DK12685D0 - Ergolinderivater - Google Patents

Ergolinderivater

Info

Publication number: DK12685D0
Authority: DK; Denmark
Prior art keywords: ergoline
Prior art date: 1984-01-12

Application number

DK12685A

Other languages

English (en)

Other versions

DK12685A (da

DK169891B1 (da

Inventor

Walter Haefliger

Original Assignee

Sandoz Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-01-12

Filing date

1985-01-10

Publication date

1985-01-10

1985-01-10 Application filed by Sandoz Ag filed Critical Sandoz Ag

1985-01-10 Publication of DK12685D0 publication Critical patent/DK12685D0/da

1985-07-13 Publication of DK12685A publication Critical patent/DK12685A/da

1995-03-27 Application granted granted Critical

1995-03-27 Publication of DK169891B1 publication Critical patent/DK169891B1/da

Links

AWFDCTXCTHGORH-HGHGUNKESA-N 6-[4-[(6ar,9r,10ar)-5-bromo-7-methyl-6,6a,8,9,10,10a-hexahydro-4h-indolo[4,3-fg]quinoline-9-carbonyl]piperazin-1-yl]-1-methylpyridin-2-one Chemical compound O=C([C@H]1CN([C@H]2[C@@H](C=3C=CC=C4NC(Br)=C(C=34)C2)C1)C)N(CC1)CCN1C1=CC=CC(=O)N1C AWFDCTXCTHGORH-HGHGUNKESA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
- C07D457/06—Lysergic acid amides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/10—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hetero atoms directly attached in position 8
- C07D457/12—Nitrogen atoms

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Anesthesiology (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

DK012685A 1984-01-12 1985-01-10 8alfa-acylaminoergoliner og syreadditionssalte deraf, fremgangsmåde til fremstilling deraf, farmaceutiske præparater indeholdende 8alfa-acylaminoergolinerne eller syreadditionssaltene deraf samt 8alfa-acylaminoergolinerne og syreadditionssalte deraf til anvendelse til lægemidler DK169891B1 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE3400853		1984-01-12
DE3400853		1984-01-12

Publications (3)

Publication Number	Publication Date
DK12685D0 true DK12685D0 (da)	1985-01-10
DK12685A DK12685A (da)	1985-07-13
DK169891B1 DK169891B1 (da)	1995-03-27

Family

ID=6224786

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK012685A DK169891B1 (da)	1984-01-12	1985-01-10	8alfa-acylaminoergoliner og syreadditionssalte deraf, fremgangsmåde til fremstilling deraf, farmaceutiske præparater indeholdende 8alfa-acylaminoergolinerne eller syreadditionssaltene deraf samt 8alfa-acylaminoergolinerne og syreadditionssalte deraf til anvendelse til lægemidler

Country Status (28)

Country	Link
US (2)	US4950672A (da)
JP (1)	JPH0655739B2 (da)
AT (1)	AT391317B (da)
AU (3)	AU583489B2 (da)
BE (1)	BE901456A (da)
CA (1)	CA1245640A (da)
CH (1)	CH664568A5 (da)
CY (1)	CY1542A (da)
DE (1)	DE3500251C2 (da)
DK (1)	DK169891B1 (da)
ES (1)	ES8605514A1 (da)
FI (1)	FI82466C (da)
FR (1)	FR2560196B1 (da)
GB (1)	GB2152507B (da)
GR (1)	GR850065B (da)
HK (1)	HK48590A (da)
HU (1)	HU197569B (da)
IE (1)	IE58228B1 (da)
IL (1)	IL74043A (da)
IT (1)	IT1214648B (da)
LU (1)	LU85725A1 (da)
NL (1)	NL193541C (da)
NZ (1)	NZ210818A (da)
PH (1)	PH23286A (da)
PT (1)	PT79818B (da)
SE (1)	SE460420B (da)
SG (1)	SG32390G (da)
ZA (1)	ZA85276B (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU197569B (en) *	1984-01-12	1989-04-28	Sandoz Ag	Process for producing 8alpha-acylaminoergoline derivatives and pharmaceuticals comprising such compounds
ATE107647T1 (de) *	1984-04-09	1994-07-15	Schering Ag	2-substituierte ergolin-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
HUT45248A (en) *	1986-01-24	1988-06-28	Sandoz Ag	Process for producing 8alpha-(acylamino)-ergoline derivatives and pharmaceuticals comprising such compounds
US4981859A (en) *	1987-06-15	1991-01-01		Cycloalkylamides of (8 beta )-1-alkyl-6-(substituted)ergolines
US4931447A (en) *	1987-06-15	1990-06-05	Eli Lilly And Company	Cycloalkylamides of (8β)-1-alkyl-6-(substituted) ergolines
IT1219652B (it) *	1987-06-23	1990-05-24	Sandoz Ag	8-acilamminoergolina,la sua preparazione e il suo impiego come medicamneto
DE3820159A1 (de) *	1987-06-23	1989-01-05	Sandoz Ag	8(alpha)-acylaminoergolin, seine herstellung und dieses enthaltende arzneimittel
DK338789A (da) *	1988-07-15	1990-01-16	Schering Ag	2-substituerede ergolinylurinstofderivater og fremgangsmaade til fremstilling deraf, deres anvendelse som laegemidler samt mellemprodukter til fremstilling deraf
GB8824744D0 (en) *	1988-10-21	1988-11-30	Erba Carlo Spa	Antiemesis ergoline derivatives
DE3915950A1 (de) *	1989-05-12	1990-11-15	Schering Ag	8(alpha)-acylamino-ergoline, ihre herstellung und verwendung als arzneimittel
CN107428745A (zh)	2015-01-20	2017-12-01	Xoc制药股份有限公司	麦角灵化合物及其用途
EP3247357A4 (en) *	2015-01-20	2018-07-11	Xoc Pharmaceuticals, Inc	Isoergoline compounds and uses thereof
WO2018223065A1 (en)	2017-06-01	2018-12-06	Xoc Pharmaceuticals, Inc.	Ergoline derivatives for use in medicine

