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DK613184A - Phenyleddikesyrederivater eller salte deraf, laegemidler indeholdende disse forbindelser og fremgangsmaader til deres fremstilling - Google Patents

Phenyleddikesyrederivater eller salte deraf, laegemidler indeholdende disse forbindelser og fremgangsmaader til deres fremstilling Download PDF

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Publication number
DK613184A
DK613184A DK613184A DK613184A DK613184A DK 613184 A DK613184 A DK 613184A DK 613184 A DK613184 A DK 613184A DK 613184 A DK613184 A DK 613184A DK 613184 A DK613184 A DK 613184A
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DK
Denmark
Prior art keywords
procedures
salts
compounds
preparation
acetic acid
Prior art date
Application number
DK613184A
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English (en)
Other versions
DK167439B1 (da
DK613184D0 (da
Inventor
Wolfgang Grell
Rudolf Hurnaus
Gerhart Griss
Robert Sauter
Eckhard Rupprecht
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Publication of DK613184D0 publication Critical patent/DK613184D0/da
Publication of DK613184A publication Critical patent/DK613184A/da
Application granted granted Critical
Publication of DK167439B1 publication Critical patent/DK167439B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/14—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)
  • Lubricants (AREA)
  • Glass Compositions (AREA)
DK613184A 1983-12-30 1984-12-20 Phenyleddikesyrederivater eller salte deraf, laegemidler indeholdende disse forbindelser, anvendelse af forbindelserne til fremstilling af et laegemiddel, fremgangsmaade til fremstilling af et laegemiddel samt en fremgangsmaade til fremstilling af phenyleddikesyrederivaterne DK167439B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE19833347565 DE3347565A1 (de) 1983-12-30 1983-12-30 Neue phenylessigsaeurederivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE3347565 1983-12-30
DE3522604 1985-06-25
DE19853522604 DE3522604A1 (de) 1983-12-30 1985-06-25 Neue feste formen von 2-(gamma)thoxy-4-(n-(1-(2-piperidino-phenyl)-3-methyl-1-butyl)-aminocarbonylmethyl)-benzoesaeure, diese formen enthaltende arzneimittel und verfahren zu ihrer herstellung

Publications (3)

Publication Number Publication Date
DK613184D0 DK613184D0 (da) 1984-12-20
DK613184A true DK613184A (da) 1985-07-01
DK167439B1 DK167439B1 (da) 1993-11-01

Family

ID=37847099

Family Applications (2)

Application Number Title Priority Date Filing Date
DK613184A DK167439B1 (da) 1983-12-30 1984-12-20 Phenyleddikesyrederivater eller salte deraf, laegemidler indeholdende disse forbindelser, anvendelse af forbindelserne til fremstilling af et laegemiddel, fremgangsmaade til fremstilling af et laegemiddel samt en fremgangsmaade til fremstilling af phenyleddikesyrederivaterne
DK296686A DK167573B1 (da) 1983-12-30 1986-06-24 Faste former af 2-ethoxy-4-oen-(1-(2-piperidino-phenyl)-3-methyl-1-butyl)-aminocarbonylmethylaa-benzoesyre, laegemidler indeholdende disse former, fremgangsmaade til fremstilling af de faste former, samt fremgangsmaade til fremstilling af et laegemiddel

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK296686A DK167573B1 (da) 1983-12-30 1986-06-24 Faste former af 2-ethoxy-4-oen-(1-(2-piperidino-phenyl)-3-methyl-1-butyl)-aminocarbonylmethylaa-benzoesyre, laegemidler indeholdende disse former, fremgangsmaade til fremstilling af de faste former, samt fremgangsmaade til fremstilling af et laegemiddel

Country Status (26)

