DK2442870T3 - Pyrazinooxazepin-derivater. - Google Patents

Pyrazinooxazepin-derivater.

Info

Publication number: DK2442870T3
Authority: DK; Denmark
Prior art keywords: pyrazinooxazepin; derivatives; pyrazinooxazepin derivatives
Prior art date: 2009-06-15

Application number

DK10727154.6T

Other languages

English (en)

Inventor

Shigekazu Sasaki

Tomokazu Kusumoto

Izumi Nomura

Hironobu Maezaki

Original Assignee

Takeda Pharmaceutical

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-06-15

Filing date

2010-06-14

Publication date

2014-06-30

2010-06-14 Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical

2014-06-30 Application granted granted Critical

2014-06-30 Publication of DK2442870T3 publication Critical patent/DK2442870T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Pulmonology (AREA)
Urology & Nephrology (AREA)
Obesity (AREA)
Hematology (AREA)
Child & Adolescent Psychology (AREA)
Surgery (AREA)
Diabetes (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

DK10727154.6T 2009-06-15 2010-06-14 Pyrazinooxazepin-derivater. DK2442870T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP2009142673		2009-06-15
PCT/JP2010/060408 WO2010147226A1 (en)	2009-06-15	2010-06-14	Pyrazinooxazepine derivatives

Publications (1)

Publication Number	Publication Date
DK2442870T3 true DK2442870T3 (da)	2014-06-30

Family

ID=42561089

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK10727154.6T DK2442870T3 (da)	2009-06-15	2010-06-14	Pyrazinooxazepin-derivater.

Country Status (40)

Country	Link
US (4)	US8318722B2 (da)
EP (1)	EP2442870B1 (da)
JP (2)	JP5579262B2 (da)
KR (1)	KR101768234B1 (da)
CN (1)	CN102458579B (da)
AR (1)	AR077094A1 (da)
AU (1)	AU2010260847B2 (da)
BR (1)	BRPI1011502A2 (da)
CA (1)	CA2765239C (da)
CL (1)	CL2011003154A1 (da)
CO (1)	CO6491037A2 (da)
CR (1)	CR20120021A (da)
CY (1)	CY1115483T1 (da)
DK (1)	DK2442870T3 (da)
DO (1)	DOP2011000393A (da)
EA (1)	EA021079B1 (da)
EC (1)	ECSP12011603A (da)
ES (1)	ES2480275T3 (da)
GE (1)	GEP20146168B (da)
HR (1)	HRP20140589T1 (da)
IL (1)	IL216761A (da)
JO (1)	JO3087B1 (da)
MA (1)	MA33430B1 (da)
ME (1)	ME01835B (da)
MX (1)	MX2011013081A (da)
MY (1)	MY157497A (da)
NZ (1)	NZ597507A (da)
PE (1)	PE20121049A1 (da)
PL (1)	PL2442870T3 (da)
PT (1)	PT2442870E (da)
RS (1)	RS53414B (da)
SG (1)	SG176696A1 (da)
SI (1)	SI2442870T1 (da)
SM (1)	SMT201400080B (da)
TN (1)	TN2011000630A1 (da)
TW (2)	TWI542592B (da)
UA (1)	UA108357C2 (da)
UY (1)	UY32707A (da)
WO (1)	WO2010147226A1 (da)
ZA (1)	ZA201109370B (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP2018863B9 (en)	2006-05-16	2015-02-18	Takeda Pharmaceutical Company Limited	Fused heterocyclic compound and use thereof
GEP20146168B (en) *	2009-06-15	2014-09-25	Takeda Pharmaceuticals Co	Pyrazinooxazepine derivatives
US20130267500A1 (en)	2010-09-01	2013-10-10	Arena Pharmaceuticals, Inc.	5-ht2c receptor agonists in the treatment of disorders ameliorated by reduction of norepinephrine level
JP2014201578A (ja) *	2013-04-09	2014-10-27	武田薬品工業株式会社	線維筋痛症治療剤
JP2014214132A (ja) *	2013-04-26	2014-11-17	武田薬品工業株式会社	ニコチン依存症の予防・治療剤
WO2015066344A1 (en)	2013-11-01	2015-05-07	Arena Pharmaceuticals, Inc.	5-ht2c receptor agonists and compositions and methods of use
WO2017026538A1 (en)	2015-08-07	2017-02-16	Takeda Pharmaceutical Company Limited	Production method of pyrazine
TW201729814A (zh)	2015-12-24	2017-09-01	武田藥品工業股份有限公司	固形製劑
US9985579B2 (en)	2016-04-12	2018-05-29	Preformed Line Products Co.	Mounting assembly for mounting a solar panel
US20210052600A1 (en)	2017-12-27	2021-02-25	Takeda Pharmaceutical Company Limited	Therapeutic agents for stress urinary incontinence and incotinence of feces

