DK535789A - Pyrimidindionderivater, fremgangsmaade til fremstilling heraf og antiarytmika omfattende samme - Google Patents
Pyrimidindionderivater, fremgangsmaade til fremstilling heraf og antiarytmika omfattende sammeInfo
- Publication number
- DK535789A DK535789A DK535789A DK535789A DK535789A DK 535789 A DK535789 A DK 535789A DK 535789 A DK535789 A DK 535789A DK 535789 A DK535789 A DK 535789A DK 535789 A DK535789 A DK 535789A
- Authority
- DK
- Denmark
- Prior art keywords
- arthymics
- dionion
- pyrimidine
- procedures
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (18)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP27199288 | 1988-10-29 | ||
| JP27199288 | 1988-10-29 | ||
| JP30684188 | 1988-12-06 | ||
| JP30684088 | 1988-12-06 | ||
| JP30684088 | 1988-12-06 | ||
| JP30684188 | 1988-12-06 | ||
| JP9641889 | 1989-04-18 | ||
| JP9641689 | 1989-04-18 | ||
| JP9641889 | 1989-04-18 | ||
| JP9641789 | 1989-04-18 | ||
| JP9641789 | 1989-04-18 | ||
| JP9641689 | 1989-04-18 | ||
| JP22927289 | 1989-09-06 | ||
| JP22927289 | 1989-09-06 | ||
| JP24631889 | 1989-09-25 | ||
| JP24631789 | 1989-09-25 | ||
| JP01246318 | 1989-09-25 | ||
| JP24631789 | 1989-09-25 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK535789D0 DK535789D0 (da) | 1989-10-27 |
| DK535789A true DK535789A (da) | 1990-04-30 |
| DK170203B1 DK170203B1 (da) | 1995-06-12 |
Family
ID=27577291
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK535789A DK170203B1 (da) | 1988-10-29 | 1989-10-27 | Pyrimidindionderivater, fremgangsmåde til fremstilling heraf og antiarrhythmika omfattende samme |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5008267A (da) |
| EP (1) | EP0369627B1 (da) |
| KR (1) | KR920002307B1 (da) |
| AT (1) | ATE115952T1 (da) |
| AU (1) | AU613805B2 (da) |
| DE (1) | DE68920125T2 (da) |
| DK (1) | DK170203B1 (da) |
| ES (1) | ES2066000T3 (da) |
| FI (1) | FI95245C (da) |
| HU (1) | HU210780B (da) |
| NO (1) | NO174711C (da) |
| NZ (1) | NZ231165A (da) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5308848A (en) * | 1989-10-24 | 1994-05-03 | Mitsui Toatsu Chemicals, Incorporated | Pyrimidinedione derivatives and antiarrythmic agents containing the same |
| JPH03173885A (ja) * | 1989-12-01 | 1991-07-29 | Mitsui Toatsu Chem Inc | ピリミジンジオン誘導体化合物、該化合物の製造法および該化合物を含む抗不整脈剤 |
| JPH0413669A (ja) * | 1990-04-27 | 1992-01-17 | Mitsui Toatsu Chem Inc | 新規ピリミジンジオン誘導体及び該化合物を含有する抗不整脈剤 |
| DE4032766A1 (de) * | 1990-10-16 | 1992-04-30 | Basf Ag | Phenylpiperidinoylamine und diese enthaltende arzneimittel |
| EP0640341A1 (en) * | 1993-08-27 | 1995-03-01 | Mitsui Toatsu Chemicals, Incorporated | Sustained release pharmaceutical composition and process for producing same |
| EP0697407B1 (en) | 1994-08-19 | 1997-06-25 | MITSUI TOATSU CHEMICALS, Inc. | Pyrimidinedione derivatives and antiarrhythmic compositions containing same |
| WO1996017831A1 (de) * | 1994-12-07 | 1996-06-13 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Uracilderivate |
| EP0722732A1 (en) * | 1995-01-24 | 1996-07-24 | Mitsui Toatsu Chemicals, Inc. | Long-acting drug formulation containing pyrimidinedione derivatives |
