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AR077094A1 - Derivados de pirazinooxazepina, composiciones farmaceuticas y su uso en el tratamiento de un sintoma del aparato urinario inferior, obesidad y/o prolapso de organos - Google Patents

Derivados de pirazinooxazepina, composiciones farmaceuticas y su uso en el tratamiento de un sintoma del aparato urinario inferior, obesidad y/o prolapso de organos

Info

Publication number
AR077094A1
AR077094A1 ARP100102101A ARP100102101A AR077094A1 AR 077094 A1 AR077094 A1 AR 077094A1 AR P100102101 A ARP100102101 A AR P100102101A AR P100102101 A ARP100102101 A AR P100102101A AR 077094 A1 AR077094 A1 AR 077094A1
Authority
AR
Argentina
Prior art keywords
group
optionally substituted
alkyl group
group optionally
cycloalkyl
Prior art date
Application number
ARP100102101A
Other languages
English (en)
Inventor
Shigekazu Sasaki
Tomokazu Kusumoto
Izumi Nomura
Hironobu Maezaki
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of AR077094A1 publication Critical patent/AR077094A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Se proporciona un compuesto que tiene una accion activadora del receptor de 5-HT2C de serotonina Reivindicacion 1: Un compuesto representado por la formula (1) caracterizado porque R1' es (1) un grupo morfolinilo opcionalmente sustituido con grupo(s) alquilo C1-6, (2) un grupo piperidilo opcionalmente sustituido con grupo(s) alquilo C1-6, (3) un grupo pirrolidinilo opcionalmente sustituido con grupo(s) alquilo C1-6 opcionalmente sustituido con grupo(s) alcoxi C1-6, (4) un grupo pirrolilo opcionalmente sustituido con grupo(s) alquilo C1-6, (5) un grupo imidazolilo opcionalmente sustituido con grupo(s) alquilo C1-6, (6) un grupo amino opcionalmente sustituido con 1 o 2 sustituyentes seleccionados de (a) un grupo alquilo C1-6 opcionalmente sustituido con sustituyentes seleccionados de un grupo cicloalquilo C3-6 y un grupo fenilo, y (b) un grupo cicloalquilo C3-6, (7) un grupo alquilsulfanilo C1-6, (8) un grupo alcoxi C1-6 opcionalmente sustituido con grupos cicloalquilo C3-6, (9) un grupo cicloalquilo C3-6, o (10) un grupo cicloalquenilo C3-6; R2' es un átomo de hidrogeno o un grupo alquilo C1-6 opcionalmente sustituido con grupo(s) alcoxi C1-6 y R3' es un átomo de hidrogeno, un átomo de halogeno o un grupo alquilo C1-6, o una de sus sales.
ARP100102101A 2009-06-15 2010-06-14 Derivados de pirazinooxazepina, composiciones farmaceuticas y su uso en el tratamiento de un sintoma del aparato urinario inferior, obesidad y/o prolapso de organos AR077094A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2009142673 2009-06-15

Publications (1)

Publication Number Publication Date
AR077094A1 true AR077094A1 (es) 2011-08-03

Family

ID=42561089

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP100102101A AR077094A1 (es) 2009-06-15 2010-06-14 Derivados de pirazinooxazepina, composiciones farmaceuticas y su uso en el tratamiento de un sintoma del aparato urinario inferior, obesidad y/o prolapso de organos

Country Status (40)

