AR054626A1 - Derivados de quinolina como agentes antibacterianos - Google Patents
Derivados de quinolina como agentes antibacterianosInfo
- Publication number
- AR054626A1 AR054626A1 ARP060102787A ARP060102787A AR054626A1 AR 054626 A1 AR054626 A1 AR 054626A1 AR P060102787 A ARP060102787 A AR P060102787A AR P060102787 A ARP060102787 A AR P060102787A AR 054626 A1 AR054626 A1 AR 054626A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- alkyloxy
- hydroxy
- hydrocarbon radical
- halo
- Prior art date
Links
- 239000003242 anti bacterial agent Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 13
- -1 cyano, hydroxy Chemical group 0.000 abstract 11
- 125000003545 alkoxy group Chemical group 0.000 abstract 7
- 125000005843 halogen group Chemical group 0.000 abstract 7
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 6
- 150000001875 compounds Chemical class 0.000 abstract 5
- 125000001188 haloalkyl group Chemical group 0.000 abstract 5
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 5
- 125000001424 substituent group Chemical group 0.000 abstract 5
- 239000004215 Carbon black (E152) Substances 0.000 abstract 4
- 125000004414 alkyl thio group Chemical group 0.000 abstract 4
- 229930195733 hydrocarbon Natural products 0.000 abstract 4
- 229920006395 saturated elastomer Polymers 0.000 abstract 4
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 3
- 208000035143 Bacterial infection Diseases 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 125000006350 alkyl thio alkyl group Chemical group 0.000 abstract 2
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 2
- 125000002618 bicyclic heterocycle group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000004122 cyclic group Chemical group 0.000 abstract 2
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 2
- 125000002883 imidazolyl group Chemical group 0.000 abstract 2
- 125000002757 morpholinyl group Chemical group 0.000 abstract 2
- 125000003386 piperidinyl group Chemical group 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 125000003373 pyrazinyl group Chemical group 0.000 abstract 2
- 125000003226 pyrazolyl group Chemical group 0.000 abstract 2
- 125000002098 pyridazinyl group Chemical group 0.000 abstract 2
- 125000004076 pyridyl group Chemical group 0.000 abstract 2
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 2
- 125000000168 pyrrolyl group Chemical group 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 229930195734 saturated hydrocarbon Natural products 0.000 abstract 2
- FTNJQNQLEGKTGD-UHFFFAOYSA-N 1,3-benzodioxole Chemical compound C1=CC=C2OCOC2=C1 FTNJQNQLEGKTGD-UHFFFAOYSA-N 0.000 abstract 1
- 125000004485 2-pyrrolidinyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])([H])C1([H])* 0.000 abstract 1
- 125000004364 3-pyrrolinyl group Chemical group [H]C1=C([H])C([H])([H])N(*)C1([H])[H] 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 abstract 1
- 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 abstract 1
- 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 abstract 1
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 abstract 1
- 125000004541 benzoxazolyl group Chemical group O1C(=NC2=C1C=CC=C2)* 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000001246 bromo group Chemical group Br* 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 125000004473 dialkylaminocarbonyl group Chemical group 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 125000004438 haloalkoxy group Chemical group 0.000 abstract 1
- 125000002632 imidazolidinyl group Chemical group 0.000 abstract 1
