EA200800154A1 - Производные хинолина в качестве антибактериальных средств - Google Patents
Производные хинолина в качестве антибактериальных средствInfo
- Publication number
- EA200800154A1 EA200800154A1 EA200800154A EA200800154A EA200800154A1 EA 200800154 A1 EA200800154 A1 EA 200800154A1 EA 200800154 A EA200800154 A EA 200800154A EA 200800154 A EA200800154 A EA 200800154A EA 200800154 A1 EA200800154 A1 EA 200800154A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- alkyl
- hydrogen
- het
- alkyloxy
- alkylthio
- Prior art date
Links
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical class N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 title 1
- 230000000844 anti-bacterial effect Effects 0.000 title 1
- 229940027991 antiseptic and disinfectant quinoline derivative Drugs 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 9
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- 150000002431 hydrogen Chemical group 0.000 abstract 5
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000004414 alkyl thio group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 208000035143 Bacterial infection Diseases 0.000 abstract 2
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 2
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 2
- -1 cyano, hydroxy Chemical group 0.000 abstract 2
- 125000001188 haloalkyl group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 206010062207 Mycobacterial infection Diseases 0.000 abstract 1
- 125000000815 N-oxide group Chemical group 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000006350 alkyl thio alkyl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 208000027531 mycobacterial infectious disease Diseases 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/04—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
- C07D215/06—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms having only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Применение соединения для изготовления лекарственного средства для лечения бактериальной инфекции при условии, что бактериальная инфекция не является микобактериальной инфекцией, где указанное соединение представляет собой соединение формулы (Ia) или (Ib), его фармацевтически приемлемую кислотно- или основно-аддитивную соль, его стереохимически изомерные формы, его таутомерные формы или его N-оксидные формы, где Rпредставляет собой водород, галоген, галогеналкил, циано, гидрокси, Ar, Het, алкил, алкилокси, алкилтио, алкилоксиалкил, алкилтиоалкил, Ar-алкил или ди(Ar)алкил; р=1, 2, 3 или 4; Rпредставляет собой водород, гидрокси, меркапто, алкилокси, алкилоксиалкилокси, алкилтио, моно или ди(алкил)амино или радикал формулы; Rпредставляет собой алкил, Ar, Ar-алкил, Het или Het-алкил; q=1, 2 или 3; Rи Rпредставляет собой водород, алкил или бензил; или Rи R, взятые вместе с атомом N, к которому они присоединены, могут образовывать кольцо; Rпредставляет собой водород, галоген, галогеналкил, гидрокси, Ar, алкил, алкилокси, алкилтио, алкилоксиалкил, алкилтиоалкил, Ar-алкил или ди(Ar)алкил; или 2 соседних радикала Rмогут быть взяты вместе для образования двухвалентного радикала формулы -СН=СН-СН=СН-; r=1, 2, 3, 4 или 5; Rпредставляет собой водород, алкил, Ar или Het; Rпредставляет собой водород или алкил; Rпредставляет собой оксо; или Rи Rвместе образуют радикал -CH=CH-N=.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05105762 | 2005-06-28 | ||
| PCT/EP2006/063553 WO2007000435A1 (en) | 2005-06-28 | 2006-06-26 | Quinoline derivatives as antibacterial agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA200800154A1 true EA200800154A1 (ru) | 2008-10-30 |
| EA014423B1 EA014423B1 (ru) | 2010-12-30 |
Family
ID=34940244
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200800154A EA014423B1 (ru) | 2005-06-28 | 2006-06-26 | Производные хинолина в качестве антибактериальных средств |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US8841321B2 (ru) |
| EP (1) | EP1898914B1 (ru) |
| JP (1) | JP5193858B2 (ru) |
| KR (1) | KR101329585B1 (ru) |
| CN (1) | CN101247811B (ru) |
| AP (1) | AP2386A (ru) |
| AR (1) | AR054626A1 (ru) |
| AU (1) | AU2006263883B2 (ru) |
| BR (1) | BRPI0612498A8 (ru) |
| CA (1) | CA2612619C (ru) |
| CY (1) | CY1113579T1 (ru) |
| DK (1) | DK1898914T3 (ru) |
| EA (1) | EA014423B1 (ru) |