Country Link
EP (2) EP0147850B1 (da)
JP (2) JPH0623200B2 (da)
KR (1) KR900005320B1 (da)
AT (1) ATE44027T1 (da)
AU (2) AU577815B2 (da)
BG (1) BG61519B2 (da)
CA (2) CA1225398A (da)
CS (1) CS409791A3 (da)
DD (1) DD231348A5 (da)
DE (4) DE3347565A1 (da)
DK (2) DK167439B1 (da)
ES (7) ES8605500A1 (da)
FI (2) FI80447C (da)
GR (2) GR82614B (da)
HK (1) HK87492A (da)
HU (1) HU194548B (da)
IE (1) IE57700B1 (da)
IL (2) IL73963A (da)
LU (1) LU90301I2 (da)
MX (1) MX9202772A (da)
NL (1) NL980034I1 (da)
NO (3) NO162819C (da)
NZ (2) NZ210657A (da)
PT (2) PT79772B (da)
SG (1) SG55492G (da)
ZA (2) ZA8410103B (da)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3347565A1 (de) * 1983-12-30 1985-07-11 Thomae Gmbh Dr K Neue phenylessigsaeurederivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE3523466A1 (de) * 1985-07-01 1987-01-08 Thomae Gmbh Dr K Neue phenylessigsaeurederivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
ES2179558T3 (es) * 1991-06-21 2003-01-16 Boehringer Ingelheim Pharma Procedimiento para preparar (s)-3-metil-1-(2-piperidino-fenil)-1-butilamina.
PL170210B1 (pl) * 1991-06-21 1996-11-29 Thomae Gmbh Dr K Sposób wytwarzania nowego kwasu (S)(+)-2-etoksy-4-/N-/1-(2-piperydynofenylo)-3-metylo- 1-butyloaminokarbonylometylo/-benzoesowego i jego soli PL
FR2763590B1 (fr) * 1997-05-22 2000-03-24 Synthelabo Derives d'acides[[[(arylmethyl)amino]carbonyl] alkyl]- aromatiques, leur preparation et leur application en therapeutique
PT1741445E (pt) 2000-01-21 2013-11-11 Novartis Ag Combinações incluindo inibidores de dipeptidilpeptidase-iv e agentes antidiabéticos
US20040102477A1 (en) * 2002-08-23 2004-05-27 Dr. Reddy's Laboratories Limited Polymorphic forms of (S)-Repaglinide and the processes for preparation thereof
WO2004101540A2 (de) * 2003-05-14 2004-11-25 Cilag Ag Verfahren zur herstellung von phenylessigsäurederivaten
WO2004103983A1 (en) * 2003-05-26 2004-12-02 Biocon Limited Process for the preparation of s(+)-2-ethoxy-4-[n-{1-(2-piperidinophelyl)-3-methyl-1- butyl} aminocarbonylmethyl]benzoic acid derivatives
WO2004108673A2 (en) * 2003-06-09 2004-12-16 Boehringer Ingelheim International Gmbh Inhibitors of papilloma virus
FR2875805B1 (fr) * 2004-09-27 2006-12-29 Genfit S A Composes derives de n-(benzyl) phenylacetamide substitues, preparation et utilisations
CN1305863C (zh) * 2004-12-27 2007-03-21 浙江大学 (s)－异丙基－(2－哌啶)苯基－甲基胺的合成方法
GT200600381A (es) 2005-08-25 2007-03-28 Compuestos organicos
