DK1625121T3 - Pyrimidinderivater til behandling af abnorm cellevækst - Google Patents
Pyrimidinderivater til behandling af abnorm cellevækstInfo
- Publication number
- DK1625121T3 DK1625121T3 DK03778613.4T DK03778613T DK1625121T3 DK 1625121 T3 DK1625121 T3 DK 1625121T3 DK 03778613 T DK03778613 T DK 03778613T DK 1625121 T3 DK1625121 T3 DK 1625121T3
- Authority
- DK
- Denmark
- Prior art keywords
- treatment
- cell growth
- abnormal cell
- pyrimidine derivatives
- pyrimidine
- Prior art date
Links
- 230000002159 abnormal effect Effects 0.000 title 1
- 230000010261 cell growth Effects 0.000 title 1
- 229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 title 1
- 150000003230 pyrimidines Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43567002P | 2002-12-20 | 2002-12-20 | |
| US50074203P | 2003-09-05 | 2003-09-05 | |
| PCT/IB2003/005883 WO2004056807A1 (en) | 2002-12-20 | 2003-12-08 | Pyrimidine derivatives for the treatment of abnormal cell growth |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1625121T3 true DK1625121T3 (da) | 2010-05-10 |
Family
ID=32685406
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK03778613.4T DK1625121T3 (da) | 2002-12-20 | 2003-12-08 | Pyrimidinderivater til behandling af abnorm cellevækst |
Country Status (31)
| Country | Link |
|---|---|
| US (4) | US7109335B2 (da) |
| EP (1) | EP1625121B1 (da) |
| AP (1) | AP2385A (da) |
| AR (1) | AR043682A1 (da) |
| AT (1) | ATE458731T1 (da) |
| AU (2) | AU2003285614B2 (da) |
| CA (1) | CA2529611C (da) |
| CR (2) | CR8266A (da) |
| CY (1) | CY1110069T1 (da) |
| DE (1) | DE60331479D1 (da) |
| DK (1) | DK1625121T3 (da) |
| DO (1) | DOP2003000793A (da) |
| EA (1) | EA013248B1 (da) |
| EC (1) | ECSP066406A (da) |
| ES (1) | ES2338545T3 (da) |
| GE (1) | GEP20084357B (da) |
| IL (1) | IL172047A (da) |
| MX (1) | MXPA06002608A (da) |
| MY (1) | MY142109A (da) |
| NL (1) | NL1025067C2 (da) |
| NZ (1) | NZ543719A (da) |
| OA (1) | OA13309A (da) |
| PA (1) | PA8593001A1 (da) |
| PE (1) | PE20041016A1 (da) |
| PL (1) | PL379330A1 (da) |
| PT (1) | PT1625121E (da) |
| RS (1) | RS20060097A (da) |
| SI (1) | SI1625121T1 (da) |
| TN (1) | TNSN06074A1 (da) |
| TW (1) | TWI283673B (da) |
| WO (1) | WO2004056807A1 (da) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1625121T3 (da) | 2002-12-20 | 2010-05-10 | Pfizer Prod Inc | Pyrimidinderivater til behandling af abnorm cellevækst |
| US7109337B2 (en) | 2002-12-20 | 2006-09-19 | Pfizer Inc | Pyrimidine derivatives for the treatment of abnormal cell growth |
| DE10349423A1 (de) * | 2003-10-16 | 2005-06-16 | Schering Ag | Sulfoximinsubstituierte Parimidine als CDK- und/oder VEGF-Inhibitoren, deren Herstellung und Verwendung als Arzneimittel |
| AU2005243397A1 (en) * | 2004-05-14 | 2005-11-24 | Pfizer Products Inc. | Pyrimidine derivatives for the treatment of abnormal cell growth |
| WO2005111022A1 (en) | 2004-05-14 | 2005-11-24 | Pfizer Products Inc. | Pyrimidines derivatives for the treatment of abnormal cell growth |
| BRPI0510963A (pt) | 2004-05-14 | 2007-11-20 | Pfizer Prod Inc | derivados pirimidina para o tratamento do crescimento anormal de células |
