DK184588A - Mellemprodukter til brug ved fremstilling af 1alfa,25-dihydroxylerede vitamin d2-derivater - Google Patents

Mellemprodukter til brug ved fremstilling af 1alfa,25-dihydroxylerede vitamin d2-derivater

Info

Publication number: DK184588A
Authority: DK; Denmark
Prior art keywords: dihydroxylered; 1alfa; intermediates; vitamin; derivatives
Prior art date: 1983-05-09

Application number

DK184588A

Other languages

English (en)

Other versions

DK184588D0 (da

DK172567B1 (da

Inventor

Hector F Deluca

Heinrich K Schnoes

Rafal R Sicinski

Yoko Tanaka

Original Assignee

Wisconsin Alumni Res Found

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-05-09

Filing date

1988-04-06

Publication date

1988-04-06

1988-04-06 Application filed by Wisconsin Alumni Res Found filed Critical Wisconsin Alumni Res Found

1988-04-06 Publication of DK184588D0 publication Critical patent/DK184588D0/da

1988-04-06 Publication of DK184588A publication Critical patent/DK184588A/da

1999-01-18 Application granted granted Critical

1999-01-18 Publication of DK172567B1 publication Critical patent/DK172567B1/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
- C07D317/24—Radicals substituted by singly bound oxygen or sulfur atoms esterified
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0036—Nitrogen-containing hetero ring
- C07J71/0042—Nitrogen only

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Endocrinology (AREA)
Nutrition Science (AREA)
Rheumatology (AREA)
Reproductive Health (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Steroid Compounds (AREA)

DK198801845A 1983-05-09 1988-04-06 3,5-cyclovitamin D2 derivat-mellemprodukter til brug ved fremstillingen af 1alfa,25-dihydroxylerede vitamin D2-derivater DK172567B1 (da)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
US49286383A	1983-05-09	1983-05-09
US49286383		1983-05-09
US60732784A	1984-05-04	1984-05-04
US60732784		1984-05-04
US8400714		1984-05-09
PCT/US1984/000714 WO1984004527A1 (en)	1983-05-09	1984-05-09	PROCESS FOR THE PREPARATION OF 1alpha,25-DIHYDROXYLATED VITAMIN D2 AND RELATED COMPOUNDS

Publications (3)

Publication Number	Publication Date
DK184588D0 DK184588D0 (da)	1988-04-06
DK184588A true DK184588A (da)	1988-04-06
DK172567B1 DK172567B1 (da)	1999-01-18

Family

ID=27050897

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
DK008685A DK171397B1 (da)	1983-05-09	1985-01-08	24-epi-1alfa,25-dihydroxylerede vitamin D2-derivater og præparater til farmaceutisk anvendelse indeholdende disse derivater
DK198801845A DK172567B1 (da)	1983-05-09	1988-04-06	3,5-cyclovitamin D2 derivat-mellemprodukter til brug ved fremstillingen af 1alfa,25-dihydroxylerede vitamin D2-derivater
DK199101832A DK172733B1 (da)	1983-05-09	1991-11-07	25-oxovitamin D2 derivat-mellemprodukter til brugved fremstillingen af 1alfa, 25-dihydroxylerede vitamin D2-derivater

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DK008685A DK171397B1 (da)	1983-05-09	1985-01-08	24-epi-1alfa,25-dihydroxylerede vitamin D2-derivater og præparater til farmaceutisk anvendelse indeholdende disse derivater

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK199101832A DK172733B1 (da)	1983-05-09	1991-11-07	25-oxovitamin D2 derivat-mellemprodukter til brugved fremstillingen af 1alfa, 25-dihydroxylerede vitamin D2-derivater

Country Status (7)

