DK3018145T3 - Midler og fremgangsmåder til behandling af dlbcl - Google Patents
Midler og fremgangsmåder til behandling af dlbcl Download PDFInfo
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- DK3018145T3 DK3018145T3 DK15195076.3T DK15195076T DK3018145T3 DK 3018145 T3 DK3018145 T3 DK 3018145T3 DK 15195076 T DK15195076 T DK 15195076T DK 3018145 T3 DK3018145 T3 DK 3018145T3
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- dlbcl
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Claims (14)
1. Sammensætning, der omfatter et bispecifikt CD19xCD3-antistof til anvendelse i en fremgangsmåde til behandling af tumormasse af lymfeknudevæv og/eller ekstranodalt lymfom forårsaget af diffust storcellet B-lymfom (DLBCL) hos en patient, der er refraktær for kemoterapibehandling og/eller ved tilbagefald efter behandling med kemoterapi.
2. Sammensætning til anvendelse ifølge krav 1, hvor tumormassen er kendetegnet ved tumorer med en størrelse på mere end 10x10 mm.
3. Sammensætning til anvendelse ifølge krav 1 eller 2, hvor lymfeknudevævet indbefatter lymfeknuder og/eller milt.
4. Sammensætning til anvendelse ifølge krav 1 eller 2, hvor det ekstranodale lymfom indbefatter centralnervesystem (CNS), kutant væv, bryst, lunger, lever, mave-tarmkanal, det urogenitale system, øjenvæv, knoglevæv og/eller knogler.
5. Sammensætning til anvendelse ifølge et hvilket som helst af de foregående krav, hvor en første dosis af sammensætningen indgives for et første tidsrum og efterfølgende en anden dosis af sammensætningen indgives for et andet tidsrum, hvor den anden dosis overstiger den første dosis.
6. Sammensætning til anvendelse ifølge krav 5, hvor den første dosis er mellem 1 og 15 pg/m2/d.
7. Sammensætning til anvendelse ifølge krav 5 eller 6, hvor den anden dosis er mellem 15 og 60 pg/m2/d.
8. Sammensætning til anvendelse ifølge krav 5, der endvidere omfatter indgivelse efter en første og anden dosis for et første og andet tidsrum af en tredje dosis af sammensætningen for et tredje tidsrum.
9. Sammensætning til anvendelse ifølge krav 8, hvor det tredje tidsrum overstiger det første og andet tidsrum, hvorved den anden dosis overstiger den første dosis.
10. Sammensætning til anvendelse ifølge krav 8 eller 9, hvor den tredje dosis overstiger den første og den anden dosis.
11. Sammensætning til anvendelse ifølge et hvilket som helst af kravene 8 til 10, hvor den første dosis er mellem 1 og 15 pg/m2/d, hvor 5 pg/m2/d foretrækkes.
12. Sammensætning til anvendelse ifølge et hvilket som helst af kravene 8 til 11, hvor den anden dosis er mellem 1 og 15 pg/m2/d, hvor 15 pg/m2/d foretrækkes.
13. Sammensætning til anvendelse ifølge et hvilket som helst af kravene 8 til 12, hvor den tredje dosis er mellem 15 og 60 pg/m2/d, eller hvor 60 pg/m2/d foretrækkes.
14. Sammensætning til anvendelse ifølge et hvilket som helst af kravene 1 til 4, hvor under behandling antistoffet doseres i en konstant dosis udvalgt fra gruppen bestående af 5 pg/m2/d, 15 pg/m2/d eller 60 pg/m2/d, hvor 60 pg/m2/d foretrækkes.
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| DK18164175.4T DK3412687T3 (da) | 2010-10-27 | 2011-10-27 | Fremgangsmåder til behandling af dlbcl |
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| CA2606081C (en) | 2005-04-26 | 2013-09-17 | Markus M. Heiss | Combination of the application of antibodies for immunostimulation together with glucocorticoids |
| EP3412687B1 (en) * | 2010-10-27 | 2020-03-18 | Amgen Research (Munich) GmbH | Methods for treating dlbcl |
| EP3831386A1 (en) * | 2010-11-10 | 2021-06-09 | Amgen Research (Munich) GmbH | Prevention of adverse effects caused by cd3 specific binding domains |
| JO3529B1 (ar) * | 2013-02-08 | 2020-07-05 | Amgen Res Munich Gmbh | مضاد التصاق خلايا الدم البيض من أجل التخفيف من الاثار السلبية الممكنة الناتجة عن مجالات ارتباط cd3- المحدد |
| ES2845924T3 (es) | 2013-10-15 | 2021-07-28 | Scripps Research Inst | Interruptores de células T con receptores de antígenos quiméricos peptídicos y usos de los mismos |
| US10800828B2 (en) | 2015-03-26 | 2020-10-13 | The Scripps Research Institute | Switchable non-scFv chimeric receptors, switches, and methods of use thereof to treat cancer |
| EP3283113A4 (en) | 2015-04-15 | 2018-12-05 | The California Institute for Biomedical Research | Optimized pne-based chimeric receptor t cell switches and uses thereof |
| CA2986254A1 (en) | 2015-05-18 | 2016-11-24 | TCR2 Therapeutics Inc. | Compositions and methods for tcr reprogramming using fusion proteins |
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