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3218323A (en) *		1965-11-16		Esters of i,g-dimethyl-b-ergolenyl carbamic acid
US2864822A (en) *	1956-10-22	1958-12-16	Lilly Co Eli	9-amino-7-methyl-belta10-ergolene and derivatives thereof
CH622519A5 (en) *	1974-07-05	1981-04-15	Hoechst Ag	Process for the preparation of hydroxyalkylxanthines
GB1517973A (en) *	1974-07-19	1978-07-19	Sandoz Ltd	6-methyl-8alpha-n,n-dimethylsulphamoylaminoergoline i
US4348392A (en) *	1974-07-19	1982-09-07	Sandoz Ltd.	8α-Substituted ergoline-I derivatives
US3922347A (en) *	1974-12-19	1975-11-25	Lilly Co Eli	Method of inhibiting prolactin secretion with 8-acylaminoergolenes
CH615929A5 (en) *	1975-06-02	1980-02-29	Sandoz Ag	Process for the preparation of novel ergoline compounds
DE2656344A1 (de) *	1975-12-23	1977-07-07	Sandoz Ag	Ergolinderivate, ihre verwendung und herstellung
CH622518A5 (en) *	1976-12-14	1981-04-15	Sandoz Ag	Process for the preparation of novel ergoline compounds
CH644606A5 (de) *	1980-09-23	1984-08-15	Sandoz Ag	Verfahren zur isomerisierung von 9,10-dihydrolysergsaeurederivaten.
DE3151912A1 (de) *	1981-12-23	1983-06-30	Schering Ag, 1000 Berlin Und 4619 Bergkamen	Neue ergolin-aminoderivate, verfahren zu ihrer herstellung und deren verwendung als arzneimittel
HU197569B (en) *	1984-01-12	1989-04-28	Sandoz Ag	Process for producing 8alpha-acylaminoergoline derivatives and pharmaceuticals comprising such compounds
NL8503426A (nl) *	1984-12-24	1986-07-16	Sandoz Ag	8alfa-acylamino-ergolinen, werkwijzen voor hun bereiding en farmaceutische preparaten die ze bevatten.
IT1219652B (it) *	1987-06-23	1990-05-24	Sandoz Ag	8-acilamminoergolina,la sua preparazione e il suo impiego come medicamneto

1985
- 1985-01-03 HU HU8524A patent/HU197569B/hu unknown
- 1985-01-03 CH CH16/85A patent/CH664568A5/de not_active IP Right Cessation
- 1985-01-03 NL NL8500008A patent/NL193541C/nl not_active IP Right Cessation
- 1985-01-05 DE DE3500251A patent/DE3500251C2/de not_active Expired - Fee Related
- 1985-01-07 FR FR8500217A patent/FR2560196B1/fr not_active Expired
- 1985-01-08 BE BE1/11168A patent/BE901456A/fr not_active IP Right Cessation
- 1985-01-08 GB GB08500454A patent/GB2152507B/en not_active Expired
- 1985-01-10 CA CA000471859A patent/CA1245640A/en not_active Expired
- 1985-01-10 PT PT79818A patent/PT79818B/pt not_active IP Right Cessation
- 1985-01-10 GR GR850065A patent/GR850065B/el unknown
- 1985-01-10 DK DK012685A patent/DK169891B1/da active
- 1985-01-10 SE SE8500107A patent/SE460420B/sv not_active IP Right Cessation
- 1985-01-10 IE IE6485A patent/IE58228B1/en not_active IP Right Cessation
- 1985-01-10 LU LU85725A patent/LU85725A1/fr unknown
- 1985-01-11 JP JP60003913A patent/JPH0655739B2/ja not_active Expired - Lifetime
- 1985-01-11 IT IT8547538A patent/IT1214648B/it active
- 1985-01-11 NZ NZ210818A patent/NZ210818A/xx unknown
- 1985-01-11 AT AT0005985A patent/AT391317B/de not_active IP Right Cessation
- 1985-01-11 ZA ZA85276A patent/ZA85276B/xx unknown
- 1985-01-11 FI FI850130A patent/FI82466C/fi not_active IP Right Cessation
- 1985-01-11 AU AU37609/85A patent/AU583489B2/en not_active Ceased
- 1985-01-11 ES ES539511A patent/ES8605514A1/es not_active Expired
- 1985-01-11 IL IL74043A patent/IL74043A/xx not_active IP Right Cessation
- 1985-01-14 PH PH31714A patent/PH23286A/en unknown
1988
- 1988-11-11 AU AU25067/88A patent/AU618290B2/en not_active Ceased
- 1988-11-11 AU AU25066/88A patent/AU609539B2/en not_active Ceased
1989
- 1989-02-27 US US07/316,363 patent/US4950672A/en not_active Expired - Fee Related
1990
- 1990-05-02 SG SG32390A patent/SG32390G/en unknown
- 1990-06-21 HK HK485/90A patent/HK48590A/xx not_active IP Right Cessation
- 1990-07-02 US US07/547,899 patent/US5077298A/en not_active Expired - Lifetime
1991
- 1991-03-22 CY CY1542A patent/CY1542A/en unknown