| DE19600934A1 (de) | 1996-01-12 | 1997-07-17 | Basf Ag | Substituierte Aza- und Diazacycloheptan- und Cyclooctanverbindungen und deren Verwendung |
| IT1293807B1 (it) * | 1997-08-01 | 1999-03-10 | Recordati Chem Pharm | Derivati 1- (n-fenilaminoalchil) piperazinici sostituiti alla posizione 2 dell'anello fenilico |
| US6399614B1 (en) | 1997-08-01 | 2002-06-04 | Recordati S.A. Chemical And Pharmaceutical Company | 1-(N-phenylaminoalkyl)piperazine derivatives substituted at position 2 of the phenyl ring |
| US6458952B1 (en) * | 1999-05-19 | 2002-10-01 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade |
| US7015230B1 (en) | 1999-05-19 | 2006-03-21 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade |
| US6653316B1 (en) * | 1999-05-19 | 2003-11-25 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade |
| US6906068B1 (en) | 1999-05-19 | 2005-06-14 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl 1,2,4 - triazinones useful as anticoagulants |
| US6867217B1 (en) | 1999-05-19 | 2005-03-15 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade |
| US6664255B1 (en) | 1999-05-19 | 2003-12-16 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade |
| US6750342B1 (en) * | 1999-05-19 | 2004-06-15 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade |
| US6716838B1 (en) | 1999-05-19 | 2004-04-06 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl uracils as anticoagulative agents |
| US6660885B2 (en) * | 2000-03-13 | 2003-12-09 | Pharmacia Corporation | Polycyclic aryl and heteroaryl substituted benzenes useful for selective inhibition of the coagulation cascade |
| PT1268463E (pt) | 2000-04-05 | 2005-05-31 | Pharmacia Corp | 4-pironas substituidas com arilo e heteroarilo policiclicos uteis para a inibicao selectiva da cascata de coagulacao |
| US6693121B2 (en) | 2000-04-05 | 2004-02-17 | Pharmacia Corporation | Polycyclic aryl and heteroaryl substituted 4-pyridones useful for selective inhibition of the coagulation cascade |
| EP1274676A2 (en) * | 2000-04-17 | 2003-01-15 | Pharmacia Corporation | Polycyclic aryl and heteroaryl substituted 1,4-quinones useful for selective inhibition of the coagulation cascade |
| CA2430037A1 (en) * | 2000-11-20 | 2002-05-30 | Michael S. South | Substituted polycyclic aryl and heteroaryl pyridines useful for selective inhibition of the coagulation cascade |
| PL215049B1 (pl) * | 2001-08-02 | 2013-10-31 | Sumitomo Chemical Co | Zwiazek pirydonowy o wlasciwosciach chwastobójczych |
| US20040068113A1 (en) * | 2001-11-20 | 2004-04-08 | South Michael S. | Substituted polycyclic aryl and heteroaryl pyridines useful for selective inhibition of the coagulation cascade |
| PT1778236E (pt) | 2004-07-02 | 2010-10-19 | Corcept Therapeutics Inc | Moduladores do receptor de glucocorticóide de pirimidina modificada |
| ES2563444T3 (es) | 2011-03-18 | 2016-03-15 | Corcept Therapeutics, Inc. | Moduladores del receptor de glucocorticoide de tipo pirimidina ciclohexilo |
| CN102617486B (zh) * | 2012-03-01 | 2014-04-16 | 江西吉翔医药化工有限公司 | 一种6-氯-1,3-二甲基脲嘧啶的制备方法 |
| CN103288751B (zh) * | 2013-06-03 | 2016-04-20 | 四川百利药业有限责任公司 | 一种高纯度盐酸尼非卡兰的制备方法 |
| SMT202000071T1 (it) * | 2013-06-21 | 2020-03-13 | Myokardia Inc | Composti di pirimidinadione contro le condizioni cardiache |