Country Link
US (4) US9115139B2 (es)
EP (1) EP2442870B1 (es)
JP (2) JP5579262B2 (es)
KR (1) KR101768234B1 (es)
CN (1) CN102458579B (es)
AR (1) AR077094A1 (es)
AU (1) AU2010260847B2 (es)
BR (1) BRPI1011502A2 (es)
CA (1) CA2765239C (es)
CL (1) CL2011003154A1 (es)
CO (1) CO6491037A2 (es)
CR (1) CR20120021A (es)
CY (1) CY1115483T1 (es)
DK (1) DK2442870T3 (es)
DO (1) DOP2011000393A (es)
EA (1) EA021079B1 (es)
EC (1) ECSP12011603A (es)
ES (1) ES2480275T3 (es)
GE (1) GEP20146168B (es)
HR (1) HRP20140589T1 (es)
IL (1) IL216761A (es)
JO (1) JO3087B1 (es)
MA (1) MA33430B1 (es)
ME (1) ME01835B (es)
MX (1) MX2011013081A (es)
MY (1) MY157497A (es)
NZ (1) NZ597507A (es)
PE (1) PE20121049A1 (es)
PL (1) PL2442870T3 (es)
PT (1) PT2442870E (es)
RS (1) RS53414B (es)
SG (1) SG176696A1 (es)
SI (1) SI2442870T1 (es)
SM (1) SMT201400080B (es)
TN (1) TN2011000630A1 (es)
TW (2) TW201529584A (es)
UA (1) UA108357C2 (es)
UY (1) UY32707A (es)
WO (1) WO2010147226A1 (es)
ZA (1) ZA201109370B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8158617B2 (en) * 2006-05-16 2012-04-17 Takeda Pharmaceutical Company Limited Fused heterocyclic compound and use thereof
EP2442870B1 (en) * 2009-06-15 2014-04-16 Takeda Pharmaceutical Company Limited Pyrazinooxazepine derivatives
US20130267500A1 (en) 2010-09-01 2013-10-10 Arena Pharmaceuticals, Inc. 5-ht2c receptor agonists in the treatment of disorders ameliorated by reduction of norepinephrine level
JP2014201578A (ja) * 2013-04-09 2014-10-27 武田薬品工業株式会社 線維筋痛症治療剤
JP2014214132A (ja) * 2013-04-26 2014-11-17 武田薬品工業株式会社 ニコチン依存症の予防・治療剤
WO2015066344A1 (en) 2013-11-01 2015-05-07 Arena Pharmaceuticals, Inc. 5-ht2c receptor agonists and compositions and methods of use
WO2017026538A1 (en) 2015-08-07 2017-02-16 Takeda Pharmaceutical Company Limited Production method of pyrazine
TW201729814A (zh) 2015-12-24 2017-09-01 武田藥品工業股份有限公司 固形製劑
US9985579B2 (en) 2016-04-12 2018-05-29 Preformed Line Products Co. Mounting assembly for mounting a solar panel
WO2019131902A1 (ja) * 2017-12-27 2019-07-04 武田薬品工業株式会社 腹圧性尿失禁および便失禁の治療薬

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JP2992677B2 (ja) 1995-06-05 1999-12-20 武田薬品工業株式会社 骨形成促進医薬組成物
SE0002754D0 (sv) 2000-07-21 2000-07-21 Pharmacia & Upjohn Ab New pharmaceutical combination formulation and method of treatment with the combination
CN1227237C (zh) 2000-11-20 2005-11-16 比奥维特罗姆股份公司 作为五羟色胺5－ht2受体拮抗剂的哌嗪基吡嗪化合物
WO2002083863A2 (en) 2001-04-17 2002-10-24 Sepracor, Inc. Thiazole and other heterocyclic ligands and use thereof
SE0201544D0 (sv) 2002-05-17 2002-05-17 Biovitrum Ab Novel compounds and thier use
DE60321606D1 (de) 2002-06-19 2008-07-24 Biovitrum Ab Publ Piperazinylpyrazine als Modulatoren des Serotonin 5-HT2C Rezeptors
EA008148B1 (ru) 2002-06-19 2007-04-27 Биовитрум Аб Новые соединения, их применение и получение
WO2004067008A1 (ja) 2003-01-28 2004-08-12 Takeda Pharmaceutical Company Limited 受容体作動薬
CL2004000826A1 (es) 2003-04-25 2005-03-04 Pfizer Uso de un agonista para el receptor 5-ht2c para preparar un medicamento util en el tratamiento de la incontinencia urinaria provocada por estres, con la condicion de que el agonista no sea 1-[6-cloro-5-(trifluorometil)-2-piridinil]piperazina (org-129
PL2332921T3 (pl) * 2003-06-17 2016-08-31 Arena Pharm Inc Chlorowodorek 8-chloro-1-metylo-2,3,4,5-tetrahydro-1H-3-benzazepiny
CA2888392A1 (en) 2003-06-17 2005-03-03 Arena Pharmaceuticals, Inc. Processes for preparing 3-benzazepines
JP2006056881A (ja) 2004-07-21 2006-03-02 Takeda Chem Ind Ltd 縮合環化合物
DK1926712T3 (da) 2005-09-01 2009-11-09 Lilly Co Eli 6-Substituerede 2,3,4,5-tetrahydro-1H-benzo[D]azepiner som 5-HT2C-receptoragonister
FR2895259B1 (fr) 2005-12-22 2008-02-22 Urosphere Sas Methodes de traitement des incontinences urinaires
US8158617B2 (en) * 2006-05-16 2012-04-17 Takeda Pharmaceutical Company Limited Fused heterocyclic compound and use thereof
JP5497429B2 (ja) * 2007-03-07 2014-05-21 武田薬品工業株式会社 ベンゾオキサゼピン誘導体およびその用途
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JP5361733B2 (ja) 2007-11-15 2013-12-04 武田薬品工業株式会社 ピリドオキサゼピン誘導体およびその用途
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Also Published As