Also Published As

Publication number	Publication date
GB2152507B (en)	1987-07-15
AU583489B2 (en)	1989-05-04
SG32390G (en)	1990-08-03
AU618290B2 (en)	1991-12-19
NL193541C (nl)	2000-01-04
ES8605514A1 (es)	1986-03-16
CY1542A (en)	1991-03-22
ZA85276B (en)	1986-08-27
DE3500251A1 (de)	1985-07-18
AU3760985A (en)	1985-07-18
AU2506688A (en)	1989-02-23
FI850130A0 (fi)	1985-01-11
PT79818B (en)	1987-01-07
IT8547538A0 (it)	1985-01-11
SE8500107L (sv)	1985-07-13
JPS60174783A (ja)	1985-09-09
FR2560196A1 (fr)	1985-08-30
NL193541B (nl)	1999-09-01
AU609539B2 (en)	1991-05-02
DK12685A (da)	1985-07-13
SE8500107D0 (sv)	1985-01-10
GB8500454D0 (en)	1985-02-13
US5077298A (en)	1991-12-31
IE850064L (en)	1985-07-12
GB2152507A (en)	1985-08-07
IL74043A0 (en)	1985-04-30
HK48590A (en)	1990-06-29
CH664568A5 (de)	1988-03-15
CA1245640A (en)	1988-11-29
SE460420B (sv)	1989-10-09
AU2506788A (en)	1989-03-02
HUT37148A (en)	1985-11-28
FR2560196B1 (fr)	1986-07-18
ES539511A0 (es)	1986-03-16
GR850065B (da)	1985-05-03
IL74043A (en)	1988-10-31
FI82466B (fi)	1990-11-30
FI82466C (fi)	1991-03-11
LU85725A1 (fr)	1985-10-22
HU197569B (en)	1989-04-28
FI850130L (fi)	1985-07-13
DK169891B1 (da)	1995-03-27
IT1214648B (it)	1990-01-18
US4950672A (en)	1990-08-21
AT391317B (de)	1990-09-25
IE58228B1 (en)	1993-08-11
NZ210818A (en)	1989-02-24
PH23286A (en)	1989-06-30
NL8500008A (nl)	1985-08-01
JPH0655739B2 (ja)	1994-07-27
BE901456A (fr)	1985-07-08
ATA5985A (de)	1990-03-15
DE3500251C2 (de)	1995-01-26
PT79818A (en)	1985-02-01

Publication	Publication Date	Title
AT380762B (de)	1986-07-10	Hoergeraet
AT379929B (de)	1986-03-10	Hoergeraet
DK12685A (da)	1985-07-13	Ergolinderivater
ATA98284A (de)	1991-06-15	Schalplatte
AT386724B (de)	1988-10-10	Haecksler
ATA135485A (de)	1990-07-15	Maishaecksler
DK35787A (da)	1987-07-25	Ergolinderivater
ATA237384A (de)	1989-03-15	Maehwerk
ATE36715T1 (de)	1988-09-15	7-d-mandelamido-3-(1-sulfomethyltetrazol-5us840229
ATA45484A (de)	1985-05-15	Kimme
AT389296B (de)	1989-11-10	Elektrokoagulator
BR8402733A (pt)	1986-01-07	Divisoria
ES283027Y (es)	1988-06-16	Piezas portafichas
AR231237A1 (es)	1984-10-31	Calzado-patin
SE8405602D0 (sv)	1984-11-09	N-festet
BR8404648A (pt)	1986-06-03	Minifone
BR8400417A (pt)	1985-09-03	Moto-continuo magnetico
BR8405625A (pt)	1986-06-10	Gasogenio
BR8406630A (pt)	1986-07-01	Volumometro
BR8404566A (pt)	1986-04-15	Paramortecedor
DK271485A (da)	1985-12-17	Plaenesaks
BR8404385A (pt)	1986-04-08	Regua nautica
FI840371A0 (fi)	1984-01-30	Foerpackning foer skodon
BR8401508A (pt)	1985-11-05	Arquibancada
BR8401157A (pt)	1985-10-29	Auto-balsa