- 125000001041 indolyl group Chemical group 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 125000002346 iodo group Chemical group I* 0.000 abstract 1
- 125000001786 isothiazolyl group Chemical group 0.000 abstract 1
- 125000000842 isoxazolyl group Chemical group 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 125000002911 monocyclic heterocycle group Chemical group 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000002971 oxazolyl group Chemical group 0.000 abstract 1
- 125000004043 oxo group Chemical group O=* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000004193 piperazinyl group Chemical group 0.000 abstract 1
- 125000003072 pyrazolidinyl group Chemical group 0.000 abstract 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 abstract 1
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 abstract 1
- 125000001567 quinoxalinyl group Chemical group N1=C(C=NC2=CC=CC=C12)* 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000001712 tetrahydronaphthyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 abstract 1
- 125000000335 thiazolyl group Chemical group 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
- 125000004568 thiomorpholinyl group Chemical group 0.000 abstract 1
- 125000004306 triazinyl group Chemical group 0.000 abstract 1
- 125000001425 triazolyl group Chemical group 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/04—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
- C07D215/06—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms having only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Reivindicacion 1: Uso de un compuesto para la fabricacion de un medicamento para el tratamiento de una infeccion bacteriana, dicho compuesto es un compuesto de formula (1) o (2), una de sus sales de adicion con ácido o base aceptables desde el punto de vista farmacéutico, una de sus formas estereoquímicamente isoméricas, una de sus formas tautoméricas o uno de sus N-oxidos, en los cuales: R1 es hidrogeno, halo, haloalquilo, ciano, hidroxi, Ar, Het, alquilo, alquiloxi, alquiltio, alquiloxialquilo, alquiltioalquilo, Ar-alquilo o di(Ar)alquilo; p es un numero entero igual a 1, 2, 3 o 4; R2 es hidrogeno, hidroxi, mercapto, alquiloxi, alquiloxialquiloxi, alquiltio, mono o di(alquil)amino o un radical de formula (3), donde Y es CH2, O, S, NH o N-alquilo; R3 es alquilo, Ar, Ar-alquilo, Het o Het-alquilo; q es un numero entero igual a 1, 2 o 3; R4 y R5 son, cada uno en forma independiente, hidrogeno, alquilo o bencilo; o R4 y R5 juntos e incluyendo el N al cual están unidos pueden formar un radical seleccionado del grupo de pirrolidinilo, 2-pirrolidinilo, 3-pirrolinilo, pirrolilo, imidazolidinilo, pirazolidinilo, 2-imidazolinilo, 2-pirazolinilo, imidazolilo, pirazolilo, triazolilo, piperidinilo, piridinilo, piperazinilo, piridazinilo, pirimidinilo, pirazinilo, triazinilo, morfolinilo o tiomorfolinilo, sustituido en forma opcional con alquilo, halo, haloalquilo, hidroxi, alquiloxi, amino, mono- o dialquilamino, alquiltio, alquiloxialquilo, alquiltioalquilo o pirimidinilo; R6 es hidrogeno, halo, haloalquilo, hidroxi, Ar, alquilo, alquiloxi, alquiltio, alquiloxialquilo, alquiltioalquilo, Ar-alquilo o di(Ar)alquilo; o dos radicales R6 vecinos pueden unirse para formar un radical bivalente de formula -CH=CH-CH=CH-; r es un numero entero igual a 1, 2, 3, 4 o 5; R7 es hidrogeno, alquilo, Ar o Het; R8 es hidrogeno o alquilo; R9 es oxo; o R8 y R9 juntos forman el radical -CH=CH-N=; alquilo es un radical de hidrocarburo saturado, recto o ramificado C1-6; o es un radical de hidrocarburo saturado cíclico C3-6; o es un radical de hidrocarburo saturado