| US20060205945A1 (en) * | 2004-05-14 | 2006-09-14 | Pfizer Inc | Pyrimidine derivatives for the treatment of abnormal cell growth |
| MXPA06011658A (es) * | 2004-05-14 | 2006-12-14 | Pfizer Prod Inc | Derivados de pirimidina para el tratamiento del crecimiento celular anormal. |
| WO2005118544A2 (en) * | 2004-05-18 | 2005-12-15 | Rigel Pharmaceuticals, Inc. | Cycloalkyl substituted pyrimidinediamine compounds and their uses |
| MXPA06015170A (es) * | 2004-06-21 | 2007-08-21 | Pharmacia & Upjohn Co Llc | Procedimiento para aumentar la cantidad de hueso. |
| EP1741709A1 (en) * | 2005-06-28 | 2007-01-10 | Sanofi-Aventis Deutschland GmbH | Heteroaryl-substituted amides comprising a saturated linker group, and their use as pharmaceuticals |
| TW200800963A (en) * | 2005-10-28 | 2008-01-01 | Astrazeneca Ab | Chemical compounds |
| CA2632149C (en) * | 2005-12-01 | 2011-11-15 | Pfizer Products Inc. | Pyrimidine derivatives for the treatment of abnormal cell growth |
| ATE497496T1 (de) | 2006-10-19 | 2011-02-15 | Rigel Pharmaceuticals Inc | 2,4-pyridimediamon-derivate als hemmer von jak- kinasen zur behandlung von autoimmunerkrankungen |
| DE102007010801A1 (de) | 2007-03-02 | 2008-09-04 | Bayer Cropscience Ag | Diaminopyrimidine als Fungizide |
| EP2136829A4 (en) * | 2007-03-16 | 2012-07-18 | Univ Florida | KINASE PROTEIN BINDING INHIBITORS |
| UA97834C2 (ru) | 2007-04-18 | 2012-03-26 | Пфайзер Продактс Инк. | Производные сульфониламида для лечения анормального роста клеток |
| KR101294731B1 (ko) * | 2007-06-04 | 2013-08-16 | 삼성디스플레이 주식회사 | 어레이 기판, 이를 갖는 표시패널 및 이의 제조방법 |
| WO2009012421A1 (en) | 2007-07-17 | 2009-01-22 | Rigel Pharmaceuticals, Inc. | Cyclic amine substituted pyrimidinediamines as pkc inhibitors |
| CL2009000600A1 (es) * | 2008-03-20 | 2010-05-07 | Bayer Cropscience Ag | Uso de compuestos de diaminopirimidina como agentes fitosanitarios; compuestos de diaminopirimidina; su procedimiento de preparacion; agente que los contiene; procedimiento para la preparacion de dicho agente; y procedimiento para combatir plagas de animales y/u hongos dañinos patogenos de plantas. |
| EP2161259A1 (de) | 2008-09-03 | 2010-03-10 | Bayer CropScience AG | 4-Halogenalkylsubstituierte Diaminopyrimidine als Fungizide |
| US8410126B2 (en) * | 2009-05-29 | 2013-04-02 | Boehringer Ingelheim International Gmbh | Pyrimidine inhibitors of PKTK2 |
| TW201100441A (en) | 2009-06-01 | 2011-01-01 | Osi Pharm Inc | Amino pyrimidine anticancer compounds |
| US8933227B2 (en) | 2009-08-14 | 2015-01-13 | Boehringer Ingelheim International Gmbh | Selective synthesis of functionalized pyrimidines |
| JP5539518B2 (ja) | 2009-08-14 | 2014-07-02 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ２−アミノ−５−トリフルオロメチルピリミジン誘導体の位置選択的調製 |
| CA2798578C (en) | 2010-05-21 | 2015-12-29 | Chemilia Ab | Novel pyrimidine derivatives |
| EP2395001A1 (en) | 2010-05-21 | 2011-12-14 | Chemilia AB | Novel pyrimidine derivatives |
| US10420665B2 (en) | 2010-06-13 | 2019-09-24 | W. L. Gore & Associates, Inc. | Intragastric device for treating obesity |
| US8628554B2 (en) | 2010-06-13 | 2014-01-14 | Virender K. Sharma | Intragastric device for treating obesity |
