DK1040119T3 - Hemiasterlinanaloger - Google Patents
HemiasterlinanalogerInfo
- Publication number
- DK1040119T3 DK1040119T3 DK98962157T DK98962157T DK1040119T3 DK 1040119 T3 DK1040119 T3 DK 1040119T3 DK 98962157 T DK98962157 T DK 98962157T DK 98962157 T DK98962157 T DK 98962157T DK 1040119 T3 DK1040119 T3 DK 1040119T3
- Authority
- DK
- Denmark
- Prior art keywords
- hemiasterline
- analogues
- analogs
- hemiasterlin
- synthesis
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Crystallography & Structural Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Junction Field-Effect Transistors (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Amplifiers (AREA)
- Steroid Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA002225325A CA2225325A1 (en) | 1997-12-19 | 1997-12-19 | Hemiasterlin analogs |
| PCT/CA1998/001184 WO1999032509A2 (en) | 1997-12-19 | 1998-12-18 | Hemiasterlin analogs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1040119T3 true DK1040119T3 (da) | 2009-04-14 |
Family
ID=4161925
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK98962157T DK1040119T3 (da) | 1997-12-19 | 1998-12-18 | Hemiasterlinanaloger |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US7579323B1 (da) |
| EP (1) | EP1040119B1 (da) |
| JP (1) | JP4417551B2 (da) |
| KR (1) | KR100937756B1 (da) |
| CN (1) | CN100422208C (da) |
| AT (1) | ATE419268T1 (da) |
| AU (1) | AU762691C (da) |
| BR (1) | BR9813817A (da) |
| CA (2) | CA2225325A1 (da) |
| DE (1) | DE69840415D1 (da) |
| DK (1) | DK1040119T3 (da) |
| ES (1) | ES2320499T3 (da) |
| HU (1) | HUP0105460A3 (da) |
| IL (1) | IL136654A0 (da) |
| NZ (1) | NZ505086A (da) |
| WO (1) | WO1999032509A2 (da) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003224644A1 (en) * | 2002-02-27 | 2003-09-09 | The Government Of The United States Of America, Represented By The Secretary, Department Of Healtan | Conjugates of ligand, linker and cytotoxic agent and related compositions and methods of use |
| RU2342399C2 (ru) * | 2002-03-22 | 2008-12-27 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Производные гемиастерлина и их применение при лечении рака |
| US7064211B2 (en) | 2002-03-22 | 2006-06-20 | Eisai Co., Ltd. | Hemiasterlin derivatives and uses thereof |
| US20040121965A1 (en) * | 2002-09-20 | 2004-06-24 | Wyeth Holdings Corporation | Method of treating resistant tumors |
| WO2004026814A2 (en) | 2002-09-20 | 2004-04-01 | Wyeth Holdings Corporation | Process for the synthesis of intermediates useful for the synthesis of tubulin inhibitors |
| US20070026478A1 (en) * | 2002-11-21 | 2007-02-01 | Wyeth | Hemiasterlin affinity probes and their uses |
| US7390910B2 (en) | 2003-08-08 | 2008-06-24 | Wyeth | Compounds for treating tumors |
| GB201001070D0 (en) | 2010-01-22 | 2010-03-10 | St George's Hospital Medical School | Theraputic compounds and their use |
| TR201911139T4 (tr) | 2013-03-15 | 2019-08-21 | Zymeworks Inc | Sitotoksik ve anti-mitotik bileşikler ve bunları kullanmanın yöntemleri. |
| EP3086815B1 (en) * | 2013-12-27 | 2022-02-09 | Zymeworks Inc. | Sulfonamide-containing linkage systems for drug conjugates |
| AU2014373640B2 (en) * | 2013-12-27 | 2018-08-30 | Var2 Pharmaceuticals Aps | VAR2CSA-drug conjugates |
| SG11201702143PA (en) | 2014-09-17 | 2017-04-27 | Zymeworks Inc | Cytotoxic and anti-mitotic compounds, and methods of using the same |
| EP3892305A1 (en) * | 2015-01-30 | 2021-10-13 | Sutro Biopharma, Inc. | Hemiasterlin derivatives for conjugation and therapy |
| AU2017273857B2 (en) | 2016-06-01 | 2021-08-19 | Athira Pharma, Inc. | Compounds |
| US10517958B2 (en) | 2016-10-04 | 2019-12-31 | Zymeworks Inc. | Compositions and methods for the treatment of platinum-drug resistant cancer |
| US11179441B2 (en) | 2017-01-06 | 2021-11-23 | The Board Of Trustees Of The Leland Stanford Junior University | Ciliary neurotrophic factor receptor ligands and methods of using the same |
| TWI805602B (zh) | 2017-08-10 | 2023-06-21 | 日商住友製藥股份有限公司 | 包含半星芒體衍生物之抗體藥物複合體 |
| WO2019031615A1 (ja) | 2017-08-10 | 2019-02-14 | 大日本住友製薬株式会社 | ヘミアスタリン誘導体及びこれらの抗体薬物複合体 |
| CN113412271B (zh) | 2019-02-13 | 2024-10-22 | 住友制药株式会社 | 具有半胱氨酸残基的哈米特林衍生物 |