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2992677B2 (ja)	1995-06-05	1999-12-20	武田薬品工業株式会社	骨形成促進医薬組成物
SE0002754D0 (sv)	2000-07-21	2000-07-21	Pharmacia & Upjohn Ab	New pharmaceutical combination formulation and method of treatment with the combination
EP1337518B1 (en)	2000-11-20	2009-06-17	Biovitrum AB (publ)	Piperazinylpyrazines compounds as antagonists of serotonin 5-ht2 receptor
US6699866B2 (en)	2001-04-17	2004-03-02	Sepracor Inc.	Thiazole and other heterocyclic ligands for mammalian dopamine, muscarinic and serotonin receptors and transporters, and methods of use thereof
SE0201544D0 (sv)	2002-05-17	2002-05-17	Biovitrum Ab	Novel compounds and thier use
BR0311970A (pt)	2002-06-19	2005-03-29	Biovitrum Ab	Novos compostos, seu uso e preparação
SI1645558T1 (sl)	2002-06-19	2008-10-31	Biovitrum Ab Publ	Piperazinilpirazini kot modulatorji serotonin 5-HT2C receptorja
US7625887B2 (en)	2003-01-28	2009-12-01	Takeda Pharmaceutical Company Limited	Receptor agonists
CL2004000826A1 (es)	2003-04-25	2005-03-04	Pfizer	Uso de un agonista para el receptor 5-ht2c para preparar un medicamento util en el tratamiento de la incontinencia urinaria provocada por estres, con la condicion de que el agonista no sea 1-[6-cloro-5-(trifluorometil)-2-piridinil]piperazina (org-129
US7704993B2 (en)	2003-06-17	2010-04-27	Arena Pharmaceuticals, Inc.	Benzazepine derivatives and methods of prophylaxis or treatment of 5ht2c receptor associated diseases
SI2332921T1 (sl)	2003-06-17	2016-06-30	Arena Pharmaceuticals, Inc.	8-kloro-1-metil-2,3,4,5-tetrahidro-1H-3-benzazapin hidroklorid
JP2006056881A (ja)	2004-07-21	2006-03-02	Takeda Chem Ind Ltd	縮合環化合物
BRPI0615033A2 (pt)	2005-09-01	2011-04-26	Lilly Co Eli	composto, composição farmacêutica, e, uso de um composto
FR2895259B1 (fr)	2005-12-22	2008-02-22	Urosphere Sas	Methodes de traitement des incontinences urinaires
EP2018863B9 (en) *	2006-05-16	2015-02-18	Takeda Pharmaceutical Company Limited	Fused heterocyclic compound and use thereof
EP2123644B1 (en) *	2007-03-07	2014-12-17	Takeda Pharmaceutical Company Limited	Benzoxazepine derivatives and use thereof
US20090062253A1 (en)	2007-08-31	2009-03-05	Kalypsys, Inc.	Heterocyclodiazepine cannabinoid receptor modulators for treatment of disease
EP2213675B1 (en) *	2007-11-15	2013-08-14	Takeda Pharmaceutical Company Limited	Pyridooxazepine derivative and use thereof
WO2009063993A1 (ja) *	2007-11-15	2009-05-22	Takeda Pharmaceutical Company Limited	縮合ピリジン誘導体およびその用途
EP2789338A3 (en)	2007-11-15	2015-01-14	Takeda Pharmaceutical Company Limited	Condensed pyridine derivate and use thereof
US8299103B2 (en)	2009-06-15	2012-10-30	Boehringer Ingelheim International Gmbh	Compounds which selectively modulate the CB2 receptor
GEP20146168B (en) *	2009-06-15	2014-09-25	Takeda Pharmaceuticals Co	Pyrazinooxazepine derivatives