| US9526648B2 (en) | 2010-06-13 | 2016-12-27 | Synerz Medical, Inc. | Intragastric device for treating obesity |
| US10010439B2 (en) | 2010-06-13 | 2018-07-03 | Synerz Medical, Inc. | Intragastric device for treating obesity |
| DE102010034699A1 (de) | 2010-08-18 | 2012-02-23 | Merck Patent Gmbh | Pyrimidinderivate |
| US20120244141A1 (en) | 2010-09-28 | 2012-09-27 | Boehringer Ingelheim International Gmbh | Stratification of cancer patients for susceptibility to therapy with PTK2 inhibitors |
| WO2012074951A1 (en) | 2010-11-29 | 2012-06-07 | OSI Pharmaceuticals, LLC | Macrocyclic kinase inhibitors |
| ES2724525T3 (es) | 2011-02-17 | 2019-09-11 | Cancer Therapeutics Crc Pty Ltd | Inhibidores selectivos de FAK |
| US20130324532A1 (en) | 2011-02-17 | 2013-12-05 | Cancer Therapeutics Crc Pty Limited | Fak inhibitors |
| EP2502924A1 (en) | 2011-03-24 | 2012-09-26 | Chemilia AB | Novel pyrimidine derivatives |
| JP5886411B2 (ja) | 2011-03-24 | 2016-03-16 | ノビガ・リサーチ・エービーＮｏｖｉｇａ Ｒｅｓｅａｒｃｈ ＡＢ | 新規のピリミジン誘導体 |
| DE102011111400A1 (de) | 2011-08-23 | 2013-02-28 | Merck Patent Gmbh | Bicyclische heteroaromatische Verbindungen |
| WO2013079505A1 (en) * | 2011-11-29 | 2013-06-06 | F. Hoffmann-La Roche Ag | Aminopyrimidine derivatives as lrrk2 modulators |
| CA2860095A1 (en) | 2011-12-23 | 2013-06-27 | Cellzome Limited | Pyrimidine-2,4-diamine derivatives as kinase inhibitors |
| EP2711365A1 (en) | 2012-09-21 | 2014-03-26 | Chemilia AB | 4-Indazolylamino-2-(2-(indol-3-yl)ethyl)aminopyrimidines useful for the treatment of cancer |
| EP2711364A1 (en) | 2012-09-21 | 2014-03-26 | Chemilia AB | 4-(Indolyl or benzimidazolyl)amino-2-(2-(indol-3-yl)ethyl)aminopyrimidines useful for the treatment of cancer |
| US10779980B2 (en) | 2016-04-27 | 2020-09-22 | Synerz Medical, Inc. | Intragastric device for treating obesity |
| WO2019117813A1 (en) * | 2017-12-15 | 2019-06-20 | National University Of Singapore | Focal adhesion kinase targeted therapeutics for the treatment of glaucoma and fibrosis |
| CN116888100B (zh) * | 2021-04-08 | 2025-12-23 | 杭州阿诺生物医药科技有限公司 | 一种高活性的hpk1激酶抑制剂 |
Family Cites Families (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4507146A (en) | 1982-12-28 | 1985-03-26 | Ciba-Geigy Corporation | 2,4-Diamino-6-halo-5-trifluoromethylpyrimidines having herbicidal activity |
| GB8607683D0 (en) | 1986-03-27 | 1986-04-30 | Ici Plc | Anti-tumor agents |
| US4983608A (en) | 1989-09-05 | 1991-01-08 | Hoechst-Roussell Pharmaceuticals, Inc. | N-substituted-4-pyrimidinamines and pyrimidinediamines |
| DE4029650A1 (de) | 1990-09-19 | 1992-03-26 | Hoechst Ag | 2-anilino-pyrimidine, verfahren zu ihrer herstellung, sie enthaltene mittel und ihre verwendung als fungizide |
| ES2108120T3 (es) | 1991-05-10 | 1997-12-16 | Rhone Poulenc Rorer Int | Compuestos bis arilicos y heteroarilicos mono- y biciclicos que inhiben tirosina quinasa receptora de egf y/o pdgf. |
| NZ243082A (en) | 1991-06-28 | 1995-02-24 | Ici Plc | 4-anilino-quinazoline derivatives; pharmaceutical compositions, preparatory processes, and use thereof |
