CL2011001923A1 - Compuestos agonistas y antagonistas del receptor s1p5; y uso de los compuestos en la preparacion de medicamentos útiles para el tratamiento de enfermedades mediadas por el refceptor s1p, tales como enfermedades neurodedenerativas. - Google Patents
Compuestos agonistas y antagonistas del receptor s1p5; y uso de los compuestos en la preparacion de medicamentos útiles para el tratamiento de enfermedades mediadas por el refceptor s1p, tales como enfermedades neurodedenerativas.Info
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- CL2011001923A1 CL2011001923A1 CL2011001923A CL2011001923A CL2011001923A1 CL 2011001923 A1 CL2011001923 A1 CL 2011001923A1 CL 2011001923 A CL2011001923 A CL 2011001923A CL 2011001923 A CL2011001923 A CL 2011001923A CL 2011001923 A1 CL2011001923 A1 CL 2011001923A1
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- Prior art keywords
- compounds
- diseases
- receptor
- refceptor
- agonist
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- 150000001875 compounds Chemical class 0.000 title abstract 3
- 102000011011 Sphingosine 1-phosphate receptors Human genes 0.000 title abstract 2
- 108050001083 Sphingosine 1-phosphate receptors Proteins 0.000 title abstract 2
- 201000010099 disease Diseases 0.000 title 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 2
- 239000000556 agonist Substances 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 230000001404 mediated effect Effects 0.000 title 1
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 abstract 1
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 abstract 1
- 208000015802 attention deficit-hyperactivity disease Diseases 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 208000035231 inattentive type attention deficit hyperactivity disease Diseases 0.000 abstract 1
- 208000004296 neuralgia Diseases 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 208000021722 neuropathic pain Diseases 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
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- A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
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- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
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Abstract
Compuestos derivados de heterociclos, moduladores del receptor s1p5; y su uso para tratar o prevenir condiciones tales como trastornos neurodegenerativos, trastorno de déficit de atención, esquizofrenia, dolor neuropático, entre otros.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20730109P | 2009-02-10 | 2009-02-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2011001923A1 true CL2011001923A1 (es) | 2011-11-11 |
Family
ID=42562045
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2011001923A CL2011001923A1 (es) | 2009-02-10 | 2011-08-09 | Compuestos agonistas y antagonistas del receptor s1p5; y uso de los compuestos en la preparacion de medicamentos útiles para el tratamiento de enfermedades mediadas por el refceptor s1p, tales como enfermedades neurodedenerativas. |
Country Status (19)
| Country | Link |
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| US (1) | US20100216762A1 (es) |
| EP (1) | EP2395835A4 (es) |
| JP (1) | JP2012517446A (es) |
| KR (1) | KR20110117706A (es) |
| CN (1) | CN102387704A (es) |
| AU (1) | AU2010213794A1 (es) |
| BR (1) | BRPI1008060A2 (es) |
| CA (1) | CA2749960A1 (es) |
| CL (1) | CL2011001923A1 (es) |
| CO (1) | CO6400170A2 (es) |
| CR (1) | CR20110421A (es) |
| EC (1) | ECSP11011243A (es) |
| IL (1) | IL214049A0 (es) |
| MX (1) | MX2011008450A (es) |
| PE (1) | PE20120578A1 (es) |
| RU (1) | RU2011137454A (es) |
| SG (1) | SG172982A1 (es) |
| WO (1) | WO2010093704A1 (es) |
| ZA (1) | ZA201105323B (es) |
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| WO2011109471A1 (en) | 2010-03-03 | 2011-09-09 | Arena Pharmaceuticals, Inc. | Processes for the preparation of s1p1 receptor modulators and crystalline forms thereof |
| EP2646415A1 (en) | 2010-12-03 | 2013-10-09 | Allergan, Inc. | Novel azetidine derivatives as sphingosine 1-phosphate (s1p) receptor modulators |
| CA2819624A1 (en) | 2010-12-03 | 2012-06-07 | Allergan, Inc. | Alkyne and alkene derivatives as sphingosine 1-phosphate-1 receptor modulators |
| US8975235B2 (en) | 2011-03-20 | 2015-03-10 | Intermune, Inc. | Lysophosphatidic acid receptor antagonists |
| US8507686B2 (en) * | 2011-04-14 | 2013-08-13 | Allergan, Inc. | Substituted bicyclic methyl azetidines as sphingosine-1 phosphate receptors modulators |
| CA2833305A1 (en) | 2011-04-14 | 2012-10-18 | Allergan, Inc. | Phenyl bicyclic methyl azetidine derivatives as sphingosine-1 phosphate receptors modulators |
