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EA201201435A1 - ГЕТЕРОДИМЕРНЫЕ АНТИТЕЛО-Fc-СОДЕРЖАЩИЕ БЕЛКИ И СПОСОБЫ ИХ ПОЛУЧЕНИЯ - Google Patents

ГЕТЕРОДИМЕРНЫЕ АНТИТЕЛО-Fc-СОДЕРЖАЩИЕ БЕЛКИ И СПОСОБЫ ИХ ПОЛУЧЕНИЯ

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Publication number
EA201201435A1
EA201201435A1 EA201201435A EA201201435A EA201201435A1 EA 201201435 A1 EA201201435 A1 EA 201201435A1 EA 201201435 A EA201201435 A EA 201201435A EA 201201435 A EA201201435 A EA 201201435A EA 201201435 A1 EA201201435 A1 EA 201201435A1
Authority
EA
Eurasian Patent Office
Prior art keywords
methods
antibody
heterodimerny
receiving
containing proteins
Prior art date
Application number
EA201201435A
Other languages
English (en)
Inventor
Аран Франк Лабрейн
Йойсе Местерс
Эвалд ван ден Бремер
Йост Й. Нейссен
Патрик ван Беркел
Барт де Гуэй
Том Винк
Ян Ван Де Винкел
Янине Схюирман
Пауль Паррен
Original Assignee
Генмаб А/С
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Генмаб А/С filed Critical Генмаб А/С
Publication of EA201201435A1 publication Critical patent/EA201201435A1/ru

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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C—CHEMISTRY; METALLURGY
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
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Abstract

Описываются новые гетеродимерные антитело-Fc-содержащие белки, такие как биспецифические антитела, и новые способы получения таких белков.
EA201201435A 2010-04-20 2011-04-20 ГЕТЕРОДИМЕРНЫЕ АНТИТЕЛО-Fc-СОДЕРЖАЩИЕ БЕЛКИ И СПОСОБЫ ИХ ПОЛУЧЕНИЯ EA201201435A1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US32608210P 2010-04-20 2010-04-20
DKPA201000330 2010-04-20
DKPA201001066 2010-11-24
PCT/EP2011/056388 WO2011131746A2 (en) 2010-04-20 2011-04-20 Heterodimeric antibody fc-containing proteins and methods for production thereof

Publications (1)

Publication Number Publication Date
EA201201435A1 true EA201201435A1 (ru) 2013-04-30

Family

ID=44226045

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201201435A EA201201435A1 (ru) 2010-04-20 2011-04-20 ГЕТЕРОДИМЕРНЫЕ АНТИТЕЛО-Fc-СОДЕРЖАЩИЕ БЕЛКИ И СПОСОБЫ ИХ ПОЛУЧЕНИЯ

Country Status (25)

Country Link
US (5) US9150663B2 (ru)
EP (2) EP4477668A3 (ru)
JP (5) JP6040148B2 (ru)
KR (2) KR102152109B1 (ru)
CN (2) CN110066339A (ru)
AU (1) AU2011244282A1 (ru)
BR (2) BR112012026766B1 (ru)
CA (1) CA2796181C (ru)
DK (1) DK2560993T3 (ru)
EA (1) EA201201435A1 (ru)
ES (1) ES2989108T3 (ru)
FI (1) FI2560993T3 (ru)
HR (1) HRP20241208T1 (ru)
HU (1) HUE068268T2 (ru)
IL (1) IL222507B (ru)
LT (1) LT2560993T (ru)
MX (2) MX391041B (ru)
NZ (1) NZ701825A (ru)
PL (1) PL2560993T3 (ru)
PT (1) PT2560993T (ru)
RS (1) RS65965B1 (ru)
SG (2) SG184427A1 (ru)
SI (1) SI2560993T1 (ru)
SM (1) SMT202400377T1 (ru)
WO (1) WO2011131746A2 (ru)

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