DE68920125D1 - Pyrimidindion-Derivate, Verfahren zu deren Herstellung und diese enthaltende antiarrythmische Mittel. - Google Patents
Pyrimidindion-Derivate, Verfahren zu deren Herstellung und diese enthaltende antiarrythmische Mittel.Info
- Publication number
- DE68920125D1 DE68920125D1 DE68920125T DE68920125T DE68920125D1 DE 68920125 D1 DE68920125 D1 DE 68920125D1 DE 68920125 T DE68920125 T DE 68920125T DE 68920125 T DE68920125 T DE 68920125T DE 68920125 D1 DE68920125 D1 DE 68920125D1
- Authority
- DE
- Germany
- Prior art keywords
- processes
- preparation
- pyrimidinedione
- agents containing
- antiarrhythmic agents
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP27199288 | 1988-10-29 | ||
| JP30684088 | 1988-12-06 | ||
| JP30684188 | 1988-12-06 | ||
| JP9641789 | 1989-04-18 | ||
| JP9641889 | 1989-04-18 | ||
| JP9641689 | 1989-04-18 | ||
| JP22927289 | 1989-09-06 | ||
| JP24631789 | 1989-09-25 | ||
| JP01246318 | 1989-09-25 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE68920125D1 true DE68920125D1 (de) | 1995-02-02 |
| DE68920125T2 DE68920125T2 (de) | 1995-08-03 |
Family
ID=27577291
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE68920125T Expired - Lifetime DE68920125T2 (de) | 1988-10-29 | 1989-10-27 | Pyrimidindion-Derivate, Verfahren zu deren Herstellung und diese enthaltende antiarrythmische Mittel. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5008267A (de) |
| EP (1) | EP0369627B1 (de) |
| KR (1) | KR920002307B1 (de) |
| AT (1) | ATE115952T1 (de) |
| AU (1) | AU613805B2 (de) |
| DE (1) | DE68920125T2 (de) |
| DK (1) | DK170203B1 (de) |
| ES (1) | ES2066000T3 (de) |
| FI (1) | FI95245C (de) |
| HU (1) | HU210780B (de) |
| NO (1) | NO174711C (de) |
| NZ (1) | NZ231165A (de) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5308848A (en) * | 1989-10-24 | 1994-05-03 | Mitsui Toatsu Chemicals, Incorporated | Pyrimidinedione derivatives and antiarrythmic agents containing the same |
| JPH03173885A (ja) * | 1989-12-01 | 1991-07-29 | Mitsui Toatsu Chem Inc | ピリミジンジオン誘導体化合物、該化合物の製造法および該化合物を含む抗不整脈剤 |
| JPH0413669A (ja) * | 1990-04-27 | 1992-01-17 | Mitsui Toatsu Chem Inc | 新規ピリミジンジオン誘導体及び該化合物を含有する抗不整脈剤 |
| DE4032766A1 (de) * | 1990-10-16 | 1992-04-30 | Basf Ag | Phenylpiperidinoylamine und diese enthaltende arzneimittel |
| EP0640341A1 (de) * | 1993-08-27 | 1995-03-01 | Mitsui Toatsu Chemicals, Incorporated | Arzneimittel mit verzögerter Wirkstoffabgabe und Verfahren |
| DE69500377T2 (de) | 1994-08-19 | 1997-10-09 | Mitsui Toatsu Chemicals | Pyrimidin-Dion-Derivate und diese enthaltende antiarrhythmische Zusammensetzungen |
| EP0796251B1 (de) * | 1994-12-07 | 2001-10-17 | Byk Gulden Lomberg Chemische Fabrik GmbH | Uracilderivate |
| EP0722732A1 (de) * | 1995-01-24 | 1996-07-24 | Mitsui Toatsu Chemicals, Inc. | Pyrimidindionderivate enthaltendes Arzneimittel mit verlängerter Wirkstoffabgabe |
| DE19600934A1 (de) | 1996-01-12 | 1997-07-17 | Basf Ag | Substituierte Aza- und Diazacycloheptan- und Cyclooctanverbindungen und deren Verwendung |
| IT1293807B1 (it) * | 1997-08-01 | 1999-03-10 | Recordati Chem Pharm | Derivati 1- (n-fenilaminoalchil) piperazinici sostituiti alla posizione 2 dell'anello fenilico |