| WO2014018881A1 (en) | 2012-07-27 | 2014-01-30 | Biogen Idec Ma Inc. | Atx modulating agents |
| EP2925721B1 (en) | 2012-11-20 | 2017-06-07 | Biogen MA Inc. | S1p and/or atx modulating agents |
| US8871755B2 (en) | 2013-02-12 | 2014-10-28 | Allergan, Inc. | Alkene azetidine derivatives as sphingosine 1-phosphate (S1P) receptor modulators |
| WO2014127033A1 (en) * | 2013-02-13 | 2014-08-21 | Allergan, Inc. | Azetidine derivatives as sphingosine 1-phosphate (s1p) receptor modulators |
| US20150045341A1 (en) * | 2013-08-08 | 2015-02-12 | Allergan, Inc. | Disubstituted aryl azetidine derivatives as sphingosine-1 phosphate receptors modulators |
| JPWO2015129859A1 (ja) | 2014-02-28 | 2017-03-30 | キッセイ薬品工業株式会社 | 新規なアニリン誘導体、それを含有する医薬組成物およびそれらの用途 |
| EP4445956A3 (en) | 2015-01-06 | 2024-12-04 | Arena Pharmaceuticals, Inc. | Compound for use in treating conditions related to the s1p1 receptor |
| PL3310760T3 (pl) | 2015-06-22 | 2023-03-06 | Arena Pharmaceuticals, Inc. | Krystaliczna sól L-argininy kwasu (R)-2-(7-(4-cyklopentylo-3-(trifluorometylo)benzyloksy)- 1,2,3,4-tetrahydrocyklo-penta[b]indol-3-ilo)octowego do zastosowania w zaburzeniach związanych z receptorem S1P1 |
| JP2018526371A (ja) * | 2015-08-27 | 2018-09-13 | ジェネンテック, インコーポレイテッド | 治療化合物及びその使用方法 |
| EP3500308A4 (en) * | 2016-08-18 | 2020-04-22 | Memorial Sloan Kettering Cancer Center | INHIBITION OF THE SPHINGOSIN-1-PHOSPHATE RECEPTOR FOR TREATING AND PREVENTING LYMPHEDEMES |
| CN110520124A (zh) | 2017-02-16 | 2019-11-29 | 艾尼纳制药公司 | 用于治疗原发性胆汁性胆管炎的化合物和方法 |
| AU2018222747A1 (en) | 2017-02-16 | 2019-09-05 | Arena Pharmaceuticals, Inc. | Compounds and methods for treatment of inflammatory bowel disease with extra-intestinal manifestations |
| IL270251B2 (en) | 2017-05-15 | 2025-01-01 | Cognition Therapeutics Inc | 1-Phenyl-1,1-dimethyl-2-(piperidinyl/pyrrolidinyl/piperazinyl)ethane derivatives and pharmaceutical preparations containing them |
| EP3655392A1 (en) * | 2017-07-17 | 2020-05-27 | Abbvie Deutschland GmbH & Co. KG | 1,2,3,4-substituted quinoline compounds as s1p modulators |
| US11046646B2 (en) | 2017-08-09 | 2021-06-29 | Bristol-Myers Squibb Company | Alkylphenyl compounds |
| WO2019032631A1 (en) | 2017-08-09 | 2019-02-14 | Bristol-Myers Squibb Company | Oxime ether compounds |
| CA3102136A1 (en) | 2018-06-06 | 2019-12-12 | Arena Pharmaceuticals, Inc. | Methods of treating conditions related to the s1p1 receptor |
| EP3847158A1 (en) | 2018-09-06 | 2021-07-14 | Arena Pharmaceuticals, Inc. | Compounds useful in the treatment of autoimmune and inflammatory disorders |
| CN113072474A (zh) * | 2018-12-06 | 2021-07-06 | 上海济煜医药科技有限公司 | 作为免疫调节剂的化合物及其制备方法和应用 |
| EP3936192B1 (en) | 2019-03-06 | 2025-04-09 | Daiichi Sankyo Company, Limited | Pyrrolopyrazole derivative |
| CN114460217B (zh) * | 2022-01-29 | 2023-06-30 | 杭州沐源生物医药科技有限公司 | 一种分离检测硫酸特布他林注射液及其杂质的方法 |
| TW202515535A (zh) * | 2023-08-31 | 2025-04-16 | 美商速通醫療公司 | 醯胺前藥及其用途 |
| CN119638586A (zh) * | 2023-09-15 | 2025-03-18 | 中国医学科学院药物研究所 | 一种三氟甲基环己基苄醚取代的含氮有机酸类衍生物、其制法和用途 |
| CN119638588A (zh) * | 2023-09-15 | 2025-03-18 | 中国医学科学院药物研究所 | 一种三氟甲基苄醚取代的氨基酸类衍生物、其制法和用途 |
| CN119874633B (zh) * | 2023-10-25 | 2025-10-21 | 中国石油化工股份有限公司 | 一种油田水处理缓蚀剂及其合成方法 |
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| EP1965807A4 (en) * | 2005-11-23 | 2010-10-27 | Epix Delaware Inc | S1P RECEPTOR MODULATING COMPOUNDS AND THEIR USE |
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| TW200906396A (en) * | 2007-02-14 | 2009-02-16 | Janssen Pharmaceutica Nv | LTA4H modulators and uses thereof |
| WO2009011850A2 (en) * | 2007-07-16 | 2009-01-22 | Abbott Laboratories | Novel therapeutic compounds |
| US7939513B2 (en) * | 2007-09-07 | 2011-05-10 | Dr. Reddy's Laboratories Limited | Tetracycline derivatives as antibacterial agents |
| CN102186845B (zh) * | 2008-10-17 | 2016-09-07 | 阿卡制药有限公司 | S1p受体调节剂以及它们的用途 |
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| SG172982A1 (en) | 2011-08-29 |
| US20100216762A1 (en) | 2010-08-26 |
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| KR20110117706A (ko) | 2011-10-27 |
| CA2749960A1 (en) | 2010-08-19 |
| CR20110421A (es) | 2011-12-08 |
| AU2010213794A1 (en) | 2011-09-01 |
| ECSP11011243A (es) | 2011-09-30 |
| IL214049A0 (en) | 2011-08-31 |
| JP2012517446A (ja) | 2012-08-02 |
| EP2395835A4 (en) | 2013-04-17 |
| WO2010093704A1 (en) | 2010-08-19 |
| RU2011137454A (ru) | 2013-03-20 |
| CO6400170A2 (es) | 2012-03-15 |
| MX2011008450A (es) | 2011-09-01 |
| CN102387704A (zh) | 2012-03-21 |
| BRPI1008060A2 (pt) | 2015-08-25 |
| PE20120578A1 (es) | 2012-06-17 |
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