Publication number Publication date
AU2010260847A1 (en) 2012-01-19
PL2442870T3 (pl) 2014-12-31
US8318722B2 (en) 2012-11-27
JP2012530051A (ja) 2012-11-29
ZA201109370B (en) 2012-10-31
HRP20140589T1 (hr) 2014-08-01
US8324201B2 (en) 2012-12-04
AU2010260847B2 (en) 2016-11-24
EP2442870B1 (en) 2014-04-16
US20110288291A1 (en) 2011-11-24
MX2011013081A (es) 2012-01-20
UY32707A (es) 2011-01-31
JO3087B1 (ar) 2017-03-15
US20120135979A1 (en) 2012-05-31
NZ597507A (en) 2013-09-27
US9115139B2 (en) 2015-08-25
ME01835B (me) 2014-12-20
ECSP12011603A (es) 2012-03-30
CN102458579B (zh) 2014-11-05
EA021079B1 (ru) 2015-03-31
EP2442870A1 (en) 2012-04-25
IL216761A (en) 2016-03-31
CY1115483T1 (el) 2017-01-04
GEP20146168B (en) 2014-09-25
SI2442870T1 (sl) 2014-07-31
EA201270017A1 (ru) 2012-07-30
CL2011003154A1 (es) 2012-06-15
ES2480275T3 (es) 2014-07-25
CR20120021A (es) 2012-03-06
CA2765239A1 (en) 2010-12-23
SG176696A1 (en) 2012-01-30
KR20120034734A (ko) 2012-04-12
KR101768234B1 (ko) 2017-08-14
HK1169623A1 (en) 2013-02-01
SMT201400080B (it) 2014-09-08
TW201529584A (zh) 2015-08-01
JP2012107032A (ja) 2012-06-07
CN102458579A (zh) 2012-05-16
MA33430B1 (fr) 2012-07-03
US20110282054A1 (en) 2011-11-17
BRPI1011502A2 (pt) 2016-03-22
CO6491037A2 (es) 2012-07-31
TWI542592B (zh) 2016-07-21
TW201109338A (en) 2011-03-16
WO2010147226A1 (en) 2010-12-23
IL216761A0 (en) 2012-02-29
PE20121049A1 (es) 2012-08-22
PT2442870E (pt) 2014-07-16
JP5579262B2 (ja) 2014-08-27
US20100317651A1 (en) 2010-12-16
TN2011000630A1 (en) 2013-05-24
RS53414B (sr) 2014-12-31
MY157497A (en) 2016-06-15
DK2442870T3 (da) 2014-06-30
UA108357C2 (xx) 2015-04-27
JP5579203B2 (ja) 2014-08-27
CA2765239C (en) 2018-08-07
US8314088B2 (en) 2012-11-20
DOP2011000393A (es) 2012-02-15

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