Country	Link
JP (3)	JPH0651624B2 (da)
AU (1)	AU568549B2 (da)
CH (1)	CH665834A5 (da)
DE (4)	DE3448412C2 (da)
DK (3)	DK171397B1 (da)
NL (1)	NL193245C (da)
WO (1)	WO1984004527A1 (da)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS62500301A (ja) *	1984-10-04	1987-02-05	ウイスコンシン　アラムナイ　リサ−チ　フオンデ−シヨン	２４―ホモビタミンｄ誘導体
WO1986004333A1 (en) *	1985-01-17	1986-07-31	Wisconsin Alumni Research Foundation	Vitamin d derivatives and methods for preparing same
US5104864A (en) *	1988-08-02	1992-04-14	Bone Care International, Inc.	Method for treating and preventing loss of bone mass
CA1341408C (en) *	1988-08-02	2002-12-10	Charles W. Bishop	Method for treating and preventing loss of bone mass
US4973584A (en) *	1989-03-09	1990-11-27	Deluca Hector F	Novel 1α-hydroxyvitamin D2 epimer and derivatives
JP2645130B2 (ja) *	1989-03-31	1997-08-25	日清製粉株式会社	ステロイド誘導体
GB8914963D0 (en) *	1989-06-29	1989-08-23	Leo Pharm Prod Ltd	Chemical compounds
IN171426B (da) *	1990-02-14	1992-10-10	Wisconsin Alumni Res Found
US5795882A (en) *	1992-06-22	1998-08-18	Bone Care International, Inc.	Method of treating prostatic diseases using delayed and/or sustained release vitamin D formulations
ES2170069T3 (es) *	1992-06-22	2002-08-01	Bone Care Int Inc	1-alfa-hidroxiprevitamina d para administracion oral.
US5763429A (en)	1993-09-10	1998-06-09	Bone Care International, Inc.	Method of treating prostatic diseases using active vitamin D analogues
US6242434B1 (en)	1997-08-08	2001-06-05	Bone Care International, Inc.	24-hydroxyvitamin D, analogs and uses thereof
US6566353B2 (en)	1996-12-30	2003-05-20	Bone Care International, Inc.	Method of treating malignancy associated hypercalcemia using active vitamin D analogues
US6573256B2 (en)	1996-12-30	2003-06-03	Bone Care International, Inc.	Method of inhibiting angiogenesis using active vitamin D analogues
US6503893B2 (en)	1996-12-30	2003-01-07	Bone Care International, Inc.	Method of treating hyperproliferative diseases using active vitamin D analogues
PL336231A1 (en)	1997-02-13	2000-06-19	Bone Care International	System for aimed therapeutic delivery of vitamin d compounds
EP1301479A2 (en)	2000-07-18	2003-04-16	Bone Care International, Inc.	STABILIZED 1$g(a)-HYDROXY VITAMIN D
US7148211B2 (en)	2002-09-18	2006-12-12	Genzyme Corporation	Formulation for lipophilic agents
US7094775B2 (en)	2004-06-30	2006-08-22	Bone Care International, Llc	Method of treating breast cancer using a combination of vitamin D analogues and other agents
ES2759874T3 (es)	2008-03-12	2020-05-12	Opko Ireland Global Holdings Ltd	1,25-Dihidroxivitamina D2 estabilizada y método de preparación de la misma

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4260549A (en) *	1979-05-21	1981-04-07	Wisconsin Alumni Research Foundation	Process for preparing 1α-hydroxylated compounds
US4267117A (en) *	1978-06-19	1981-05-12	The Upjohn Company	Compounds and process
US4269777A (en) *	1979-05-21	1981-05-26	Wisconsin Alumni Research Foundation	Isotopically labeled vitamin D derivatives and processes for preparing same

1984
- 1984-05-09 DE DE3448412A patent/DE3448412C2/de not_active Expired - Lifetime
- 1984-05-09 DE DE19843490215 patent/DE3490215T/de active Pending
- 1984-05-09 DE DE3490215A patent/DE3490215C2/de not_active Expired - Lifetime
- 1984-05-09 WO PCT/US1984/000714 patent/WO1984004527A1/en not_active Ceased
- 1984-05-09 CH CH145/85A patent/CH665834A5/de not_active IP Right Cessation
- 1984-05-09 NL NL8420137A patent/NL193245C/nl not_active IP Right Cessation
- 1984-05-09 DE DE3448360A patent/DE3448360C2/de not_active Expired - Lifetime
- 1984-05-09 AU AU30115/84A patent/AU568549B2/en not_active Ceased
1985
- 1985-01-08 DK DK008685A patent/DK171397B1/da not_active IP Right Cessation
1988
- 1988-04-06 DK DK198801845A patent/DK172567B1/da not_active IP Right Cessation
1989
- 1989-12-26 JP JP1338023A patent/JPH0651624B2/ja not_active Expired - Lifetime
- 1989-12-26 JP JP1338024A patent/JPH02288873A/ja active Granted
- 1989-12-26 JP JP1338025A patent/JPH0610188B2/ja not_active Expired - Fee Related
1991
- 1991-11-07 DK DK199101832A patent/DK172733B1/da not_active IP Right Cessation

