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AU3011584A - PROCESS FOR THE PREPARATION OF 1a, 25-DIHYDROXYLATED VITAMIN D2 AND RELATED COMPOUNDS - Google Patents

PROCESS FOR THE PREPARATION OF 1a, 25-DIHYDROXYLATED VITAMIN D2 AND RELATED COMPOUNDS

Info

Publication number
AU3011584A
AU3011584A AU30115/84A AU3011584A AU3011584A AU 3011584 A AU3011584 A AU 3011584A AU 30115/84 A AU30115/84 A AU 30115/84A AU 3011584 A AU3011584 A AU 3011584A AU 3011584 A AU3011584 A AU 3011584A
Authority
AU
Australia
Prior art keywords
preparation
related compounds
dihydroxylated vitamin
dihydroxylated
vitamin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU30115/84A
Other versions
AU568549B2 (en
Inventor
Hector F. Deluca
Heinrich K. Schnoes
Rafal R. Sicinski
Yoko Tanaka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wisconsin Alumni Research Foundation
Original Assignee
Wisconsin Alumni Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Research Foundation filed Critical Wisconsin Alumni Research Foundation
Publication of AU3011584A publication Critical patent/AU3011584A/en
Application granted granted Critical
Publication of AU568549B2 publication Critical patent/AU568549B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/24—Radicals substituted by singly bound oxygen or sulfur atoms esterified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0042—Nitrogen only

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Nutrition Science (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
AU30115/84A 1983-05-09 1984-05-09 Process for the preparation of 1a, 25-dihydroxylated vitamin d2 and related compounds Ceased AU568549B2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US49286383A 1983-05-09 1983-05-09
US492863 1983-05-09
US60732784A 1984-05-04 1984-05-04
US607327 1984-05-04

Publications (2)

Publication Number Publication Date
AU3011584A true AU3011584A (en) 1984-12-04
AU568549B2 AU568549B2 (en) 1988-01-07

Family

ID=27050897

Family Applications (1)

Application Number Title Priority Date Filing Date
AU30115/84A Ceased AU568549B2 (en) 1983-05-09 1984-05-09 Process for the preparation of 1a, 25-dihydroxylated vitamin d2 and related compounds

Country Status (7)

Country Link
JP (3) JPH0651624B2 (en)
AU (1) AU568549B2 (en)
CH (1) CH665834A5 (en)
DE (4) DE3490215T (en)
DK (3) DK171397B1 (en)
NL (1) NL193245C (en)
WO (1) WO1984004527A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU582789B2 (en) * 1984-10-04 1989-04-13 Wisconsin Alumni Research Foundation Vitamin d derivatives and methods for preparing same
AU629666B2 (en) * 1989-06-29 1992-10-08 Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktionsaktieselskab) Novel vitamin d analogues

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3687377T2 (en) * 1985-01-17 1993-04-29 Wisconsin Alumni Res Found VITAMIN-D-COMBINATIONS AND THEIR PRODUCTION METHOD.
CA1341408C (en) * 1988-08-02 2002-12-10 Charles W. Bishop Method for treating and preventing loss of bone mass
US5104864A (en) * 1988-08-02 1992-04-14 Bone Care International, Inc. Method for treating and preventing loss of bone mass
US4973584A (en) * 1989-03-09 1990-11-27 Deluca Hector F Novel 1α-hydroxyvitamin D2 epimer and derivatives
JP2645130B2 (en) * 1989-03-31 1997-08-25 日清製粉株式会社 Steroid derivatives
IN171449B (en) * 1990-02-14 1992-10-17 Wisconsin Alumni Res Found
EP0600079B1 (en) * 1992-06-22 2002-01-02 Bone Care International, Inc. Oral 1alpha-hydroxyprevitamin d
US5795882A (en) * 1992-06-22 1998-08-18 Bone Care International, Inc. Method of treating prostatic diseases using delayed and/or sustained release vitamin D formulations
US5763429A (en) 1993-09-10 1998-06-09 Bone Care International, Inc. Method of treating prostatic diseases using active vitamin D analogues
US6242434B1 (en) 1997-08-08 2001-06-05 Bone Care International, Inc. 24-hydroxyvitamin D, analogs and uses thereof
US6573256B2 (en) 1996-12-30 2003-06-03 Bone Care International, Inc. Method of inhibiting angiogenesis using active vitamin D analogues
US6566353B2 (en) 1996-12-30 2003-05-20 Bone Care International, Inc. Method of treating malignancy associated hypercalcemia using active vitamin D analogues
US6503893B2 (en) 1996-12-30 2003-01-07 Bone Care International, Inc. Method of treating hyperproliferative diseases using active vitamin D analogues
AU750451B2 (en) 1997-02-13 2002-07-18 Bone Care International, Inc. Targeted therapeutic delivery of vitamin D compounds
IL153378A0 (en) 2000-07-18 2003-07-06 Bone Care Internat Inc STABILIZED 1alpha-HYDROXY VITAMIN D
US7148211B2 (en) 2002-09-18 2006-12-12 Genzyme Corporation Formulation for lipophilic agents
US7094775B2 (en) 2004-06-30 2006-08-22 Bone Care International, Llc Method of treating breast cancer using a combination of vitamin D analogues and other agents
ES2575003T3 (en) 2008-03-12 2016-06-23 Opko Ireland Global Holdings, Limited 1,25-Stabilized Dihydroxyvitamin D2 and method of preparation thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4260549A (en) * 1979-05-21 1981-04-07 Wisconsin Alumni Research Foundation Process for preparing 1α-hydroxylated compounds
US4267117A (en) * 1978-06-19 1981-05-12 The Upjohn Company Compounds and process
US4269777A (en) * 1979-05-21 1981-05-26 Wisconsin Alumni Research Foundation Isotopically labeled vitamin D derivatives and processes for preparing same

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU582789B2 (en) * 1984-10-04 1989-04-13 Wisconsin Alumni Research Foundation Vitamin d derivatives and methods for preparing same
AU629666B2 (en) * 1989-06-29 1992-10-08 Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktionsaktieselskab) Novel vitamin d analogues

Also Published As

Publication number Publication date
DK184588D0 (en) 1988-04-06
JPH0339505B2 (en) 1991-06-14
JPH02288829A (en) 1990-11-28
JPH0610188B2 (en) 1994-02-09
DK183291A (en) 1991-11-07
NL193245C (en) 1999-04-02
DK8685D0 (en) 1985-01-08
DK8685A (en) 1985-01-08
JPH0651624B2 (en) 1994-07-06
NL193245B (en) 1998-12-01
NL8420137A (en) 1985-04-01
JPH02288873A (en) 1990-11-28
DK172733B1 (en) 1999-06-21
DE3490215T (en) 1985-05-15
DE3448360C2 (en) 1991-10-02
DE3490215C2 (en) 1991-07-25
DE3448412C2 (en) 1991-12-12
DK171397B1 (en) 1996-10-14
JPH02288854A (en) 1990-11-28
WO1984004527A1 (en) 1984-11-22
CH665834A5 (en) 1988-06-15
AU568549B2 (en) 1988-01-07
DK183291D0 (en) 1991-11-07
DK172567B1 (en) 1999-01-18
DK184588A (en) 1988-04-06

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Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired