DK167978B1 - Glycero-3(2)-phospho-l-serin-derivater og salte deraf, fremgangsmaade til fremstilling af saadanne forbindelser og farmaceutiske praeparater indeholdende disse - Google Patents

Glycero-3(2)-phospho-l-serin-derivater og salte deraf, fremgangsmaade til fremstilling af saadanne forbindelser og farmaceutiske praeparater indeholdende disse Download PDF

Info

Publication number: DK167978B1
Authority: DK; Denmark
Prior art keywords: serine; glycero; groups; group; general formula
Prior art date: 1985-07-03

Application number

DK106287A

Other languages

Danish (da)

English (en)

Other versions

DK106287D0 (da

DK106287A (da

Inventor

Hans Brachwitz

Peter Langen

Christine Lehmann

Eckart Matthes

Juergen Schildt

Iduna Fichtner

Albin Hermetter

Friedrich Paltauf

Original Assignee

Hafslund Nycomed Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-07-03

Filing date

1987-03-02

Publication date

1994-01-10

1985-07-03 Priority claimed from DD27823185A external-priority patent/DD238979A1/de

1985-07-03 Priority claimed from DD27823085A external-priority patent/DD238978A1/de

1985-07-15 Priority claimed from DD27856285A external-priority patent/DD239405A1/de

1985-07-15 Priority claimed from DD27856085A external-priority patent/DD239208B1/de

1985-07-15 Priority claimed from DD27856185A external-priority patent/DD239209A1/de

1987-03-02 Application filed by Hafslund Nycomed Pharma filed Critical Hafslund Nycomed Pharma

1987-03-02 Publication of DK106287D0 publication Critical patent/DK106287D0/da

1987-03-02 Publication of DK106287A publication Critical patent/DK106287A/da

1994-01-10 Application granted granted Critical

1994-01-10 Publication of DK167978B1 publication Critical patent/DK167978B1/da

Links

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229910052736 halogen Inorganic materials 0.000 claims description 15
150000002367 halogens Chemical class 0.000 claims description 15
125000006239 protecting group Chemical group 0.000 claims description 14
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102000011420 Phospholipase D Human genes 0.000 claims description 8
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239000008194 pharmaceutical composition Substances 0.000 claims description 5
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125000006678 phenoxycarbonyl group Chemical group 0.000 description 1
150000008105 phosphatidylcholines Chemical class 0.000 description 1
125000002525 phosphocholine group Chemical group OP(=O)(OCC[N+](C)(C)C)O* 0.000 description 1
150000003904 phospholipids Chemical class 0.000 description 1
229910052698 phosphorus Inorganic materials 0.000 description 1
239000011574 phosphorus Substances 0.000 description 1
BZQFBWGGLXLEPQ-REOHCLBHSA-N phosphoserine Chemical class OC(=O)[C@@H](N)COP(O)(O)=O BZQFBWGGLXLEPQ-REOHCLBHSA-N 0.000 description 1
239000010773 plant oil Substances 0.000 description 1
239000003495 polar organic solvent Substances 0.000 description 1
229920001515 polyalkylene glycol Polymers 0.000 description 1
239000011591 potassium Substances 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
239000002244 precipitate Substances 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
230000002265 prevention Effects 0.000 description 1
238000010926 purge Methods 0.000 description 1
229920006395 saturated elastomer Polymers 0.000 description 1
230000003248 secreting effect Effects 0.000 description 1
150000003354 serine derivatives Chemical class 0.000 description 1
150000003355 serines Chemical class 0.000 description 1
125000003808 silyl group Chemical group [H][Si]([H])([H])[*] 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
235000017281 sodium acetate Nutrition 0.000 description 1
239000007974 sodium acetate buffer Substances 0.000 description 1
229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
235000017557 sodium bicarbonate Nutrition 0.000 description 1
RZWQDAUIUBVCDD-UHFFFAOYSA-M sodium;benzenethiolate Chemical compound [Na+].[S-]C1=CC=CC=C1 RZWQDAUIUBVCDD-UHFFFAOYSA-M 0.000 description 1
239000007787 solid Substances 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
238000010561 standard procedure Methods 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
239000008107 starch Substances 0.000 description 1
230000001954 sterilising effect Effects 0.000 description 1
238000004659 sterilization and disinfection Methods 0.000 description 1
239000006228 supernatant Substances 0.000 description 1
239000000829 suppository Substances 0.000 description 1
238000003786 synthesis reaction Methods 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
235000012222 talc Nutrition 0.000 description 1
125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
125000001412 tetrahydropyranyl group Chemical group 0.000 description 1
125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 description 1
125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
229940099259 vaseline Drugs 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/10—Phosphatides, e.g. lecithin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicinal Preparation (AREA)

