IL136654A0 - Hemiasterlin analogs - Google Patents
Hemiasterlin analogsInfo
- Publication number
- IL136654A0 IL136654A0 IL13665498A IL13665498A IL136654A0 IL 136654 A0 IL136654 A0 IL 136654A0 IL 13665498 A IL13665498 A IL 13665498A IL 13665498 A IL13665498 A IL 13665498A IL 136654 A0 IL136654 A0 IL 136654A0
- Authority
- IL
- Israel
- Prior art keywords
- analogs
- hemiasterlin
- hemiasterlin analogs
- synthesis
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Junction Field-Effect Transistors (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Steroid Compounds (AREA)
- Amplifiers (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrrole Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA002225325A CA2225325A1 (en) | 1997-12-19 | 1997-12-19 | Hemiasterlin analogs |
| PCT/CA1998/001184 WO1999032509A2 (en) | 1997-12-19 | 1998-12-18 | Hemiasterlin analogs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL136654A0 true IL136654A0 (en) | 2001-06-14 |
Family
ID=4161925
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL13665498A IL136654A0 (en) | 1997-12-19 | 1998-12-18 | Hemiasterlin analogs |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US7579323B1 (xx) |
| EP (1) | EP1040119B1 (xx) |
| JP (1) | JP4417551B2 (xx) |
| KR (1) | KR100937756B1 (xx) |
| CN (1) | CN100422208C (xx) |
| AT (1) | ATE419268T1 (xx) |
| AU (1) | AU762691C (xx) |
| BR (1) | BR9813817A (xx) |
| CA (2) | CA2225325A1 (xx) |
| DE (1) | DE69840415D1 (xx) |
| DK (1) | DK1040119T3 (xx) |
| ES (1) | ES2320499T3 (xx) |
| HU (1) | HUP0105460A3 (xx) |
| IL (1) | IL136654A0 (xx) |
| NZ (1) | NZ505086A (xx) |
| WO (1) | WO1999032509A2 (xx) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003072754A2 (en) * | 2002-02-27 | 2003-09-04 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Conjugates of ligand, linker and cytotoxic agent and related compositions and methods of use |
| US7064211B2 (en) | 2002-03-22 | 2006-06-20 | Eisai Co., Ltd. | Hemiasterlin derivatives and uses thereof |
| NZ555951A (en) * | 2002-03-22 | 2009-01-31 | Eisai Co Ltd | Hemiasterlin derivatives and uses thereof |
| US20040121965A1 (en) * | 2002-09-20 | 2004-06-24 | Wyeth Holdings Corporation | Method of treating resistant tumors |
| CA2498759A1 (en) | 2002-09-20 | 2004-04-01 | Wyeth Holdings Corporation | Process for the synthesis of intermediates useful for the synthesis of tubulin inhibitors |
| US20070026478A1 (en) * | 2002-11-21 | 2007-02-01 | Wyeth | Hemiasterlin affinity probes and their uses |
| US7390910B2 (en) * | 2003-08-08 | 2008-06-24 | Wyeth | Compounds for treating tumors |
| GB201001070D0 (en) | 2010-01-22 | 2010-03-10 | St George's Hospital Medical School | Theraputic compounds and their use |
| US10201614B2 (en) | 2013-03-15 | 2019-02-12 | Zymeworks Inc. | Cytotoxic and anti-mitotic compounds, and methods of using the same |
| EP3086815B1 (en) | 2013-12-27 | 2022-02-09 | Zymeworks Inc. | Sulfonamide-containing linkage systems for drug conjugates |
| BR112016015105A8 (pt) * | 2013-12-27 | 2018-04-24 | Var2 Pharmaceuticals Aps | conjugados var2csa-droga |
| US10450378B2 (en) | 2014-09-17 | 2019-10-22 | Zymeworks Inc. | Cytotoxic and anti-mitotic compounds, and methods of using the same |
| WO2016123582A1 (en) * | 2015-01-30 | 2016-08-04 | Sutro Biopharma, Inc. | Hemiasterlin derivatives for conjugation and therapy |
| DK3464336T3 (da) | 2016-06-01 | 2022-05-09 | Athira Pharma Inc | Forbindelser |
| US10517958B2 (en) | 2016-10-04 | 2019-12-31 | Zymeworks Inc. | Compositions and methods for the treatment of platinum-drug resistant cancer |
| US11179441B2 (en) | 2017-01-06 | 2021-11-23 | The Board Of Trustees Of The Leland Stanford Junior University | Ciliary neurotrophic factor receptor ligands and methods of using the same |
| EP4321523A3 (en) | 2017-08-10 | 2024-04-24 | Sumitomo Pharma Co., Ltd. | Hemiasterlin derivatives and antibody-drug conjugates including same |
| WO2019031614A1 (ja) | 2017-08-10 | 2019-02-14 | 大日本住友製薬株式会社 | ヘミアスタリン誘導体を含む抗体薬物複合体 |
| WO2020166592A1 (ja) | 2019-02-13 | 2020-08-20 | 大日本住友製薬株式会社 | ヘミアスタリン誘導体とその抗体薬物複合体 |