cíclico C3-6 unido a un radical de hidrocarburo saturado, recto o ramificado, C1-6; donde cada átomo de carbono puede estar sustituido en forma opcional con hidroxi, alquiloxi u oxo; Ar es un homociclo seleccionado del grupo de fenilo, naftilo, acenaftilo, tetrahidronaftilo, cada homociclo sustituido en forma opcional con 1, 2 o 3 sustituyentes, cada sustituyente seleccionado en forma independiente del grupo de hidroxi, halo, ciano, nitro, amino, mono- o dialquilamino, alquilo, haloalquilo, alquiloxi, haloalquiloxi, carboxilo, alquiloxicarbonilo, aminocarbonilo, morfolinilo y mono- o dialquilaminocarbonilo; Het es un heterociclo monocíclico seleccionado del grupo de N-fenoxipiperidinilo, piperidinilo, pirrolilo, pirazolilo, imidazolilo, furanilo, tienilo, oxazolilo, isoxazolilo, tiazolilo, isotiazolilo, piridinilo, pirimidinilo, pirazinilo y piridazinilo; o un heterociclo bicíclico seleccionado del grupo de quinolinilo, quinoxalinilo, indolilo, bencimidazolilo, benzoxazolilo, bencisoxazolilo, benzotiazolilo, bencisotiazolilo, benzofuranilo, benzotienilo, 2,3-dihidrobenzo[1,4]dioxinilo y benzo[1,3]dioxolilo; cada heterociclo monocíclico o bicíclico puede estar sustituido en forma opcional con 1, 2 o 3 sustituyentes, cada sustituyente seleccionado en forma independiente del grupo de halo, hidroxi, alquilo, alquiloxi y Ar-carbonilo; halo es un sustituyente seleccionado del grupo de fluoro, cloro, bromo y yodo; y haloalquilo es un radical de hidrocarburo saturado, recto o ramificado C1-6 o un radical de hidrocarburo cíclico saturado C3-6 o un radical de hidrocarburo cíclico saturado C3-6 unido a un radical de hidrocarburo saturado, recto o ramificado, C1-6; donde uno o más átomos de carbono están sustituidos con uno o más átomos de halo; siempre que la infeccion bacteriana sea distinta de una infeccion por Microbacterias. Reivindicacion 26: Un compuesto en el cual el compuesto se selecciona de las formulas (4) a (17), una de sus sales de adicion con ácido o base aceptables desde el punto de vista farmacéutico, una de sus formas tautoméricas o una de sus formas se N-oxido.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05105762 | 2005-06-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR054626A1 true AR054626A1 (es) | 2007-07-04 |
Family
ID=34940244
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060102787A AR054626A1 (es) | 2005-06-28 | 2006-06-28 | Derivados de quinolina como agentes antibacterianos |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US8841321B2 (es) |
| EP (1) | EP1898914B1 (es) |
| JP (1) | JP5193858B2 (es) |
| KR (1) | KR101329585B1 (es) |
| CN (1) | CN101247811B (es) |
| AP (1) | AP2386A (es) |
| AR (1) | AR054626A1 (es) |
| AU (1) | AU2006263883B2 (es) |
| BR (1) | BRPI0612498A8 (es) |
| CA (1) | CA2612619C (es) |
| CY (1) | CY1113579T1 (es) |
| DK (1) | DK1898914T3 (es) |
| EA (1) | EA014423B1 (es) |
| ES (1) | ES2393203T3 (es) |
| HR (1) | HRP20120912T1 (es) |
| IL (1) | IL188393A0 (es) |
| JO (1) | JO2752B1 (es) |
| ME (1) | ME01484B (es) |
| MX (1) | MX2008000081A (es) |
| MY (1) | MY153291A (es) |
| NO (1) | NO342701B1 (es) |
| NZ (1) | NZ564379A (es) |
| PA (1) | PA8683801A1 (es) |
| PL (1) | PL1898914T3 (es) |
| PT (1) | PT1898914E (es) |
| RS (1) | RS52517B (es) |
| SI (1) | SI1898914T1 (es) |
| TW (1) | TWI387457B (es) |
| UA (1) | UA92175C2 (es) |
| WO (1) | WO2007000435A1 (es) |
| ZA (1) | ZA200711165B (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO2683B1 (en) * | 2006-12-06 | 2013-03-03 | جانسين فارماسوتيكا ان. في | Quinoline antibacterial derivatives |
