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BRPI0809594A2 - polipeptídeo, seqüência de ácido nucléico, vetor, hospedeiro, processo para a produção de um polipeptídeo, composição farmacêutica, uso de um polipeptídeo, método para prevenção, tratamento ou melhora de uma doença, em um indivíduo com necessidade do mesmo, kit, método para a identificação de um polipeptídeo(s) - Google Patents

polipeptídeo, seqüência de ácido nucléico, vetor, hospedeiro, processo para a produção de um polipeptídeo, composição farmacêutica, uso de um polipeptídeo, método para prevenção, tratamento ou melhora de uma doença, em um indivíduo com necessidade do mesmo, kit, método para a identificação de um polipeptídeo(s)

Info

Publication number
BRPI0809594A2
BRPI0809594A2 BRPI0809594-9A BRPI0809594A BRPI0809594A2 BR PI0809594 A2 BRPI0809594 A2 BR PI0809594A2 BR PI0809594 A BRPI0809594 A BR PI0809594A BR PI0809594 A2 BRPI0809594 A2 BR PI0809594A2
Authority
BR
Brazil
Prior art keywords
polypeptide
vector
identification
pharmaceutical composition
host
Prior art date
Application number
BRPI0809594-9A
Other languages
English (en)
Inventor
Kufer Peter
Rau Doris
Mangold Susanne
Raum Tobias
Kischel Roman
Lutterbüse Ralf
Hoffmann Patrick
Klinger Matthias
Original Assignee
Micromet Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Micromet Ag filed Critical Micromet Ag
Priority claimed from PCT/EP2008/002664 external-priority patent/WO2008119567A2/en
Publication of BRPI0809594A2 publication Critical patent/BRPI0809594A2/pt

Links

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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
    • C07K16/082—Hepadnaviridae, e.g. hepatitis B virus
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
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  • Analytical Chemistry (AREA)

Abstract

polipeptídeo i seqüência de ácido nucléico i vetor i hospedeiro, processo para a produção de um polipeptídeo, composição farmacêutica, uso de um polipeptídeo, método para prevenção, tratamento ou melhora de uma doença, em um indivíduo com necessidade do mesmo, kit, método para a identificação de um polipeptídeo(s) a presente invenção refere-se a um polipeptídeo que compreende um domínio de ligação humano que pode se ligar a um epítopo de cadeia cd3 (épsilon) de seres humanos e de primatas não-chimpanzés, produção do polipeptídeo bem como a um processo para a mencionado. a invenção também se refere aos ácidos nucléicos que codificam para o polipeptídeo, aos vetores que compreendem os mesmos e às células hospedeiras que compreendem o vetor. em um outro aspecto, a invenção apresenta uma composição farmacêutica que compreende o polipeptídeo mencionado e usos médicos do polipeptídeo. em um aspecto adicional, a invenção apresenta um método para a identificação de polipeptídeos que compreende um domínio de ligação específico de espécie de cruzamento que pode se ligar a um epítopo cd3e (cd3 épsilon) de ser humano e de primata não-chimpanzé.
BRPI0809594-9A 2007-04-03 2008-04-03 polipeptídeo, seqüência de ácido nucléico, vetor, hospedeiro, processo para a produção de um polipeptídeo, composição farmacêutica, uso de um polipeptídeo, método para prevenção, tratamento ou melhora de uma doença, em um indivíduo com necessidade do mesmo, kit, método para a identificação de um polipeptídeo(s) BRPI0809594A2 (pt)

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EP07006988.5 2007-04-03
EP07006988 2007-04-03
EP07006990.1 2007-04-03
EP07006990 2007-04-03
US91366807P 2007-04-24 2007-04-24
US60/913,668 2007-04-24
EP08004741.8 2008-03-13
EP08004741 2008-03-13
PCT/EP2008/002664 WO2008119567A2 (en) 2007-04-03 2008-04-03 Cross-species-specific cd3-epsilon binding domain

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