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DK1425270T3 - Fremgangsmåder og intermediater til fremstilling af 4-aminoquinolin CETP inhibitorer - Google Patents

Fremgangsmåder og intermediater til fremstilling af 4-aminoquinolin CETP inhibitorer

Info

Publication number
DK1425270T3
DK1425270T3 DK02722567T DK02722567T DK1425270T3 DK 1425270 T3 DK1425270 T3 DK 1425270T3 DK 02722567 T DK02722567 T DK 02722567T DK 02722567 T DK02722567 T DK 02722567T DK 1425270 T3 DK1425270 T3 DK 1425270T3
Authority
DK
Denmark
Prior art keywords
aminoquinoline
intermediates
preparation
methods
cetp inhibitors
Prior art date
Application number
DK02722567T
Other languages
English (en)
Inventor
David Burns Damon
Robert Wayne Dugger
Robert William Scott
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Application granted granted Critical
Publication of DK1425270T3 publication Critical patent/DK1425270T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/24—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/62—Compounds containing any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylcarbamates
    • C07C271/64—Y being a hydrogen or a carbon atom, e.g. benzoylcarbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK02722567T 2001-04-30 2002-04-08 Fremgangsmåder og intermediater til fremstilling af 4-aminoquinolin CETP inhibitorer DK1425270T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US28752201P 2001-04-30 2001-04-30

Publications (1)

Publication Number Publication Date
DK1425270T3 true DK1425270T3 (da) 2006-07-03

Family

ID=23103272

Family Applications (2)

Application Number Title Priority Date Filing Date
DK02722567T DK1425270T3 (da) 2001-04-30 2002-04-08 Fremgangsmåder og intermediater til fremstilling af 4-aminoquinolin CETP inhibitorer
DK02722569T DK1383734T3 (da) 2001-04-30 2002-04-08 Forbindelser, der er anvendelige som mellemprodukter til 4-aminoquinolinderivater

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK02722569T DK1383734T3 (da) 2001-04-30 2002-04-08 Forbindelser, der er anvendelige som mellemprodukter til 4-aminoquinolinderivater

Country Status (24)

Country Link
US (3) US6689897B2 (da)
EP (2) EP1383734B1 (da)
JP (2) JP3924250B2 (da)
KR (2) KR100591998B1 (da)
CN (3) CN1297541C (da)
AR (3) AR035963A1 (da)
AT (2) ATE316957T1 (da)
AU (1) AU2002253448B2 (da)
BR (2) BR0209238A (da)
CA (2) CA2445693A1 (da)
CZ (2) CZ20032900A3 (da)
DE (2) DE60210265T2 (da)
DK (2) DK1425270T3 (da)
ES (2) ES2259080T3 (da)
HU (2) HU225777B1 (da)
IL (2) IL157546A0 (da)
MX (2) MXPA03009936A (da)
PL (2) PL366700A1 (da)
PT (1) PT1425270E (da)
RU (2) RU2265010C2 (da)
TW (1) TWI250974B (da)
WO (2) WO2002088085A2 (da)
YU (2) YU84303A (da)
ZA (2) ZA200306600B (da)

