[go: up one dir, main page]

DK183291A - 25-oxovitamin d2 derivat-mellemprodukter til brug ved fremstillingen af 1alfa, 25-dihydroxylerede vitamin d2-derivater - Google Patents

25-oxovitamin d2 derivat-mellemprodukter til brug ved fremstillingen af 1alfa, 25-dihydroxylerede vitamin d2-derivater Download PDF

Info

Publication number
DK183291A
DK183291A DK183291A DK183291A DK183291A DK 183291 A DK183291 A DK 183291A DK 183291 A DK183291 A DK 183291A DK 183291 A DK183291 A DK 183291A DK 183291 A DK183291 A DK 183291A
Authority
DK
Denmark
Prior art keywords
dihydroxyled
oxovitamin
1alfa
derivate
derivates
Prior art date
Application number
DK183291A
Other languages
English (en)
Other versions
DK172733B1 (da
DK183291D0 (da
Inventor
Hector F Deluca
Heinrich K Schnoes
Rafael R Sicinski
Yoko Tanaka
Original Assignee
Wisconsin Alumni Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Res Found filed Critical Wisconsin Alumni Res Found
Publication of DK183291D0 publication Critical patent/DK183291D0/da
Publication of DK183291A publication Critical patent/DK183291A/da
Application granted granted Critical
Publication of DK172733B1 publication Critical patent/DK172733B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/24—Radicals substituted by singly bound oxygen or sulfur atoms esterified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0042—Nitrogen only

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Nutrition Science (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
DK199101832A 1983-05-09 1991-11-07 25-oxovitamin D2 derivat-mellemprodukter til brugved fremstillingen af 1alfa, 25-dihydroxylerede vitamin D2-derivater DK172733B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US49286383A 1983-05-09 1983-05-09
US49286383 1983-05-09
US60732784A 1984-05-04 1984-05-04
US60732784 1984-05-04

Publications (3)

Publication Number Publication Date
DK183291D0 DK183291D0 (da) 1991-11-07
DK183291A true DK183291A (da) 1991-11-07
DK172733B1 DK172733B1 (da) 1999-06-21

Family

ID=27050897

Family Applications (3)

Application Number Title Priority Date Filing Date
DK008685A DK171397B1 (da) 1983-05-09 1985-01-08 24-epi-1alfa,25-dihydroxylerede vitamin D2-derivater og præparater til farmaceutisk anvendelse indeholdende disse derivater
DK198801845A DK172567B1 (da) 1983-05-09 1988-04-06 3,5-cyclovitamin D2 derivat-mellemprodukter til brug ved fremstillingen af 1alfa,25-dihydroxylerede vitamin D2-derivater
DK199101832A DK172733B1 (da) 1983-05-09 1991-11-07 25-oxovitamin D2 derivat-mellemprodukter til brugved fremstillingen af 1alfa, 25-dihydroxylerede vitamin D2-derivater

Family Applications Before (2)

Application Number Title Priority Date Filing Date
DK008685A DK171397B1 (da) 1983-05-09 1985-01-08 24-epi-1alfa,25-dihydroxylerede vitamin D2-derivater og præparater til farmaceutisk anvendelse indeholdende disse derivater
DK198801845A DK172567B1 (da) 1983-05-09 1988-04-06 3,5-cyclovitamin D2 derivat-mellemprodukter til brug ved fremstillingen af 1alfa,25-dihydroxylerede vitamin D2-derivater

Country Status (7)

Country Link
JP (3) JPH0610188B2 (da)
AU (1) AU568549B2 (da)
CH (1) CH665834A5 (da)
DE (4) DE3448412C2 (da)
DK (3) DK171397B1 (da)
NL (1) NL193245C (da)
WO (1) WO1984004527A1 (da)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62500301A (ja) * 1984-10-04 1987-02-05 ウイスコンシン　アラムナイ　リサ−チ　フオンデ−シヨン ２４―ホモビタミンｄ誘導体
DE3687377T2 (de) * 1985-01-17 1993-04-29 Wisconsin Alumni Res Found Vitamin-d-abkoemmlinge und deren herstellungsverfahren.
US5104864A (en) * 1988-08-02 1992-04-14 Bone Care International, Inc. Method for treating and preventing loss of bone mass
CA1341408C (en) * 1988-08-02 2002-12-10 Charles W. Bishop Method for treating and preventing loss of bone mass
US4973584A (en) * 1989-03-09 1990-11-27 Deluca Hector F Novel 1α-hydroxyvitamin D2 epimer and derivatives
JP2645130B2 (ja) * 1989-03-31 1997-08-25 日清製粉株式会社 ステロイド誘導体
GB8914963D0 (en) * 1989-06-29 1989-08-23 Leo Pharm Prod Ltd Chemical compounds
IN171426B (da) * 1990-02-14 1992-10-10 Wisconsin Alumni Res Found
US5795882A (en) * 1992-06-22 1998-08-18 Bone Care International, Inc. Method of treating prostatic diseases using delayed and/or sustained release vitamin D formulations
CA2116238C (en) * 1992-06-22 2007-09-04 Joyce C. Knutson Oral 1 .alpha.-hydroxyprevitamin d
US5763429A (en) 1993-09-10 1998-06-09 Bone Care International, Inc. Method of treating prostatic diseases using active vitamin D analogues
US6242434B1 (en) 1997-08-08 2001-06-05 Bone Care International, Inc. 24-hydroxyvitamin D, analogs and uses thereof
US6566353B2 (en) 1996-12-30 2003-05-20 Bone Care International, Inc. Method of treating malignancy associated hypercalcemia using active vitamin D analogues
US6573256B2 (en) 1996-12-30 2003-06-03 Bone Care International, Inc. Method of inhibiting angiogenesis using active vitamin D analogues
US6503893B2 (en) 1996-12-30 2003-01-07 Bone Care International, Inc. Method of treating hyperproliferative diseases using active vitamin D analogues
JP2001511811A (ja) 1997-02-13 2001-08-14 ボーン ケア インターナショナル インコーポレイテッド ビタミンｄ化合物の標的治療放出
CA2414407A1 (en) 2000-07-18 2002-01-24 Bone Care International, Inc. Stabilized 1.alpha.-hydroxy vitamin d
US7148211B2 (en) 2002-09-18 2006-12-12 Genzyme Corporation Formulation for lipophilic agents
US7094775B2 (en) 2004-06-30 2006-08-22 Bone Care International, Llc Method of treating breast cancer using a combination of vitamin D analogues and other agents
US20090233889A1 (en) 2008-03-12 2009-09-17 Uttam Saha Stabilized 1,25-dihydroxyvitamin d2 and method of making same