DK106287A 1985-07-03 1987-03-02 Glycero-3(2)-phospho-l-serin-derivater og salte deraf, fremgangsmaade til fremstilling af saadanne forbindelser og farmaceutiske praeparater indeholdende disse DK167978B1 (da)

Applications Claiming Priority (12)

Application Number	Priority Date	Filing Date	Title
DD27823185		1985-07-03
DD27823185A DD238979A1 (de)	1985-07-03	1985-07-03	Verfahren zur herstellung von o-alkylglycerophosphoserin-analogen
DD27823085A DD238978A1 (de)	1985-07-03	1985-07-03	Verfahren zur herstellung von 2-o-alkyl-i-des oxy-1-halogenglycero-3-phospho-l-serinen
DD27823085		1985-07-03
DD27856285A DD239405A1 (de)	1985-07-15	1985-07-15	Verfahren zur herstellung von trifluoralkyl-glycerophospho-l-serinen
DD27856085A DD239208B1 (de)	1985-07-15	1985-07-15	Verfahren zur herstellung von 1-o-alkyl-2-o-trifluoralkylglycerophospho-l-serinen
DD27856285		1985-07-15
DD27856185A DD239209A1 (de)	1985-07-15	1985-07-15	Verfahren zur herstellung von o-alkylsubstituierten glycero- sowie desoxyglycerophospho-serinen
DD27856185		1985-07-15
DD27856085		1985-07-15
PCT/EP1986/000390 WO1987000173A1 (fr)	1985-07-03	1986-07-02	Derives de glycero-3(2)-phospho-l-serine et preparations pharmaceutiques les contenant
EP8600390		1986-07-02

Publications (3)

Publication Number	Publication Date
DK106287D0 DK106287D0 (da)	1987-03-02
DK106287A DK106287A (da)	1987-03-02
DK167978B1 true DK167978B1 (da)	1994-01-10

Family

ID=27509737

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK106287A DK167978B1 (da)	1985-07-03	1987-03-02	Glycero-3(2)-phospho-l-serin-derivater og salte deraf, fremgangsmaade til fremstilling af saadanne forbindelser og farmaceutiske praeparater indeholdende disse

Country Status (8)

Country	Link
EP (1)	EP0229128B1 (no)
JP (1)	JPH0751588B2 (no)
DE (1)	DE3671630D1 (no)
DK (1)	DK167978B1 (no)
FI (1)	FI82473C (no)
HU (1)	HU198076B (no)
NO (1)	NO169171C (no)
WO (1)	WO1987000173A1 (no)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1249063B (it) *	1991-05-28	1995-02-11	Fidia Spa	Impiego di derivati fosfolipidici per la preparazione di composizioni farmaceutiche aventi attivita' immunosoppressiva
ES2034885B1 (es) *	1991-07-10	1994-03-01	Menarini Lab	Procedimiento para la preparacion de cetoalquilglicerofosfolipidos.
DE4229877C2 (de) *	1992-09-04	1994-09-15	Max Delbrueck Centrum	Phospho- bzw. Phosphono-(N-acyl)-serine und ihre Herstellung
IT1311929B1 (it) *	1999-04-28	2002-03-20	Chemi Spa	Procedimento per la preparazione di fosfatidilserine.
WO2005077963A1 (fr) *	2004-01-16	2005-08-25	Institut Superieur Agricole De Beauvais	DErivEs de saccharides et d'itols possEdant un groupement O-alkyle ou un groupement O-alkyle et un groupement O-n-butanoyle. Applications comme mEdicaments dans les pathologies prolifEratives tumorales ou bEnignes.
CN119215059A (zh) *	2023-06-28	2024-12-31	兰州大学	右磷丝氨酸在用于制备预防和/或治疗肾损伤药物中的应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1123142B (it) *	1979-09-14	1986-04-30	Lpb Ist Farm	Uso di glicerilfosforil derivati nella terapia di dislipemie ed epatiti,e composizioni farmaceutiche relative
DD222595A1 (de) *	1984-01-24	1985-05-22	Zi F Molekularbiologie	Verfahren zur herstellung von 1-0-alkyl-2-0-(2,2,2-trifluorethyl)glycero-3-phosphocholinen