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US6197786B1 (en) * 1998-09-17 2001-03-06 Pfizer Inc 4-Carboxyamino-2-substituted-1,2,3,4-tetrahydroquinolines
US20040002615A1 (en) * 2002-06-28 2004-01-01 Allen David Robert Preparation of chiral amino-nitriles
JP2006021999A (ja) * 2002-07-12 2006-01-26 Kaneka Corp 光学活性β−アミノニトリル化合物およびその対掌体アミド化合物の製造方法
US20090181966A1 (en) * 2002-10-04 2009-07-16 Millennium Pharmaceuticals, Inc. PGD2 receptor antagonists for the treatment of inflammatory diseases
KR20050055747A (ko) 2002-10-04 2005-06-13 밀레니엄 파머슈티컬스 인코퍼레이티드 염증 질환 치료용의 ｐｇｄ2 수용체 길항제
US7504508B2 (en) 2002-10-04 2009-03-17 Millennium Pharmaceuticals, Inc. PGD2 receptor antagonists for the treatment of inflammatory diseases
EP1578415B1 (en) 2002-12-20 2008-09-10 Pfizer Products Inc. Dosage forms comprising a cetp inhibitor and an hmg-coa reductase inhibitor
EP1594843B1 (en) 2003-02-18 2013-05-22 Takasago International Corporation METHOD FOR PRODUCING AN OPTICALLY ACTIVE beta-amino acid derivative
BRPI0407954A (pt) * 2003-03-17 2006-03-07 Kaneka Corp processo para a produção de derivado de amida de ácido (r)-3-[4-(trifluorometil) fenilamino]-pentanóico
US7223859B2 (en) 2003-03-17 2007-05-29 Pfizer Inc. Method for producing (R)-3-[4-(trifluoromethyl) phenylamino]-pentanoic acid amide derivative
CN1886124A (zh) 2003-09-26 2006-12-27 日本烟草产业株式会社 抑制残余脂蛋白产生的方法
US7749992B2 (en) * 2003-10-08 2010-07-06 Eli Lilly And Company Compounds and methods for treating dislipidemia
JP4839221B2 (ja) * 2003-11-07 2011-12-21 ジェイ ジェイ ファーマ，インコーポレイテッド Ｈｄｌを高める併用療法用複合物
WO2005100321A1 (en) * 2004-04-07 2005-10-27 Millennium Pharmaceuticals, Inc. Pgd2 receptor antagonists for the treatment of inflammatory diseases
KR20070041452A (ko) * 2004-06-24 2007-04-18 일라이 릴리 앤드 캄파니 이상지혈증 치료를 위한 화합물 및 방법
DE102004031656A1 (de) * 2004-06-30 2006-01-19 Merck Patent Gmbh Tetrahydrochinoline
US7700774B2 (en) * 2004-12-20 2010-04-20 Dr. Reddy's Laboratories Ltd. Heterocyclic compounds and their pharmaceutical compositions
RU2007135224A (ru) 2005-02-24 2009-03-27 Милленниум Фармасьютикалз, Инк. (Us) Антагонисты рецептора pgd2 для лечения воспалительных заболеваний
EP1896402A4 (en) * 2005-06-20 2010-07-28 Astrazeneca Ab PROCESS FOR THE SYNTHESIS OF (ALKOXYCARBONYLAMINO) ALKYLSULFONATES
TW200808731A (en) 2006-03-30 2008-02-16 Tanabe Seiyaku Co A process for preparing tetrahydroquinoline derivatives
DE102006031143A1 (de) * 2006-07-04 2008-01-24 Merck Patent Gmbh Fluortenside
DE102006032391A1 (de) * 2006-07-04 2008-01-17 Merck Patent Gmbh Fluortenside
DE102006031149A1 (de) * 2006-07-04 2008-01-10 Merck Patent Gmbh Fluortenside
DE102006031262A1 (de) * 2006-07-04 2008-01-10 Merck Patent Gmbh Fluortenside
DE102006031151A1 (de) * 2006-07-04 2008-01-10 Merck Patent Gmbh Fluortenside
CL2008000684A1 (es) 2007-03-09 2008-08-01 Indigene Pharmaceuticals Inc Composicion farmaceutica que comprende metformina r-(+) lipoato y un inhibidor de reductasa hmg-coa; formulacion de dosis unitaria; y uso en el tratamiento de una complicacion diabetica.
JP2011256110A (ja) * 2008-09-30 2011-12-22 Takeda Chem Ind Ltd ヘキサヒドロピロロキノリンの製造法
AR077208A1 (es) 2009-06-30 2011-08-10 Lilly Co Eli Derivados del acido trans-4-[[(5s)-5-[[[3,5-bis(trifluorometil) fenil] metil] (2-metil-2h-tetrazol-5-il) amino) -2,3,4,5-tetrahidro-7,9-dimetil-1h-1-benzazepin-1-il) metil)-ciclohexancarboxilico y sus formas cristalinas, composiciones farmaceuticas que los comprenden, su uso para preparar un medicam
RU2597266C2 (ru) 2011-04-12 2016-09-10 Чхон Кхун Дан Фармасьютикал Корп. Циклоалкениларильные производные для ингибирования транспортного белка холестериновых эфиров
CN103648495A (zh) 2011-07-08 2014-03-19 诺华股份有限公司 在高甘油三酯对象中治疗动脉粥样硬化的方法
HUE033790T2 (en) 2013-01-31 2017-12-28 Chong Kun Dang Pharmaceutical Corp Biaryl- or heterocyclic biaryl-substituted cyclohexene derivative compounds as cetp inhibitors
CA2926010A1 (en) * 2013-11-11 2015-05-14 Lonza Ltd Method for preparation of cyano compounds of the 13th group with a lewis acid
SG11201701077XA (en) * 2014-08-12 2017-03-30 Dezima Pharma B V Process for preparing synthetic intermediates for preparing tetrahydroquinoline derivatives
CN105294559B (zh) * 2015-06-24 2017-11-14 厦门法茉维特动物药业有限公司 一种医药中间体4‑氨基喹啉类化合物的合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW205037B (da) * 1989-10-06 1993-05-01 Takeda Pharm Industry Co Ltd
ES2257864T3 (es) 1998-07-10 2006-08-01 Massachusetts Institute Of Technology Ligandos para metales y procesos mejorados catalizados por metales basados en los mismos.
US6197786B1 (en) 1998-09-17 2001-03-06 Pfizer Inc 4-Carboxyamino-2-substituted-1,2,3,4-tetrahydroquinolines
GT199900147A (es) 1998-09-17 1999-09-06 1, 2, 3, 4- tetrahidroquinolinas 2-sustituidas 4-amino sustituidas.