2010
- 2010-06-14 GE GEAP201012529A patent/GEP20146168B/en unknown
- 2010-06-14 AR ARP100102101A patent/AR077094A1/es not_active Application Discontinuation
- 2010-06-14 CN CN201080036178.1A patent/CN102458579B/zh not_active Expired - Fee Related
- 2010-06-14 HR HRP20140589AT patent/HRP20140589T1/hr unknown
- 2010-06-14 MA MA34535A patent/MA33430B1/fr unknown
- 2010-06-14 TW TW099119242A patent/TWI542592B/zh not_active IP Right Cessation
- 2010-06-14 NZ NZ597507A patent/NZ597507A/xx not_active IP Right Cessation
- 2010-06-14 PE PE2011002104A patent/PE20121049A1/es active IP Right Grant
- 2010-06-14 US US12/814,692 patent/US8318722B2/en not_active Expired - Fee Related
- 2010-06-14 BR BRPI1011502A patent/BRPI1011502A2/pt not_active Application Discontinuation
- 2010-06-14 UY UY0001032707A patent/UY32707A/es not_active Application Discontinuation
- 2010-06-14 UA UAA201200408A patent/UA108357C2/ru unknown
- 2010-06-14 US US13/377,918 patent/US9115139B2/en not_active Expired - Fee Related
- 2010-06-14 ME MEP-2014-81A patent/ME01835B/me unknown
- 2010-06-14 EA EA201270017A patent/EA021079B1/ru not_active IP Right Cessation
- 2010-06-14 WO PCT/JP2010/060408 patent/WO2010147226A1/en not_active Ceased
- 2010-06-14 MX MX2011013081A patent/MX2011013081A/es active IP Right Grant
- 2010-06-14 MY MYPI2011006107A patent/MY157497A/en unknown
- 2010-06-14 PT PT107271546T patent/PT2442870E/pt unknown
- 2010-06-14 RS RS20140373A patent/RS53414B/sr unknown
- 2010-06-14 JP JP2012514674A patent/JP5579262B2/ja not_active Expired - Fee Related
- 2010-06-14 DK DK10727154.6T patent/DK2442870T3/da active
- 2010-06-14 SI SI201030641T patent/SI2442870T1/sl unknown
- 2010-06-14 KR KR1020127000935A patent/KR101768234B1/ko not_active Expired - Fee Related
- 2010-06-14 TW TW104112674A patent/TW201529584A/zh unknown
- 2010-06-14 ES ES10727154.6T patent/ES2480275T3/es active Active
- 2010-06-14 PL PL10727154T patent/PL2442870T3/pl unknown
- 2010-06-14 EP EP10727154.6A patent/EP2442870B1/en active Active
- 2010-06-14 AU AU2010260847A patent/AU2010260847B2/en not_active Ceased
- 2010-06-14 SG SG2011090149A patent/SG176696A1/en unknown
- 2010-06-14 JO JOP/2010/0194A patent/JO3087B1/ar active
- 2010-06-14 CA CA2765239A patent/CA2765239C/en not_active Expired - Fee Related
2011
- 2011-07-28 US US13/192,845 patent/US8314088B2/en not_active Expired - Fee Related
- 2011-07-28 US US13/192,865 patent/US8324201B2/en not_active Expired - Fee Related
- 2011-12-04 IL IL216761A patent/IL216761A/en not_active IP Right Cessation
- 2011-12-08 TN TNP2011000630A patent/TN2011000630A1/en unknown
- 2011-12-14 CL CL2011003154A patent/CL2011003154A1/es unknown
- 2011-12-14 DO DO2011000393A patent/DOP2011000393A/es unknown
- 2011-12-20 ZA ZA2011/09370A patent/ZA201109370B/en unknown
2012
- 2012-01-13 EC ECSP12011603 patent/ECSP12011603A/es unknown
- 2012-01-13 CO CO12004620A patent/CO6491037A2/es active IP Right Grant
- 2012-01-13 CR CR20120021A patent/CR20120021A/es unknown
- 2012-01-31 JP JP2012019274A patent/JP5579203B2/ja not_active Expired - Fee Related
2014
- 2014-06-25 SM SM201400080T patent/SMT201400080B/xx unknown
- 2014-07-11 CY CY20141100527T patent/CY1115483T1/el unknown

