Inc. Compounds useful in the treatment of autoimmune and inflammatory disorders
CN113072474A (zh) * 2018-12-06 2021-07-06 上海济煜医药科技有限公司 作为免疫调节剂的化合物及其制备方法和应用
EP3936192B1 (en) 2019-03-06 2025-04-09 Daiichi Sankyo Company, Limited Pyrrolopyrazole derivative
CN114460217B (zh) * 2022-01-29 2023-06-30 杭州沐源生物医药科技有限公司 一种分离检测硫酸特布他林注射液及其杂质的方法
TW202515535A (zh) * 2023-08-31 2025-04-16 美商速通醫療公司 醯胺前藥及其用途
CN119638586A (zh) * 2023-09-15 2025-03-18 中国医学科学院药物研究所 一种三氟甲基环己基苄醚取代的含氮有机酸类衍生物、其制法和用途
CN119638588A (zh) * 2023-09-15 2025-03-18 中国医学科学院药物研究所 一种三氟甲基苄醚取代的氨基酸类衍生物、其制法和用途
CN119874633B (zh) * 2023-10-25 2025-10-21 中国石油化工股份有限公司 一种油田水处理缓蚀剂及其合成方法

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4133881A (en) * 1977-04-27 1979-01-09 A. H. Robins Company, Incorporated Azetidinyl acetonitrile and acetamide antiarrhythmia compositions and methods
US4379151A (en) * 1978-03-14 1983-04-05 A. H. Robins Company, Inc. 3-Phenoxyazetidines for anorexigenic activity
US4529544A (en) * 1982-03-15 1985-07-16 The Dow Chemical Company Formation of azetidines by decarboxylation of tetrahydro-1,3-oxazin-2-ones
US4571393A (en) * 1982-08-19 1986-02-18 A. H. Robins Company, Incorporated 3-Phenoxy-1-azetidinecarboxamides
GB8627493D0 (en) * 1986-11-18 1986-12-17 Shell Int Research Catalytic hydrogenolysis
US6221865B1 (en) * 1995-11-06 2001-04-24 University Of Pittsburgh Inhibitors of protein isoprenyl transferases
US6462036B1 (en) * 1998-11-06 2002-10-08 Basf Aktiengesellschaft Tricyclic pyrazole derivatives
US6699873B1 (en) * 1999-08-04 2004-03-02 Millennium Pharmaceuticals, Inc. Melanocortin-4 receptor binding compounds and methods of use thereof
US6303638B1 (en) * 1999-08-06 2001-10-16 The Regents Of The University Of California Substituted pyridines as modulators of the mammalian neuronal nicotinic acetylcholine receptor
US20040077853A1 (en) * 2001-10-10 2004-04-22 Pfizer Inc. 2-amino-6-(2,4,5-substituted-phenyl)-pyridines
US7479504B2 (en) * 2002-01-18 2009-01-20 Merck & Co., Inc. Edg receptor agonists
JP2005533058A (ja) * 2002-06-17 2005-11-04 メルク　エンド　カムパニー　インコーポレーテッド Ｅｄｇ受容体アゴニストとしての１−（（５−アリール−１，２，４−オキサジアゾール−３−イル）ベンジル）アゼチジン−３−カルボキシラートおよび１−（（５−アリール−１，２，４−オキサジアゾール−３−イル）ベンジル）ピロリジン−３−カルボキシラート
KR100554157B1 (ko) * 2003-08-21 2006-02-22 학교법인 포항공과대학교 저유전 특성의 유기 실리케이트 고분자 복합체
WO2005082370A1 (en) * 2004-01-29 2005-09-09 Pfizer Products Inc. Combinations of an atypical antipsychotic and an aminomethylpyridyloxymethyl/benzisoxazole azabicyclic derivatives for treating cns disorders
ES2244313B1 (es) * 2004-02-16 2007-02-16 Laboratorios Del Dr. Esteve, S.A. Compuestos de azetidina substituidos, su preparacion y su uso como medicamentos.
US20060014733A1 (en) * 2004-07-19 2006-01-19 Pfizer Inc Histamine-3 agonists and antagonists
JP2008506766A (ja) * 2004-07-21 2008-03-06 ファイザー・プロダクツ・インク ヒスタミン−３受容体拮抗薬
EP1965807A4 (en) * 2005-11-23 2010-10-27 Epix Delaware Inc S1P RECEPTOR MODULATING COMPOUNDS AND THEIR USE
US7919519B2 (en) * 2005-11-23 2011-04-05 Epix Pharmaceuticals Inc. S1P receptor modulating compounds and use thereof
EP2044086A2 (en) * 2006-06-30 2009-04-08 Janssen Pharmaceutica N.V. Thiazolopyrimidine modulators of trpv1
TW200906396A (en) * 2007-02-14 2009-02-16 Janssen Pharmaceutica Nv LTA4H modulators and uses thereof
WO2009011850A2 (en) * 2007-07-16 2009-01-22 Abbott Laboratories Novel therapeutic compounds
US7939513B2 (en) * 2007-09-07 2011-05-10 Dr. Reddy's Laboratories Limited Tetracycline derivatives as antibacterial agents
CN102186845B (zh) * 2008-10-17 2016-09-07 阿卡制药有限公司 S1p受体调节剂以及它们的用途

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