HRP20140091T4 (hr) 2005-09-14 2021-12-24 Takeda Pharmaceutical Company Limited Davanje inhibitora dipeptidil peptidaze
EP2177221A1 (en) 2008-10-20 2010-04-21 Krka Tovarna Zdravil, D.D., Novo Mesto Process for the preparation of substantially optically pure Repaglinide and precursors thereof
JP5659224B2 (ja) 2009-05-15 2015-01-28 ノバルティス アーゲー アルドステロンシンターゼ阻害剤としてのアリールピリジン
KR20120036850A (ko) 2009-05-15 2012-04-18 노파르티스 아게 알도스테론 신타제 억제제로서의 벤족사졸론 유도체
ME01923B (me) 2009-05-28 2015-05-20 Novartis Ag Supstituisani derivati aminopropionske kiseline kao inhibitori neprilizina
UY32660A (es) 2009-05-28 2010-12-31 Novartis Ag Derivados aminobutricos sustituidos como inhibidores de neprilisina
WO2011041293A1 (en) 2009-09-30 2011-04-07 Takeda Pharmaceutical Company Limited Pyrazolo [1, 5-a] pyrimidine derivatives as apoptosis signal-regulating kinase 1 inhibitors
ES2663351T3 (es) 2009-11-17 2018-04-12 Novartis Ag Derivados de aril-piridina como inhibidores de la aldosterona sintasa
JO2967B1 (en) 2009-11-20 2016-03-15 نوفارتس ايه جي Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors
CN102666535B (zh) 2009-11-30 2015-02-25 诺华股份有限公司 作为醛固酮合酶抑制剂的咪唑衍生物
CN102834393B (zh) 2010-02-03 2015-07-22 武田药品工业株式会社 细胞凋亡信号调节激酶1抑制剂
US8877815B2 (en) 2010-11-16 2014-11-04 Novartis Ag Substituted carbamoylcycloalkyl acetic acid derivatives as NEP
US8673974B2 (en) 2010-11-16 2014-03-18 Novartis Ag Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors
WO2012095548A2 (es) 2011-01-13 2012-07-19 Centro De Investigación Biomédica En Red De Enfermedades Neurodegenerativas (Ciberned) Compuestos para el tratamiento de enfermedades neurodegenerativas
UY35144A (es) 2012-11-20 2014-06-30 Novartis Ag Miméticos lineales sintéticos de apelina para el tratamiento de insuficiencia cardiaca
LT2956464T (lt) 2013-02-14 2018-07-10 Novartis Ag Pakeisti bisfenilbutanoinės fosfonrūgšties dariniai, kaip nep (neutralios endopeptidazės) inhibitoriai
JP6501775B2 (ja) 2013-07-25 2019-04-17 ノバルティス アーゲー 心不全治療用の環状ポリペプチド
AP2016009019A0 (en) 2013-07-25 2016-02-29 Novartis Ag Bioconjugates of synthetic apelin polypeptides
PE20171328A1 (es) 2015-01-23 2017-09-12 Novartis Ag Conjugados de acidos grasos y apelina sintetica con mayor vida media
UY38072A (es) 2018-02-07 2019-10-01 Novartis Ag Compuestos derivados de éster butanoico sustituido con bisfenilo como inhibidores de nep, composiciones y combinaciones de los mismos