1986
- 1986-07-02 WO PCT/EP1986/000390 patent/WO1987000173A1/de not_active Ceased
- 1986-07-02 JP JP61503925A patent/JPH0751588B2/ja not_active Expired - Lifetime
- 1986-07-02 EP EP86904150A patent/EP0229128B1/de not_active Expired - Lifetime
- 1986-07-02 DE DE8686904150T patent/DE3671630D1/de not_active Expired - Fee Related
- 1986-07-03 HU HU862805A patent/HU198076B/hu not_active IP Right Cessation
1987
- 1987-02-20 FI FI870732A patent/FI82473C/fi not_active IP Right Cessation
- 1987-02-27 NO NO87870834A patent/NO169171C/no unknown
- 1987-03-02 DK DK106287A patent/DK167978B1/da active

Also Published As

Publication number	Publication date
NO169171B (no)	1992-02-10
FI82473C (fi)	1991-03-11
FI870732A7 (fi)	1987-02-20
EP0229128B1 (de)	1990-05-30
EP0229128A1 (de)	1987-07-22
JPS63500658A (ja)	1988-03-10
FI870732A0 (fi)	1987-02-20
NO870834L (no)	1987-02-27
HU198076B (en)	1989-07-28
DE3671630D1 (de)	1990-07-05
HUT43861A (en)	1987-12-28
NO169171C (no)	1992-05-20
NO870834D0 (no)	1987-02-27
DK106287D0 (da)	1987-03-02
FI82473B (fi)	1990-11-30
JPH0751588B2 (ja)	1995-06-05
DK106287A (da)	1987-03-02
WO1987000173A1 (fr)	1987-01-15

Publication	Publication Date	Title
EP1117669B1 (en)	2003-01-29	Antiviral purine derivatives
US4562179A (en)	1985-12-31	Phospholipid derivatives, and pharmaceutical composition of the same
US4804789A (en)	1989-02-14	D-mannite derivatives as starting products for the synthesis of phospholipids
EP0337706A1 (en)	1989-10-18	Substituted aminomethylenebis(phosphonic acid) derivatives
DK167978B1 (da)	1994-01-10	Glycero-3(2)-phospho-l-serin-derivater og salte deraf, fremgangsmaade til fremstilling af saadanne forbindelser og farmaceutiske praeparater indeholdende disse
US4916249A (en)	1990-04-10	Glycero-3(2)-phospho-L-serine derivatives and salts thereof
US4163748A (en)	1979-08-07	Propane-1,3-diol phosphatides and method of preparing the same
JPH0531560B2 (no)	1993-05-12
DK167810B1 (da)	1993-12-20	Alkylphyosphonoserin, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat indeholdende en saadan forbindelse
AU690805B2 (en)	1998-04-30	Heteroaryl-substituted deoxy glycero-phosphoethanolamines
US4386079A (en)	1983-05-31	Method of treating depression
PT97281A (pt)	1992-01-31	Processo para a preparacao de novos derivados contendo fosforo
EP0355899B1 (en)	1994-11-02	Nucleotide derivatives
US4531004A (en)	1985-07-23	Dimetronidazole phosphates
EP0071892A2 (en)	1983-02-16	Phospholipid derivatives, process for preparation thereof and pharmaceutical composition of the same
JPH0692424B2 (ja)	1994-11-16	リン酸エステルの製造法
JP3619277B2 (ja)	2005-02-09	ジヒドロポリプレニルモノホスフェートの製造方法及びその中間体化合物
EP0118090B1 (en)	1986-11-05	New 3-alkylthio-2-o-carbamoyl-propane-1.2-diol-1-o-phosphocholines, and processes for their preparation
AU750407B2 (en)	2002-07-18	Prodrugs of phosphorous-containing pharmaceuticals
FI65261B (fi)	1983-12-30	Foerfarande foer framstaellning av farmakologiskt anvaendbart dinatriumsalt av n-(fosfonoacetyl)-l-asparaginsyra
EP0548834A1 (en)	1993-06-30	Stable hexahydrate of etoposide 4'-phosphate disodium salt
KR0149217B1 (ko)	1998-10-15	이노시톨 유도체와 그의 제조방법
HK1036455B (en)	2003-05-30	Antiviral purine derivatives
CZ20011145A3 (cs)	2001-07-11	Antivirové purinové deriváty a jejich použití
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