Also Published As

Publication number	Publication date
DK8685D0 (da)	1985-01-08
DK183291A (da)	1991-11-07
JPH02288829A (ja)	1990-11-28
JPH02288873A (ja)	1990-11-28
DE3490215T (de)	1985-05-15
CH665834A5 (de)	1988-06-15
DK184588D0 (da)	1988-04-06
AU568549B2 (en)	1988-01-07
DE3448412C2 (da)	1991-12-12
JPH0651624B2 (ja)	1994-07-06
DE3490215C2 (da)	1991-07-25
DK8685A (da)	1985-01-08
DK172567B1 (da)	1999-01-18
NL193245C (nl)	1999-04-02
NL8420137A (nl)	1985-04-01
NL193245B (nl)	1998-12-01
JPH0610188B2 (ja)	1994-02-09
DK172733B1 (da)	1999-06-21
DE3448360C2 (da)	1991-10-02
JPH0339505B2 (da)	1991-06-14
JPH02288854A (ja)	1990-11-28
DK183291D0 (da)	1991-11-07
WO1984004527A1 (en)	1984-11-22
DK171397B1 (da)	1996-10-14
AU3011584A (en)	1984-12-04

Publication	Publication Date	Title
DK184588D0 (da)	1988-04-06	Mellemprodukter til brug ved fremstilling af 1alfa,25-dihydroxylerede vitamin d2-derivater
FI830922A0 (fi)	1983-03-18	Foerslutningsbar behaollare med halkfria kanter som underlaettar oeppning och behandling
ES539852A0 (es)	1986-07-16	Un nuevo procedimiento para la preparacion de nuevos derivados. de carbazolona.
ES520180A0 (es)	1983-12-01	Procedimiento para la preparacion de nuevos derivados de la aminometil-5-aril-3-oxazolidinona-2.
FI833931A7 (fi)	1984-05-02	Parannuksia menetelmiin 3-aryyli-5- pyratsolijohdannaisten valmistamiseksi.
ES503188A0 (es)	1982-04-16	Un procedimiento para la preparacion de una 1-benzoil-urea 3-sustituida
DK416888D0 (da)	1988-07-25	Cephalosporinforbindelser, krystallinske derivater deraf, mellemprodukter til brug ved fremstilling af cephalosporinforbindelser og fremgangsmaader til fremstilling af cephalosporinforbindelser
DK177489A (da)	1989-04-13	Cholestadienderivater som mellemprodukter til brug ved fremstillingen af homovitamin-d3-derivater
ES500455A0 (es)	1982-02-01	Procedimiento para la preparacion de nuevos derivados de urea
ES533618A0 (es)	1985-10-16	Procedimiento de preparacion de nuevos derivados de guarnina.
DK68784A (da)	1984-08-16	Kontinuert fremgangsmaade til fremstilling af 5-oxo-2,4-dichlor-4-substituerede pentannitriler
DK56490A (da)	1990-03-05	Homocholestenderivater som mellemprodukter til brug ved fremstillingen af 26-homovitamin d3 derivater
DK296290D0 (da)	1990-12-13	Mellemprodukter til brug ved fremstilling af pyrimido(4,5-g)quinolin-derivater eller salte deraf
ES500306A0 (es)	1982-02-01	Procedimiento para la preparacion de nuevos derivados este- roide-espiro-oxatiazolidinos
DK451281A (da)	1982-04-14	Fremgangsmaade til fremstilling af cephalexin-derivater
ES508078A0 (es)	1982-10-01	"procedimiento para la preparacion de derivados de formamidina".
DK422382A (da)	1983-01-03	Oxiraner til anvendelse som mellemprodukter ved fremstilling af substituerede 2-hydroxy-3-azolyl-propanderivater
DK422582A (da)	1983-01-03	Oxiraner til anvendelse som mellemprodukter ved fremstilling af substituerede 1-azolyl-2-hydroxy-alkanderivater
NO166082C (no)	1991-05-29	Mellomprodukter til bruk ved fremstilling av imidazokinolinonderivater.
ES507775A0 (es)	1982-09-01	Procedimiento para la preparacion de derivados de piridina .
ES547820A0 (es)	1986-04-01	Procedimiento de preparacion de nuevos derivados nucleosidos.
FI872559A7 (fi)	1987-06-08	Välituotteet puriinijohdannaisten valmistamiseksi.
AR223763A1 (es)	1981-09-15	Procedimiento para la preparacion de nuevos derivados alcoxicarbonil-3-benzodiazepinas utilizables especialmente en terapeutica
NO166081C (no)	1991-05-29	Mellomprodukter til bruk ved fremstilling av imidazokinolinderivater
ES503408A0 (es)	1982-04-16	Procedimiento para la preparacion de derivados de imidazoli-din-2,4-diona

Legal Events

Date	Code	Title	Description
1999-01-18	B1	Patent granted (law 1993)
2004-02-02	PBP	Patent lapsed	Country of ref document: DK