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3100575A1 (de) * 1981-01-10 1982-09-02 Dr. Karl Thomae Gmbh, 7950 Biberach "neue benzoesaeuren, ihre herstellung und ihre verwendung als arzneimittel"
DE3100535A1 (de) * 1981-01-10 1982-08-12 Dr. Karl Thomae Gmbh, 7950 Biberach "neue carbonsaeure-derivate, ihre herstellung und ihre verwendung als arzneimittel"
SU1170969A3 (ru) * 1982-07-06 1985-07-30 Др.Карл Томэ,Гмбх (Фирма) Способ получени производных фенилуксусной кислоты или их солей
FR2554875B1 (fr) * 1983-11-10 1986-02-28 Dba Amplificateur hydraulique de freinage
DE3347565A1 (de) * 1983-12-30 1985-07-11 Thomae Gmbh Dr K Neue phenylessigsaeurederivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE3523466A1 (de) * 1985-07-01 1987-01-08 Thomae Gmbh Dr K Neue phenylessigsaeurederivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
JPS60158171A (ja) 1985-08-19
DE3347565A1 (de) 1985-07-11
JPH0623200B2 (ja) 1994-03-30
EP0207331B1 (de) 1990-05-23
IE57700B1 (en) 1993-03-10
ATE44027T1 (de) 1989-06-15
LU90301I2 (fr) 1998-12-21
ES556495A0 (es) 1988-04-01
ES8802145A1 (es) 1988-04-01
KR900005320B1 (ko) 1990-07-27
ES8604546A1 (es) 1986-02-01
AU577815B2 (en) 1988-10-06
NL980034I1 (nl) 1999-02-01
AU583631B2 (en) 1989-05-04
FI845145A0 (fi) 1984-12-28
DE19875044I2 (de) 2002-07-18
FI845145L (fi) 1985-07-01
SG55492G (en) 1992-10-02
PT79772B (de) 1987-01-05
ES8604545A1 (es) 1986-02-01
NO162819B (no) 1989-11-13
PT79772A (de) 1985-01-01
NO862532L (no) 1986-12-29
NO168302C (no) 1992-02-05
KR850004590A (ko) 1985-07-25
DD231348A5 (de) 1985-12-24
FI80447C (fi) 1990-06-11
HUT37773A (en) 1986-02-28
DK167439B1 (da) 1993-11-01
DE3522604A1 (de) 1987-01-08
PT82832A (de) 1986-07-01
DK167573B1 (da) 1993-11-22
FI862650L (fi) 1986-12-26
ES8604544A1 (es) 1986-02-01
GR82614B (en) 1985-05-02
NZ210657A (en) 1988-10-28
NO1999016I1 (no) 1999-07-20
NO862532D0 (no) 1986-06-24
ES8604547A1 (es) 1986-02-01
DK296686A (da) 1986-12-26
ES8605500A1 (es) 1986-03-16
IL79217A0 (en) 1986-09-30
NO162819C (no) 1990-02-21
FI82689B (fi) 1990-12-31
ZA864695B (en) 1988-02-24
ES545879A0 (es) 1986-02-01
FI862650A0 (fi) 1986-06-23
PT82832B (pt) 1988-12-15
IL73963A (en) 1989-01-31
EP0207331A1 (de) 1987-01-07
FI82689C (fi) 1991-04-10
NO168302B (no) 1991-10-28
NZ216640A (en) 1989-02-24
AU5913986A (en) 1987-01-08
HU194548B (en) 1988-02-29
EP0147850A2 (de) 1985-07-10
DK296686D0 (da) 1986-06-24
GR861558B (en) 1986-10-17
JPH0739405B2 (ja) 1995-05-01
DK613184D0 (da) 1984-12-20
CA1225398A (en) 1987-08-11
JPS62474A (ja) 1987-01-06
ES545882A0 (es) 1986-02-01
IE843349L (en) 1985-06-30
BG61519B2 (bg) 1997-10-31
ES8604548A1 (es) 1986-02-01
ES545883A0 (es) 1986-02-01
FI80447B (fi) 1990-02-28
CA1292000C (en) 1991-11-12
MX9202772A (es) 1992-06-30
ZA8410103B (en) 1986-09-24
NO845282L (no) 1985-07-01
ES545880A0 (es) 1986-02-01
HK87492A (en) 1992-11-13
EP0147850B1 (de) 1989-06-14
IL73963A0 (en) 1985-03-31
ES545881A0 (es) 1986-02-01
AU3721084A (en) 1985-08-01
DE3478682D1 (en) 1989-07-20
ES539078A0 (es) 1986-03-16
IL79217A (en) 1991-01-31
CS409791A3 (en) 1992-07-15
EP0147850A3 (en) 1985-08-07

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
CTFF Application for supplementary protection certificate (spc) filed

Free format text: CA 1999 00005, 19990215, EXPIRES: 20091220

CTFG Supplementary protection certificate (spc) issued

Free format text: PRODUCT NAME: REPAGLINIDE

Spc suppl protection certif: CA 1999 00005

Filing date: 19990215