| CA3127312A1 (en) | 2019-02-13 | 2020-08-20 | Sumitomo Dainippon Pharma Co., Ltd. | Hemiasterlin derivative having cysteine residue |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1049404B (it) | 1975-04-09 | 1981-01-20 | Zambeletti Spa L | Tripeptidi loro esteri ed amidi ad attivita antiulcera |
| EP0150227A1 (en) | 1983-12-23 | 1985-08-07 | FUJIREBIO KABUSHIKI KAISHA also trading as FUJIREBIO INC. | Dipeptide derivatives and their use in determining the activity of carboxypeptidase A |
| IT1209644B (it) * | 1985-06-21 | 1989-08-30 | Isf Spa | Composti farmacologicamente attivi. |
| US4820691A (en) * | 1987-06-24 | 1989-04-11 | E. R. Squibb & Sons, Inc. | Amino acid 1,2-diketo derivatives as renin inhibitors |
| WO1991004040A1 (en) | 1989-09-15 | 1991-04-04 | Biomeasure, Inc. | Treatment of colon cancer |
| GB9508195D0 (en) | 1995-04-20 | 1995-06-07 | Univ British Columbia | Novel biologically active compounds and compositions,their use and derivation |
| US5811515A (en) * | 1995-06-12 | 1998-09-22 | California Institute Of Technology | Synthesis of conformationally restricted amino acids, peptides, and peptidomimetics by catalytic ring closing metathesis |
| US5661175A (en) | 1995-06-20 | 1997-08-26 | Kashman; Yoel | Hemiasterlin and geodiamolide TA |
| AU716716B2 (en) * | 1995-07-17 | 2000-03-02 | Medivir Uk Ltd | Cysteine protease inhibitors for use in treatment of IgE mediated allergic diseases |
| US6214799B1 (en) * | 1996-05-14 | 2001-04-10 | Agouron Pharmaceuticals, Inc. | Antipicornaviral compounds and methods for their use and preparation |
| US6126939A (en) * | 1996-09-03 | 2000-10-03 | Yeda Research And Development Co. Ltd. | Anti-inflammatory dipeptide and pharmaceutical composition thereof |
| US6331554B1 (en) * | 1997-03-28 | 2001-12-18 | Agouron Pharmaceuticals, Inc. | Antipicornaviral compounds, compositions containing them, and methods for their use |
| US6194578B1 (en) | 1998-11-20 | 2001-02-27 | Pfizer Inc. | Dipeptide derivatives |
-
1997
- 1997-12-19 CA CA002225325A patent/CA2225325A1/en not_active Abandoned
-
1998
- 1998-12-13 US US09/581,511 patent/US7579323B1/en not_active Expired - Fee Related
- 1998-12-18 BR BR9813817-0A patent/BR9813817A/pt not_active Application Discontinuation
- 1998-12-18 WO PCT/CA1998/001184 patent/WO1999032509A2/en not_active Ceased
- 1998-12-18 CN CNB988124343A patent/CN100422208C/zh not_active Expired - Fee Related
- 1998-12-18 IL IL13665498A patent/IL136654A0/xx unknown
- 1998-12-18 AT AT98962157T patent/ATE419268T1/de not_active IP Right Cessation
- 1998-12-18 DK DK98962157T patent/DK1040119T3/da active
- 1998-12-18 EP EP98962157A patent/EP1040119B1/en not_active Expired - Lifetime
- 1998-12-18 DE DE69840415T patent/DE69840415D1/de not_active Expired - Lifetime
- 1998-12-18 NZ NZ505086A patent/NZ505086A/en unknown
- 1998-12-18 ES ES98962157T patent/ES2320499T3/es not_active Expired - Lifetime
- 1998-12-18 JP JP2000525446A patent/JP4417551B2/ja not_active Expired - Fee Related
- 1998-12-18 CA CA2312826A patent/CA2312826C/en not_active Expired - Fee Related
- 1998-12-18 HU HU0105460A patent/HUP0105460A3/hu unknown
- 1998-12-18 AU AU17459/99A patent/AU762691C/en not_active Ceased
- 1998-12-18 KR KR1020007006814A patent/KR100937756B1/ko not_active Expired - Fee Related
-
2009
- 2009-06-25 US US12/491,839 patent/US20090264487A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2312826A1 (en) | 1999-07-01 |
| EP1040119B1 (en) | 2008-12-31 |
| CA2225325A1 (en) | 1999-06-19 |
| CN1282336A (zh) | 2001-01-31 |
| AU762691C (en) | 2004-07-08 |
| DE69840415D1 (de) | 2009-02-12 |
| KR20010024783A (ko) | 2001-03-26 |
| DK1040119T3 (da) | 2009-04-14 |
| EP1040119A2 (en) | 2000-10-04 |
| HUP0105460A2 (en) | 2002-06-29 |
| CN100422208C (zh) | 2008-10-01 |
| NZ505086A (en) | 2003-05-30 |
| CA2312826C (en) | 2013-06-11 |
| AU1745999A (en) | 1999-07-12 |
| KR100937756B1 (ko) | 2010-01-20 |
| US20090264487A1 (en) | 2009-10-22 |
| US7579323B1 (en) | 2009-08-25 |
| WO1999032509A2 (en) | 1999-07-01 |
| WO1999032509A3 (en) | 1999-10-07 |
| HK1034523A1 (zh) | 2001-10-26 |
| JP2001526294A (ja) | 2001-12-18 |
| AU762691B2 (en) | 2003-07-03 |
| ATE419268T1 (de) | 2009-01-15 |
| BR9813817A (pt) | 2000-10-10 |
| HUP0105460A3 (en) | 2002-08-28 |
| ES2320499T3 (es) | 2009-05-22 |
| JP4417551B2 (ja) | 2010-02-17 |
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