| DE4131184A1 (de) | 1991-09-19 | 1993-03-25 | Bayer Ag | Wasserbasierte, loesungsmittel- und emulgatorfreie mikrobizide wirkstoffkombination |
| DE4137291A1 (de) | 1991-11-13 | 1993-05-19 | Bayer Ag | Verfahren zur kontinuierlichen umsetzung von halogenpyrimidinen mit aminen |
| WO1993010086A1 (de) | 1991-11-13 | 1993-05-27 | MTA Központi Kémiai Kutató Intézete | Verfahren zur herstellung von n-(arylsulfonyl)-carbamid-säure-derivaten und den in diesem verfahren verwendbaren intermedieren |
| GB9300059D0 (en) | 1992-01-20 | 1993-03-03 | Zeneca Ltd | Quinazoline derivatives |
| FR2686339B1 (fr) | 1992-01-22 | 1994-03-11 | Adir Cie | Nouveaux amides et sulfonamides naphtaleniques, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent. |
| US5521184A (en) * | 1992-04-03 | 1996-05-28 | Ciba-Geigy Corporation | Pyrimidine derivatives and processes for the preparation thereof |
| EP1008589A1 (en) | 1992-05-22 | 2000-06-14 | E.I. Du Pont De Nemours & Company Incorporated | Fungicidal imidazolinones |
| US6177401B1 (en) | 1992-11-13 | 2001-01-23 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften | Use of organic compounds for the inhibition of Flk-1 mediated vasculogenesis and angiogenesis |
| GB9323290D0 (en) | 1992-12-10 | 1994-01-05 | Zeneca Ltd | Quinazoline derivatives |
| GB9314884D0 (en) | 1993-07-19 | 1993-09-01 | Zeneca Ltd | Tricyclic derivatives |
| GB9314893D0 (en) | 1993-07-19 | 1993-09-01 | Zeneca Ltd | Quinazoline derivatives |
| GB9510757D0 (en) | 1994-09-19 | 1995-07-19 | Wellcome Found | Therapeuticaly active compounds |
| GB9424233D0 (en) | 1994-11-30 | 1995-01-18 | Zeneca Ltd | Quinazoline derivatives |
| WO1997012880A1 (en) | 1995-10-02 | 1997-04-10 | F.Hoffmann-La Roche Ag | Pyrimidine derivatives as 5ht2c-receptor antagonists |
| GB9523675D0 (en) * | 1995-11-20 | 1996-01-24 | Celltech Therapeutics Ltd | Chemical compounds |
| GB9603095D0 (en) | 1996-02-14 | 1996-04-10 | Zeneca Ltd | Quinazoline derivatives |
| TW440563B (en) | 1996-05-23 | 2001-06-16 | Hoffmann La Roche | Aryl pyrimidine derivatives and a pharmaceutical composition thereof |
| HRP970371A2 (en) | 1996-07-13 | 1998-08-31 | Kathryn Jane Smith | Heterocyclic compounds |
| EA199900021A1 (ru) | 1996-07-13 | 1999-08-26 | Глаксо, Груп Лимитед | Бициклические гетероароматические соединения в качестве ингибиторов протеинтирозинкиназы |
| ID19609A (id) | 1996-07-13 | 1998-07-23 | Glaxo Group Ltd | Senyawa-senyawa heterosiklik |
| ATE232863T1 (de) | 1996-08-06 | 2003-03-15 | Pfizer | Substituierte pyrido- oder pyrimidogruppen enthaltende 6,6- oder 6,7-bicyclische derivate |
| US6262040B1 (en) | 1996-09-04 | 2001-07-17 | Pfizer Inc | Indazole derivatives and their use as inhibitors of phosphodiesterase (PDE) type IV and the production of tumor necrosis factor (TNF) |
| ID18494A (id) | 1996-10-02 | 1998-04-16 | Novartis Ag | Turunan pirazola leburan dan proses pembuatannya |
| DE19701931C1 (de) * | 1997-01-21 | 1998-05-28 | Siemens Ag | Verfahren zur Detektion von Synchronizität zwischen mehreren digitalen Meßreihen mit Hilfe eines Rechners |
| IL131475A0 (en) | 1997-02-19 | 2001-01-28 | Berlex Lab | N-heterocyclic derivatives as nos inhibitors |