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4260549A (en) * 1979-05-21 1981-04-07 Wisconsin Alumni Research Foundation Process for preparing 1α-hydroxylated compounds
US4267117A (en) * 1978-06-19 1981-05-12 The Upjohn Company Compounds and process
US4269777A (en) * 1979-05-21 1981-05-26 Wisconsin Alumni Research Foundation Isotopically labeled vitamin D derivatives and processes for preparing same

Also Published As

Publication number Publication date
DK184588A (da) 1988-04-06
DK8685D0 (da) 1985-01-08
DE3448412C2 (da) 1991-12-12
DE3490215T (de) 1985-05-15
JPH0339505B2 (da) 1991-06-14
JPH02288829A (ja) 1990-11-28
AU568549B2 (en) 1988-01-07
JPH02288854A (ja) 1990-11-28
DK171397B1 (da) 1996-10-14
DE3448360C2 (da) 1991-10-02
AU3011584A (en) 1984-12-04
DK172567B1 (da) 1999-01-18
DK8685A (da) 1985-01-08
CH665834A5 (de) 1988-06-15
JPH0610188B2 (ja) 1994-02-09
NL193245B (nl) 1998-12-01
JPH0651624B2 (ja) 1994-07-06
NL8420137A (nl) 1985-04-01
WO1984004527A1 (en) 1984-11-22
NL193245C (nl) 1999-04-02
DE3490215C2 (da) 1991-07-25
DK172733B1 (da) 1999-06-21
DK183291D0 (da) 1991-11-07
JPH02288873A (ja) 1990-11-28
DK184588D0 (da) 1988-04-06

Similar Documents

Publication Publication Date Title
DK183291D0 (da) 25-oxovitamin d2 derivat-mellemprodukter til brug ved fremstillingen af 1alfa, 25-dihydroxylerede vitamin d2-derivater
ES507761A0 (es) Procedimiento para la preparacion de nuevas pirimidinonas .
ES502546A0 (es) Procedimiento para la preparacion de nuevas n-ariloxazolidi-nonas-2
AR228468A1 (es) Procedimiento para la preparacion de nuevas imidazolil-fenilamidinas
ES507635A0 (es) Procedimiento para la preparacion de nuevas fenilalcohilaminas .
DK15681A (da) Fremgangsmaade til fremstilling af cyclohexenderivater
ES501245A0 (es) Procedimiento para la preparacion de -aminocarbonil-1-ben- cil-3,4-dihidro-isoquinoleinas
ES502212A0 (es) Procedimiento para la preparacion de n-di-n-propil-2,6-dini-tro-4-trifluorometilanilina
ES501464A0 (es) Procedimiento para la preparacion de nuevas fenilureas
DK15290D0 (da) Cholestadienderivat som mellemprodukt til brug ved fremstillingen af homovitamin-d3-derivater
ES503975A0 (es) Procedimiento para la preparacion de nuevas fenilureas
AR225813A1 (es) Procedimiento para la preparacion de 3-picolina
DK56490A (da) Homocholestenderivater som mellemprodukter til brug ved fremstillingen af 26-homovitamin d3 derivater
ES500071A0 (es) Procedimiento para la preparacion de nuevos 2-nitro-5-feno- xifenil-oxazoles,-oxacinas,-imidazoles,-pirimidinas o-tiazo-les
AR228051A1 (es) Procedimiento para la preparacion de nuevos 2-piperidino-4-amino-6,7-dimetoxiquinazolinas sustituidas
AR229350A1 (es) Procedimiento para la preparacion de nuevas guanilamidinas
DK451281A (da) Fremgangsmaade til fremstilling af cephalexin-derivater
IT8125157A0 (it) Procedimento per la preparazione di 2-amminoetanoli.
DK537081A (da) Fremgangsmaade til fremstilling af estra-4,9-dienderivater
MX152439A (es) Procedimiento para la preparacion de 1-acetoacetilamino-4-cloro-2,5-dimetoxibenceno
DK178586A (da) Fremgangsmaade til fremstilling af staebeforme ved komprimering af formstof-styrtgods
IT8026346A0 (it) Procedimento per la preparazione di dicumilperossido.
ES499860A0 (es) Procedimiento para la preparacion de nuevos 1-feniltio-2- propar ŸgiloxietanosŸ
DK160583D0 (da) Fremgangsmade til fremstilling af dibenzindolderivater
DK263583A (da) Fremgangsmaade til fremstilling af aminobenzamidderivater

Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PBP Patent lapsed

Country of ref document: DK