| AU2019282047B2 (en) | 2018-06-04 | 2022-06-02 | Corcept Therapeutics Incorporated | Pyrimidine cyclohexenyl glucocorticoid receptor modulators |
| US11851409B2 (en) | 2019-01-25 | 2023-12-26 | Qingdao Jião Pharmaceutical Technology Co., Ltd | Deuterated benzylaminopyrimidinedione derivatives and use thereof |
| JP7569492B2 (ja) | 2019-12-11 | 2024-10-18 | コーセプト セラピューティクス， インコーポレイテッド | 抗精神病薬誘発性体重増加のミリコリラントによる治療方法 |
| AU2021268944B2 (en) | 2020-05-06 | 2024-04-18 | Corcept Therapeutics Incorporated | Polymorphs of pyrimidine cyclohexyl glucocorticoid receptor modulators |
| EP4146173A4 (en) | 2020-05-06 | 2024-05-29 | Corcept Therapeutics Incorporated | FORMULATIONS OF PYRIMIDINE CYCLOHEXYL GLUCOCORTICOID RECEPTOR MODULATORS |
| EP4263508A4 (en) | 2020-12-21 | 2024-11-27 | Corcept Therapeutics Incorporated | Method of preparing pyrimidine cyclohexyl glucocorticoid receptor modulators |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE787103A (fr) * | 1971-08-04 | 1973-02-02 | Pfizer | Nouveaux derives de propanolamine et composition pharmaceutiqueles contenant |
| DE2329399A1 (de) * | 1973-06-08 | 1975-01-02 | Wuelfing J A Fa | 4-alkyl-aminouracile, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| LU77339A1 (da) * | 1977-05-16 | 1979-01-19 |
-
1989
- 1989-10-24 US US07/425,730 patent/US5008267A/en not_active Expired - Lifetime
- 1989-10-26 NZ NZ231165A patent/NZ231165A/en unknown
- 1989-10-27 DE DE68920125T patent/DE68920125T2/de not_active Expired - Lifetime
- 1989-10-27 FI FI895121A patent/FI95245C/fi active IP Right Grant
- 1989-10-27 NO NO894299A patent/NO174711C/no unknown
- 1989-10-27 AU AU43869/89A patent/AU613805B2/en not_active Expired
- 1989-10-27 EP EP89311135A patent/EP0369627B1/en not_active Expired - Lifetime
- 1989-10-27 ES ES89311135T patent/ES2066000T3/es not_active Expired - Lifetime
- 1989-10-27 AT AT89311135T patent/ATE115952T1/de not_active IP Right Cessation
- 1989-10-27 HU HU895468A patent/HU210780B/hu unknown
- 1989-10-27 DK DK535789A patent/DK170203B1/da not_active IP Right Cessation
- 1989-10-28 KR KR1019890015569A patent/KR920002307B1/ko not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| EP0369627A3 (en) | 1990-12-12 |
| DK170203B1 (da) | 1995-06-12 |
| FI95245C (fi) | 1996-01-10 |
| ATE115952T1 (de) | 1995-01-15 |
| EP0369627B1 (en) | 1994-12-21 |
| DE68920125D1 (de) | 1995-02-02 |
| HU210780B (en) | 1995-07-28 |
| NO174711C (no) | 1994-06-22 |
| HU895468D0 (en) | 1990-01-28 |
| KR920002307B1 (ko) | 1992-03-21 |
| NZ231165A (en) | 1992-02-25 |
| NO174711B (no) | 1994-03-14 |
| KR900006300A (ko) | 1990-05-07 |
| FI95245B (fi) | 1995-09-29 |
| AU613805B2 (en) | 1991-08-08 |
| ES2066000T3 (es) | 1995-03-01 |
| NO894299L (no) | 1990-04-30 |
| DE68920125T2 (de) | 1995-08-03 |
| US5008267A (en) | 1991-04-16 |
| HUT52764A (en) | 1990-08-28 |
| DK535789D0 (da) | 1989-10-27 |
| FI895121A0 (fi) | 1989-10-27 |
| NO894299D0 (no) | 1989-10-27 |
| AU4386989A (en) | 1990-05-31 |
| EP0369627A2 (en) | 1990-05-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B1 | Patent granted (law 1993) | ||
| PUP | Patent expired |