| US6399614B1 (en) | 1997-08-01 | 2002-06-04 | Recordati S.A. Chemical And Pharmaceutical Company | 1-(N-phenylaminoalkyl)piperazine derivatives substituted at position 2 of the phenyl ring |
| US6750342B1 (en) * | 1999-05-19 | 2004-06-15 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade |
| US6664255B1 (en) | 1999-05-19 | 2003-12-16 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade |
| US6906068B1 (en) | 1999-05-19 | 2005-06-14 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl 1,2,4 - triazinones useful as anticoagulants |
| US6458952B1 (en) * | 1999-05-19 | 2002-10-01 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade |
| US6716838B1 (en) | 1999-05-19 | 2004-04-06 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl uracils as anticoagulative agents |
| US7015230B1 (en) | 1999-05-19 | 2006-03-21 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade |
| US6653316B1 (en) | 1999-05-19 | 2003-11-25 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade |
| US6867217B1 (en) | 1999-05-19 | 2005-03-15 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade |
| US6852761B2 (en) * | 2000-03-13 | 2005-02-08 | Pharmacia Corporation | Polycyclic aryl and heteroaryl substituted benzenes useful for selective inhibition of the coagulation cascade |
| EP1268428A2 (de) * | 2000-04-05 | 2003-01-02 | Pharmacia Corporation | Polyzyklische aryl und heteroaryl substituierte 4-pyridon-derivate verwendbar zur selektiven hemmung der blutgerinnungskaskade |
| CA2405561A1 (en) * | 2000-04-05 | 2001-10-18 | Pharmacia Corporation | Polycyclic aryl and heteroaryl substituted 4-pyrones useful for selective inhibition of the coagulation cascade |
| US6686484B2 (en) | 2000-04-17 | 2004-02-03 | Pharmacia Corporation | Polycyclic aryl and heteroaryl substituted 1,4-quinones useful for selective inhibition of the coagulation cascade |
| MXPA03004458A (es) * | 2000-11-20 | 2005-01-25 | Pharmacia Corp | Arilpiridinas y heteroarilpiridinas sustituidas utiles para inhibicion selectiva de la cascada de coagulacion. |
| KR100846649B1 (ko) * | 2001-08-02 | 2008-07-16 | 스미또모 가가꾸 가부시끼가이샤 | 피리딘 화합물의 제조 방법 |
| US20040068113A1 (en) * | 2001-11-20 | 2004-04-08 | South Michael S. | Substituted polycyclic aryl and heteroaryl pyridines useful for selective inhibition of the coagulation cascade |
| JP4958774B2 (ja) | 2004-07-02 | 2012-06-20 | コーセプト セラピューティクス， インコーポレイテッド | 改変されたピリミジン糖質コルチコイドレセプター調節因子 |
| UA109931C2 (xx) | 2011-03-18 | 2015-10-26 | Піримідинциклогексильні модулятори глюкокортикоїдних рецепторів | |
| CN102617486B (zh) * | 2012-03-01 | 2014-04-16 | 江西吉翔医药化工有限公司 | 一种6-氯-1,3-二甲基脲嘧啶的制备方法 |
| CN103288751B (zh) * | 2013-06-03 | 2016-04-20 | 四川百利药业有限责任公司 | 一种高纯度盐酸尼非卡兰的制备方法 |
| SMT202000071T1 (it) | 2013-06-21 | 2020-03-13 | Myokardia Inc | Composti di pirimidinadione contro le condizioni cardiache |
| CN112236416B (zh) | 2018-06-04 | 2024-03-01 | 科赛普特治疗公司 | 嘧啶环己烯基糖皮质激素受体调节剂 |
| US11851409B2 (en) | 2019-01-25 | 2023-12-26 | Qingdao Jião Pharmaceutical Technology Co., Ltd | Deuterated benzylaminopyrimidinedione derivatives and use thereof |