| US12178879B2 (en) | 2019-02-13 | 2024-12-31 | Sumitomo Pharma Co., Ltd. | Hemiasterlin derivative and antibody-drug conjugate thereof |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1049404B (it) | 1975-04-09 | 1981-01-20 | Zambeletti Spa L | Tripeptidi loro esteri ed amidi ad attivita antiulcera |
| EP0150227A1 (en) | 1983-12-23 | 1985-08-07 | FUJIREBIO KABUSHIKI KAISHA also trading as FUJIREBIO INC. | Dipeptide derivatives and their use in determining the activity of carboxypeptidase A |
| IT1209644B (it) * | 1985-06-21 | 1989-08-30 | Isf Spa | Composti farmacologicamente attivi. |
| US4820691A (en) | 1987-06-24 | 1989-04-11 | E. R. Squibb & Sons, Inc. | Amino acid 1,2-diketo derivatives as renin inhibitors |
| CA2042027A1 (en) | 1989-09-15 | 1991-03-16 | Arthur E. Bogden | Treatment of colon cancer |
| GB9508195D0 (en) | 1995-04-20 | 1995-06-07 | Univ British Columbia | Novel biologically active compounds and compositions,their use and derivation |
| US5811515A (en) * | 1995-06-12 | 1998-09-22 | California Institute Of Technology | Synthesis of conformationally restricted amino acids, peptides, and peptidomimetics by catalytic ring closing metathesis |
| US5661175A (en) | 1995-06-20 | 1997-08-26 | Kashman; Yoel | Hemiasterlin and geodiamolide TA |
| ES2230566T3 (es) * | 1995-07-17 | 2005-05-01 | Medivir Uk Ltd | Inhibidores de la cisteina proteasa para el tratamiento de enfermedades alergicas mediadas por la inmunoglobulina e (ige). |
| US6214799B1 (en) * | 1996-05-14 | 2001-04-10 | Agouron Pharmaceuticals, Inc. | Antipicornaviral compounds and methods for their use and preparation |
| US6126939A (en) * | 1996-09-03 | 2000-10-03 | Yeda Research And Development Co. Ltd. | Anti-inflammatory dipeptide and pharmaceutical composition thereof |
| US6331554B1 (en) * | 1997-03-28 | 2001-12-18 | Agouron Pharmaceuticals, Inc. | Antipicornaviral compounds, compositions containing them, and methods for their use |
| US6194578B1 (en) | 1998-11-20 | 2001-02-27 | Pfizer Inc. | Dipeptide derivatives |
-
1997
- 1997-12-19 CA CA002225325A patent/CA2225325A1/en not_active Abandoned
-
1998
- 1998-12-13 US US09/581,511 patent/US7579323B1/en not_active Expired - Fee Related
- 1998-12-18 WO PCT/CA1998/001184 patent/WO1999032509A2/en not_active Ceased
- 1998-12-18 BR BR9813817-0A patent/BR9813817A/pt not_active Application Discontinuation
- 1998-12-18 DK DK98962157T patent/DK1040119T3/da active
- 1998-12-18 DE DE69840415T patent/DE69840415D1/de not_active Expired - Lifetime
- 1998-12-18 JP JP2000525446A patent/JP4417551B2/ja not_active Expired - Fee Related
- 1998-12-18 CN CNB988124343A patent/CN100422208C/zh not_active Expired - Fee Related
- 1998-12-18 AT AT98962157T patent/ATE419268T1/de not_active IP Right Cessation
- 1998-12-18 AU AU17459/99A patent/AU762691C/en not_active Ceased
- 1998-12-18 IL IL13665498A patent/IL136654A0/xx unknown
- 1998-12-18 KR KR1020007006814A patent/KR100937756B1/ko not_active Expired - Fee Related
- 1998-12-18 HU HU0105460A patent/HUP0105460A3/hu unknown
- 1998-12-18 EP EP98962157A patent/EP1040119B1/en not_active Expired - Lifetime
- 1998-12-18 CA CA2312826A patent/CA2312826C/en not_active Expired - Fee Related
- 1998-12-18 ES ES98962157T patent/ES2320499T3/es not_active Expired - Lifetime
- 1998-12-18 NZ NZ505086A patent/NZ505086A/en unknown
-
2009
- 2009-06-25 US US12/491,839 patent/US20090264487A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ES2320499T3 (es) | 2009-05-22 |
| JP4417551B2 (ja) | 2010-02-17 |
| IL136654A0 (en) | 2001-06-14 |
| DE69840415D1 (de) | 2009-02-12 |
| EP1040119B1 (en) | 2008-12-31 |
| AU762691B2 (en) | 2003-07-03 |
| US7579323B1 (en) | 2009-08-25 |
| KR20010024783A (ko) | 2001-03-26 |
| AU1745999A (en) | 1999-07-12 |
| HUP0105460A3 (en) | 2002-08-28 |
| NZ505086A (en) | 2003-05-30 |
| ATE419268T1 (de) | 2009-01-15 |
| US20090264487A1 (en) | 2009-10-22 |
| HUP0105460A2 (en) | 2002-06-29 |
| AU762691C (en) | 2004-07-08 |
| CN100422208C (zh) | 2008-10-01 |
| EP1040119A2 (en) | 2000-10-04 |
| HK1034523A1 (zh) | 2001-10-26 |
| CA2225325A1 (en) | 1999-06-19 |
| WO1999032509A2 (en) | 1999-07-01 |
| CN1282336A (zh) | 2001-01-31 |
| CA2312826C (en) | 2013-06-11 |
| CA2312826A1 (en) | 1999-07-01 |
| BR9813817A (pt) | 2000-10-10 |
| WO1999032509A3 (en) | 1999-10-07 |
| KR100937756B1 (ko) | 2010-01-20 |
| JP2001526294A (ja) | 2001-12-18 |
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