| ES (1) | ES2393203T3 (ru) |
| HR (1) | HRP20120912T1 (ru) |
| IL (1) | IL188393A0 (ru) |
| JO (1) | JO2752B1 (ru) |
| ME (1) | ME01484B (ru) |
| MX (1) | MX2008000081A (ru) |
| MY (1) | MY153291A (ru) |
| NO (1) | NO342701B1 (ru) |
| NZ (1) | NZ564379A (ru) |
| PA (1) | PA8683801A1 (ru) |
| PL (1) | PL1898914T3 (ru) |
| PT (1) | PT1898914E (ru) |
| RS (1) | RS52517B (ru) |
| SI (1) | SI1898914T1 (ru) |
| TW (1) | TWI387457B (ru) |
| UA (1) | UA92175C2 (ru) |
| WO (1) | WO2007000435A1 (ru) |
| ZA (1) | ZA200711165B (ru) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO2683B1 (en) * | 2006-12-06 | 2013-03-03 | جانسين فارماسوتيكا ان. في | Quinoline antibacterial derivatives |
| JO2970B1 (en) | 2006-12-06 | 2016-03-15 | جانسين فارماسوتيكا ان. في | Quinoline antibacterial derivatives |
| JP6153603B2 (ja) | 2012-04-27 | 2017-06-28 | ヤンセン ファーマシューティカ エヌ．ベー． | 抗菌性キノリン誘導体 |
| DK2841425T3 (en) | 2012-04-27 | 2016-06-27 | Janssen Pharmaceutica Nv | ANTIBACTERIAL QUINOLIN DERIVATIVES |
| PT3237383T (pt) | 2014-12-23 | 2020-01-15 | Albemarle Corp | Processo num passo para a síntese de análogos de metirapona alquilados |
| CN106928139B (zh) * | 2017-05-08 | 2019-06-25 | 福建省微生物研究所 | 一种贝达喹啉杂质的合成方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19937116A1 (de) * | 1999-08-06 | 2001-02-08 | Bayer Ag | Moxifloxacin Kochsalzformulierung |
| DK2301544T3 (da) * | 2002-07-25 | 2013-01-02 | Janssen Pharmaceutica Nv | Quinolinderivater som mellemprodukter til mykobakterielle inhibitorer |
| WO2005033108A1 (en) | 2003-09-22 | 2005-04-14 | Janssen Pharmaceutica, N.V. | 7-amino alkylidenyl-heterocyclic quinolones and naphthyridones |
| DE602005005810T2 (de) * | 2004-05-28 | 2009-04-09 | Janssen Pharmaceutica N.V. | Verwendung von substituierten chinolin-derivaten zur behandlung von arzneimittelresistenten mycobakteriellen erkrankungen |
| EE05394B1 (et) * | 2004-12-24 | 2011-04-15 | Janssen Pharmaceutica N.V. | Kinoliinihendid kasutamiseks latentse tuberkuloosi ravis |
| PL1898909T3 (pl) | 2005-06-28 | 2017-03-31 | Janssen Pharmaceutica Nv | Pochodne chinoliny jako środki przeciwbakteryjne |
-
2006
- 2006-06-25 JO JO2006188A patent/JO2752B1/en active
- 2006-06-26 PL PL06763889T patent/PL1898914T3/pl unknown
- 2006-06-26 EA EA200800154A patent/EA014423B1/ru unknown
- 2006-06-26 RS RS20120480A patent/RS52517B/sr unknown
- 2006-06-26 BR BRPI0612498A patent/BRPI0612498A8/pt not_active Application Discontinuation
- 2006-06-26 DK DK06763889.0T patent/DK1898914T3/da active
- 2006-06-26 HR HRP20120912TT patent/HRP20120912T1/hr unknown
- 2006-06-26 ME MEP-2012-127A patent/ME01484B/me unknown
- 2006-06-26 US US11/993,145 patent/US8841321B2/en not_active Expired - Fee Related
- 2006-06-26 SI SI200631468T patent/SI1898914T1/sl unknown
- 2006-06-26 CA CA2612619A patent/CA2612619C/en not_active Expired - Fee Related
- 2006-06-26 MX MX2008000081A patent/MX2008000081A/es active IP Right Grant
- 2006-06-26 PT PT06763889T patent/PT1898914E/pt unknown
- 2006-06-26 UA UAA200714927A patent/UA92175C2/ru unknown
- 2006-06-26 EP EP06763889A patent/EP1898914B1/en active Active
- 2006-06-26 AU AU2006263883A patent/AU2006263883B2/en not_active Ceased
- 2006-06-26 CN CN2006800310552A patent/CN101247811B/zh not_active Expired - Fee Related
- 2006-06-26 JP JP2008518810A patent/JP5193858B2/ja not_active Expired - Fee Related
- 2006-06-26 WO PCT/EP2006/063553 patent/WO2007000435A1/en not_active Ceased
- 2006-06-26 NZ NZ564379A patent/NZ564379A/en not_active IP Right Cessation
- 2006-06-26 AP AP2008004303A patent/AP2386A/xx active
- 2006-06-26 KR KR1020087002107A patent/KR101329585B1/ko not_active Expired - Fee Related
- 2006-06-26 ES ES06763889T patent/ES2393203T3/es active Active
- 2006-06-27 MY MYPI20063044A patent/MY153291A/en unknown
- 2006-06-27 TW TW095123127A patent/TWI387457B/zh not_active IP Right Cessation
- 2006-06-28 AR ARP060102787A patent/AR054626A1/es unknown
- 2006-06-28 PA PA20068683801A patent/PA8683801A1/es unknown
-
2007
- 2007-12-20 ZA ZA2007/11165A patent/ZA200711165B/en unknown
- 2007-12-25 IL IL188393A patent/IL188393A0/en active IP Right Grant
-
2008
- 2008-01-28 NO NO20080501A patent/NO342701B1/no not_active IP Right Cessation
-
2012
- 2012-11-14 CY CY20121101090T patent/CY1113579T1/el unknown
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