| TW436485B (en) | 1997-08-01 | 2001-05-28 | American Cyanamid Co | Substituted quinazoline derivatives |
| KR100446363B1 (ko) | 1997-11-11 | 2004-09-01 | 화이자 프로덕츠 인코포레이티드 | 항암제로 유용한 티에노피리미딘 및 티에노피리딘 유도체 |
| US6200977B1 (en) | 1998-02-17 | 2001-03-13 | Tularik Inc. | Pyrimidine derivatives |
| WO2000012485A1 (en) | 1998-08-29 | 2000-03-09 | Astrazeneca Ab | Pyrimidine compounds |
| US6297258B1 (en) | 1998-09-29 | 2001-10-02 | American Cyanamid Company | Substituted 3-cyanoquinolines |
| ES2457396T3 (es) | 1998-09-29 | 2014-04-25 | Wyeth Holdings Llc | 3-Cianoquinolinas sustituidas como inhibidores de las proteínas tirosina quinasas |
| GB9828511D0 (en) * | 1998-12-24 | 1999-02-17 | Zeneca Ltd | Chemical compounds |
| GB9922171D0 (en) | 1999-09-21 | 1999-11-17 | Zeneca Ltd | Chemical compounds |
| GB9924862D0 (en) * | 1999-10-20 | 1999-12-22 | Celltech Therapeutics Ltd | Chemical compounds |
| AU2001237041B9 (en) * | 2000-02-17 | 2005-07-28 | Amgen Inc. | Kinase inhibitors |
| GB0004887D0 (en) | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
| GB0004890D0 (en) * | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
| EP1263503B1 (en) | 2000-03-13 | 2005-11-02 | Wyeth Holdings Corporation | Use of cyanoquinolines for treating or inhibiting colonic polyps |
| US6525051B2 (en) | 2000-03-27 | 2003-02-25 | Schering Aktiengesellschaft | N-heterocyclic derivatives as NOS inhibitors |
| WO2002008193A2 (en) | 2000-07-07 | 2002-01-31 | Cancer Research Technology Limited | Therapeutic acridone and acridine compounds |
| ES2317923T3 (es) | 2000-08-09 | 2009-05-01 | Astrazeneca Ab | Compuestos de cinolina. |
| WO2002016348A1 (en) | 2000-08-09 | 2002-02-28 | Astrazeneca Ab | Antiangiogenic bicyclic derivatives |
| JP2004505965A (ja) | 2000-08-09 | 2004-02-26 | アストラゼネカ アクチボラグ | 化合物 |
| US7115615B2 (en) | 2000-08-21 | 2006-10-03 | Astrazeneca | Quinazoline derivatives |
| JO2654B1 (en) | 2000-09-04 | 2012-06-17 | شركة جانسين فارماسوتيكا ان. في | Multiple aryl caroxa amides are useful as lipid - lowering agents |
| CA2432000C (en) | 2000-12-21 | 2011-03-15 | Glaxo Group Limited | Pyrimidineamines as angiogenesis modulators |
| ATE420077T1 (de) | 2001-05-29 | 2009-01-15 | Bayer Schering Pharma Ag | Cdk inhibitorische pyrimidine, deren herstellung und verwendung als arzneimittel |
| GB0113041D0 (en) | 2001-05-30 | 2001-07-18 | Astrazeneca Ab | Chemical compounds |
| WO2002102313A2 (en) | 2001-06-19 | 2002-12-27 | Bristol-Myers Squibb Company | Pyrimidine inhibitors of phosphodiesterase (pde) 7 |
| US6939874B2 (en) | 2001-08-22 | 2005-09-06 | Amgen Inc. | Substituted pyrimidinyl derivatives and methods of use |
| WO2003020276A1 (en) | 2001-08-30 | 2003-03-13 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| WO2003030909A1 (en) | 2001-09-25 | 2003-04-17 | Bayer Pharmaceuticals Corporation | 2- and 4-aminopyrimidines n-substtituded by a bicyclic ring for use as kinase inhibitors in the treatment of cancer |
| ATE407678T1 (de) * | 2001-10-17 | 2008-09-15 | Boehringer Ingelheim Pharma | Pyrimidinderivate, arzneimittel enthaltend diese verbindungen, deren verwendung und verfahren zu ihrer herstellung |
