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IL136654A0 - Hemiasterlin analogs - Google Patents

Hemiasterlin analogs

Info

Publication number
IL136654A0
IL136654A0 IL13665498A IL13665498A IL136654A0 IL 136654 A0 IL136654 A0 IL 136654A0 IL 13665498 A IL13665498 A IL 13665498A IL 13665498 A IL13665498 A IL 13665498A IL 136654 A0 IL136654 A0 IL 136654A0
Authority
IL
Israel
Prior art keywords
analogs
hemiasterlin
hemiasterlin analogs
synthesis
methods
Prior art date
Application number
IL13665498A
Other languages
English (en)
Original Assignee
Univ British Columbia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ British Columbia filed Critical Univ British Columbia
Publication of IL136654A0 publication Critical patent/IL136654A0/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06008Dipeptides with the first amino acid being neutral
    • C07K5/06078Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06Esters of carbamic acids
    • C07C271/08Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Junction Field-Effect Transistors (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Amplifiers (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrrole Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
IL13665498A 1997-12-19 1998-12-18 Hemiasterlin analogs IL136654A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CA002225325A CA2225325A1 (en) 1997-12-19 1997-12-19 Hemiasterlin analogs
PCT/CA1998/001184 WO1999032509A2 (en) 1997-12-19 1998-12-18 Hemiasterlin analogs

Publications (1)

Publication Number Publication Date
IL136654A0 true IL136654A0 (en) 2001-06-14

Family

ID=4161925

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13665498A IL136654A0 (en) 1997-12-19 1998-12-18 Hemiasterlin analogs

Country Status (16)

Country Link
US (2) US7579323B1 (xx)
EP (1) EP1040119B1 (xx)
JP (1) JP4417551B2 (xx)
KR (1) KR100937756B1 (xx)
CN (1) CN100422208C (xx)
AT (1) ATE419268T1 (xx)
AU (1) AU762691C (xx)
BR (1) BR9813817A (xx)
CA (2) CA2225325A1 (xx)
DE (1) DE69840415D1 (xx)
DK (1) DK1040119T3 (xx)
ES (1) ES2320499T3 (xx)
HU (1) HUP0105460A3 (xx)
IL (1) IL136654A0 (xx)
NZ (1) NZ505086A (xx)
WO (1) WO1999032509A2 (xx)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003072754A2 (en) * 2002-02-27 2003-09-04 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Conjugates of ligand, linker and cytotoxic agent and related compositions and methods of use
US7064211B2 (en) 2002-03-22 2006-06-20 Eisai Co., Ltd. Hemiasterlin derivatives and uses thereof
NZ555951A (en) * 2002-03-22 2009-01-31 Eisai Co Ltd Hemiasterlin derivatives and uses thereof
US20040121965A1 (en) * 2002-09-20 2004-06-24 Wyeth Holdings Corporation Method of treating resistant tumors
CA2498759A1 (en) 2002-09-20 2004-04-01 Wyeth Holdings Corporation Process for the synthesis of intermediates useful for the synthesis of tubulin inhibitors
US20070026478A1 (en) * 2002-11-21 2007-02-01 Wyeth Hemiasterlin affinity probes and their uses
US7390910B2 (en) * 2003-08-08 2008-06-24 Wyeth Compounds for treating tumors
GB201001070D0 (en) 2010-01-22 2010-03-10 St George's Hospital Medical School Theraputic compounds and their use
US10201614B2 (en) 2013-03-15 2019-02-12 Zymeworks Inc. Cytotoxic and anti-mitotic compounds, and methods of using the same
EP3086815B1 (en) 2013-12-27 2022-02-09 Zymeworks Inc. Sulfonamide-containing linkage systems for drug conjugates
BR112016015105A8 (pt) * 2013-12-27 2018-04-24 Var2 Pharmaceuticals Aps conjugados var2csa-droga
US10450378B2 (en) 2014-09-17 2019-10-22 Zymeworks Inc. Cytotoxic and anti-mitotic compounds, and methods of using the same
WO2016123582A1 (en) * 2015-01-30 2016-08-04 Sutro Biopharma, Inc. Hemiasterlin derivatives for conjugation and therapy
DK3464336T3 (da) 2016-06-01 2022-05-09 Athira Pharma Inc Forbindelser
US10517958B2 (en) 2016-10-04 2019-12-31 Zymeworks Inc. Compositions and methods for the treatment of platinum-drug resistant cancer
US11179441B2 (en) 2017-01-06 2021-11-23 The Board Of Trustees Of The Leland Stanford Junior University Ciliary neurotrophic factor receptor ligands and methods of using the same
EP4321523A3 (en) 2017-08-10 2024-04-24 Sumitomo Pharma Co., Ltd. Hemiasterlin derivatives and antibody-drug conjugates including same
WO2019031614A1 (ja) 2017-08-10 2019-02-14 大日本住友製薬株式会社 ヘミアスタリン誘導体を含む抗体薬物複合体
WO2020166592A1 (ja) 2019-02-13 2020-08-20 大日本住友製薬株式会社 ヘミアスタリン誘導体とその抗体薬物複合体
CA3127312A1 (en) 2019-02-13 2020-08-20 Sumitomo Dainippon Pharma Co., Ltd. Hemiasterlin derivative having cysteine residue