| CA3158745A1 (en) | 2019-12-11 | 2021-06-17 | Corcept Therapeutics Incorporated | Methods of treating antipsychotic-induced weight gain with miricorilant |
| CN115551836A (zh) | 2020-05-06 | 2022-12-30 | 科赛普特治疗公司 | 嘧啶环己基糖皮质激素受体调节剂的多晶型物 |
| MX2022013805A (es) | 2020-05-06 | 2022-11-30 | Corcept Therapeutics Inc | Formulaciones de moduladores del receptor glucocorticoide de pirimidin ciclohexilo. |
| AU2021409656B2 (en) | 2020-12-21 | 2025-04-10 | Corcept Therapeutics Incorporated | Method of preparing pyrimidine cyclohexyl glucocorticoid receptor modulators |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE787103A (fr) * | 1971-08-04 | 1973-02-02 | Pfizer | Nouveaux derives de propanolamine et composition pharmaceutiqueles contenant |
| DE2329399A1 (de) * | 1973-06-08 | 1975-01-02 | Wuelfing J A Fa | 4-alkyl-aminouracile, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| LU77339A1 (de) * | 1977-05-16 | 1979-01-19 |
-
1989
- 1989-10-24 US US07/425,730 patent/US5008267A/en not_active Expired - Lifetime
- 1989-10-26 NZ NZ231165A patent/NZ231165A/en unknown
- 1989-10-27 NO NO894299A patent/NO174711C/no unknown
- 1989-10-27 HU HU895468A patent/HU210780B/hu unknown
- 1989-10-27 FI FI895121A patent/FI95245C/fi active IP Right Grant
- 1989-10-27 AT AT89311135T patent/ATE115952T1/de not_active IP Right Cessation
- 1989-10-27 AU AU43869/89A patent/AU613805B2/en not_active Expired
- 1989-10-27 DE DE68920125T patent/DE68920125T2/de not_active Expired - Lifetime
- 1989-10-27 ES ES89311135T patent/ES2066000T3/es not_active Expired - Lifetime
- 1989-10-27 EP EP89311135A patent/EP0369627B1/de not_active Expired - Lifetime
- 1989-10-27 DK DK535789A patent/DK170203B1/da not_active IP Right Cessation
- 1989-10-28 KR KR1019890015569A patent/KR920002307B1/ko not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ES2066000T3 (es) | 1995-03-01 |
| NO894299D0 (no) | 1989-10-27 |
| AU4386989A (en) | 1990-05-31 |
| DK535789D0 (da) | 1989-10-27 |
| DK535789A (da) | 1990-04-30 |
| US5008267A (en) | 1991-04-16 |
| FI895121A0 (fi) | 1989-10-27 |
| EP0369627B1 (de) | 1994-12-21 |
| NZ231165A (en) | 1992-02-25 |
| EP0369627A2 (de) | 1990-05-23 |
| HUT52764A (en) | 1990-08-28 |
| DK170203B1 (da) | 1995-06-12 |
| KR920002307B1 (ko) | 1992-03-21 |
| EP0369627A3 (en) | 1990-12-12 |
| NO174711B (no) | 1994-03-14 |
| DE68920125T2 (de) | 1995-08-03 |
| KR900006300A (ko) | 1990-05-07 |
| FI95245B (fi) | 1995-09-29 |
| ATE115952T1 (de) | 1995-01-15 |
| HU210780B (en) | 1995-07-28 |
| AU613805B2 (en) | 1991-08-08 |
| NO174711C (no) | 1994-06-22 |
| HU895468D0 (en) | 1990-01-28 |
| NO894299L (no) | 1990-04-30 |
| FI95245C (fi) | 1996-01-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: MITSUI CHEMICALS, INC., TOKIO/TOKYO, JP |
|
| 8327 | Change in the person/name/address of the patent owner |
Owner name: SCHERING AG, 13353 BERLIN, DE |
|
| 8327 | Change in the person/name/address of the patent owner |
Owner name: BAYER SCHERING PHARMA AG, 13353 BERLIN, DE |
|
| 8327 | Change in the person/name/address of the patent owner |
Owner name: BAYER SCHERING PHARMA AKIENGESELLSCHAFT, 13353, DE |