| WO2003032994A2 (de) * | 2001-10-17 | 2003-04-24 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 5-substituierte 4-amino-2-phenylamino-pyrimidinderivate und ihre verwendung als beta-amyloid modulatoren |
| TWI329105B (en) | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
| CN101050189A (zh) | 2002-02-05 | 2007-10-10 | 惠氏公司 | N－酰基－2－氨基－4－烷氧基－5－硝基苯甲酸类化合物的合成方法 |
| DE10205336A1 (de) | 2002-02-07 | 2003-08-21 | Bdd Group Holding Ag Zug | Deuterierte Biphenylderivate |
| GB0206215D0 (en) | 2002-03-15 | 2002-05-01 | Novartis Ag | Organic compounds |
| WO2003095448A1 (en) | 2002-05-06 | 2003-11-20 | Bayer Pharmaceuticals Corporation | Pyridinyl amino pyrimidine derivatives useful for treating hyper-proliferative disorders |
| DE60322947D1 (de) | 2002-12-20 | 2008-09-25 | Sosei R & D Ltd | Deraufnahme inhibitoren |
| US7109337B2 (en) * | 2002-12-20 | 2006-09-19 | Pfizer Inc | Pyrimidine derivatives for the treatment of abnormal cell growth |
| UA80767C2 (en) | 2002-12-20 | 2007-10-25 | Pfizer Prod Inc | Pyrimidine derivatives for the treatment of abnormal cell growth |
| DK1625121T3 (da) | 2002-12-20 | 2010-05-10 | Pfizer Prod Inc | Pyrimidinderivater til behandling af abnorm cellevækst |
| PL1663991T3 (pl) * | 2003-09-05 | 2007-04-30 | Pfizer Prod Inc | Selektywna synteza CF3 – podstawionych pirymidyn |
| WO2005111022A1 (en) * | 2004-05-14 | 2005-11-24 | Pfizer Products Inc. | Pyrimidines derivatives for the treatment of abnormal cell growth |
| MXPA06011658A (es) * | 2004-05-14 | 2006-12-14 | Pfizer Prod Inc | Derivados de pirimidina para el tratamiento del crecimiento celular anormal. |
| BRPI0510963A (pt) * | 2004-05-14 | 2007-11-20 | Pfizer Prod Inc | derivados pirimidina para o tratamento do crescimento anormal de células |
-
2003
- 2003-12-08 DK DK03778613.4T patent/DK1625121T3/da active
- 2003-12-08 EP EP03778613A patent/EP1625121B1/en not_active Expired - Lifetime
- 2003-12-08 WO PCT/IB2003/005883 patent/WO2004056807A1/en not_active Ceased
- 2003-12-08 CA CA002529611A patent/CA2529611C/en not_active Expired - Lifetime
- 2003-12-08 GE GEAP20039074A patent/GEP20084357B/en unknown
- 2003-12-08 MX MXPA06002608A patent/MXPA06002608A/es active IP Right Grant
- 2003-12-08 OA OA1200600067A patent/OA13309A/en unknown
- 2003-12-08 PT PT03778613T patent/PT1625121E/pt unknown
- 2003-12-08 ES ES03778613T patent/ES2338545T3/es not_active Expired - Lifetime
- 2003-12-08 SI SI200331771T patent/SI1625121T1/sl unknown
- 2003-12-08 AU AU2003285614A patent/AU2003285614B2/en not_active Expired
- 2003-12-08 AP AP2005003438A patent/AP2385A/xx active
- 2003-12-08 RS YUP-2006/0097A patent/RS20060097A/sr unknown
- 2003-12-08 AT AT03778613T patent/ATE458731T1/de active
- 2003-12-08 DE DE60331479T patent/DE60331479D1/de not_active Expired - Lifetime
- 2003-12-08 PL PL379330A patent/PL379330A1/pl not_active Application Discontinuation
- 2003-12-08 EA EA200600122A patent/EA013248B1/ru not_active IP Right Cessation
- 2003-12-11 US US10/733,215 patent/US7109335B2/en not_active Expired - Lifetime