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1049404B (it) 1975-04-09 1981-01-20 Zambeletti Spa L Tripeptidi loro esteri ed amidi ad attivita antiulcera
EP0150227A1 (en) 1983-12-23 1985-08-07 FUJIREBIO KABUSHIKI KAISHA also trading as FUJIREBIO INC. Dipeptide derivatives and their use in determining the activity of carboxypeptidase A
IT1209644B (it) * 1985-06-21 1989-08-30 Isf Spa Composti farmacologicamente attivi.
US4820691A (en) * 1987-06-24 1989-04-11 E. R. Squibb & Sons, Inc. Amino acid 1,2-diketo derivatives as renin inhibitors
WO1991004040A1 (en) 1989-09-15 1991-04-04 Biomeasure, Inc. Treatment of colon cancer
GB9508195D0 (en) 1995-04-20 1995-06-07 Univ British Columbia Novel biologically active compounds and compositions,their use and derivation
US5811515A (en) * 1995-06-12 1998-09-22 California Institute Of Technology Synthesis of conformationally restricted amino acids, peptides, and peptidomimetics by catalytic ring closing metathesis
US5661175A (en) 1995-06-20 1997-08-26 Kashman; Yoel Hemiasterlin and geodiamolide TA
AU716716B2 (en) * 1995-07-17 2000-03-02 Medivir Uk Ltd Cysteine protease inhibitors for use in treatment of IgE mediated allergic diseases
US6214799B1 (en) * 1996-05-14 2001-04-10 Agouron Pharmaceuticals, Inc. Antipicornaviral compounds and methods for their use and preparation
US6126939A (en) * 1996-09-03 2000-10-03 Yeda Research And Development Co. Ltd. Anti-inflammatory dipeptide and pharmaceutical composition thereof
US6331554B1 (en) * 1997-03-28 2001-12-18 Agouron Pharmaceuticals, Inc. Antipicornaviral compounds, compositions containing them, and methods for their use
US6194578B1 (en) 1998-11-20 2001-02-27 Pfizer Inc. Dipeptide derivatives

Also Published As

Publication number Publication date
CA2312826A1 (en) 1999-07-01
EP1040119B1 (en) 2008-12-31
CA2225325A1 (en) 1999-06-19
CN1282336A (zh) 2001-01-31
AU762691C (en) 2004-07-08
DE69840415D1 (de) 2009-02-12
KR20010024783A (ko) 2001-03-26
DK1040119T3 (da) 2009-04-14
EP1040119A2 (en) 2000-10-04
HUP0105460A2 (en) 2002-06-29
CN100422208C (zh) 2008-10-01
NZ505086A (en) 2003-05-30
CA2312826C (en) 2013-06-11
AU1745999A (en) 1999-07-12
KR100937756B1 (ko) 2010-01-20
US20090264487A1 (en) 2009-10-22
US7579323B1 (en) 2009-08-25
WO1999032509A2 (en) 1999-07-01
WO1999032509A3 (en) 1999-10-07
HK1034523A1 (zh) 2001-10-26
JP2001526294A (ja) 2001-12-18
AU762691B2 (en) 2003-07-03
ATE419268T1 (de) 2009-01-15
BR9813817A (pt) 2000-10-10
HUP0105460A3 (en) 2002-08-28
ES2320499T3 (es) 2009-05-22
JP4417551B2 (ja) 2010-02-17

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