Also Published As

Publication number	Publication date
US20100317651A1 (en)	2010-12-16
KR101768234B1 (ko)	2017-08-14
ZA201109370B (en)	2012-10-31
JP2012107032A (ja)	2012-06-07
MY157497A (en)	2016-06-15
CY1115483T1 (el)	2017-01-04
ME01835B (me)	2014-12-20
SG176696A1 (en)	2012-01-30
PT2442870E (pt)	2014-07-16
JO3087B1 (ar)	2017-03-15
SMT201400080B (it)	2014-09-08
CN102458579A (zh)	2012-05-16
JP2012530051A (ja)	2012-11-29
NZ597507A (en)	2013-09-27
PL2442870T3 (pl)	2014-12-31
CA2765239C (en)	2018-08-07
HK1169623A1 (en)	2013-02-01
EP2442870A1 (en)	2012-04-25
CO6491037A2 (es)	2012-07-31
DOP2011000393A (es)	2012-02-15
MX2011013081A (es)	2012-01-20
IL216761A0 (en)	2012-02-29
AR077094A1 (es)	2011-08-03
CR20120021A (es)	2012-03-06
RS53414B (sr)	2014-12-31
CL2011003154A1 (es)	2012-06-15
US20110288291A1 (en)	2011-11-24
WO2010147226A1 (en)	2010-12-23
BRPI1011502A2 (pt)	2016-03-22
ECSP12011603A (es)	2012-03-30
EA021079B1 (ru)	2015-03-31
US20110282054A1 (en)	2011-11-17
US8324201B2 (en)	2012-12-04
IL216761A (en)	2016-03-31
JP5579262B2 (ja)	2014-08-27
HRP20140589T1 (hr)	2014-08-01
TWI542592B (zh)	2016-07-21
MA33430B1 (fr)	2012-07-03
AU2010260847A1 (en)	2012-01-19
UY32707A (es)	2011-01-31
TW201529584A (zh)	2015-08-01
ES2480275T3 (es)	2014-07-25
EA201270017A1 (ru)	2012-07-30
TW201109338A (en)	2011-03-16
CA2765239A1 (en)	2010-12-23
EP2442870B1 (en)	2014-04-16
SI2442870T1 (sl)	2014-07-31
US9115139B2 (en)	2015-08-25
US20120135979A1 (en)	2012-05-31
US8318722B2 (en)	2012-11-27
PE20121049A1 (es)	2012-08-22
AU2010260847B2 (en)	2016-11-24
GEP20146168B (en)	2014-09-25
KR20120034734A (ko)	2012-04-12
JP5579203B2 (ja)	2014-08-27
US8314088B2 (en)	2012-11-20
CN102458579B (zh)	2014-11-05
TN2011000630A1 (en)	2013-05-24
UA108357C2 (xx)	2015-04-27

Publication	Publication Date	Title
BRPI1013246A2 (pt)	2016-04-05	derivados de benzofuralina
BR112012002828A2 (pt)	2015-10-13	derivados de 5-fluorpirimidinona
NO2021006I1 (no)	2021-02-15	Quofenix, delafloksacin
ECSP12011999A (es)	2012-07-31	Derivados benzamida sustituidos
BRPI1010301A2 (pt)	2016-03-15	composição.
DK2308877T3 (da)	2014-04-22	Imidazopyridin-2-on-derivater
DK2462134T3 (da)	2014-08-11	N1-sulfonyl-5-fluorpyrimidinonderivater
BRPI1008774A2 (pt)	2016-03-08	espiroamida substituída
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DK2397480T3 (da)	2013-09-02	Diazepindionderivat
BRPI1013844A2 (pt)	2016-04-12	derivados de piridina-isoxazol
BRPI1016117A8 (pt)	2018-01-02	derivados de isoxazol-isoxazol e isoxazol-isotiazol.
BRPI1008827A2 (pt)	2016-02-23	deisobutenizador
UY33125A (es)	2011-07-29	Diaza-espiro-[5,5]-undecanos
DK2344471T3 (da)	2013-10-07	7-piperidinalkyl-3,4-dihydroquinolon-derivat
DK2275414T3 (da)	2015-06-22	Cyclopentylacrylamidderivat
BRPI1014454A2 (pt)	2016-04-05	derivados de isoxazol-pirazol
IT1396487B1 (it)	2012-12-14	Convogliatore.
BRPI0917446A2 (pt)	2015-12-22	derivados de acilaminobenzamida.
DK2387580T3 (da)	2014-10-13	Deoxyactagardinderivater
BR112012002810A2 (pt)	2015-09-15	derivados de n1-acil-5-fluoropirimidinona
DK2442870T3 (da)	2014-06-30	Pyrazinooxazepin-derivater.
BRPI1016192A2 (pt)	2016-04-19	derivados de soxazol.
BRPI0906714A2 (pt)	2015-06-30	Derivados de oxazepinopirimidona heteroarilamida substituídos.
BRPI1011416A2 (pt)	2016-03-15	derivados de antraquinova novos