- 2003-12-16 TW TW092135619A patent/TWI283673B/zh not_active IP Right Cessation
- 2003-12-17 DO DO2003000793A patent/DOP2003000793A/es unknown
- 2003-12-17 MY MYPI20034835A patent/MY142109A/en unknown
- 2003-12-18 PA PA20038593001A patent/PA8593001A1/es unknown
- 2003-12-18 NL NL1025067A patent/NL1025067C2/nl not_active IP Right Cessation
- 2003-12-18 AR ARP030104715A patent/AR043682A1/es unknown
-
2004
- 2004-01-05 PE PE2004000041A patent/PE20041016A1/es not_active Application Discontinuation
- 2004-12-08 NZ NZ543719A patent/NZ543719A/en not_active IP Right Cessation
-
2005
- 2005-11-20 IL IL172047A patent/IL172047A/en active IP Right Grant
-
2006
- 2006-03-02 CR CR8266A patent/CR8266A/es unknown
- 2006-03-03 EC EC2006006406A patent/ECSP066406A/es unknown
- 2006-03-03 TN TNP2006000074A patent/TNSN06074A1/en unknown
- 2006-08-17 US US11/506,689 patent/US7351712B2/en not_active Expired - Lifetime
-
2008
- 2008-03-31 US US12/059,889 patent/US7674796B2/en not_active Expired - Lifetime
- 2008-07-29 US US12/181,991 patent/US7741336B2/en not_active Expired - Lifetime
-
2009
- 2009-08-14 AU AU2009208172A patent/AU2009208172B2/en not_active Expired
-
2010
- 2010-04-20 CY CY20101100360T patent/CY1110069T1/el unknown
-
2011
- 2011-07-06 CR CR20110380A patent/CR20110380A/es not_active Application Discontinuation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK1625121T3 (da) | Pyrimidinderivater til behandling af abnorm cellevækst | |
| DK1292591T3 (da) | Bicykliske derivater til behandling af abnorm cellevækst | |
| ZA200804488B (en) | Pyrimidine derivatives for the treatment of abnormal cell growth | |
| AU2003288603A8 (en) | Pyrimidine derivates for the treatment of abnormal cell growth | |
| DK1633726T3 (da) | Pyrimidinderivater, der er egnede til behandling af CRTH2-formidlede sygdomme | |
| DK1701941T3 (da) | Forbindelser til behandling af sygdomme med celleproliferation | |
| DK1803718T3 (da) | 4-Tetrazolyl-4-phenylpiperidin-derivater til behandling af smerter | |
| DK2308507T3 (da) | Fremgangsmåder til behandling af præeklampsi | |
| NO20042882L (no) | Kinazolinderivater for behandling av unormal celle vekst | |
| DK1504126T3 (da) | Fremgangsmåde til regulering af genekspression | |
| DK1362050T3 (da) | Pyrimidinderivater til inhibition af celleproliferation | |
| DK1474416T3 (da) | Dihydrobenzodiazepin-2-on-derivater til behandlingen af neurologiske lidelser | |
| DK1491212T3 (da) | Middel til behandling af søvnforstyrrelser | |
| DK1563061T3 (da) | Dyrkning af hårinducerende celler | |
| ZA200608394B (en) | Pyrimidine derivatives for the treatment of abnormal cell growth | |
| NO20053483D0 (no) | 4-Anilinokinazolinderivater for behandling av unormal cellevekst | |
| DK1511724T3 (da) | Fremgangsmåde til fremstilling af thioalkylaminderivater | |
| DK1567524T3 (da) | Thia-epothilonderivater til behandling af cancer | |
| DK1699794T3 (da) | Fremgangsmåde til fremstilling af triazolpyrimidiner | |
| IS8328A (is) | Pýrimidín afleiður til notkunar í meðferð á afbrigðilegum frumuvexti | |
| DE50204133D1 (de) | Sektionaltor und führungsanordnung dafür | |
| ITPI20020002A1 (it) | Stelo stabilizzato per protesi |