| JO2970B1 (en) | 2006-12-06 | 2016-03-15 | جانسين فارماسوتيكا ان. في | Quinoline antibacterial derivatives |
| WO2013160435A1 (en) | 2012-04-27 | 2013-10-31 | Janssen Pharmaceutica Nv | Antibacterial quinoline derivatives |
| WO2013160431A1 (en) | 2012-04-27 | 2013-10-31 | Janssen Pharmaceutica Nv | Antibacterial quinoline derivatives |
| EP3237383B1 (en) | 2014-12-23 | 2019-12-04 | Albemarle Corporation | One-step process for the synthesis of alkylated metyrapone analogs |
| CN106928139B (zh) * | 2017-05-08 | 2019-06-25 | 福建省微生物研究所 | 一种贝达喹啉杂质的合成方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19937116A1 (de) * | 1999-08-06 | 2001-02-08 | Bayer Ag | Moxifloxacin Kochsalzformulierung |
| ATE463482T1 (de) * | 2002-07-25 | 2010-04-15 | Janssen Pharmaceutica Nv | Chinolinderivate und deren verwendung als mycobakterielle inhibitoren |
| JP2007522093A (ja) * | 2003-09-22 | 2007-08-09 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ７−アミノアルキリデニル−複素環式キノロンおよびナフチリドン |
| ATE390925T1 (de) * | 2004-05-28 | 2008-04-15 | Janssen Pharmaceutica Nv | Verwendung von substituierten chinolin-derivaten zur behandlung von arzneimittelresistenten mycobakteriellen erkrankungen |
| EE05394B1 (et) * | 2004-12-24 | 2011-04-15 | Janssen Pharmaceutica N.V. | Kinoliinihendid kasutamiseks latentse tuberkuloosi ravis |
| NZ564340A (en) | 2005-06-28 | 2011-02-25 | Janssen Pharmaceutica Nv | Quinoline derivatives as antibacterial agents |
-
2006
- 2006-06-25 JO JO2006188A patent/JO2752B1/en active
- 2006-06-26 MX MX2008000081A patent/MX2008000081A/es active IP Right Grant
- 2006-06-26 EP EP06763889A patent/EP1898914B1/en active Active
- 2006-06-26 ES ES06763889T patent/ES2393203T3/es active Active
- 2006-06-26 US US11/993,145 patent/US8841321B2/en not_active Expired - Fee Related
- 2006-06-26 PT PT06763889T patent/PT1898914E/pt unknown
- 2006-06-26 CN CN2006800310552A patent/CN101247811B/zh not_active Expired - Fee Related
- 2006-06-26 KR KR1020087002107A patent/KR101329585B1/ko not_active Expired - Fee Related
- 2006-06-26 UA UAA200714927A patent/UA92175C2/ru unknown
- 2006-06-26 SI SI200631468T patent/SI1898914T1/sl unknown
- 2006-06-26 PL PL06763889T patent/PL1898914T3/pl unknown
- 2006-06-26 HR HRP20120912TT patent/HRP20120912T1/hr unknown
- 2006-06-26 DK DK06763889.0T patent/DK1898914T3/da active
- 2006-06-26 BR BRPI0612498A patent/BRPI0612498A8/pt not_active Application Discontinuation
- 2006-06-26 ME MEP-2012-127A patent/ME01484B/me unknown
- 2006-06-26 AU AU2006263883A patent/AU2006263883B2/en not_active Ceased
- 2006-06-26 RS RS20120480A patent/RS52517B/sr unknown
- 2006-06-26 EA EA200800154A patent/EA014423B1/ru unknown
- 2006-06-26 NZ NZ564379A patent/NZ564379A/en not_active IP Right Cessation
- 2006-06-26 WO PCT/EP2006/063553 patent/WO2007000435A1/en not_active Ceased
- 2006-06-26 JP JP2008518810A patent/JP5193858B2/ja not_active Expired - Fee Related
- 2006-06-26 CA CA2612619A patent/CA2612619C/en not_active Expired - Fee Related
- 2006-06-26 AP AP2008004303A patent/AP2386A/xx active
- 2006-06-27 TW TW095123127A patent/TWI387457B/zh not_active IP Right Cessation
- 2006-06-27 MY MYPI20063044A patent/MY153291A/en unknown
- 2006-06-28 AR ARP060102787A patent/AR054626A1/es unknown
- 2006-06-28 PA PA20068683801A patent/PA8683801A1/es unknown
-
2007
- 2007-12-20 ZA ZA2007/11165A patent/ZA200711165B/en unknown
- 2007-12-25 IL IL188393A patent/IL188393A0/en active IP Right Grant
-
2008
- 2008-01-28 NO NO20080501A patent/NO342701B1/no not_active IP Right Cessation
-
2012
- 2012-11-14 CY CY20121101090T patent/CY1113579T1/el unknown
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