Also Published As

Publication number Publication date
AR035963A1 (es) 2004-07-28
IL157544A0 (en) 2004-03-28
IL157546A0 (en) 2004-03-28
CN1297541C (zh) 2007-01-31
KR100591998B1 (ko) 2006-06-22
WO2002088085A3 (en) 2004-03-25
US6706881B2 (en) 2004-03-16
RU2003131871A (ru) 2005-04-10
EP1425270B1 (en) 2006-03-29
ZA200306600B (en) 2004-08-25
KR20040030603A (ko) 2004-04-09
RU2259355C2 (ru) 2005-08-27
KR100639745B1 (ko) 2006-10-30
HK1062294A1 (en) 2004-10-29
HUP0304041A3 (en) 2005-08-29
JP3924250B2 (ja) 2007-06-06
MXPA03009935A (es) 2004-01-29
KR20040015200A (ko) 2004-02-18
CA2445693A1 (en) 2002-11-07
US20020177716A1 (en) 2002-11-28
MXPA03009936A (es) 2004-01-29
JP2004527556A (ja) 2004-09-09
WO2002088069A3 (en) 2003-02-20
RU2265010C2 (ru) 2005-11-27
WO2002088069A9 (en) 2003-12-04
US6689897B2 (en) 2004-02-10
WO2002088069A2 (en) 2002-11-07
BR0209291A (pt) 2004-07-13
EP1383734A2 (en) 2004-01-28
ATE321755T1 (de) 2006-04-15
US20030216576A1 (en) 2003-11-20
YU84403A (sh) 2006-08-17
CZ20032898A3 (cs) 2004-07-14
HUP0304039A3 (en) 2005-10-28
PT1425270E (pt) 2006-07-31
CA2445623A1 (en) 2002-11-07
DE60209004D1 (de) 2006-04-13
ZA200306599B (en) 2004-10-22
US20030073843A1 (en) 2003-04-17
CN1529696A (zh) 2004-09-15
YU84303A (sh) 2006-05-25
EP1383734B1 (en) 2006-02-01
ES2259080T3 (es) 2006-09-16
DE60209004T2 (de) 2006-09-28
JP3924251B2 (ja) 2007-06-06
AU2002253448B2 (en) 2007-07-05
CN100357265C (zh) 2007-12-26
DK1383734T3 (da) 2006-05-15
CN1505609A (zh) 2004-06-16
US6600045B2 (en) 2003-07-29
ATE316957T1 (de) 2006-02-15
HUP0304039A2 (hu) 2004-03-29
WO2002088085A2 (en) 2002-11-07
CZ20032900A3 (cs) 2004-06-16
PL366700A1 (en) 2005-02-07
AR036331A1 (es) 2004-09-01
BR0209238A (pt) 2004-06-15
CN1680292A (zh) 2005-10-12
HUP0304041A2 (hu) 2004-04-28
PL366584A1 (en) 2005-02-07
ES2256461T3 (es) 2006-07-16
TWI250974B (en) 2006-03-11
JP2004531541A (ja) 2004-10-14
DE60210265T2 (de) 2006-10-12
RU2003131870A (ru) 2005-01-27
HU225777B1 (en) 2007-08-28
DE60210265D1 (de) 2006-05-18
EP1425270A2 (en) 2004-06-09
AR044706A2 (es) 2005-09-21
CN1267411C (zh) 2006-08-02

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